Gene Page: BTRC
Summary ?
| GeneID | 8945 |
| Symbol | BTRC |
| Synonyms | BETA-TRCP|FBW1A|FBXW1|FBXW1A|FWD1|bTrCP|bTrCP1|betaTrCP |
| Description | beta-transducin repeat containing E3 ubiquitin protein ligase |
| Reference | MIM:603482|HGNC:HGNC:1144|Ensembl:ENSG00000166167|HPRD:04596|Vega:OTTHUMG00000018932 |
| Gene type | protein-coding |
| Map location | 10q24.32 |
| Pascal p-value | 0.006 |
| Sherlock p-value | 0.11 |
| eGene | Myers' cis & trans |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs2209358 | chr1 | 157274426 | BTRC | 8945 | 0.15 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section IV. Protein-protein interaction annotation
| Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
|---|---|---|---|---|---|
| BTRC | BETA-TRCP | FBW1A | FBXW1 | FBXW1A | FWD1 | MGC4643 | bTrCP | bTrCP1 | betaTrCP | beta-transducin repeat containing | Affinity Capture-Western | BioGRID | 10644755 |
| CD4 | CD4mut | CD4 molecule | - | HPRD,BioGRID | 9660940 |
| CDC25A | CDC25A2 | cell division cycle 25 homolog A (S. pombe) | - | HPRD | 14603323 |
| CDC34 | E2-CDC34 | UBC3 | UBE2R1 | cell division cycle 34 homolog (S. cerevisiae) | Biochemical Activity Reconstituted Complex | BioGRID | 10531035 |12037680 |
| CHUK | IKBKA | IKK-alpha | IKK1 | IKKA | NFKBIKA | TCF16 | conserved helix-loop-helix ubiquitous kinase | I-kappa-B-alpha interacts with beta-TrCP. | BIND | 15994554 |
| CTNNB1 | CTNNB | DKFZp686D02253 | FLJ25606 | FLJ37923 | catenin (cadherin-associated protein), beta 1, 88kDa | - | HPRD | 11818547 |12114015 |
| CTNNB1 | CTNNB | DKFZp686D02253 | FLJ25606 | FLJ37923 | catenin (cadherin-associated protein), beta 1, 88kDa | BTRC (Beta-TrCP1) interacts with CTNNB1 (Beta-catenin). | BIND | 15735746 |
| CUL1 | MGC149834 | MGC149835 | cullin 1 | Affinity Capture-Western | BioGRID | 10531035 |10644755 |12609982 |
| DLG1 | DKFZp761P0818 | DKFZp781B0426 | DLGH1 | SAP97 | dJ1061C18.1.1 | hdlg | discs, large homolog 1 (Drosophila) | Affinity Capture-Western Reconstituted Complex | BioGRID | 12902344 |
| DLGAP5 | DLG1 | DLG7 | HURP | KIAA0008 | discs, large (Drosophila) homolog-associated protein 5 | - | HPRD | 12902344 |
| E2F4 | E2F-4 | E2F transcription factor 4, p107/p130-binding | E2F4 interacts with BTRC promoter. | BIND | 15782160 |
| FBXW11 | BTRC2 | BTRCP2 | FBW1B | FBXW1B | Fbw11 | Hos | KIAA0696 | F-box and WD repeat domain containing 11 | - | HPRD,BioGRID | 10644755 |
| IKBKB | FLJ40509 | IKK-beta | IKK2 | IKKB | MGC131801 | NFKBIKB | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta | Affinity Capture-Western | BioGRID | 11158290 |
| JUP | ARVD12 | CTNNG | DP3 | DPIII | PDGB | PKGB | junction plakoglobin | - | HPRD,BioGRID | 10803460 |
| NFKB1 | DKFZp686C01211 | EBP-1 | KBF1 | MGC54151 | NF-kappa-B | NFKB-p105 | NFKB-p50 | p105 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | Affinity Capture-Western | BioGRID | 11158290 |
| NFKB2 | LYT-10 | LYT10 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) | - | HPRD,BioGRID | 11994270 |
| NFKBIA | IKBA | MAD-3 | NFKBI | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | - | HPRD,BioGRID | 9990853 |
| NFKBIA | IKBA | MAD-3 | NFKBI | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | h-beta-TrCP interacts with and promotes ubiquitination of phosphorylated I-kappa-B-alpha. This interaction was modeled on a demonstrated interaction between human beta-TrCP (h-beta-TrCP) and I-kappa-B-alpha from an unspecified species. | BIND | 9990853 |
