Gene Page: SNX16
Summary ?
| GeneID | 64089 |
| Symbol | SNX16 |
| Synonyms | - |
| Description | sorting nexin 16 |
| Reference | MIM:614903|HGNC:HGNC:14980|Ensembl:ENSG00000104497|HPRD:15411|Vega:OTTHUMG00000164727 |
| Gene type | protein-coding |
| Map location | 8q21.13 |
| Pascal p-value | 0.842 |
| Sherlock p-value | 0.847 |
| Fetal beta | 0.259 |
| eGene | Caudate basal ganglia Cerebellar Hemisphere Cerebellum Cortex Frontal Cortex BA9 Hippocampus Hypothalamus Putamen basal ganglia Myers' cis & trans Meta |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:GWASdb | Genome-wide Association Studies | GWASdb records for schizophrenia | |
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs1817107 | chr8 | 82789608 | SNX16 | 64089 | 0.04 | cis | ||
| rs1463253 | chr8 | 82820172 | SNX16 | 64089 | 0.06 | cis | ||
| rs1966850 | chr8 | 82833012 | SNX16 | 64089 | 0.06 | cis | ||
| rs4739632 | chr8 | 82849463 | SNX16 | 64089 | 0.12 | cis | ||
| rs2948491 | chrX | 40180688 | SNX16 | 64089 | 0.17 | trans | ||
| rs78596908 | 8 | 82707507 | SNX16 | ENSG00000104497.9 | 3.054E-6 | 0 | 47594 | gtex_brain_putamen_basal |
| rs4272332 | 8 | 82708029 | SNX16 | ENSG00000104497.9 | 2.945E-6 | 0 | 47072 | gtex_brain_putamen_basal |
| rs7460280 | 8 | 82709825 | SNX16 | ENSG00000104497.9 | 2.921E-6 | 0 | 45276 | gtex_brain_putamen_basal |
| rs35970944 | 8 | 82710470 | SNX16 | ENSG00000104497.9 | 2.9E-6 | 0 | 44631 | gtex_brain_putamen_basal |
| rs1489587 | 8 | 82715852 | SNX16 | ENSG00000104497.9 | 2.854E-6 | 0 | 39249 | gtex_brain_putamen_basal |
| rs62514324 | 8 | 82716569 | SNX16 | ENSG00000104497.9 | 2.854E-6 | 0 | 38532 | gtex_brain_putamen_basal |
| rs59101671 | 8 | 82716906 | SNX16 | ENSG00000104497.9 | 2.854E-6 | 0 | 38195 | gtex_brain_putamen_basal |
| rs35208380 | 8 | 82717258 | SNX16 | ENSG00000104497.9 | 2.854E-6 | 0 | 37843 | gtex_brain_putamen_basal |
| rs2600599 | 8 | 82719000 | SNX16 | ENSG00000104497.9 | 2.85E-6 | 0 | 36101 | gtex_brain_putamen_basal |
| rs2635489 | 8 | 82719583 | SNX16 | ENSG00000104497.9 | 2.838E-6 | 0 | 35518 | gtex_brain_putamen_basal |
| rs2635488 | 8 | 82719613 | SNX16 | ENSG00000104497.9 | 2.829E-6 | 0 | 35488 | gtex_brain_putamen_basal |
| rs2600603 | 8 | 82720351 | SNX16 | ENSG00000104497.9 | 2.854E-6 | 0 | 34750 | gtex_brain_putamen_basal |
| rs2635487 | 8 | 82720404 | SNX16 | ENSG00000104497.9 | 2.854E-6 | 0 | 34697 | gtex_brain_putamen_basal |
| rs2600605 | 8 | 82720760 | SNX16 | ENSG00000104497.9 | 2.496E-6 | 0 | 34341 | gtex_brain_putamen_basal |
