| Tag | Content |
|---|---|
| Uniprot ID | Q91W43 |
| Entrez ID | 104174 |
| Genbank protein ID | AAH17135.1 |
| Genbank nucleotide ID | NM_138595.2 |
| Ensembl protein ID | ENSMUSP00000025778 |
| Ensembl nucleotide ID | ENSMUSG00000024827 |
| Gene name | Glycine dehydrogenase (decarboxylating), mitochondrial |
| Gene symbol | Gldc |
| Organism | Mus musculus |
| NCBI taxa ID | 10090 |
| Cleft type | CPO |
| Developmental stage | |
| Data sources | Manually collected |
| Reference | 25807483 |
| Functional description | The glycine cleavage system catalyzes the degradation of glycine. The P protein (GLDC) binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (GCSH) (By similarity). |
| Sequence | MQLCARAWGL RLGRGAGGGH RLARGTGLSW AQRSRDSSGG GGGGGGGDRG AAGASRLLER 60 LLPRHDDFSR RHIGPGDKDR REMLQALGLA SIDELIEKTV PASIRLKRPL KMEDPICENE 120 ILETLHAIAS KNQIWRSYIG MGYYNCSVPQ TILRNLLENS GWVTQYTPYQ PEVSQGRLES 180 LLNYQTMVSD ITGLDMANAS LLDEATAAAE AMQLCHRHNK RKKFFVDPRC HPQTIAVVQT 240 RAKYRGVLVE LKLPHEMDFS GKDVCGVLFQ YPDTEGKVED FTELVDRAHQ TGSLTCCATD 300 LLALCILRPP GEFGVDIALG NSQRFGVPLG YGGPHAAFFA VKENLVRMMP GRMVGVTRDA 360 TGKEVYRLAL QTREQHIRRD KATSNICTAQ ALLANMAAMF AIYHGSQGLK HIAKRVHNAT 420 LILSEGLKRA GHQLQHDLFF DTLKVQCGCS VKEVLGRAAQ RQINFRLFDD GTLGISLDET 480 VTEKDLDDLL WIFGCESSAE LVAEGMGEER RGLLGSSFKR TSPFLTHQVF NSYHSETNLV 540 RYMKKLENKD ISLVHSMIPL GSCTMKLNSS SELAPITWRE FANIHPFVPL DQAQGYQQLF 600 QGLEKDLCEI TGYDRVSFQP NSGAQGEYAG LATIRAYLDQ KGERHRTVCL IPKSAHGTNP 660 ASAHMAGMKI QPVEVDRYGN IDVAHLKAMV DQHKENLAAI MITYPSTNGV FEENIGDVCA 720 LIHQHGGQVY LDGANMNAQV GICRPGDFGS DVSHLNLHKT FCIPHGGGGP GMGPIGVKKH 780 LSPFLPSHPV ISIKPTEGTW PVGTVSAAPW GSSSILPISW AYIKMMGGKG LKEATEIAIL 840 NANYMAKRLE KHYRVLFRGA RGYVAHEFIL DTRPFKKSAN VEAVDVAKRL QDYGFHAPTM 900 SWPVAGTLMI EPTESEDKAE LDRFCDAMIS IRQEIADIEE GRIDPRVNPL KMSPHSLTCV 960 TSSCWDRPYS REVAAFPLPF VKPENKFWPT IARIDDIYGD QHLVCTCPPM EVYESPFSEQ 1020 KRASS 1025 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | GLDC | 507688 | E1BJQ1 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | GLDC | 481534 | A0A5F4C8B1 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | GLDC | 102174205 | A0A452FM63 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | GLDC | 2731 | P23378 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Gldc | 104174 | Q91W43 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | GLDC | A0A2I3RPM1 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | A0A480TLS3 | Sus scrofa | Prediction | More>> | ||||
| 1:1 ortholog | GLDC | 100343694 | G1SL36 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Gldc | A0A0G2JUZ5 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | gldc | A0A0G2KSN1 | Danio rerio | Prediction | More>> |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0004375 | glycine dehydrogenase (decarboxylating) activity | ISO |
| GO:0004375 | glycine dehydrogenase (decarboxylating) activity | ISS |
| GO:0004375 | glycine dehydrogenase (decarboxylating) activity | IBA |
| GO:0016594 | glycine binding | ISO |
| GO:0016594 | glycine binding | IBA |
| GO:0016829 | lyase activity | IEA |
| GO:0019899 | enzyme binding | ISO |
| GO:0030170 | pyridoxal phosphate binding | ISO |
| GO:0030170 | pyridoxal phosphate binding | IBA |
| GO:0042803 | protein homodimerization activity | ISO |
| GO:0042803 | protein homodimerization activity | ISS |
| GO:0070280 | pyridoxal binding | ISS |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0006546 | glycine catabolic process | ISS |
| GO:0006546 | glycine catabolic process | ISO |
| GO:0019464 | glycine decarboxylation via glycine cleavage system | ISO |
| GO:0019464 | glycine decarboxylation via glycine cleavage system | IBA |
| GO:0036255 | response to methylamine | ISS |
| GO:0055114 | oxidation-reduction process | IEA |
| GO:0065003 | protein-containing complex assembly | ISO |
| GO:1903442 | response to lipoic acid | ISS |
| GO:1990830 | cellular response to leukemia inhibitory factor | IEP |
| GO ID | GO Term | Evidence |
|---|---|---|
| GO:0005654 | nucleoplasm | ISO |
| GO:0005739 | mitochondrion | ISO |
| GO:0005739 | mitochondrion | HDA |
| GO:0005739 | mitochondrion | IBA |
| GO:0005886 | plasma membrane | ISO |
| GO:0005960 | glycine cleavage complex | ISO |
| GO:0005960 | glycine cleavage complex | IBA |
| Reactome ID | Reactome Term | Evidence |
|---|---|---|
| R-MMU-1430728 | Metabolism | IEA |
| R-MMU-389661 | Glyoxylate metabolism and glycine degradation | IEA |
| R-MMU-6783984 | Glycine degradation | IEA |
| R-MMU-71291 | Metabolism of amino acids and derivatives | IEA |