Target Gene Table ▼
VIS IDVirusEnsembl IDGene TypeTarget GeneOncogeneTumor Suppressor GeneNCBI IDUniprot ID
TVIS10046591HBVENSG00000022355.18protein_codingGABRA1NoNo2554P14867
TVIS30082845HIVENSG00000022355.18protein_codingGABRA1NoNo2554P14867
TCGA Plot Options ▼
Drug Information ▼
GeneGABRA1
DrugBank IDDB01355
Drug NameHexobarbital
Target IDBE0000795
UniProt IDP14867
Regulation Typepotentiator
PubMed IDs14579514; 10209232; 11264449; 10487207; 10360871; 11752352; 17139284; 17016423
CitationsWhiting PJ: The GABAA receptor gene family: new opportunities for drug development. Curr Opin Drug Discov Devel. 2003 Sep;6(5):648-57.@@Mehta AK, Ticku MK: An update on GABAA receptors. Brain Res Brain Res Rev. 1999 Apr;29(2-3):196-217.@@Yamakura T, Bertaccini E, Trudell JR, Harris RA: Anesthetics and ion channels: molecular models and sites of action. Annu Rev Pharmacol Toxicol. 2001;41:23-51.@@Krasowski MD, Harrison NL: General anaesthetic actions on ligand-gated ion channels. Cell Mol Life Sci. 1999 Aug 15;55(10):1278-303.@@Tomlin SL, Jenkins A, Lieb WR, Franks NP: Preparation of barbiturate optical isomers and their effects on GABA(A) receptors. Anesthesiology. 1999 Jun;90(6):1714-22.@@Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5.@@Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.@@Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34.
GroupsExperimental
Direct ClassificationPyrimidones
SMILESCN1C(=O)NC(=O)C(C)(C1=O)C1=CCCCC1
Pathways
PharmGKBPA449875
ChEMBLCHEMBL7728