Gene Page: RICS

Summary
GeneID  9743
Symbol  RICS
Synonyms  GC-GAP|GRIT|KIAA0712|MGC1892|p200RhoGAP|p250GAP
Description  Rho GTPase-activating protein
See related  MIM:608541|Ensembl:ENSG00000134909|HPRD:12257|
Locus tag  -
Gene type  protein-coding
Map location  11q24-q25
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.5164 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
ANKRD170.930.94
ADAR0.930.94
DYRK1A0.930.94
ANAPC10.930.94
NOLC10.930.93
KIAA00900.930.93
SLC12A60.920.95
FTO0.920.93
HERC10.920.93
ARHGEF70.920.94
Top 10 negatively co-expressed genes
FXYD1-0.77-0.79
MT-CO2-0.77-0.81
AF347015.31-0.76-0.79
HIGD1B-0.76-0.81
AF347015.21-0.74-0.83
IFI27-0.73-0.77
C1orf54-0.72-0.85
AF347015.33-0.72-0.74
AC021016.1-0.72-0.74
MT-CYB-0.71-0.75
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005096GTPase activator activityIEA-
GO:0005515protein bindingIEA-
GO:0035091phosphoinositide bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007165signal transductionIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0042995cell projectionIEAaxon (GO term level: 4)-
GO:0045211postsynaptic membraneIEASynap, Neurotransmitter (GO term level: 5)-
GO:0045202synapseIEAneuron, Synap, Neurotransmitter, Glial (GO term level: 2)-
GO:0000139Golgi membraneIEA-
GO:0005794Golgi apparatusIEA-
GO:0005789endoplasmic reticulum membraneIEA-
GO:0005622intracellularIEA-
GO:0005737cytoplasmIEA-
GO:0005768endosomeIEA-
GO:0005783endoplasmic reticulumIEA-
GO:0005886plasma membraneIEA-
GO:0010008endosome membraneIEA-
GO:0030054cell junctionIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
AKT1AKT | MGC99656 | PKB | PKB-ALPHA | PRKBA | RAC | RAC-ALPHAv-akt murine thymoma viral oncogene homolog 1Biochemical ActivityBioGRID12446789 
BCAR1CAS | CAS1 | CASS1 | CRKAS | P130Casbreast cancer anti-estrogen resistance 1-HPRD,BioGRID12446789 |12819203 
CAMK2N2CAM-KIIN | CAMKIINcalcium/calmodulin-dependent protein kinase II inhibitor 2-HPRD12531901 
CDC42CDC42Hs | G25Kcell division cycle 42 (GTP binding protein, 25kDa)Biochemical ActivityBioGRID12446789 |12819203 
|12857875 
CDH1Arc-1 | CD324 | CDHE | ECAD | LCAM | UVOcadherin 1, type 1, E-cadherin (epithelial)-HPRD12531901 
CDH2CD325 | CDHN | CDw325 | NCADcadherin 2, type 1, N-cadherin (neuronal)-HPRD12531901 
CRKCRKIIv-crk sarcoma virus CT10 oncogene homolog (avian)Crk interacts with GC-GAP. This interaction was modelled on a demonstrated interaction between Crk from an unspecified species and human GC-GAP.BIND12819203 
Affinity Capture-Western
Reconstituted Complex		BioGRID12454018 |12819203 
-HPRD12446789 |12454018 
CRKL-v-crk sarcoma virus CT10 oncogene homolog (avian)-like-HPRD,BioGRID12446789 
CTNNB1CTNNB | DKFZp686D02253 | FLJ25606 | FLJ37923catenin (cadherin-associated protein), beta 1, 88kDa-HPRD12531901 
DLG4FLJ97752 | FLJ98574 | PSD95 | SAP90discs, large homolog 4 (Drosophila)-HPRD12531901 
FYNMGC45350 | SLK | SYNFYN oncogene related to SRC, FGR, YES-HPRD,BioGRID12788081 |12857875 
GAB1-GRB2-associated binding protein 1Gab1 interacts with GC-GAP.BIND12819203 
-HPRD,BioGRID12819203 
GAB2KIAA0571GRB2-associated binding protein 2Gab2 interacts with GC-GAP.BIND12819203 
-HPRD,BioGRID12819203 
GRAPMGC64880GRB2-related adaptor proteinGrap interacts with GC-GAP. This interaction was modelled on a demonstrated interaction between Grap from an unspecified species and human GC-GAP.BIND12819203 
