Gene Page: NOG

Summary ?
GeneID9241
SymbolNOG
SynonymsSYM1|SYNS1|SYNS1A
Descriptionnoggin
ReferenceMIM:602991|HGNC:HGNC:7866|Ensembl:ENSG00000183691|HPRD:04291|Vega:OTTHUMG00000151770
Gene typeprotein-coding
Map location17q22
Pascal p-value0.143
Fetal beta0.182

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
CV:PheWASPhenome-wide association studies (PheWAS)157 SNPs associated with schizophrenia 0
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 

Section I. Genetics and epigenetics annotation

@CV:PheWAS

SNP IDChromosomePositionAllelePFunctionGeneUp/Down Distance


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
SLC6A200.810.56
SLC22A20.750.63
SLC13A40.730.78
SLC5A50.690.77
OGN0.660.69
DSP0.620.56
SERPIND10.610.69
GJB20.600.60
SLC22A60.590.69
OMD0.590.54
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
LRRC37A-0.18-0.36
CHMP4A-0.17-0.30
NBR2-0.17-0.20
C11orf51-0.14-0.23
ACP6-0.14-0.06
USF2-0.13-0.31
ZRSR2-0.13-0.36
HES4-0.13-0.23
SLC25A28-0.13-0.17
C14orf80-0.13-0.15

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0019955cytokine bindingIPI8752214 
GO:0042803protein homodimerization activityIDA11562478 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007420brain developmentIEABrain (GO term level: 7)-
GO:0048712negative regulation of astrocyte differentiationISSastrocyte, Glial (GO term level: 12)10780858 
GO:0001657ureteric bud developmentIEA-
GO:0001649osteoblast differentiationISS10780858 
GO:0001837epithelial to mesenchymal transitionISS10780858 
GO:0009953dorsal/ventral pattern formationIDA7666191 
GO:0007605sensory perception of soundIEA-
GO:0007389pattern specification processIEA-
GO:0042060wound healingISS10780858 
GO:0035019somatic stem cell maintenanceIMP17889703 
GO:0042733embryonic digit morphogenesisIMP10080184 
GO:0030514negative regulation of BMP signaling pathwayIEA-
GO:0042474middle ear morphogenesisIMP10080184 
GO:0051216cartilage developmentIEA-
GO:0045596negative regulation of cell differentiationIEA-
GO:0048570notochord morphogenesisIEA-
GO:0048706embryonic skeletal system developmentIMP10080184 
GO:0048646anatomical structure formationIEA-
GO:0060044negative regulation of cardiac muscle cell proliferationISS10780858 
GO:0060173limb developmentIMP10080184 
GO:0060272embryonic skeletal joint morphogenesisIMP16151340 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionEXP17029022 
GO:0005576extracellular regionIEA-
GO:0005615extracellular spaceTAS10080184 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG TGF BETA SIGNALING PATHWAY 8664All SZGR 2.0 genes in this pathway
BIOCARTA ALK PATHWAY 3729All SZGR 2.0 genes in this pathway
PID BMP PATHWAY 4231All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY BMP 2315All SZGR 2.0 genes in this pathway
HOOI ST7 TARGETS DN 12378All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 8D UP 15791All SZGR 2.0 genes in this pathway
SENESE HDAC1 AND HDAC2 TARGETS DN 232139All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC UP 722443All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP 1037673All SZGR 2.0 genes in this pathway
INGRAM SHH TARGETS UP 12779All SZGR 2.0 genes in this pathway
BENPORATH SUZ12 TARGETS 1038678All SZGR 2.0 genes in this pathway
BENPORATH EED TARGETS 1062725All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 17Q21 Q25 AMPLICON 335181All SZGR 2.0 genes in this pathway
SHEPARD CRUSH AND BURN MUTANT UP 197110All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS 882572All SZGR 2.0 genes in this pathway
WONG IFNA2 RESISTANCE DN 3420All SZGR 2.0 genes in this pathway
DOUGLAS BMI1 TARGETS UP 566371All SZGR 2.0 genes in this pathway
YAUCH HEDGEHOG SIGNALING PARACRINE UP 14985All SZGR 2.0 genes in this pathway
LEE NAIVE T LYMPHOCYTE 1910All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 1069729All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3K4ME2 AND H3K27ME3 349234All SZGR 2.0 genes in this pathway
MIKKELSEN MCV6 HCP WITH H3K27ME3 435318All SZGR 2.0 genes in this pathway
MIKKELSEN NPC HCP WITH H3K4ME3 AND H3K27ME3 210148All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE DN 841431All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 DN 918550All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP A 898516All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY 1725838All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-148/152172178m8hsa-miR-148aUCAGUGCACUACAGAACUUUGU
hsa-miR-152brainUCAGUGCAUGACAGAACUUGGG
hsa-miR-148bUCAGUGCAUCACAGAACUUUGU
miR-1811921981Ahsa-miR-181abrainAACAUUCAACGCUGUCGGUGAGU
hsa-miR-181bSZAACAUUCAUUGCUGUCGGUGGG
hsa-miR-181cbrainAACAUUCAACCUGUCGGUGAGU
hsa-miR-181dbrainAACAUUCAUUGUUGUCGGUGGGUU
miR-200bc/4292472541A,m8hsa-miR-200bUAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200cUAAUACUGCCGGGUAAUGAUGG
hsa-miR-429UAAUACUGUCUGGUAAAACCGU
miR-3292042101Ahsa-miR-329brainAACACACCUGGUUAACCUCUUU
miR-369-3p2492561A,m8hsa-miR-369-3pAAUAAUACAUGGUUGAUCUUU
miR-374250256m8hsa-miR-374UUAUAAUACAACCUGAUAAGUG