| rs774466 | 8 | 82721390 | SNX16 | ENSG00000104497.9 | 2.841E-6 | 0 | 33711 | gtex_brain_putamen_basal |
| rs774467 | 8 | 82721591 | SNX16 | ENSG00000104497.9 | 2.854E-6 | 0 | 33510 | gtex_brain_putamen_basal |
| rs799332 | 8 | 82722134 | SNX16 | ENSG00000104497.9 | 2.854E-6 | 0 | 32967 | gtex_brain_putamen_basal |
| rs774468 | 8 | 82723111 | SNX16 | ENSG00000104497.9 | 2.854E-6 | 0 | 31990 | gtex_brain_putamen_basal |
| rs774470 | 8 | 82724326 | SNX16 | ENSG00000104497.9 | 1.525E-6 | 0 | 30775 | gtex_brain_putamen_basal |
| rs774473 | 8 | 82724962 | SNX16 | ENSG00000104497.9 | 2.854E-6 | 0 | 30139 | gtex_brain_putamen_basal |
| rs140676724 | 8 | 82725764 | SNX16 | ENSG00000104497.9 | 2.836E-6 | 0 | 29337 | gtex_brain_putamen_basal |
| rs2635482 | 8 | 82727515 | SNX16 | ENSG00000104497.9 | 2.854E-6 | 0 | 27586 | gtex_brain_putamen_basal |
| rs2600606 | 8 | 82727520 | SNX16 | ENSG00000104497.9 | 2.854E-6 | 0 | 27581 | gtex_brain_putamen_basal |
| rs774476 | 8 | 82728114 | SNX16 | ENSG00000104497.9 | 2.854E-6 | 0 | 26987 | gtex_brain_putamen_basal |
| rs774477 | 8 | 82728303 | SNX16 | ENSG00000104497.9 | 2.854E-6 | 0 | 26798 | gtex_brain_putamen_basal |
| rs774479 | 8 | 82729083 | SNX16 | ENSG00000104497.9 | 2.854E-6 | 0 | 26018 | gtex_brain_putamen_basal |
| rs774461 | 8 | 82731406 | SNX16 | ENSG00000104497.9 | 2.854E-6 | 0 | 23695 | gtex_brain_putamen_basal |
| rs799331 | 8 | 82732843 | SNX16 | ENSG00000104497.9 | 2.854E-6 | 0 | 22258 | gtex_brain_putamen_basal |
| rs774462 | 8 | 82733140 | SNX16 | ENSG00000104497.9 | 2.854E-6 | 0 | 21961 | gtex_brain_putamen_basal |
| rs774463 | 8 | 82733239 | SNX16 | ENSG00000104497.9 | 2.854E-6 | 0 | 21862 | gtex_brain_putamen_basal |
| rs774465 | 8 | 82734131 | SNX16 | ENSG00000104497.9 | 2.854E-6 | 0 | 20970 | gtex_brain_putamen_basal |
| rs2635492 | 8 | 82734903 | SNX16 | ENSG00000104497.9 | 2.854E-6 | 0 | 20198 | gtex_brain_putamen_basal |
| rs1463257 | 8 | 82738039 | SNX16 | ENSG00000104497.9 | 1.298E-6 | 0 | 17062 | gtex_brain_putamen_basal |
| rs56125566 | 8 | 82739513 | SNX16 | ENSG00000104497.9 | 2.854E-6 | 0 | 15588 | gtex_brain_putamen_basal |
| rs12546081 | 8 | 82740048 | SNX16 | ENSG00000104497.9 | 2.854E-6 | 0 | 15053 | gtex_brain_putamen_basal |
| rs1470787 | 8 | 82740502 | SNX16 | ENSG00000104497.9 | 2.854E-6 | 0 | 14599 | gtex_brain_putamen_basal |
| rs11998593 | 8 | 82743215 | SNX16 | ENSG00000104497.9 | 2.854E-6 | 0 | 11886 | gtex_brain_putamen_basal |
| rs56845285 | 8 | 82744179 | SNX16 | ENSG00000104497.9 | 2.854E-6 | 0 | 10922 | gtex_brain_putamen_basal |
| rs61339058 | 8 | 82744342 | SNX16 | ENSG00000104497.9 | 2.827E-6 | 0 | 10759 | gtex_brain_putamen_basal |