GRIN2ANMDAR2A | NR2Aglutamate receptor, ionotropic, N-methyl D-aspartate 2A-HPRD12531901 
GRIN2BMGC142178 | MGC142180 | NMDAR2B | NR2B | hNR3glutamate receptor, ionotropic, N-methyl D-aspartate 2B-HPRD,BioGRID12531901 |12857875 
MEGF10DKFZp781K1852 | FLJ41574 | KIAA1780multiple EGF-like-domains 10-HPRD12421765 
NCK1MGC12668 | NCK | NCKalphaNCK adaptor protein 1Nck interacts with GC-GAP. This interaction was modelled on a demonstrated interaction between Nck from an unspecified species and human GC-GAP.BIND12819203 
-HPRD,BioGRID12819203 
NF2ACN | BANF | SCHneurofibromin 2 (merlin)Affinity Capture-WesternBioGRID12446789 
NTRK1DKFZp781I14186 | MTC | TRK | TRK1 | TRKA | p140-TrkAneurotrophic tyrosine kinase, receptor, type 1-HPRD,BioGRID12446789 
PIK3R1GRB1 | p85 | p85-ALPHAphosphoinositide-3-kinase, regulatory subunit 1 (alpha)-HPRD,BioGRID12454018 
PLCG1PLC-II | PLC1 | PLC148 | PLCgamma1phospholipase C, gamma 1-HPRD,BioGRID12454018 
RAC1MGC111543 | MIG5 | TC-25 | p21-Rac1ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)Biochemical ActivityBioGRID12454018 |12819203 
RHOAARH12 | ARHA | RHO12 | RHOH12ras homolog gene family, member ABiochemical ActivityBioGRID12446789 |12454018 
|12857875 
SFNYWHASstratifinAffinity Capture-MSBioGRID15778465 
SHC2SCK | SHCB | SLISHC (Src homology 2 domain containing) transforming protein 2Affinity Capture-WesternBioGRID12446789 
SHC3N-Shc | NSHC | RAI | SHCCSHC (Src homology 2 domain containing) transforming protein 3-HPRD,BioGRID12446789 
SRCASV | SRC1 | c-SRC | p60-Srcv-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)-HPRD,BioGRID12454018 
Src interacts with GC-GAP. This interaction was modelled on a demonstrated interaction between Src from an unspecified species and human GC-GAP.BIND12819203 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
PID_TRKR_PATHWAY 6248All SZGR genes in this pathway
DEURIG_T_CELL_PROLYMPHOCYTIC_LEUKEMIA_UP 368234All SZGR genes in this pathway
JAEGER_METASTASIS_DN 258141All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_UP 1821933All SZGR genes in this pathway
GAUSSMANN_MLL_AF4_FUSION_TARGETS_A_UP 191128All SZGR genes in this pathway
LASTOWSKA_NEUROBLASTOMA_COPY_NUMBER_DN 800473All SZGR genes in this pathway
RICKMAN_TUMOR_DIFFERENTIATED_MODERATELY_VS_POORLY_UP 12171All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_20HR_UP 240152All SZGR genes in this pathway
WANG_CISPLATIN_RESPONSE_AND_XPC_DN 228146All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_STEM_CELL 254164All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_STEM_CELL_AND_PROGENITOR 681420All SZGR genes in this pathway
SMID_BREAST_CANCER_BASAL_DN 701446All SZGR genes in this pathway
TOYOTA_TARGETS_OF_MIR34B_AND_MIR34C 463262All SZGR genes in this pathway
ROME_INSULIN_TARGETS_IN_MUSCLE_DN 204114All SZGR genes in this pathway
WONG_ADULT_TISSUE_STEM_MODULE 721492All SZGR genes in this pathway
KOINUMA_TARGETS_OF_SMAD2_OR_SMAD3 824528All SZGR genes in this pathway
PECE_MAMMARY_STEM_CELL_DN 14688All SZGR genes in this pathway
HOLLEMAN_VINCRISTINE_RESISTANCE_ALL_UP 2716All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-132/2124450m8hsa-miR-212SZUAACAGUCUCCAGUCACGGCC
hsa-miR-132brainUAACAGUCUACAGCCAUGGUCG
miR-1379151Ahsa-miR-137UAUUGCUUAAGAAUACGCGUAG
miR-33832381Ahsa-miR-338brainUCCAGCAUCAGUGAUUUUGUUGA
miR-485-5p2531m8hsa-miR-485-5pAGAGGCUGGCCGUGAUGAAUUC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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