Gene Page: SOCS1

Summary ?
GeneID8651
SymbolSOCS1
SynonymsCIS1|CISH1|JAB|SOCS-1|SSI-1|SSI1|TIP3
Descriptionsuppressor of cytokine signaling 1
ReferenceMIM:603597|HGNC:HGNC:19383|Ensembl:ENSG00000185338|HPRD:04669|Vega:OTTHUMG00000129792
Gene typeprotein-coding
Map location16p13.13
Pascal p-value0.756
Fetal beta-0.294
DMG1 (# studies)

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Nishioka_2013Genome-wide DNA methylation analysisThe authors investigated the methylation profiles of DNA in peripheral blood cells from 18 patients with first-episode schizophrenia (FESZ) and from 15 normal controls. 2

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg017177061611349308SOCS1-0.0260.69DMG:Nishioka_2013
cg260121031611349372SOCS1-0.0260.85DMG:Nishioka_2013


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
ALDOA0.860.89
TPST20.830.85
P4HTM0.830.82
RUNDC3A0.830.83
TMX20.820.82
ANXA70.820.84
GNPTG0.820.84
GBA0.810.83
BDH10.810.81
RHBDD20.810.85
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
EIF5B-0.57-0.64
UPF3B-0.54-0.59
THOC2-0.53-0.54
RBMX2-0.53-0.61
KIAA1949-0.51-0.40
FNBP1L-0.51-0.35
ZNF326-0.51-0.51
TUBB2B-0.50-0.46
YBX1-0.50-0.42
ATAD2B-0.50-0.48

