Gene Page: LRRFIP2
Summary ?
GeneID | 9209 |
Symbol | LRRFIP2 |
Synonyms | HUFI-2 |
Description | leucine rich repeat (in FLII) interacting protein 2 |
Reference | MIM:614043|HGNC:HGNC:6703|Ensembl:ENSG00000093167|HPRD:10061|Vega:OTTHUMG00000130796 |
Gene type | protein-coding |
Map location | 3p22.2 |
Pascal p-value | 0.002 |
Sherlock p-value | 0.978 |
eGene | Myers' cis & trans Meta |
Gene in Data Sources
Gene set name | Method of gene set | Description | Info |
---|---|---|---|
CV:PGCnp | Genome-wide Association Study | GWAS | |
GSMA_I | Genome scan meta-analysis | Psr: 0.006 |
Section I. Genetics and epigenetics annotation
eQTL annotation
SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
---|---|---|---|---|---|---|---|---|
rs17202548 | chr3 | 36995986 | LRRFIP2 | 9209 | 0.08 | cis | ||
rs4647269 | chr3 | 37057590 | LRRFIP2 | 9209 | 0.03 | cis | ||
rs3774339 | chr3 | 37062853 | LRRFIP2 | 9209 | 0.03 | cis | ||
rs3774326 | chr3 | 37099565 | LRRFIP2 | 9209 | 0.14 | cis | ||
rs11720064 | chr3 | 37101518 | LRRFIP2 | 9209 | 0.08 | cis | ||
rs1468712 | chr3 | 37106012 | LRRFIP2 | 9209 | 0.07 | cis | ||
rs7651033 | chr3 | 37116041 | LRRFIP2 | 9209 | 0.03 | cis | ||
rs2302504 | chr3 | 37116385 | LRRFIP2 | 9209 | 0.1 | cis | ||
rs17204801 | chr3 | 37143433 | LRRFIP2 | 9209 | 0.02 | cis | ||
rs6800554 | chr3 | 37143878 | LRRFIP2 | 9209 | 0.18 | cis | ||
rs9869432 | chr3 | 37196600 | LRRFIP2 | 9209 | 0.05 | cis | ||
rs1392749 | chr3 | 37205190 | LRRFIP2 | 9209 | 0.07 | cis | ||
rs11711937 | chr3 | 37224837 | LRRFIP2 | 9209 | 0.05 | cis | ||
rs6800842 | chr3 | 37289603 | LRRFIP2 | 9209 | 0.16 | cis | ||
rs4678564 | chr3 | 37437303 | LRRFIP2 | 9209 | 0.08 | cis |
Section II. Transcriptome annotation
General gene expression (GTEx)

Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
Top 10 positively co-expressed genes | ||
Gene | Pearson's Correlation | Spearman's Correlation |
GAK | 0.91 | 0.91 |
AP3D1 | 0.89 | 0.89 |
ARFGAP1 | 0.89 | 0.88 |
LPHN1 | 0.89 | 0.92 |
KIAA0664 | 0.89 | 0.89 |
CABIN1 | 0.89 | 0.90 |
CES2 | 0.88 | 0.88 |
LRRC68 | 0.88 | 0.89 |
PPAN-P2RY11 | 0.88 | 0.90 |
DNAJC11 | 0.88 | 0.87 |
Top 10 negatively co-expressed genes | ||
Gene | Pearson's Correlation | Spearman's Correlation |
AF347015.21 | -0.73 | -0.69 |
AF347015.31 | -0.71 | -0.64 |
C1orf54 | -0.68 | -0.68 |
MT-CO2 | -0.68 | -0.62 |
AF347015.27 | -0.66 | -0.62 |
GNG11 | -0.65 | -0.63 |
AF347015.8 | -0.64 | -0.60 |
AF347015.33 | -0.64 | -0.57 |
MT-CYB | -0.64 | -0.58 |
HIGD1B | -0.64 | -0.58 |
Section III. Gene Ontology annotation
Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
---|---|---|---|---|
GO:0005515 | protein binding | IPI | 15677333 | |
GO:0030275 | LRR domain binding | NAS | 10366446 | |
Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
GO:0016055 | Wnt receptor signaling pathway | IEA | - | |
