VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
---|---|---|---|---|---|---|---|---|
TVIS10046591 | HBV | ENSG00000022355.18 | protein_coding | GABRA1 | No | No | 2554 | P14867 |
TVIS30082845 | HIV | ENSG00000022355.18 | protein_coding | GABRA1 | No | No | 2554 | P14867 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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Gene | GABRA1 |
---|---|
DrugBank ID | DB00555 |
Drug Name | Lamotrigine |
Target ID | BE0004797 |
UniProt ID | Q9UN88 |
Regulation Type | antagonist |
PubMed IDs | 22306746; 11955522; 8941036; 11927166 |
Citations | Abelaira HM, Reus GZ, Ribeiro KF, Zappellini G, Cipriano AL, Scaini G, Streck EL, Quevedo J: Lamotrigine treatment reverses depressive-like behavior and alters BDNF levels in the brains of maternally deprived adult rats. Pharmacol Biochem Behav. 2012 May;101(3):348-53. doi: 10.1016/j.pbb.2012.01.019. Epub 2012 Jan 27.@@Braga MF, Aroniadou-Anderjaska V, Post RM, Li H: Lamotrigine reduces spontaneous and evoked GABAA receptor-mediated synaptic transmission in the basolateral amygdala: implications for its effects in seizure and affective disorders. Neuropharmacology. 2002 Mar;42(4):522-9. doi: 10.1016/s0028-3908(01)00198-8.@@Meldrum BS: Update on the mechanism of action of antiepileptic drugs. Epilepsia. 1996;37 Suppl 6:S4-11. doi: 10.1111/j.1528-1157.1996.tb06038.x.@@Wang JF, Sun X, Chen B, Young LT: Lamotrigine increases gene expression of GABA-A receptor beta3 subunit in primary cultured rat hippocampus cells. Neuropsychopharmacology. 2002 Apr;26(4):415-21. doi: 10.1016/S0893-133X(01)00385-2. |
Groups | Approved; Investigational |
Direct Classification | Dichlorobenzenes |
SMILES | NC1=NC(N)=C(N=N1)C1=C(Cl)C(Cl)=CC=C1 |
Pathways | |
PharmGKB | PA450164 |
ChEMBL | CHEMBL741 |
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