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
AXLJTK11 | UFOAXL receptor tyrosine kinaseAxl interacts with SOCS-1.BIND12470648 
CRKCRKIIv-crk sarcoma virus CT10 oncogene homolog (avian)Reconstituted ComplexBioGRID10022833 
CSF1MCSF | MGC31930colony stimulating factor 1 (macrophage)-HPRD11297560 
CSF1RC-FMS | CD115 | CSFR | FIM2 | FMScolony stimulating factor 1 receptor-HPRD,BioGRID10022833 |11297560 
CSF1RC-FMS | CD115 | CSFR | FIM2 | FMScolony stimulating factor 1 receptorSocs1 interacts with CSF1-R. This interaction was modeled on a demonstrated interaction between mouse proteins.BIND10022833 
EGFRERBB | ERBB1 | HER1 | PIG61 | mENAepidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)-HPRD,BioGRID12070153 
FLT3CD135 | FLK2 | STK1fms-related tyrosine kinase 3Socs1 interacts with Flt3. This interaction was modeled on a demonstrated interaction between mouse Socs1 and Flt3.BIND10022833 
FLT3CD135 | FLK2 | STK1fms-related tyrosine kinase 3-HPRD,BioGRID10022833 
FYNMGC45350 | SLK | SYNFYN oncogene related to SRC, FGR, YESSocs1 interacts with Fyn. This interaction was modeled on a demonstrated interaction between mouse Socs1 and Fyn from an unspecified species.BIND10022833 
FYNMGC45350 | SLK | SYNFYN oncogene related to SRC, FGR, YES-HPRD,BioGRID10022833 
GHRGHBPgrowth hormone receptor-HPRD,BioGRID10585430 
GRB2ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084growth factor receptor-bound protein 2Socs1 interacts with Grb2. This interaction was modeled on a demonstrated interaction between mouse Socs1 and human Grb2.BIND10022833 
GRB2ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084growth factor receptor-bound protein 2-HPRD,BioGRID10022833 
IGF1RCD221 | IGFIR | JTK13 | MGC142170 | MGC142172 | MGC18216insulin-like growth factor 1 receptor-HPRD,BioGRID9727029 
IGF1RCD221 | IGFIR | JTK13 | MGC142170 | MGC142172 | MGC18216insulin-like growth factor 1 receptorInsulin-like Growth Factor-I Receptor interacts with SOCS1BIND9727029 
IL2RBCD122 | P70-75interleukin 2 receptor, beta-HPRD,BioGRID11133764 
INSRCD220 | HHF5insulin receptorSuppressors of cytokine signaling-1 associates with and inhibits the insulin receptor.BIND11342531 
IRS1HIRS-1insulin receptor substrate 1-HPRD,BioGRID11208867 |12228220 
IRS2-insulin receptor substrate 2Affinity Capture-WesternBioGRID12228220 
ITKEMT | LYK | MGC126257 | MGC126258 | PSCTK2IL2-inducible T-cell kinaseSocs1 interacts with Itk. This interaction was modeled on a demonstrated interaction between mouse Socs1 and Itk from an unspecified species.BIND10022833 
ITKEMT | LYK | MGC126257 | MGC126258 | PSCTK2IL2-inducible T-cell kinase-HPRD,BioGRID10022833 
JAK1JAK1A | JAK1B | JTK3Janus kinase 1 (a protein tyrosine kinase)-HPRD11133764 
JAK2JTK10Janus kinase 2 (a protein tyrosine kinase)-HPRD9202126 |10064597 
|11971965 
JAK2JTK10Janus kinase 2 (a protein tyrosine kinase)Affinity Capture-Western
in vitro
in vivo
Reconstituted Complex
Two-hybrid		BioGRID9202126 |10064597 
|10455112 |11713228 
|11971965 
JAK3JAK-3 | JAK3_HUMAN | JAKL | L-JAK | LJAKJanus kinase 3 (a protein tyrosine kinase, leukocyte)-HPRD11133764 
KITC-Kit | CD117 | PBT | SCFRv-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog-HPRD,BioGRID10022833 
KITC-Kit | CD117 | PBT | SCFRv-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homologSocs1 interacts with Kit. This interaction was modeled on a demonstrated interaction between mouse proteinsBIND10022833 
MPLC-MPL | CD110 | MPLV | TPORmyeloproliferative leukemia virus oncogeneAffinity Capture-WesternBioGRID10517496 
NCK1MGC12668 | NCK | NCKalphaNCK adaptor protein 1Socs1 interacts with Nck. This interaction was modeled on a demonstrated interaction between mouse Socs1 and Nck from an unspecified species.BIND10022833 
NCK1MGC12668 | NCK | NCKalphaNCK adaptor protein 1-HPRD,BioGRID10022833 
PDGFRBCD140B | JTK12 | PDGF-R-beta | PDGFR | PDGFR1platelet-derived growth factor receptor, beta polypeptideSocs1 interacts with PDGF-R. This interaction was modeled on a demonstrated interaction between mouse Socs1 and human PDGF-R.BIND10022833 
PIK3R2P85B | p85 | p85-BETAphosphoinositide-3-kinase, regulatory subunit 2 (beta)Socs1 interacts with p85-beta. This interaction was modeled on a demonstrated interaction between mouse Socs1 and p85-beta from an unspecified species.BIND10022833 
TCEB1SIIItranscription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)-HPRD,BioGRID10051596 
TCEB2ELOB | SIIItranscription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)-HPRD10051596 
TCEB3FLJ38760 | FLJ42849 | SIII | TCEB3Atranscription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A)Affinity Capture-WesternBioGRID10051596 
TECMGC126760 | MGC126762 | PSCTK4tec protein tyrosine kinase-HPRD,BioGRID9341160 
TEKCD202B | TIE-2 | TIE2 | VMCM | VMCM1TEK tyrosine kinase, endothelialSocs1 interacts with TEK. This interaction was modeled on a demonstrated interaction between mouse Socs1 and Tek from an unspecified species.BIND10022833 
TEKCD202B | TIE-2 | TIE2 | VMCM | VMCM1TEK tyrosine kinase, endothelial-HPRD10022833 
TRIM8GERP | RNF27tripartite motif-containing 8-HPRD12163497 
VAV1VAVvav 1 guanine nucleotide exchange factor-HPRD,BioGRID10022833 
VAV1VAVvav 1 guanine nucleotide exchange factorSocs1 interacts with Vav. This interaction was modeled on a demonstrated interaction between mouse Socs1 and Vav.BIND10022833 
VAV2-vav 2 guanine nucleotide exchange factor-HPRD,BioGRID10022833 