| rs200166390 | 8 | 82745641 | SNX16 | ENSG00000104497.9 | 2.818E-6 | 0 | 9460 | gtex_brain_putamen_basal |
| rs55737721 | 8 | 82745642 | SNX16 | ENSG00000104497.9 | 2.731E-6 | 0 | 9459 | gtex_brain_putamen_basal |
| rs10110803 | 8 | 82746436 | SNX16 | ENSG00000104497.9 | 3.183E-6 | 0 | 8665 | gtex_brain_putamen_basal |
| rs6984904 | 8 | 82746751 | SNX16 | ENSG00000104497.9 | 2.854E-6 | 0 | 8350 | gtex_brain_putamen_basal |
| rs56845979 | 8 | 82748349 | SNX16 | ENSG00000104497.9 | 2.854E-6 | 0 | 6752 | gtex_brain_putamen_basal |
| rs12674735 | 8 | 82748674 | SNX16 | ENSG00000104497.9 | 2.854E-6 | 0 | 6427 | gtex_brain_putamen_basal |
| rs59171702 | 8 | 82748849 | SNX16 | ENSG00000104497.9 | 2.854E-6 | 0 | 6252 | gtex_brain_putamen_basal |
| rs12674769 | 8 | 82748896 | SNX16 | ENSG00000104497.9 | 2.854E-6 | 0 | 6205 | gtex_brain_putamen_basal |
| rs12674770 | 8 | 82748928 | SNX16 | ENSG00000104497.9 | 2.855E-6 | 0 | 6173 | gtex_brain_putamen_basal |
| rs56274445 | 8 | 82750649 | SNX16 | ENSG00000104497.9 | 2.854E-6 | 0 | 4452 | gtex_brain_putamen_basal |
| rs56400334 | 8 | 82750966 | SNX16 | ENSG00000104497.9 | 2.854E-6 | 0 | 4135 | gtex_brain_putamen_basal |
| rs1814534 | 8 | 82751822 | SNX16 | ENSG00000104497.9 | 2.854E-6 | 0 | 3279 | gtex_brain_putamen_basal |
| rs12056632 | 8 | 82752291 | SNX16 | ENSG00000104497.9 | 2.854E-6 | 0 | 2810 | gtex_brain_putamen_basal |
| rs74275144 | 8 | 82753188 | SNX16 | ENSG00000104497.9 | 2.854E-6 | 0 | 1913 | gtex_brain_putamen_basal |
| rs111801710 | 8 | 82753350 | SNX16 | ENSG00000104497.9 | 2.827E-6 | 0 | 1751 | gtex_brain_putamen_basal |
| rs4316108 | 8 | 82754365 | SNX16 | ENSG00000104497.9 | 2.054E-6 | 0 | 736 | gtex_brain_putamen_basal |
| rs62514356 | 8 | 82754522 | SNX16 | ENSG00000104497.9 | 3.182E-6 | 0 | 579 | gtex_brain_putamen_basal |
| rs62514359 | 8 | 82755799 | SNX16 | ENSG00000104497.9 | 2.854E-6 | 0 | -698 | gtex_brain_putamen_basal |
| rs62515560 | 8 | 82755874 | SNX16 | ENSG00000104497.9 | 2.854E-6 | 0 | -773 | gtex_brain_putamen_basal |
| rs62515562 | 8 | 82758193 | SNX16 | ENSG00000104497.9 | 2.854E-6 | 0 | -3092 | gtex_brain_putamen_basal |
| rs62515563 | 8 | 82758349 | SNX16 | ENSG00000104497.9 | 2.854E-6 | 0 | -3248 | gtex_brain_putamen_basal |
| rs62515564 | 8 | 82759063 | SNX16 | ENSG00000104497.9 | 2.854E-6 | 0 | -3962 | gtex_brain_putamen_basal |
| rs57750343 | 8 | 82761251 | SNX16 | ENSG00000104497.9 | 2.854E-6 | 0 | -6150 | gtex_brain_putamen_basal |
| rs4541852 | 8 | 82761982 | SNX16 | ENSG00000104497.9 | 2.854E-6 | 0 | -6881 | gtex_brain_putamen_basal |
