Target Gene Table
VIS IDVirusEnsembl IDGene TypeTarget GeneOncogeneTumor Suppressor GeneNCBI IDUniprot ID
TVIS10046591HBVENSG00000022355.18protein_codingGABRA1NoNo2554P14867
TVIS30082845HIVENSG00000022355.18protein_codingGABRA1NoNo2554P14867
TCGA Plot Options
Drug Information
GeneGABRA1
DrugBank IDDB00404
Drug NameAlprazolam
Target IDBE0004797
UniProt IDQ9UN88
Regulation Typepositive allosteric modulator
PubMed IDs18384456; 14978513; 29950725; 23038269
CitationsRiss J, Cloyd J, Gates J, Collins S: Benzodiazepines in epilepsy: pharmacology and pharmacokinetics. Acta Neurol Scand. 2008 Aug;118(2):69-86. doi: 10.1111/j.1600-0404.2008.01004.x. Epub 2008 Mar 31.@@Verster JC, Volkerts ER: Clinical pharmacology, clinical efficacy, and behavioral toxicity of alprazolam: a review of the literature. CNS Drug Rev. 2004 Spring;10(1):45-76.@@Zhu S, Noviello CM, Teng J, Walsh RM Jr, Kim JJ, Hibbs RE: Structure of a human synaptic GABAA receptor. Nature. 2018 Jul;559(7712):67-72. doi: 10.1038/s41586-018-0255-3. Epub 2018 Jun 27.@@Sigel E, Steinmann ME: Structure, function, and modulation of GABA(A) receptors. J Biol Chem. 2012 Nov 23;287(48):40224-31. doi: 10.1074/jbc.R112.386664. Epub 2012 Oct 4.
GroupsApproved; Illicit; Investigational
Direct Classification1,2,4-triazolo[4,3-a][1,4]benzodiazepines
SMILESCC1=NN=C2CN=C(C3=CC=CC=C3)C3=C(C=CC(Cl)=C3)N12
Pathways
PharmGKBPA448333
ChEMBLCHEMBL661