| Tag | Content |
|---|---|
| Uniprot ID | A0A0G2JUZ5 |
| Entrez ID | |
| Genbank protein ID | |
| Genbank nucleotide ID | |
| Ensembl protein ID | ENSRNOP00000069291 |
| Ensembl nucleotide ID | ENSRNOG00000011599 |
| Gene name | Glycine cleavage system P protein |
| Gene symbol | Gldc |
| Organism | Rattus norvegicus |
| NCBI taxa ID | 10116 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | The glycine cleavage system catalyzes the degradation of glycine. |
| Sequence | MLQALGLASI DELIEKTVPA SIRLKRPLKL EDPVCENEIL ETLHAIASKN QIWRSYIGMG 60 YYNCSVPQTI LRNLLENSGW VTQYTPYQPE VSQGRLESLL NYQTMVSDIT GLDMANASLL 120 DEATAAAEAM QLCHRHNKRK RFFIDPRCHP QTIAVVQTRA KYRGVIVELK LPHEMDFSGK 180 DVSGVLFQYP DTEGKVEDFT ELVERAHQTG SLTCCATDLL ALCILRPPGE FGVDIALGNS 240 QRFGVPLGYG GPHAAFFAVR ESLVRMMPGR MVGVTRDATG KEVYRLALQT REQHIRRDKA 300 TSNICTAQAL LANMAAMFAI YHGSHGLQHI AKRVHNATLI LSEGLKRAGH QLQHDLFFDT 360 LKVQCGCSLK EVLGRAAQRQ INFRLFDDGT LGISLDETVT EKDLDDLLWI FGCESSTELV 420 AEGMGEEWRG LLGSSFKRTS PFLTHQVFNS YHSETNLVRY MKKLENKDIS LVHSMIPLGS 480 CTMKLNSSSE LTPITWREFA NIHPFVPLDQ AQGYQQLFQE LEKDLCELTG YDRVSFQPNS 540 GAQGEYAGLA TIRAYLDQKG ERHRTVCLIP KSAHGTNPAS AYMAGMKIQP VEVDRYGNID 600 VAHLKAMVDK HKENLAAIMI TYPSTNGVFE ENISDVCALI HQHGGQVYLD GANMNAQVGI 660 CRPGDFGSDV SHLNLHKTFC IPHGGGGPGM GPIGVKKHLV PFLPSHPIVC LKPNEDTWPV 720 GTVSAAPWGS SSILPISWAY IKMMGGKGLK EATEIAILNA NYMAKRLERY YRVLFRGARG 780 YVAHEFILDT RPFKKSANIE AVDVAKRLQD YGFHAPTMSW PVAGTLMIEP TESEDKAELD 840 RFCDAMISIR QEIADIEEGR IDPRVNPLKM SPHSLTCVTS SRWDRPYSRE VAAFPLPFVK 900 PENKFWPTIA RIDDIYGDQH LVCTCPPMEV YESPFSEQKR ASS 943 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | GLDC | 507688 | E1BJQ1 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | GLDC | 481534 | A0A5F4C8B1 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | GLDC | 102174205 | A0A452FM63 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | GLDC | 2731 | P23378 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Gldc | 104174 | Q91W43 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | GLDC | A0A2I3RPM1 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | A0A480TLS3 | Sus scrofa | Prediction | More>> | ||||
| 1:1 ortholog | GLDC | 100343694 | G1SL36 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Gldc | A0A0G2JUZ5 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | gldc | A0A0G2KSN1 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005960 | glycine cleavage complex |
| GO:0005739 | mitochondrion |
| GO:0005654 | nucleoplasm |
| GO:0005886 | plasma membrane |
| GO:0019899 | enzyme binding |
| GO:0016594 | glycine binding |
| GO:0004375 | glycine dehydrogenase (decarboxylating) activity |
| GO:0016829 | lyase activity |
| GO:0030170 | pyridoxal phosphate binding |
| GO:1990830 | cellular response to leukemia inhibitory factor |
| GO:0006546 | glycine catabolic process |
| GO:0019464 | glycine decarboxylation via glycine cleavage system |
| GO:0065003 | protein-containing complex assembly |