| rs61654083 | 8 | 82762481 | SNX16 | ENSG00000104497.9 | 2.837E-6 | 0 | -7380 | gtex_brain_putamen_basal |
| rs59690252 | 8 | 82762603 | SNX16 | ENSG00000104497.9 | 2.854E-6 | 0 | -7502 | gtex_brain_putamen_basal |
| rs57080410 | 8 | 82762834 | SNX16 | ENSG00000104497.9 | 2.812E-6 | 0 | -7733 | gtex_brain_putamen_basal |
| rs62515566 | 8 | 82764306 | SNX16 | ENSG00000104497.9 | 2.854E-6 | 0 | -9205 | gtex_brain_putamen_basal |
| rs6989070 | 8 | 82766775 | SNX16 | ENSG00000104497.9 | 2.854E-6 | 0 | -11674 | gtex_brain_putamen_basal |
| rs1452000 | 8 | 82767398 | SNX16 | ENSG00000104497.9 | 2.854E-6 | 0 | -12297 | gtex_brain_putamen_basal |
| rs12541224 | 8 | 82768174 | SNX16 | ENSG00000104497.9 | 2.854E-6 | 0 | -13073 | gtex_brain_putamen_basal |
| rs10958047 | 8 | 82772562 | SNX16 | ENSG00000104497.9 | 2.854E-6 | 0 | -17461 | gtex_brain_putamen_basal |
| rs1451998 | 8 | 82773042 | SNX16 | ENSG00000104497.9 | 2.87E-6 | 0 | -17941 | gtex_brain_putamen_basal |
| rs397958803 | 8 | 82773228 | SNX16 | ENSG00000104497.9 | 2.854E-6 | 0 | -18127 | gtex_brain_putamen_basal |
| rs12545508 | 8 | 82774442 | SNX16 | ENSG00000104497.9 | 2.854E-6 | 0 | -19341 | gtex_brain_putamen_basal |
| rs2895739 | 8 | 82775364 | SNX16 | ENSG00000104497.9 | 2.854E-6 | 0 | -20263 | gtex_brain_putamen_basal |
| rs1839898 | 8 | 82776970 | SNX16 | ENSG00000104497.9 | 2.259E-6 | 0 | -21869 | gtex_brain_putamen_basal |
| rs34987378 | 8 | 82777851 | SNX16 | ENSG00000104497.9 | 1.883E-6 | 0 | -22750 | gtex_brain_putamen_basal |
| rs1597755 | 8 | 82777939 | SNX16 | ENSG00000104497.9 | 1.851E-6 | 0 | -22838 | gtex_brain_putamen_basal |
| rs10958051 | 8 | 82802679 | SNX16 | ENSG00000104497.9 | 3.427E-6 | 0 | -47578 | gtex_brain_putamen_basal |
| rs1463255 | 8 | 82807349 | SNX16 | ENSG00000104497.9 | 8.408E-8 | 0 | -52248 | gtex_brain_putamen_basal |
| rs4739831 | 8 | 82808312 | SNX16 | ENSG00000104497.9 | 8.397E-8 | 0 | -53211 | gtex_brain_putamen_basal |
| rs7462039 | 8 | 82808807 | SNX16 | ENSG00000104497.9 | 9.149E-8 | 0 | -53706 | gtex_brain_putamen_basal |
| rs11786401 | 8 | 82815807 | SNX16 | ENSG00000104497.9 | 9.341E-8 | 0 | -60706 | gtex_brain_putamen_basal |
| rs7814896 | 8 | 82816713 | SNX16 | ENSG00000104497.9 | 3.911E-7 | 0 | -61612 | gtex_brain_putamen_basal |
| rs1869080 | 8 | 82818005 | SNX16 | ENSG00000104497.9 | 1.843E-7 | 0 | -62904 | gtex_brain_putamen_basal |
| rs1349578 | 8 | 82819323 | SNX16 | ENSG00000104497.9 | 1.957E-7 | 0 | -64222 | gtex_brain_putamen_basal |