| NFKBIB | IKBB | TRIP9 | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta | - | HPRD,BioGRID | 10514424 |
| RELA | MGC131774 | NFKB3 | p65 | v-rel reticuloendotheliosis viral oncogene homolog A (avian) | - | HPRD,BioGRID | 9990853 |
| SKP1 | EMC19 | MGC34403 | OCP-II | OCP2 | SKP1A | TCEB1L | p19A | S-phase kinase-associated protein 1 | Affinity Capture-Western Reconstituted Complex Two-hybrid | BioGRID | 9660940 |10531035 |10644755 |10918611 |12609982 |
| SKP1 | EMC19 | MGC34403 | OCP-II | OCP2 | SKP1A | TCEB1L | p19A | S-phase kinase-associated protein 1 | Skp1 interacts with Fbw1a. | BIND | 10531035 |
| SMAD3 | DKFZp586N0721 | DKFZp686J10186 | HSPC193 | HsT17436 | JV15-2 | MADH3 | MGC60396 | SMAD family member 3 | Affinity Capture-Western | BioGRID | 14988407 |
| SMAD4 | DPC4 | JIP | MADH4 | SMAD family member 4 | - | HPRD,BioGRID | 14988407 |
| SUFU | PRO1280 | SUFUH | SUFUXL | suppressor of fused homolog (Drosophila) | - | HPRD | 10564661 |
| TBK1 | FLJ11330 | NAK | T2K | TANK-binding kinase 1 | Affinity Capture-MS | BioGRID | 14743216 |
| TRIM9 | KIAA0282 | RNF91 | SPRING | tripartite motif-containing 9 | Two-hybrid | BioGRID | 16189514 |
| TSPAN15 | 2700063A19Rik | NET-7 | TM4SF15 | tetraspanin 15 | - | HPRD | 12037680 |
| UBE2D2 | E2(17)KB2 | PUBC1 | UBC4 | UBC4/5 | UBCH5B | ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast) | Biochemical Activity | BioGRID | 10531035 |
| UBE2D2 | E2(17)KB2 | PUBC1 | UBC4 | UBC4/5 | UBCH5B | ubiquitin-conjugating enzyme E2D 2 (UBC4/5 homolog, yeast) | - | HPRD | 10918611 |
| UBE2R2 | CDC34B | FLJ20419 | MGC10481 | UBC3B | ubiquitin-conjugating enzyme E2R 2 | - | HPRD,BioGRID | 12037680 |
| UBQLN2 | CHAP1 | CHAP1/DSK2 | Dsk2 | HRIHFB2157 | LIC-2 | N4BP4 | PLIC-2 | PLIC2 | RIHFB2157 | ubiquilin 2 | - | HPRD,BioGRID | 10983987 |
| WEE1 | DKFZp686I18166 | FLJ16446 | WEE1A | WEE1hu | WEE1 homolog (S. pombe) | Wee1A interacts with an unspecified isoform of beta-TrCP1. | BIND | 15070733 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG OOCYTE MEIOSIS | 114 | 79 | All SZGR 2.0 genes in this pathway |
| KEGG UBIQUITIN MEDIATED PROTEOLYSIS | 138 | 98 | All SZGR 2.0 genes in this pathway |
| KEGG WNT SIGNALING PATHWAY | 151 | 112 | All SZGR 2.0 genes in this pathway |
| KEGG HEDGEHOG SIGNALING PATHWAY | 56 | 42 | All SZGR 2.0 genes in this pathway |
| BIOCARTA PS1 PATHWAY | 14 | 14 | All SZGR 2.0 genes in this pathway |
| BIOCARTA WNT PATHWAY | 26 | 24 | All SZGR 2.0 genes in this pathway |
| WNT SIGNALING | 89 | 71 | All SZGR 2.0 genes in this pathway |
| REACTOME SIGNALING BY WNT | 65 | 41 | All SZGR 2.0 genes in this pathway |
| REACTOME CELL CYCLE | 421 | 253 | All SZGR 2.0 genes in this pathway |
| REACTOME SIGNALING BY ERBB4 | 90 | 67 | All SZGR 2.0 genes in this pathway |
| REACTOME PROLACTIN RECEPTOR SIGNALING | 14 | 11 | All SZGR 2.0 genes in this pathway |
| REACTOME NUCLEAR SIGNALING BY ERBB4 | 38 | 30 | All SZGR 2.0 genes in this pathway |
| REACTOME DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR | 97 | 66 | All SZGR 2.0 genes in this pathway |
| REACTOME ACTIVATION OF NF KAPPAB IN B CELLS | 64 | 43 | All SZGR 2.0 genes in this pathway |
| REACTOME SIGNALING BY THE B CELL RECEPTOR BCR | 126 | 90 | All SZGR 2.0 genes in this pathway |
