SZGR2

Summary ?

GeneID	940
Symbol	CD28
Synonyms	Tp44
Description	CD28 molecule
Reference	MIM:186760\|HGNC:HGNC:1653\|Ensembl:ENSG00000178562\|HPRD:01727\|Vega:OTTHUMG00000132878
Gene type	protein-coding
Map location	2q33
Pascal p-value	0.328
Fetal beta	-0.11

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenias	Click to show details

Section I. Genetics and epigenetics annotation

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
C3AR1	0.76	0.69
ADORA3	0.76	0.69
LAPTM5	0.75	0.69
C3	0.75	0.70
ALOX5AP	0.75	0.70
TBXAS1	0.74	0.69
C1QC	0.73	0.68
CD53	0.73	0.67
LILRB4	0.72	0.66
LY86	0.71	0.62

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
ANP32C	-0.27	-0.33
AC005921.3	-0.26	-0.33
FBN3	-0.26	-0.16
SH3BP2	-0.26	-0.29
GJC1	-0.26	-0.18
TMC2	-0.26	-0.15
SCUBE1	-0.26	-0.21
AC010300.1	-0.26	-0.28
AC004017.1	-0.26	-0.13
SH2B2	-0.25	-0.30

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
CD247	CD3-ZETA \| CD3H \| CD3Q \| CD3Z \| T3Z \| TCRZ	CD247 molecule	-	HPRD	8760790
CD4	CD4mut	CD4 molecule	-	HPRD	7539755
CD80	CD28LG \| CD28LG1 \| LAB7	CD80 molecule	CD80 interacts with CD28.	BIND	15610849
CD80	CD28LG \| CD28LG1 \| LAB7	CD80 molecule	-	HPRD,BioGRID	7545666
CD86	B7-2 \| B70 \| CD28LG2 \| LAB72 \| MGC34413	CD86 molecule	-	HPRD	11021528
DUSP14	MKP-L \| MKP6	dual specificity phosphatase 14	-	HPRD,BioGRID	11123293
GRAP2	GADS \| GRAP-2 \| GRB2L \| GRBLG \| GRID \| GRPL \| GrbX \| Grf40 \| Mona \| P38	GRB2-related adaptor protein 2	-	HPRD,BioGRID	10820259
GRAP2	GADS \| GRAP-2 \| GRB2L \| GRBLG \| GRID \| GRPL \| GrbX \| Grf40 \| Mona \| P38	GRB2-related adaptor protein 2	GRAP2 (GRID) interacts with CD28.	BIND	10820259
GRB2	ASH \| EGFRBP-GRB2 \| Grb3-3 \| MST084 \| MSTP084	growth factor receptor-bound protein 2	-	HPRD,BioGRID	7737275 \|8576157 \|9694876
ITK	EMT \| LYK \| MGC126257 \| MGC126258 \| PSCTK2	IL2-inducible T-cell kinase	-	HPRD	10586033
LCK	YT16 \| p56lck \| pp58lck	lymphocyte-specific protein tyrosine kinase	-	HPRD	10430626
LRRC23	LRPB7	leucine rich repeat containing 23	Reconstituted Complex	BioGRID	1847722
NSF	SKD2	N-ethylmaleimide-sensitive factor	CD28 interacts with NSF.	BIND	11680900
PIK3R1	GRB1 \| p85 \| p85-ALPHA	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	-	HPRD,BioGRID	7737275 \|8621607
PLCG1	PLC-II \| PLC1 \| PLC148 \| PLCgamma1	phospholipase C, gamma 1	-	HPRD	8386518
PTPRC	B220 \| CD45 \| CD45R \| GP180 \| LCA \| LY5 \| T200	protein tyrosine phosphatase, receptor type, C	-	HPRD	1355979

