Gene Page: CD86

Summary ?
GeneID942
SymbolCD86
SynonymsB7-2|B7.2|B70|CD28LG2|LAB72
DescriptionCD86 molecule
ReferenceMIM:601020|HGNC:HGNC:1705|Ensembl:ENSG00000114013|HPRD:03011|Vega:OTTHUMG00000159482
Gene typeprotein-coding
Map location3q21
Pascal p-value0.571
Fetal beta-0.493
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs621071chr1182682810CD869420.19trans
rs10994209chr1061877705CD869420.19trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
SEMA3G0.830.82
MMRN20.810.82
ENG0.790.80
A2M0.780.76
ABCB10.780.70
TGM20.760.78
ACVRL10.760.73
SLCO2B10.760.80
EPAS10.760.71
NPR10.750.73
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
ZNF32-0.51-0.56
SPATA7-0.50-0.51
NDUFAF2-0.50-0.55
C12orf45-0.50-0.60
ST20-0.49-0.59
OXSM-0.49-0.54
PPP2R3C-0.48-0.53
FRG1-0.48-0.54
PSMA6-0.47-0.54
C18orf21-0.47-0.48

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG CELL ADHESION MOLECULES CAMS 13493All SZGR 2.0 genes in this pathway
KEGG TOLL LIKE RECEPTOR SIGNALING PATHWAY 10288All SZGR 2.0 genes in this pathway
KEGG INTESTINAL IMMUNE NETWORK FOR IGA PRODUCTION 4836All SZGR 2.0 genes in this pathway
KEGG TYPE I DIABETES MELLITUS 4438All SZGR 2.0 genes in this pathway
KEGG AUTOIMMUNE THYROID DISEASE 5349All SZGR 2.0 genes in this pathway
KEGG SYSTEMIC LUPUS ERYTHEMATOSUS 140100All SZGR 2.0 genes in this pathway
KEGG ALLOGRAFT REJECTION 3834All SZGR 2.0 genes in this pathway
KEGG GRAFT VERSUS HOST DISEASE 4231All SZGR 2.0 genes in this pathway
KEGG VIRAL MYOCARDITIS 7358All SZGR 2.0 genes in this pathway
BIOCARTA TH1TH2 PATHWAY 1914All SZGR 2.0 genes in this pathway
BIOCARTA CTLA4 PATHWAY 2118All SZGR 2.0 genes in this pathway
PID TCR PATHWAY 6651All SZGR 2.0 genes in this pathway
PID CD8 TCR PATHWAY 5342All SZGR 2.0 genes in this pathway
PID IL12 STAT4 PATHWAY 3329All SZGR 2.0 genes in this pathway
REACTOME CD28 CO STIMULATION 3226All SZGR 2.0 genes in this pathway
REACTOME CD28 DEPENDENT VAV1 PATHWAY 1110All SZGR 2.0 genes in this pathway
REACTOME COSTIMULATION BY THE CD28 FAMILY 6348All SZGR 2.0 genes in this pathway
REACTOME CD28 DEPENDENT PI3K AKT SIGNALING 2218All SZGR 2.0 genes in this pathway
REACTOME CTLA4 INHIBITORY SIGNALING 2115All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933616All SZGR 2.0 genes in this pathway
REACTOME ADAPTIVE IMMUNE SYSTEM 539350All SZGR 2.0 genes in this pathway
PARENT MTOR SIGNALING UP 567375All SZGR 2.0 genes in this pathway
HOLLMANN APOPTOSIS VIA CD40 UP 201125All SZGR 2.0 genes in this pathway
GARY CD5 TARGETS DN 431263All SZGR 2.0 genes in this pathway
GAL LEUKEMIC STEM CELL DN 244153All SZGR 2.0 genes in this pathway
WIKMAN ASBESTOS LUNG CANCER DN 2813All SZGR 2.0 genes in this pathway
AKL HTLV1 INFECTION DN 6841All SZGR 2.0 genes in this pathway
JAATINEN HEMATOPOIETIC STEM CELL DN 226132All SZGR 2.0 genes in this pathway
GRUETZMANN PANCREATIC CANCER UP 358245All SZGR 2.0 genes in this pathway
MANTOVANI VIRAL GPCR SIGNALING DN 4937All SZGR 2.0 genes in this pathway
SAKAI TUMOR INFILTRATING MONOCYTES DN 8151All SZGR 2.0 genes in this pathway
SHIN B CELL LYMPHOMA CLUSTER 3 2823All SZGR 2.0 genes in this pathway
LU IL4 SIGNALING 9456All SZGR 2.0 genes in this pathway
PENG GLUCOSE DEPRIVATION DN 169112All SZGR 2.0 genes in this pathway
LENAOUR DENDRITIC CELL MATURATION UP 11484All SZGR 2.0 genes in this pathway
VERHAAK AML WITH NPM1 MUTATED UP 183111All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 16911088All SZGR 2.0 genes in this pathway
CHANG IMMORTALIZED BY HPV31 UP 8455All SZGR 2.0 genes in this pathway
FOSTER TOLERANT MACROPHAGE DN 409268All SZGR 2.0 genes in this pathway
KONDO PROSTATE CANCER WITH H3K27ME3 19693All SZGR 2.0 genes in this pathway
HELLER SILENCED BY METHYLATION UP 282183All SZGR 2.0 genes in this pathway
WALLACE PROSTATE CANCER RACE UP 299167All SZGR 2.0 genes in this pathway
ACEVEDO METHYLATED IN LIVER CANCER DN 940425All SZGR 2.0 genes in this pathway
GAURNIER PSMD4 TARGETS 7355All SZGR 2.0 genes in this pathway
CHUNG BLISTER CYTOTOXICITY UP 13484All SZGR 2.0 genes in this pathway
BOHN PRIMARY IMMUNODEFICIENCY SYNDROM UP 4730All SZGR 2.0 genes in this pathway
VILIMAS NOTCH1 TARGETS UP 5241All SZGR 2.0 genes in this pathway
LINDSTEDT DENDRITIC CELL MATURATION C 6949All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO CSF2RB AND IL4 UP 338225All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF DN 235144All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 DN 245150All SZGR 2.0 genes in this pathway
CHEN METABOLIC SYNDROM NETWORK 1210725All SZGR 2.0 genes in this pathway
CROONQUIST NRAS SIGNALING UP 4124All SZGR 2.0 genes in this pathway
CROONQUIST NRAS VS STROMAL STIMULATION UP 4126All SZGR 2.0 genes in this pathway
VALK AML CLUSTER 5 3324All SZGR 2.0 genes in this pathway
POOLA INVASIVE BREAST CANCER UP 288168All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA HP DN 4723All SZGR 2.0 genes in this pathway