Gene Page: RIN1
Summary ?
| GeneID | 9610 |
| Symbol | RIN1 |
| Synonyms | - |
| Description | Ras and Rab interactor 1 |
| Reference | MIM:605965|HGNC:HGNC:18749|Ensembl:ENSG00000174791|HPRD:05813|Vega:OTTHUMG00000167085 |
| Gene type | protein-coding |
| Map location | 11q13.2 |
| Pascal p-value | 0.049 |
| Sherlock p-value | 0.202 |
| eGene | Myers' cis & trans |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs10490123 | chr2 | 49124701 | RIN1 | 9610 | 0.17 | trans | ||
| rs2215912 | chr2 | 49124804 | RIN1 | 9610 | 0.17 | trans | ||
| rs1445550 | chr13 | 64202211 | RIN1 | 9610 | 0.09 | trans |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| NOTCH4 | 0.74 | 0.74 |
| MFSD2 | 0.73 | 0.78 |
| CDH5 | 0.73 | 0.81 |
| ENG | 0.71 | 0.78 |
| NOS3 | 0.70 | 0.76 |
| TIE1 | 0.69 | 0.75 |
| CXorf36 | 0.68 | 0.74 |
| ROBO4 | 0.68 | 0.74 |
| DOCK6 | 0.67 | 0.72 |
| TNFRSF1B | 0.67 | 0.73 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| MTIF3 | -0.54 | -0.54 |
| C8orf59 | -0.48 | -0.55 |
| MRPS18C | -0.47 | -0.51 |
| VRK2 | -0.46 | -0.48 |
| BXDC1 | -0.46 | -0.47 |
| UQCRB | -0.45 | -0.48 |
| RWDD1 | -0.45 | -0.49 |
| CRYZL1 | -0.44 | -0.46 |
| ATP5J | -0.44 | -0.49 |
| C11orf51 | -0.43 | -0.46 |
Section IV. Protein-protein interaction annotation
| Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
|---|---|---|---|---|---|
| ABL1 | ABL | JTK7 | bcr/abl | c-ABL | p150 | v-abl | c-abl oncogene 1, receptor tyrosine kinase | ABL1 interacts with and phosphorylates RIN1. | BIND | 15886098 |
| ABL1 | ABL | JTK7 | bcr/abl | c-ABL | p150 | v-abl | c-abl oncogene 1, receptor tyrosine kinase | - | HPRD | 9144171 |
| ABL2 | ABLL | ARG | FLJ22224 | FLJ31718 | FLJ41441 | v-abl Abelson murine leukemia viral oncogene homolog 2 (arg, Abelson-related gene) | ABL2 interacts with and phosphorylates RIN1. | BIND | 15886098 |
| HRAS | C-BAS/HAS | C-H-RAS | C-HA-RAS1 | CTLO | H-RASIDX | HAMSV | HRAS1 | K-RAS | N-RAS | RASH1 | v-Ha-ras Harvey rat sarcoma viral oncogene homolog | Reconstituted Complex Two-hybrid | BioGRID | 7862125 |15031288 |
| HRAS | C-BAS/HAS | C-H-RAS | C-HA-RAS1 | CTLO | H-RASIDX | HAMSV | HRAS1 | K-RAS | N-RAS | RASH1 | v-Ha-ras Harvey rat sarcoma viral oncogene homolog | - | HPRD | 7862125 |9144171 |
| MLLT4 | AF-6 | AF6 | AFADIN | FLJ34371 | RP3-431P23.3 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4 | Two-hybrid | BioGRID | 10545207 |
| RAB5A | RAB5 | RAB5A, member RAS oncogene family | - | HPRD,BioGRID | 11703925 |
| RAB5B | - | RAB5B, member RAS oncogene family | Two-hybrid | BioGRID | 11703925 |
| RALGDS | FLJ20922 | RGF | RalGEF | ral guanine nucleotide dissociation stimulator | Two-hybrid | BioGRID | 10545207 |
| RRAS2 | TC21 | related RAS viral (r-ras) oncogene homolog 2 | - | HPRD,BioGRID | 11788587 |
| YWHAB | GW128 | HS1 | KCIP-1 | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide | - | HPRD | 9144171 |11784866 |
| YWHAE | 14-3-3E | FLJ45465 | KCIP-1 | MDCR | MDS | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide | - | HPRD | 9144171 |11784866 |
| YWHAZ | KCIP-1 | MGC111427 | MGC126532 | MGC138156 | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide | - | HPRD | 9144171 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| PID ERBB1 DOWNSTREAM PATHWAY | 105 | 78 | All SZGR 2.0 genes in this pathway |
| PID RAS PATHWAY | 30 | 22 | All SZGR 2.0 genes in this pathway |
| HUMMERICH SKIN CANCER PROGRESSION UP | 88 | 58 | All SZGR 2.0 genes in this pathway |
| DAIRKEE TERT TARGETS UP | 380 | 213 | All SZGR 2.0 genes in this pathway |
| GRUETZMANN PANCREATIC CANCER UP | 358 | 245 | All SZGR 2.0 genes in this pathway |
| LOPEZ MBD TARGETS | 957 | 597 | All SZGR 2.0 genes in this pathway |
| NIKOLSKY BREAST CANCER 11Q12 Q14 AMPLICON | 158 | 93 | All SZGR 2.0 genes in this pathway |
| HOFMANN CELL LYMPHOMA DN | 39 | 29 | All SZGR 2.0 genes in this pathway |
| TAVOR CEBPA TARGETS DN | 30 | 21 | All SZGR 2.0 genes in this pathway |
| MOREAUX MULTIPLE MYELOMA BY TACI UP | 412 | 249 | All SZGR 2.0 genes in this pathway |
| LU AGING BRAIN UP | 262 | 186 | All SZGR 2.0 genes in this pathway |
| BROWNE HCMV INFECTION 6HR DN | 160 | 101 | All SZGR 2.0 genes in this pathway |
| BROWNE HCMV INFECTION 12HR DN | 101 | 64 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN ES ICP WITH H3K4ME3 | 718 | 401 | All SZGR 2.0 genes in this pathway |
| BROWNE HCMV INFECTION 4HR DN | 254 | 158 | All SZGR 2.0 genes in this pathway |
| VERHAAK GLIOBLASTOMA CLASSICAL | 162 | 122 | All SZGR 2.0 genes in this pathway |
| BRUINS UVC RESPONSE VIA TP53 GROUP B | 549 | 316 | All SZGR 2.0 genes in this pathway |
| BRUINS UVC RESPONSE LATE | 1137 | 655 | All SZGR 2.0 genes in this pathway |
| KOINUMA TARGETS OF SMAD2 OR SMAD3 | 824 | 528 | All SZGR 2.0 genes in this pathway |