| VIS ID | Virus | Ensembl ID | Gene Type | Target Gene | Oncogene | Tumor Suppressor Gene | NCBI ID | Uniprot ID |
|---|---|---|---|---|---|---|---|---|
| TVIS10046591 | HBV | ENSG00000022355.18 | protein_coding | GABRA1 | No | No | 2554 | P14867 |
| TVIS30082845 | HIV | ENSG00000022355.18 | protein_coding | GABRA1 | No | No | 2554 | P14867 |
Target Gene Table
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TCGA Plot Options
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Drug Information
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| Gene | GABRA1 |
|---|---|
| DrugBank ID | DB00962 |
| Drug Name | Zaleplon |
| Target ID | BE0000795 |
| UniProt ID | P14867 |
| Regulation Type | potentiator |
| PubMed IDs | 17139284; 17016423; 12404558; 15783240; 10515302; 12608888 |
| Citations | Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.@@Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34.@@Patat A, Paty I, Hindmarch I: Pharmacodynamic profile of Zaleplon, a new non-benzodiazepine hypnotic agent. Hum Psychopharmacol. 2001 Jul;16(5):369-392.@@Barbera J, Shapiro C: Benefit-risk assessment of zaleplon in the treatment of insomnia. Drug Saf. 2005;28(4):301-18.@@Sanger DJ, Griebel G, Perrault G, Claustre Y, Schoemaker H: Discriminative stimulus effects of drugs acting at GABA(A) receptors: differential profiles and receptor selectivity. Pharmacol Biochem Behav. 1999 Oct;64(2):269-73.@@Terzano MG, Rossi M, Palomba V, Smerieri A, Parrino L: New drugs for insomnia: comparative tolerability of zopiclone, zolpidem and zaleplon. Drug Saf. 2003;26(4):261-82. |
| Groups | Approved; Illicit; Investigational |
| Direct Classification | Phenylpyrimidines |
| SMILES | CCN(C(C)=O)C1=CC=CC(=C1)C1=CC=NC2=C(C=NN12)C#N |
| Pathways | |
| PharmGKB | PA451952 |
| ChEMBL | CHEMBL1521 |
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