Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
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Found 81 literature records
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Entrez ID
Description
4495
MT1G acts as a tumor suppressor gene in hepatocellular carcinoma
1029
A quantitative model for age-dependent expression of the p16INK4a tumor suppressor.
3659
IRF-1 could be nominated as one of the tumor suppressor factors and could aid in the early detection of HCC.-e
171023
These findings suggest that ASXL1 may function as a tumor suppressor in malignancies of the myeloid lineage by affecting stem or progenitor cell self-renewal or differentiation.
5728
PTEN is a tumor suppressor in CML stem cells and BCR-ABL-induced leukemias in mice.
7249
Suppression of tumor suppressor Tsc2 and DNA repair glycosylase Nth1 during spontaneous liver tumorigenesis in Long-Evans Cinnamon rats.
54790
"With diverse genetic methods, TET2 on chromosome 4q24 was identified as candidate tumor suppressor gene."
283518
"Pro-apoptotic and antiproliferative activity of human KCNRG, a putative tumor suppressor in 13q14 region."
1030
"new animal model demonstrates experimentally that p15Ink4b is a tumor suppressor for myeloid leukemia, and its loss may play an active role in the establishment of preleukemic conditions"
167465
DC-SCRIPT can act as a tumor suppressor in breast cancer development.[review]
7128
Mutation analysis of the TNFAIP3 (A20) tumor suppressor gene in chronic lymphocytic leukemia
27250
"Data provide evidence that the tumor suppressor, programmed cell death factor 4 (PDCD4), is a previously unidentified phosphorylation target of CXCL12 signaling in all Chronic Lymphocytic Leukemia cells probed."
864
studies identify RUNX3 as a novel cellular target of H. pylori CagA and also reveal a mechanism by which CagA functions as an oncoprotein by blocking the activity of gastric tumor suppressor RUNX3.
23239
Reduced expression of the tumor suppressor PHLPP1 enhances the antiapoptotic B-cell receptor signal in chronic lymphocytic leukemia B-cells.
6711
"reduced SPTBN1 expression correlated with shorter survival of pancreatic cancer patients, suggesting a tumor suppressor function of this gene"
10395
MicroRNA silencing of tumor suppressor DLC-1 promotes efficient hepatitis C virus replication in primary human hepatocytes.
5728
Alkylation of the tumor suppressor PTEN activates Akt and ??-catenin signaling: a mechanism linking inflammation and oxidative stress with cancer.
2952
"GSTT1 is a potential tumor suppressor gene, and its deletion and null genotype are suggested to be related to development of CML and to clinical outcome in CML "
8856
"These results demonstrate a novel and unsuspected role for steroid and xenobiotic receptor (SXR) signaling in the B-1 cell compartment, establish SXR as a tumor suppressor in B-1 cells"
7157
Relative role of methylator and tumor suppressor pathways in ulcerative colitis-associated colon cancer.
25855
Phosphorylation of RelA/p65 promotes DNMT-1 recruitment to chromatin and represses transcription of the tumor metastasis suppressor gene BRMS1.
117153
HBx activates hepatoma cell growth and proliferation through repression of the potential tumor suppressor MIA2.
8864
"C/EBPalpha with its associated direct core clock gene target, PER2, are highly deregulated in DLBCL, suggesting an important tumor suppressive pathway in the pathogenesis of this lymphoma entity"
407029
miR-30a acts as a tumor suppressor by downregulating ABL1 and BCR-ABL1 expression.
83989
"FAM172A may be a novel tumor-suppressor gene that plays an important role in cell cycle mediated, at least partially, by the Notch 3 signaling pathway."
8870
the interference of IER3 with the PI3K/Akt-Fyn pathway represents a novel mechanism of Nrf2 regulation that may get lost in tumors and by which IER3 exerts its stress-adaptive and tumor-suppressive activity.
407051
"results revealed that miR-9-3 was a tumor suppressor miRNA hypermethylated in chronic lymphocytic leukemia, which was associated with down-regulation of NFKB1 protein."
3621
Extension of the replicative life span of human diploid fibroblasts by inhibition of the p33ING1 candidate tumor suppressor.
10301
We conclude that the Leu1 and Leu2 genes are strong candidates as tumor suppressor gene(s) involved in B-CLL leukemogenesis.
8847
We conclude that the Leu1 and Leu2 genes are strong candidates as tumor suppressor gene(s) involved in B-CLL leukemogenesis.
10206
"A cosmid and cDNA fine physical map of a human chromosome 13q14 region frequently lost in B-cell chronic lymphocytic leukemia and identification of a new putative tumor suppressor gene, Leu5."
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