Gene Page: GRAP2

Summary ?
GeneID9402
SymbolGRAP2
SynonymsGADS|GRAP-2|GRB2L|GRBLG|GRID|GRPL|GrbX|Grf40|Mona|P38
DescriptionGRB2-related adaptor protein 2
ReferenceMIM:604518|HGNC:HGNC:4563|Ensembl:ENSG00000100351|HPRD:05156|Vega:OTTHUMG00000151097
Gene typeprotein-coding
Map location22q13.2
Pascal p-value0.157
Fetal beta0.134

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:GWASdbGenome-wide Association StudiesGWASdb records for schizophrenia
CV:PGCnpGenome-wide Association StudyGWAS
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0078 

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
KIAA13050.940.92
ADAMTS70.940.91
DCHS10.930.93
DNMT3B0.930.87
LPAR20.930.85
PLXNB20.920.93
NINL0.920.92
AC145098.20.920.85
MICAL10.920.88
PLXNA30.910.88
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
C5orf53-0.65-0.74
FBXO2-0.64-0.64
HLA-F-0.64-0.66
ACOT13-0.63-0.72
ALDOC-0.63-0.61
FAM162A-0.62-0.73
ACYP2-0.62-0.70
LDHD-0.62-0.58
AIFM3-0.62-0.58
CA4-0.62-0.70

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005070SH3/SH2 adaptor activityTAS9878555 
GO:0005515protein bindingIPI12359715 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007267cell-cell signalingTAS9878555 
GO:0007265Ras protein signal transductionTAS9878555 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolEXP11048639 |11607830 |17652306 
GO:0005634nucleusIDA18029348 
GO:0005730nucleolusIDA18029348 
GO:0005737cytoplasmTAS9878555 

