Gene Page: HIRIP3

Summary ?
GeneID8479
SymbolHIRIP3
Synonyms-
DescriptionHIRA interacting protein 3
ReferenceMIM:603365|HGNC:HGNC:4917|Ensembl:ENSG00000149929|HPRD:04531|Vega:OTTHUMG00000132118
Gene typeprotein-coding
Map location16p11.2
Pascal p-value2.515E-9
Sherlock p-value0.081
Fetal beta0.141
DMG1 (# studies)

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CNV:YESCopy number variation studiesManual curation
CV:PGCnpGenome-wide Association StudyGWAS
DMG:vanEijk_2014Genome-wide DNA methylation analysisThis dataset includes 432 differentially methylated CpG sites corresponding to 391 unique transcripts between schizophrenia patients (n=260) and unaffected controls (n=250). 1
GSMA_IIEGenome scan meta-analysis (European-ancestry samples)Psr: 0.01775 

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg059952671629822529HIRIP37.949E-44.713DMG:vanEijk_2014


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
KBTBD70.970.97
SCYL20.960.97
WDR820.960.96
KBTBD60.960.96
RBMXL10.960.95
ASB70.950.95
ZMYM40.950.97
SPAST0.950.96
GRPEL20.950.95
C5orf240.950.96
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
FXYD1-0.74-0.87
MT-CO2-0.73-0.87
AF347015.31-0.72-0.85
AIFM3-0.72-0.77
AF347015.33-0.72-0.84
AF347015.27-0.72-0.84
AF347015.8-0.71-0.87
HSD17B14-0.71-0.79
S100B-0.71-0.81
MT-CYB-0.71-0.84

Section III. Gene Ontology annotation

Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006333chromatin assembly or disassemblyTAS9710638 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusTAS9710638 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN 663425All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 1 UP 380236All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 2 UP 418263All SZGR 2.0 genes in this pathway
PUJANA BRCA2 PCC NETWORK 423265All SZGR 2.0 genes in this pathway
RICKMAN METASTASIS UP 344180All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 48HR DN 428306All SZGR 2.0 genes in this pathway
JIANG VHL TARGETS 13891All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL SHORT TERM 3215All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 1 528324All SZGR 2.0 genes in this pathway
NAKAMURA METASTASIS MODEL UP 4526All SZGR 2.0 genes in this pathway
BLUM RESPONSE TO SALIRASIB DN 342220All SZGR 2.0 genes in this pathway
JIANG HYPOXIA VIA VHL 3424All SZGR 2.0 genes in this pathway
GOBERT OLIGODENDROCYTE DIFFERENTIATION UP 570339All SZGR 2.0 genes in this pathway
PEDERSEN METASTASIS BY ERBB2 ISOFORM 7 403240All SZGR 2.0 genes in this pathway