Target Gene Table ▼
VIS IDVirusEnsembl IDGene TypeTarget GeneOncogeneTumor Suppressor GeneNCBI IDUniprot ID
TVIS10046591HBVENSG00000022355.18protein_codingGABRA1NoNo2554P14867
TVIS30082845HIVENSG00000022355.18protein_codingGABRA1NoNo2554P14867
TCGA Plot Options ▼
Drug Information ▼
GeneGABRA1
DrugBank IDDB00425
Drug NameZolpidem
Target IDBE0000795
UniProt IDP14867
Regulation Typeagonist
PubMed IDs19345234; 11306694; 2157817; 1093783; 21353710
CitationsVlainic J, Pericic D: Effects of acute and repeated zolpidem treatment on pentylenetetrazole-induced seizure threshold and on locomotor activity: comparison with diazepam. Neuropharmacology. 2009 Jun;56(8):1124-30. doi: 10.1016/j.neuropharm.2009.03.010. Epub 2009 Apr 1.@@Smith AJ, Alder L, Silk J, Adkins C, Fletcher AE, Scales T, Kerby J, Marshall G, Wafford KA, McKernan RM, Atack JR: Effect of alpha subunit on allosteric modulation of ion channel function in stably expressed human recombinant gamma-aminobutyric acid(A) receptors determined using (36)Cl ion flux. Mol Pharmacol. 2001 May;59(5):1108-18.@@Pritchett DB, Seeburg PH: Gamma-aminobutyric acidA receptor alpha 5-subunit creates novel type II benzodiazepine receptor pharmacology. J Neurochem. 1990 May;54(5):1802-4.@@Sramka M, Nadvornik P: Surgical complication of posterior hypothalamotomy. Confin Neurol. 1975;37(1-3):193-4.@@Tan KR, Rudolph U, Luscher C: Hooked on benzodiazepines: GABAA receptor subtypes and addiction. Trends Neurosci. 2011 Apr;34(4):188-97. doi: 10.1016/j.tins.2011.01.004. Epub 2011 Feb 25.
GroupsApproved
Direct ClassificationPhenylimidazoles
SMILESCN(C)C(=O)CC1=C(N=C2C=CC(C)=CN12)C1=CC=C(C)C=C1
Pathways
PharmGKBPA451976
ChEMBLCHEMBL911