GO:0008150 | biological_process | ND | - | |
Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
GO:0005575 | cellular_component | ND | - |
Section V. Pathway annotation
Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
---|---|---|---|
CHEMNITZ RESPONSE TO PROSTAGLANDIN E2 DN | 391 | 222 | All SZGR 2.0 genes in this pathway |
DAVICIONI MOLECULAR ARMS VS ERMS UP | 332 | 228 | All SZGR 2.0 genes in this pathway |
HOOI ST7 TARGETS DN | 123 | 78 | All SZGR 2.0 genes in this pathway |
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN | 663 | 425 | All SZGR 2.0 genes in this pathway |
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP | 1382 | 904 | All SZGR 2.0 genes in this pathway |
EBAUER TARGETS OF PAX3 FOXO1 FUSION DN | 48 | 31 | All SZGR 2.0 genes in this pathway |
GEORGES TARGETS OF MIR192 AND MIR215 | 893 | 528 | All SZGR 2.0 genes in this pathway |
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS | 882 | 572 | All SZGR 2.0 genes in this pathway |
BLALOCK ALZHEIMERS DISEASE UP | 1691 | 1088 | All SZGR 2.0 genes in this pathway |
CREIGHTON ENDOCRINE THERAPY RESISTANCE 1 | 528 | 324 | All SZGR 2.0 genes in this pathway |
KYNG DNA DAMAGE BY 4NQO OR GAMMA RADIATION | 15 | 13 | All SZGR 2.0 genes in this pathway |
KYNG DNA DAMAGE UP | 226 | 164 | All SZGR 2.0 genes in this pathway |
ENGELMANN CANCER PROGENITORS DN | 70 | 44 | All SZGR 2.0 genes in this pathway |
BONOME OVARIAN CANCER SURVIVAL SUBOPTIMAL DEBULKING | 510 | 309 | All SZGR 2.0 genes in this pathway |
MOOTHA PGC | 420 | 269 | All SZGR 2.0 genes in this pathway |
CHIANG LIVER CANCER SUBCLASS UNANNOTATED UP | 85 | 50 | All SZGR 2.0 genes in this pathway |
DUTERTRE ESTRADIOL RESPONSE 6HR UP | 229 | 149 | All SZGR 2.0 genes in this pathway |
BRUINS UVC RESPONSE LATE | 1137 | 655 | All SZGR 2.0 genes in this pathway |
Section VI. microRNA annotation
miRNA family | Target position | miRNA ID | miRNA seq | ||
---|---|---|---|---|---|
UTR start | UTR end | Match method | |||
miR-101 | 86 | 92 | m8 | hsa-miR-101 | UACAGUACUGUGAUAACUGAAG |
miR-124/506 | 392 | 398 | m8 | hsa-miR-506 | UAAGGCACCCUUCUGAGUAGA |
hsa-miR-124brain | UAAGGCACGCGGUGAAUGCC | ||||
miR-15/16/195/424/497 | 730 | 736 | m8 | hsa-miR-15abrain | UAGCAGCACAUAAUGGUUUGUG |
hsa-miR-16brain | UAGCAGCACGUAAAUAUUGGCG | ||||
hsa-miR-15bbrain | UAGCAGCACAUCAUGGUUUACA | ||||
hsa-miR-195SZ | UAGCAGCACAGAAAUAUUGGC | ||||
hsa-miR-424 | CAGCAGCAAUUCAUGUUUUGAA | ||||
hsa-miR-497 | CAGCAGCACACUGUGGUUUGU | ||||
miR-378* | 644 | 650 | m8 | hsa-miR-422b | CUGGACUUGGAGUCAGAAGGCC |
hsa-miR-422a | CUGGACUUAGGGUCAGAAGGCC | ||||
miR-410 | 573 | 579 | 1A | hsa-miR-410 | AAUAUAACACAGAUGGCCUGU |
miR-494 | 512 | 519 | 1A,m8 | hsa-miR-494brain | UGAAACAUACACGGGAAACCUCUU |
- SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
- Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.