Found 484 literature records

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Entrez ID	Description
9077	"provide evidences that ARHI downregulated in HCCs could play a role in liver cancer via acting as a tumor suppressor gene, which mainly was triggered by the epigenetic events in HCC specimens"
11200	"Novel evidences for a tumor suppressor role of Rev3, the catalytic subunit of Pol zeta."
324	Interaction between tumor suppressor adenomatous polyposis coli and topoisomerase IIalpha: implication for the G2/M transition.
4851	"arsenite, by decreasing generation of the tumor suppressor Notch1, contributes to skin carcinogenesis"
57447	[Expression of candidate tumor suppressor gene N-Myc downstream-regulated gene 2 in colon cancer].
7345	Epigenetic inactivation of UCHL1 is common in primary hepatocellular carcinomas(HCCs) and other digestive tumors and appears to be functional tumor suppressor involved in tumorigenesis of HCCs and other digestive cancers.
2309	Tumor suppressor Foxo3a is involved in the regulation of lipopolysaccharide-induced interleukin-8 in intestinal HT-29 cells.
5268	"P176S (C526T) substitution of maspin may result in a partial loss of the tumor suppressor function of this protein, contributing to decreased susceptibility to apoptosis and malignant progression"
4978	"OPCML is a broad tumor suppressor, which is frequently inactivated by methylation in multiple malignancies."
407040	miR-34a represents a tumor suppressor gene which is inactivated by CpG methylation and subsequent transcriptional silencing in a broad range of tumors.
407040	"miR-34a functions as a tumor suppressor, in part, through a SIRT1-p53 pathway"
116135	suggest that LRRC3B is a putative tumor suppressor gene that is silenced in gastric cancers by epigenetic mechanisms and that LRRC3B silencing in cancer may play an important role in tumor escape from immune surveillance
864	Data demonstrate that RUNX3 functions as a tumor suppressor by attenuating Wnt signaling.
114757	"Data constitute the first direct functional evidence for CYGB, the newest member of the globin family, as a tumor suppressor gene."
116135	LRRC3B may be a novel methylation-sensitive tumor suppressor gene in CRC. LRRC3B methylation has significant tumor specificity and may be a biomarker of CRC.
83595	Sox7 is a tumor suppressor that functions as an independent checkpoint for beta-catenin transcriptional activity. Inactivation of Sox7 could promote the development of a majority of colorectal tumors and approximately half of prostate tumors.
378805	Pint lincRNA connects the p53 pathway with epigenetic silencing by the Polycomb repressive complex 2.
1630	the transcriptionally active TAp73alpha tumor suppressor is implicated in the apoptosis induced by netrin-1 in a p53-independent and DCC/ubiquitin-proteasome dependent manner.
7161	the transcriptionally active TAp73alpha tumor suppressor is implicated in the apoptosis induced by netrin-1 in a p53-independent and DCC/ubiquitin-proteasome dependent manner.
1029	These findings implicate MBD2 in transcriptional repression of the methylated p14(ARF) tumor suppressor gene and suggest that repression by MBD2 selectively affects a subset of methylated promoters.
84260	"MITOSTATIN was found within a 3.2-kb transcript for an approximately 62 kDa mitochondrial protein with tumor suppressor activity. It inhibits cell growth, is proapoptotic and downregulates Hsp27."
864	Clinical and experimental data support the notion that RUNX3 is a tumor suppressor in human colon cancer.
9314	Reduced levels of KLF4 tumor suppressor activity in colon tumors may be driven by elevated beta-catenin/Tcf signaling.
2619	"Gas1 has all the expected properties of a melanoma tumor suppressor: suppression of metastasis in a spontaneous metastasis assay, promotion of apoptosis following dissemination of cells to secondary sites, and down-regulation in human melanoma metastasis."
7869	IGFBP-6 is the effector of tumor suppressor activity of SEMA3B.
65268	Epigenetic silencing of the kinase tumor suppressor WNK2 is tumor-type and tumor-grade specific.
9314	Notch inhibits expression of the Kr??ppel-like factor 4 tumor suppressor in the intestinal epithelium.
5468	PPARgamma plays an important role of suppressing tumorigenesis in the intestine by attenuating epithelial cell proliferative activity
57575	PCDH10 is a gastric tumor suppressor; its methylation at early stages of gastric carcinogenesis is an independent prognostic factor.
54845	"Results demonstrate that RBM35A functions as a tumor suppressor in colon cancer cells, and suggest that RBM35A is involved in posttranscriptional regulation of a number of genes by exerting a differential effect on protein translation via 5'UTRs of mRNAs."
324	Atonal homolog 1 is a tumor suppressor gene.
324	GPR109A is a G-protein-coupled receptor for the bacterial fermentation product butyrate and functions as a tumor suppressor in colon.
8633	UNC5C might act as a tumor suppressor and UNC5C methylation might present a malignant potential in colorectal cancer.
1029	p16 might act as a tumor suppressor in colorectal carcinomas and was more frequently methylated in advanced colorectal carcinomas.
2444	Rak functions as a tumor suppressor by regulating PTEN protein stability and function in breast and bone neoplasms.
1050	In prostate cancer cells C/EBPalpha cannot function as a tumor suppressor
406953	"miR-18a* may function as a tumor suppressor by targeting on K-Ras. Therefore, the miRNA may also be a potential therapeutic agent or target for cancer therapy."
7020	these studies support a tumor suppressor role for AP-2alpha in the gastrointestinal tract
7020	these studies support a tumor suppressor role for AP-2alpha in the gastrointestinal tract.
406937	"Data show that IGF-IR resistant to miR145 is not down-regulated by miR145 but fails to rescue colon cancer cells from growth inhibition, and indicate that down-regulation of IRS-1 plays a significant role in the tumor suppressor activity of miR145."
4221	In vitro hematopoietic differentiation of mouse embryonic stem cells requires the tumor suppressor menin and is mediated by Hoxa9.
6925	ITF-2B is a tumor suppressor that has an important function at the adenoma to carcinoma transition.
7157	Results suggest that simultaneous exposure to ACR and long-term dietary corn oil induces development of colon cancer partly by inhibiting the tumor suppressor gene p53-mediated mitochondria-dependent apoptosis.
2049	EphB3-ephrin-B interaction promotes mesenchymal-to-epithelial transition (MET) by re-establishing epithelial cell-cell junctions and such an MET-promoting effect contributes to EphB3-mediated tumor suppression.
140628	"Methylation of GATA4/5 is a common and specific event in colorectal carcinomas, and GATA4/5 exhibit tumor suppressive effects in colorectal cancer cells in vitro. GATA4 methylation in fecal DNA may be of interest for colorectal cancer detection."
2626	"Methylation of GATA4/5 is a common and specific event in colorectal carcinomas, and GATA4/5 exhibit tumor suppressive effects in colorectal cancer cells in vitro. GATA4 methylation in fecal DNA may be of interest for colorectal cancer detection."
84417	"The restoration of ECRG4 expression in ESCC cells inhibited cell proliferation, colony formation, cell cycle progression and tumor growth in vivo. ECRG4 is a novel candidate tumor suppressor gene in ESCC."
65009	NDRG4 is a candidate tumor suppressor gene in colorectal cancer whose expression is frequently inactivated by promoter methylation.
54766	these data support BTG4 as a candidate tumor suppressor gene that is epigenetically silenced in the majority of gastric cancers.
27330	Results support the concept that RSK4 may be an important tumor suppressor gene by modulating senescence induction and contributing to cell proliferation control in colon carcinogenesis and renal cell carcinomas.

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