VAV2-vav 2 guanine nucleotide exchange factorSocs1 interacts with Vav2. This interaction was modeled on a demonstrated interaction between mouse Socs1 and human Vav2.BIND10022833 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG UBIQUITIN MEDIATED PROTEOLYSIS 13898All SZGR 2.0 genes in this pathway
KEGG JAK STAT SIGNALING PATHWAY 155105All SZGR 2.0 genes in this pathway
KEGG INSULIN SIGNALING PATHWAY 137103All SZGR 2.0 genes in this pathway
KEGG TYPE II DIABETES MELLITUS 4741All SZGR 2.0 genes in this pathway
BIOCARTA GH PATHWAY 2822All SZGR 2.0 genes in this pathway
BIOCARTA IL2RB PATHWAY 3826All SZGR 2.0 genes in this pathway
SIG IL4RECEPTOR IN B LYPHOCYTES 2723All SZGR 2.0 genes in this pathway
PID IL4 2PATHWAY 6543All SZGR 2.0 genes in this pathway
PID IL12 2PATHWAY 6354All SZGR 2.0 genes in this pathway
PID IL2 1PATHWAY 5543All SZGR 2.0 genes in this pathway
PID IFNG PATHWAY 4034All SZGR 2.0 genes in this pathway
PID KIT PATHWAY 5240All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY SCF KIT 7859All SZGR 2.0 genes in this pathway
REACTOME GROWTH HORMONE RECEPTOR SIGNALING 2419All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF KIT SIGNALING 1710All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF IFNG SIGNALING 1410All SZGR 2.0 genes in this pathway
REACTOME INTERFERON GAMMA SIGNALING 6348All SZGR 2.0 genes in this pathway
REACTOME INTERFERON ALPHA BETA SIGNALING 6450All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF IFNA SIGNALING 2422All SZGR 2.0 genes in this pathway
REACTOME INTERFERON SIGNALING 159116All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933616All SZGR 2.0 genes in this pathway
REACTOME ADAPTIVE IMMUNE SYSTEM 539350All SZGR 2.0 genes in this pathway
REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM 270204All SZGR 2.0 genes in this pathway
REACTOME CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION 251156All SZGR 2.0 genes in this pathway
REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION 212129All SZGR 2.0 genes in this pathway
FRASOR TAMOXIFEN RESPONSE UP 5136All SZGR 2.0 genes in this pathway
SENGUPTA NASOPHARYNGEAL CARCINOMA UP 294178All SZGR 2.0 genes in this pathway
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL DN 275168All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION HSC DN 187115All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE LPS UP 431237All SZGR 2.0 genes in this pathway
NAGASHIMA NRG1 SIGNALING UP 176123All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN 1375806All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION UP 552347All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND SERUM DEPRIVATION UP 211136All SZGR 2.0 genes in this pathway
HUMMERICH SKIN CANCER PROGRESSION UP 8858All SZGR 2.0 genes in this pathway
SCHLESINGER H3K27ME3 IN NORMAL AND METHYLATED IN CANCER 2821All SZGR 2.0 genes in this pathway
OHM METHYLATED IN ADULT CANCERS 2723All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP 1037673All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP 811508All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 48HR DN 428306All SZGR 2.0 genes in this pathway
SHEN SMARCA2 TARGETS DN 357212All SZGR 2.0 genes in this pathway
SAKAI CHRONIC HEPATITIS VS LIVER CANCER DN 3624All SZGR 2.0 genes in this pathway
SHIN B CELL LYMPHOMA CLUSTER 6 119All SZGR 2.0 genes in this pathway
RADAEVA RESPONSE TO IFNA1 UP 5240All SZGR 2.0 genes in this pathway
BROCKE APOPTOSIS REVERSED BY IL6 14498All SZGR 2.0 genes in this pathway
LU IL4 SIGNALING 9456All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS 882572All SZGR 2.0 genes in this pathway
CHIARETTI ACUTE LYMPHOBLASTIC LEUKEMIA ZAP70 6733All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 14HR DN 298200All SZGR 2.0 genes in this pathway
MARTINEZ RESPONSE TO TRABECTEDIN UP 7149All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 18HR DN 178121All SZGR 2.0 genes in this pathway
BILD HRAS ONCOGENIC SIGNATURE 261166All SZGR 2.0 genes in this pathway
LOPES METHYLATED IN COLON CANCER UP 2720All SZGR 2.0 genes in this pathway
FOSTER TOLERANT MACROPHAGE DN 409268All SZGR 2.0 genes in this pathway
HELLER SILENCED BY METHYLATION UP 282183All SZGR 2.0 genes in this pathway
WALLACE PROSTATE CANCER RACE UP 299167All SZGR 2.0 genes in this pathway
MARZEC IL2 SIGNALING UP 11580All SZGR 2.0 genes in this pathway
MITSIADES RESPONSE TO APLIDIN UP 439257All SZGR 2.0 genes in this pathway
HOQUE METHYLATED IN CANCER 5645All SZGR 2.0 genes in this pathway
WEST ADRENOCORTICAL TUMOR DN 546362All SZGR 2.0 genes in this pathway
QI PLASMACYTOMA UP 259185All SZGR 2.0 genes in this pathway
MUELLER PLURINET 299189All SZGR 2.0 genes in this pathway
PALOMERO GSI SENSITIVITY UP 76All SZGR 2.0 genes in this pathway
ICHIBA GRAFT VERSUS HOST DISEASE D7 UP 10767All SZGR 2.0 genes in this pathway
WUNDER INFLAMMATORY RESPONSE AND CHOLESTEROL UP 5838All SZGR 2.0 genes in this pathway
HOFFMANN PRE BI TO LARGE PRE BII LYMPHOCYTE UP 3624All SZGR 2.0 genes in this pathway
MILI PSEUDOPODIA HAPTOTAXIS DN 668419All SZGR 2.0 genes in this pathway
WOO LIVER CANCER RECURRENCE UP 10575All SZGR 2.0 genes in this pathway
WORSCHECH TUMOR EVASION AND TOLEROGENICITY DN 1411All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA PR DN 4434All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 30MIN DN 15099All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 4HR DN 254158All SZGR 2.0 genes in this pathway
BOSCO ALLERGEN INDUCED TH2 ASSOCIATED MODULE 15186All SZGR 2.0 genes in this pathway
BOSCO TH1 CYTOTOXIC MODULE 11462All SZGR 2.0 genes in this pathway
SMIRNOV RESPONSE TO IR 6HR UP 16697All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY 1725838All SZGR 2.0 genes in this pathway