| rs371119701 | 8 | 82819577 | SNX16 | ENSG00000104497.9 | 7.031E-7 | 0 | -64476 | gtex_brain_putamen_basal |
| rs1463253 | 8 | 82820173 | SNX16 | ENSG00000104497.9 | 1.958E-7 | 0 | -65072 | gtex_brain_putamen_basal |
| rs1901483 | 8 | 82821221 | SNX16 | ENSG00000104497.9 | 1.004E-7 | 0 | -66120 | gtex_brain_putamen_basal |
| rs2400537 | 8 | 82821896 | SNX16 | ENSG00000104497.9 | 1.959E-7 | 0 | -66795 | gtex_brain_putamen_basal |
| rs2400538 | 8 | 82822288 | SNX16 | ENSG00000104497.9 | 1.959E-7 | 0 | -67187 | gtex_brain_putamen_basal |
| rs4560750 | 8 | 82822700 | SNX16 | ENSG00000104497.9 | 1.959E-7 | 0 | -67599 | gtex_brain_putamen_basal |
| rs6992897 | 8 | 82824046 | SNX16 | ENSG00000104497.9 | 1.004E-7 | 0 | -68945 | gtex_brain_putamen_basal |
| rs13265769 | 8 | 82824263 | SNX16 | ENSG00000104497.9 | 7.801E-8 | 0 | -69162 | gtex_brain_putamen_basal |
| rs4739834 | 8 | 82825223 | SNX16 | ENSG00000104497.9 | 1.004E-7 | 0 | -70122 | gtex_brain_putamen_basal |
| rs765755 | 8 | 82825556 | SNX16 | ENSG00000104497.9 | 7.409E-8 | 0 | -70455 | gtex_brain_putamen_basal |
| rs765756 | 8 | 82825588 | SNX16 | ENSG00000104497.9 | 1.959E-7 | 0 | -70487 | gtex_brain_putamen_basal |
| rs7009289 | 8 | 82829050 | SNX16 | ENSG00000104497.9 | 1.004E-7 | 0 | -73949 | gtex_brain_putamen_basal |
| rs13268107 | 8 | 82829472 | SNX16 | ENSG00000104497.9 | 2.049E-7 | 0 | -74371 | gtex_brain_putamen_basal |
| rs13268158 | 8 | 82829537 | SNX16 | ENSG00000104497.9 | 2.013E-7 | 0 | -74436 | gtex_brain_putamen_basal |
| rs13270729 | 8 | 82829556 | SNX16 | ENSG00000104497.9 | 1.946E-7 | 0 | -74455 | gtex_brain_putamen_basal |
| rs13269891 | 8 | 82830009 | SNX16 | ENSG00000104497.9 | 1.004E-7 | 0 | -74908 | gtex_brain_putamen_basal |
| rs13270414 | 8 | 82830044 | SNX16 | ENSG00000104497.9 | 1.004E-7 | 0 | -74943 | gtex_brain_putamen_basal |
| rs1966849 | 8 | 82832801 | SNX16 | ENSG00000104497.9 | 9.973E-8 | 0 | -77700 | gtex_brain_putamen_basal |
| rs1966850 | 8 | 82833013 | SNX16 | ENSG00000104497.9 | 1.959E-7 | 0 | -77912 | gtex_brain_putamen_basal |
| rs11779650 | 8 | 82838970 | SNX16 | ENSG00000104497.9 | 1.004E-7 | 0 | -83869 | gtex_brain_putamen_basal |
| rs13274260 | 8 | 82839164 | SNX16 | ENSG00000104497.9 | 2.05E-7 | 0 | -84063 | gtex_brain_putamen_basal |
| rs397728526 | 8 | 82839665 | SNX16 | ENSG00000104497.9 | 1.959E-7 | 0 | -84564 | gtex_brain_putamen_basal |
| rs12542978 | 8 | 82843027 | SNX16 | ENSG00000104497.9 | 4.216E-7 | 0 | -87926 | gtex_brain_putamen_basal |
| rs4582509 | 8 | 82843826 | SNX16 | ENSG00000104497.9 | 1.933E-7 | 0 | -88725 | gtex_brain_putamen_basal |