| REACTOME CELL CYCLE MITOTIC | 325 | 185 | All SZGR 2.0 genes in this pathway |
| REACTOME REGULATION OF MITOTIC CELL CYCLE | 85 | 46 | All SZGR 2.0 genes in this pathway |
| REACTOME SIGNALING BY ILS | 107 | 86 | All SZGR 2.0 genes in this pathway |
| REACTOME IL1 SIGNALING | 39 | 30 | All SZGR 2.0 genes in this pathway |
| REACTOME CIRCADIAN CLOCK | 53 | 40 | All SZGR 2.0 genes in this pathway |
| REACTOME HIV INFECTION | 207 | 122 | All SZGR 2.0 genes in this pathway |
| REACTOME HOST INTERACTIONS OF HIV FACTORS | 132 | 81 | All SZGR 2.0 genes in this pathway |
| REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1 | 51 | 32 | All SZGR 2.0 genes in this pathway |
| REACTOME IMMUNE SYSTEM | 933 | 616 | All SZGR 2.0 genes in this pathway |
| REACTOME ADAPTIVE IMMUNE SYSTEM | 539 | 350 | All SZGR 2.0 genes in this pathway |
| REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM | 270 | 204 | All SZGR 2.0 genes in this pathway |
| REACTOME CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION | 251 | 156 | All SZGR 2.0 genes in this pathway |
| REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | 212 | 129 | All SZGR 2.0 genes in this pathway |
| ENK UV RESPONSE KERATINOCYTE UP | 530 | 342 | All SZGR 2.0 genes in this pathway |
| LASTOWSKA NEUROBLASTOMA COPY NUMBER DN | 800 | 473 | All SZGR 2.0 genes in this pathway |
| DACOSTA UV RESPONSE VIA ERCC3 XPCS DN | 88 | 71 | All SZGR 2.0 genes in this pathway |
| HERNANDEZ ABERRANT MITOSIS BY DOCETACEL 2NM UP | 81 | 57 | All SZGR 2.0 genes in this pathway |
| DACOSTA UV RESPONSE VIA ERCC3 DN | 855 | 609 | All SZGR 2.0 genes in this pathway |
| SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN | 584 | 395 | All SZGR 2.0 genes in this pathway |
| SAKAI TUMOR INFILTRATING MONOCYTES UP | 27 | 19 | All SZGR 2.0 genes in this pathway |
| KENNY CTNNB1 TARGETS UP | 50 | 30 | All SZGR 2.0 genes in this pathway |
| ABRAHAM ALPC VS MULTIPLE MYELOMA UP | 26 | 22 | All SZGR 2.0 genes in this pathway |
| BROWNE HCMV INFECTION 20HR UP | 240 | 152 | All SZGR 2.0 genes in this pathway |
| BROWNE HCMV INFECTION 16HR UP | 225 | 139 | All SZGR 2.0 genes in this pathway |
| MCCLUNG COCAINE REWARD 5D | 79 | 62 | All SZGR 2.0 genes in this pathway |
| BLALOCK ALZHEIMERS DISEASE UP | 1691 | 1088 | All SZGR 2.0 genes in this pathway |
| BROWNE HCMV INFECTION 12HR UP | 111 | 68 | All SZGR 2.0 genes in this pathway |
| BROWNE HCMV INFECTION 6HR UP | 71 | 48 | All SZGR 2.0 genes in this pathway |
| MCCABE BOUND BY HOXC6 | 469 | 239 | All SZGR 2.0 genes in this pathway |
| ACEVEDO METHYLATED IN LIVER CANCER DN | 940 | 425 | All SZGR 2.0 genes in this pathway |
| MATZUK SPERMATOCYTE | 72 | 55 | All SZGR 2.0 genes in this pathway |
| BONCI TARGETS OF MIR15A AND MIR16 1 | 91 | 75 | All SZGR 2.0 genes in this pathway |
| WANG TUMOR INVASIVENESS UP | 374 | 247 | All SZGR 2.0 genes in this pathway |
| CHYLA CBFA2T3 TARGETS DN | 242 | 146 | All SZGR 2.0 genes in this pathway |
| LINSLEY MIR16 TARGETS | 206 | 127 | All SZGR 2.0 genes in this pathway |
| GOBERT OLIGODENDROCYTE DIFFERENTIATION DN | 1080 | 713 | All SZGR 2.0 genes in this pathway |
| FORTSCHEGGER PHF8 TARGETS DN | 784 | 464 | All SZGR 2.0 genes in this pathway |
| LIM MAMMARY LUMINAL MATURE UP | 116 | 65 | All SZGR 2.0 genes in this pathway |