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BEND5C1orf165 | FLJ11588BEN domain containing 5Two-hybridBioGRID16189514 
CCNDBP1DIP1 | GCIPcyclin D-type binding-protein 1-HPRD,BioGRID10801854 
CD28MGC138290 | Tp44CD28 molecule-HPRD,BioGRID10820259 
CD28MGC138290 | Tp44CD28 moleculeGRAP2 (GRID) interacts with CD28.BIND10820259 
CSF1RC-FMS | CD115 | CSFR | FIM2 | FMScolony stimulating factor 1 receptorReconstituted ComplexBioGRID9857184 
DNM2CMTDI1 | CMTDIB | DI-CMTB | DYN2 | DYNIIdynamin 2An unspecified isoform of Dyn2 interacts with Gads. This interaction was modeled on a demonstrated interaction between human Dyn2 and Gads from an unspecified species.BIND15696170 
FASLGAPT1LG1 | CD178 | CD95L | FASL | TNFSF6Fas ligand (TNF superfamily, member 6)-HPRD,BioGRID11741599 
GAB1-GRB2-associated binding protein 1-HPRD,BioGRID9878555 
GAB2KIAA0571GRB2-associated binding protein 2-HPRD11997510 
GAB3-GRB2-associated binding protein 3-HPRD11997510 
GFAPFLJ45472glial fibrillary acidic proteinTwo-hybridBioGRID16189514 
GNB2L1Gnb2-rs1 | H12.3 | HLC-7 | PIG21 | RACK1guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1GRAP2 (GRID) interacts with GNB2L1 (RACK-1).BIND10820259 
GNB2L1Gnb2-rs1 | H12.3 | HLC-7 | PIG21 | RACK1guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1-HPRD,BioGRID10820259 
HNRNPKCSBP | FLJ41122 | HNRPK | TUNPheterogeneous nuclear ribonucleoprotein KTwo-hybridBioGRID16189514 
KHDRBS1FLJ34027 | Sam68 | p62KH domain containing, RNA binding, signal transduction associated 1GRAP2 (GRID) interacts with KHDRBS1 (Sam68).BIND10820259 
KHDRBS1FLJ34027 | Sam68 | p62KH domain containing, RNA binding, signal transduction associated 1-HPRD,BioGRID9872323 |10820259 
KITC-Kit | CD117 | PBT | SCFRv-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog-HPRD9872323 
KRTAP4-12KAP4.12 | KRTAP4.12keratin associated protein 4-12Two-hybridBioGRID16189514 
LATLAT1 | pp36linker for activation of T cells-HPRD,BioGRID10021361 
LAX1FLJ20340 | LAXlymphocyte transmembrane adaptor 1Affinity Capture-WesternBioGRID12359715 
LCP2SLP-76 | SLP76lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)-HPRD,BioGRID10021361 |10224278 
LCP2SLP-76 | SLP76lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)SLP-76 interacts with Gads.BIND10021361 
MAP4K1HPK1mitogen-activated protein kinase kinase kinase kinase 1Grap2, a hematopoietic, Grb2-related adaptor protein interacts with HPK1, a Ste20-related serine/threonine kinaseBIND11313918 
MAP4K1HPK1mitogen-activated protein kinase kinase kinase kinase 1-HPRD,BioGRID11313918 
PRPH2AOFMD | AVMD | PRPH | RDS | RP7 | TSPAN22 | rd2peripherin 2 (retinal degeneration, slow)-HPRD11641407 
RBPMSHERMESRNA binding protein with multiple splicingTwo-hybridBioGRID16189514 
SHBRP11-3J10.8 | bA3J10.2Src homology 2 domain containing adaptor protein B-HPRD12084069 
SHC1FLJ26504 | SHC | SHCASHC (Src homology 2 domain containing) transforming protein 1-HPRD9872323 
SOS2FLJ25596son of sevenless homolog 2 (Drosophila)-HPRD,BioGRID10820259 
SOS2FLJ25596son of sevenless homolog 2 (Drosophila)GRAP2 (GRID) interacts with Sos2.BIND10820259 
STAMBPAMSH | MGC126516 | MGC126518STAM binding protein-HPRD,BioGRID10224278 
YWHAE14-3-3E | FLJ45465 | KCIP-1 | MDCR | MDStyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptideTwo-hybridBioGRID16189514 
ZBTB7BDKFZp686G01254 | THPOK | ZBTB15 | ZFP67 | ZNF857B | c-Krox | hcKroxzinc finger and BTB domain containing 7BTwo-hybridBioGRID16189514 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG T CELL RECEPTOR SIGNALING PATHWAY 10889All SZGR 2.0 genes in this pathway
ST T CELL SIGNAL TRANSDUCTION 4533All SZGR 2.0 genes in this pathway
PID TCR PATHWAY 6651All SZGR 2.0 genes in this pathway
PID CD8 TCR PATHWAY 5342All SZGR 2.0 genes in this pathway
PID TCR JNK PATHWAY 1411All SZGR 2.0 genes in this pathway
PID KIT PATHWAY 5240All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY SCF KIT 7859All SZGR 2.0 genes in this pathway
REACTOME TCR SIGNALING 5446All SZGR 2.0 genes in this pathway
REACTOME GENERATION OF SECOND MESSENGER MOLECULES 2725All SZGR 2.0 genes in this pathway
REACTOME CD28 CO STIMULATION 3226All SZGR 2.0 genes in this pathway
REACTOME COSTIMULATION BY THE CD28 FAMILY 6348All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933616All SZGR 2.0 genes in this pathway
REACTOME ADAPTIVE IMMUNE SYSTEM 539350All SZGR 2.0 genes in this pathway
BORCZUK MALIGNANT MESOTHELIOMA DN 10459All SZGR 2.0 genes in this pathway
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL UP 233161All SZGR 2.0 genes in this pathway
HUI MAPK14 TARGETS UP 2111All SZGR 2.0 genes in this pathway
PUJANA BRCA2 PCC NETWORK 423265All SZGR 2.0 genes in this pathway
MATSUDA NATURAL KILLER DIFFERENTIATION 475313All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 STIMULATED 1022619All SZGR 2.0 genes in this pathway
ACEVEDO METHYLATED IN LIVER CANCER DN 940425All SZGR 2.0 genes in this pathway
YAUCH HEDGEHOG SIGNALING PARACRINE DN 264159All SZGR 2.0 genes in this pathway
HAN SATB1 TARGETS DN 442275All SZGR 2.0 genes in this pathway
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR DN 8859All SZGR 2.0 genes in this pathway
RAO BOUND BY SALL4 ISOFORM B 517302All SZGR 2.0 genes in this pathway