| rs7839220 | 8 | 82844564 | SNX16 | ENSG00000104497.9 | 9.909E-8 | 0 | -89463 | gtex_brain_putamen_basal |
| rs1597756 | 8 | 82846655 | SNX16 | ENSG00000104497.9 | 9.904E-8 | 0 | -91554 | gtex_brain_putamen_basal |
| rs4739632 | 8 | 82849464 | SNX16 | ENSG00000104497.9 | 9.896E-8 | 0 | -94363 | gtex_brain_putamen_basal |
| rs13266985 | 8 | 82850773 | SNX16 | ENSG00000104497.9 | 1.931E-7 | 0 | -95672 | gtex_brain_putamen_basal |
| rs10958057 | 8 | 82855523 | SNX16 | ENSG00000104497.9 | 4.034E-7 | 0 | -100422 | gtex_brain_putamen_basal |
| rs13258623 | 8 | 82857264 | SNX16 | ENSG00000104497.9 | 9.593E-8 | 0 | -102163 | gtex_brain_putamen_basal |
| rs2895741 | 8 | 82858780 | SNX16 | ENSG00000104497.9 | 5.085E-7 | 0 | -103679 | gtex_brain_putamen_basal |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| ONKEN UVEAL MELANOMA UP | 783 | 507 | All SZGR 2.0 genes in this pathway |
| OSMAN BLADDER CANCER UP | 404 | 246 | All SZGR 2.0 genes in this pathway |
| GARGALOVIC RESPONSE TO OXIDIZED PHOSPHOLIPIDS BLACK UP | 35 | 22 | All SZGR 2.0 genes in this pathway |
| GOZGIT ESR1 TARGETS DN | 781 | 465 | All SZGR 2.0 genes in this pathway |
| GRAESSMANN APOPTOSIS BY DOXORUBICIN UP | 1142 | 669 | All SZGR 2.0 genes in this pathway |
| GRAESSMANN RESPONSE TO MC AND DOXORUBICIN UP | 612 | 367 | All SZGR 2.0 genes in this pathway |
| HAMAI APOPTOSIS VIA TRAIL UP | 584 | 356 | All SZGR 2.0 genes in this pathway |
| BUYTAERT PHOTODYNAMIC THERAPY STRESS UP | 811 | 508 | All SZGR 2.0 genes in this pathway |
| STARK PREFRONTAL CORTEX 22Q11 DELETION DN | 517 | 309 | All SZGR 2.0 genes in this pathway |
| NIKOLSKY BREAST CANCER 8Q12 Q22 AMPLICON | 132 | 82 | All SZGR 2.0 genes in this pathway |
| BLALOCK ALZHEIMERS DISEASE INCIPIENT UP | 390 | 242 | All SZGR 2.0 genes in this pathway |
| BLALOCK ALZHEIMERS DISEASE UP | 1691 | 1088 | All SZGR 2.0 genes in this pathway |
| KRIGE RESPONSE TO TOSEDOSTAT 6HR UP | 953 | 554 | All SZGR 2.0 genes in this pathway |
| KRIGE RESPONSE TO TOSEDOSTAT 24HR UP | 783 | 442 | All SZGR 2.0 genes in this pathway |
| BONCI TARGETS OF MIR15A AND MIR16 1 | 91 | 75 | All SZGR 2.0 genes in this pathway |
| CHEN HOXA5 TARGETS 9HR UP | 223 | 132 | All SZGR 2.0 genes in this pathway |
| MILI PSEUDOPODIA HAPTOTAXIS UP | 518 | 299 | All SZGR 2.0 genes in this pathway |
| JOHNSTONE PARVB TARGETS 3 DN | 918 | 550 | All SZGR 2.0 genes in this pathway |
| RAO BOUND BY SALL4 ISOFORM B | 517 | 302 | All SZGR 2.0 genes in this pathway |
| ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY | 1839 | 928 | All SZGR 2.0 genes in this pathway |