Pulmonary Arterial Hypertension KnowledgeBase (bioinfom_tsdb)
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Found 139 literature records
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Entrez ID
Description
54971
Tumor suppressor SMAR1 mediates cyclin D1 repression by recruitment of the SIN3/histone deacetylase 1 complex.
5925
data show that E2F1 has potential binding activity to the retinoblastoma control element and a different transcriptional regulation pathway which cooperates with the retinoblastoma tumor suppressor protein
5925
Structure of the human Papillomavirus E7 oncoprotein and its mechanism for inactivation of the retinoblastoma tumor suppressor.
92304
"Studies provide further evidence that HIN-1 possesses tumor suppressor functions, and that these activities may be mediated through the AKT signaling pathway."
6598
tumor suppressor activity of Snf5 depends on its regulation of cell cycle progression
5925
Down-regulation of the retinoblastoma tumor suppressor by the hepatitis C virus NS5B RNA-dependent RNA polymerase.
1871
E2F3a has a unique apoptotic activity and lacks the tumor suppressive property of E2F1 in this model system.
5925
"RB1 was not implicated, suggesting the participation of another tumor suppressor gene in this region."
5927
that RBP2-H1 exerts a broad tumor-suppressive function partially mediated by pRb modulation
1028
Compensation by tumor suppressor genes during retinal development in mice and humans.
5925
Compensation by tumor suppressor genes during retinal development in mice and humans.
5933
Compensation by tumor suppressor genes during retinal development in mice and humans.
5934
Compensation by tumor suppressor genes during retinal development in mice and humans.
6422
Compensation by tumor suppressor genes during retinal development in mice and humans.
5925
Retinoblastoma tumor suppressor: where cancer meets the cell cycle.
5925
Reverse mutational analysis reveals threonine-373 as a potentially sufficient phosphorylation site for inactivation of the retinoblastoma tumor suppressor protein (pRB).
7157
The Wnt signaling pathway has tumor suppressor properties in retinoblastoma.
5925
Nucleocytoplasmic shuttling of the retinoblastoma tumor suppressor protein via Cdk phosphorylation-dependent nuclear export.
5925
The retinoblastoma tumor suppressor modifies the therapeutic response of breast cancer.
5925
Altered structure and deregulated expression of the tumor suppressor gene retinoblastoma (RB1) in human brain tumors.
5925
Loss of the retinoblastoma tumor suppressor: differential action on transcriptional programs related to cell cycle control and immune function.
5925
"The expression level of the tumor suppressor retinoblastoma protein (Rb) influences the antileukemic efficacy of erucylphospho-N,N,N-trimethylpropylammonium (ErPC3)."
5925
the HPV16 E7-associated cullin 2 ubiquitin ligase complex contributes to aberrant degradation of the pRB tumor suppressor in HPV16 E7-expressing cells.
5925
"RbAp48-mediated transformation of HPV16 is probably because of the regulation by RbAp48 of tumor suppressors retinoblastoma and p53, apoptosis-related enzymes caspase-3 and caspase-8, E6, E7, cyclin D1 (CCND1), and c-MYC."
7157
"RbAp48-mediated transformation of HPV16 is probably because of the regulation by RbAp48 of tumor suppressors retinoblastoma and p53, apoptosis-related enzymes caspase-3 and caspase-8, E6, E7, cyclin D1 (CCND1), and c-MYC."
5925
Retinoblastoma tumor suppressor status is a critical determinant of therapeutic response in prostate cancer cells.
5925
"Retinoblastoma tumor suppressor deletion in mouse liver enhances diethylnitrosamine-induced tumorigenesis, increased hepatocyte proliferation and compromised genome integrity."
5934
"There was a strong correlation between the expression of p130 in Stage 1 & 3, but not Stage 2, tumors. High levels of p130 were detected in the cytoplasm rather than the nucleus, suggesting an aberrant subcellular localization of this tumor suppressor."
5925
Structure of the retinoblastoma protein bound to adenovirus E1A reveals the molecular basis for viral oncoprotein inactivation of a tumor suppressor.
5925
The retinoblastoma tumor suppressor is a critical intrinsic regulator for hematopoietic stem and progenitor cells under stress.
5925
Aberrant nucleocytoplasmic localization of the retinoblastoma tumor suppressor protein in human cancer correlates with moderate/poor tumor differentiation.
5925
Retinoblastoma tumor suppressor protein-dependent methylation of histone H3 lysine 27 is associated with irreversible cell cycle exit.
4804
The p75 NTR neurotrophin receptor is a tumor suppressor in human and murine retinoblastoma development.
5925
Loss of both RB1 tumor suppressor gene alleles initiates quiescent RB1(-/-) retinomas with low level genomic instability and high expression of the senescence-associated proteins p16(INK4a) and p130.
5925
Loss of retinoblastoma tumor suppressor protein makes human breast cancer cells more sensitive to antimetabolite exposure.
5925
Retinoblastoma (Rb) tumor-suppressor pathway alterations in meningeal hemangiopericytomas: High E2F transcription factor 1 expression and loss of Rb expression: study by double immunofluorescence staining and laser-scanning confocal microscopy.
4057
Lactotransferrin is likely to be a candidate tumor suppressor and downregulates the development of nasopharyngeal carcinoma (NPC) by inhibiting NPC proliferation through induction of cell cycle arrest and modulation of the MAPK signaling pathway.
7799
Hyper-methylation of RIZ1 tumor suppressor gene is involved in the early tumorigenesis of hepatocellular carcinoma.
5925
The extreme COOH terminus of the retinoblastoma tumor suppressor protein pRb is required for phosphorylation on Thr-373 and activation of E2F.
5925
The retinoblastoma protein tumor suppressor is important for appropriate osteoblast differentiation and bone development.
5371
The tumor suppressor Pml regulates cell fate in the developing neocortex.
5925
The tumor suppressor Pml regulates cell fate in the developing neocortex.
1031
Cdk4 inhibitor p18(Ink4c) is a tumor suppressor in cyclin D1-driven PNET.
5925
Aurora B determines cellular fate after an aberrant mitosis by directly regulating the Rb tumor suppressor protein.
5925
Proapoptotic function of the retinoblastoma tumor suppressor protein.
1869
study identifies a novel E2F1 gene target and further supports the growing body of evidence that the Rb/E2F1 tumor suppressor pathway is involved in the regulation of the DNA lesion recognition step of nucleotide excision repair.
5925
study identifies a novel E2F1 gene target and further supports the growing body of evidence that the Rb/E2F1 tumor suppressor pathway is involved in the regulation of the DNA lesion recognition step of nucleotide excision repair.
9821
"RB1-inducible coiled-coil 1 (RB1CC1, also known as FIP200) is a tumor suppressor implicated in the regulation of RB1 (retinoblastoma 1) expression."
407040
miR-34a functions as a tumor suppressor in RB cells and is a potential therapeutic target.
1026
Results show that that p21(Cip1) functions as a tumor suppressor in cervical carcinogenesis and that p21(Cip1) inactivation by HPV-16 E7 partially contributes to the contribution of E7 to cervical carcinogenesis.
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