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG CELL ADHESION MOLECULES CAMS	134	93	All SZGR 2.0 genes in this pathway
KEGG T CELL RECEPTOR SIGNALING PATHWAY	108	89	All SZGR 2.0 genes in this pathway
KEGG INTESTINAL IMMUNE NETWORK FOR IGA PRODUCTION	48	36	All SZGR 2.0 genes in this pathway
KEGG TYPE I DIABETES MELLITUS	44	38	All SZGR 2.0 genes in this pathway
KEGG AUTOIMMUNE THYROID DISEASE	53	49	All SZGR 2.0 genes in this pathway
KEGG SYSTEMIC LUPUS ERYTHEMATOSUS	140	100	All SZGR 2.0 genes in this pathway
KEGG ALLOGRAFT REJECTION	38	34	All SZGR 2.0 genes in this pathway
KEGG GRAFT VERSUS HOST DISEASE	42	31	All SZGR 2.0 genes in this pathway
KEGG VIRAL MYOCARDITIS	73	58	All SZGR 2.0 genes in this pathway
BIOCARTA ASBCELL PATHWAY	12	11	All SZGR 2.0 genes in this pathway
BIOCARTA TCAPOPTOSIS PATHWAY	11	8	All SZGR 2.0 genes in this pathway
BIOCARTA TOB1 PATHWAY	21	14	All SZGR 2.0 genes in this pathway
BIOCARTA NKT PATHWAY	29	21	All SZGR 2.0 genes in this pathway
BIOCARTA TCYTOTOXIC PATHWAY	14	11	All SZGR 2.0 genes in this pathway
BIOCARTA THELPER PATHWAY	14	11	All SZGR 2.0 genes in this pathway
BIOCARTA TH1TH2 PATHWAY	19	14	All SZGR 2.0 genes in this pathway
BIOCARTA CTLA4 PATHWAY	21	18	All SZGR 2.0 genes in this pathway
ST T CELL SIGNAL TRANSDUCTION	45	33	All SZGR 2.0 genes in this pathway
PID TCR PATHWAY	66	51	All SZGR 2.0 genes in this pathway
PID CD8 TCR PATHWAY	53	42	All SZGR 2.0 genes in this pathway
PID IL12 STAT4 PATHWAY	33	29	All SZGR 2.0 genes in this pathway
REACTOME NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS	21	12	All SZGR 2.0 genes in this pathway
REACTOME CD28 CO STIMULATION	32	26	All SZGR 2.0 genes in this pathway
REACTOME CD28 DEPENDENT VAV1 PATHWAY	11	10	All SZGR 2.0 genes in this pathway
REACTOME COSTIMULATION BY THE CD28 FAMILY	63	48	All SZGR 2.0 genes in this pathway
REACTOME CD28 DEPENDENT PI3K AKT SIGNALING	22	18	All SZGR 2.0 genes in this pathway
REACTOME HIV INFECTION	207	122	All SZGR 2.0 genes in this pathway
REACTOME HOST INTERACTIONS OF HIV FACTORS	132	81	All SZGR 2.0 genes in this pathway
REACTOME THE ROLE OF NEF IN HIV1 REPLICATION AND DISEASE PATHOGENESIS	28	19	All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM	933	616	All SZGR 2.0 genes in this pathway
REACTOME ADAPTIVE IMMUNE SYSTEM	539	350	All SZGR 2.0 genes in this pathway
WINTER HYPOXIA DN	52	30	All SZGR 2.0 genes in this pathway
DEURIG T CELL PROLYMPHOCYTIC LEUKEMIA DN	320	184	All SZGR 2.0 genes in this pathway
JAATINEN HEMATOPOIETIC STEM CELL DN	226	132	All SZGR 2.0 genes in this pathway
HAHTOLA SEZARY SYNDROM UP	98	58	All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN DN	584	395	All SZGR 2.0 genes in this pathway
MORI PLASMA CELL UP	51	29	All SZGR 2.0 genes in this pathway
KAUFFMANN DNA REPLICATION GENES	147	87	All SZGR 2.0 genes in this pathway
SANSOM APC TARGETS DN	366	238	All SZGR 2.0 genes in this pathway
HESS TARGETS OF HOXA9 AND MEIS1 UP	65	44	All SZGR 2.0 genes in this pathway
HU GENOTOXIN ACTION DIRECT VS INDIRECT 4HR	37	22	All SZGR 2.0 genes in this pathway
ZHENG BOUND BY FOXP3	491	310	All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 STIMULATED	1022	619	All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED	1229	713	All SZGR 2.0 genes in this pathway
ZHENG FOXP3 TARGETS IN THYMUS UP	196	137	All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS DN	292	189	All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION DN	281	179	All SZGR 2.0 genes in this pathway
WALLACE PROSTATE CANCER RACE UP	299	167	All SZGR 2.0 genes in this pathway
IWANAGA CARCINOGENESIS BY KRAS PTEN DN	353	226	All SZGR 2.0 genes in this pathway
GRADE COLON AND RECTAL CANCER DN	101	65	All SZGR 2.0 genes in this pathway
YAUCH HEDGEHOG SIGNALING PARACRINE DN	264	159	All SZGR 2.0 genes in this pathway
BOYLAN MULTIPLE MYELOMA C D DN	252	155	All SZGR 2.0 genes in this pathway
VILIMAS NOTCH1 TARGETS UP	52	41	All SZGR 2.0 genes in this pathway
KASLER HDAC7 TARGETS 1 UP	194	133	All SZGR 2.0 genes in this pathway
BOSCO TH1 CYTOTOXIC MODULE	114	62	All SZGR 2.0 genes in this pathway

Gene Page: CD28