Gene: Gldc

Basic information

Tag Content
Uniprot ID Q91W43
Entrez ID 104174
Genbank protein ID AAH17135.1
Genbank nucleotide ID NM_138595.2
Ensembl protein ID ENSMUSP00000025778
Ensembl nucleotide ID ENSMUSG00000024827
Gene name Glycine dehydrogenase (decarboxylating), mitochondrial
Gene symbol Gldc
Organism Mus musculus
NCBI taxa ID 10090
Cleft type CPO
Developmental stage
Data sources Manually collected
Reference 25807483
Functional description The glycine cleavage system catalyzes the degradation of glycine. The P protein (GLDC) binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein (GCSH) (By similarity).
Sequence
MQLCARAWGL RLGRGAGGGH RLARGTGLSW AQRSRDSSGG GGGGGGGDRG AAGASRLLER 60
LLPRHDDFSR RHIGPGDKDR REMLQALGLA SIDELIEKTV PASIRLKRPL KMEDPICENE 120
ILETLHAIAS KNQIWRSYIG MGYYNCSVPQ TILRNLLENS GWVTQYTPYQ PEVSQGRLES 180
LLNYQTMVSD ITGLDMANAS LLDEATAAAE AMQLCHRHNK RKKFFVDPRC HPQTIAVVQT 240
RAKYRGVLVE LKLPHEMDFS GKDVCGVLFQ YPDTEGKVED FTELVDRAHQ TGSLTCCATD 300
LLALCILRPP GEFGVDIALG NSQRFGVPLG YGGPHAAFFA VKENLVRMMP GRMVGVTRDA 360
TGKEVYRLAL QTREQHIRRD KATSNICTAQ ALLANMAAMF AIYHGSQGLK HIAKRVHNAT 420
LILSEGLKRA GHQLQHDLFF DTLKVQCGCS VKEVLGRAAQ RQINFRLFDD GTLGISLDET 480
VTEKDLDDLL WIFGCESSAE LVAEGMGEER RGLLGSSFKR TSPFLTHQVF NSYHSETNLV 540
RYMKKLENKD ISLVHSMIPL GSCTMKLNSS SELAPITWRE FANIHPFVPL DQAQGYQQLF 600
QGLEKDLCEI TGYDRVSFQP NSGAQGEYAG LATIRAYLDQ KGERHRTVCL IPKSAHGTNP 660
ASAHMAGMKI QPVEVDRYGN IDVAHLKAMV DQHKENLAAI MITYPSTNGV FEENIGDVCA 720
LIHQHGGQVY LDGANMNAQV GICRPGDFGS DVSHLNLHKT FCIPHGGGGP GMGPIGVKKH 780
LSPFLPSHPV ISIKPTEGTW PVGTVSAAPW GSSSILPISW AYIKMMGGKG LKEATEIAIL 840
NANYMAKRLE KHYRVLFRGA RGYVAHEFIL DTRPFKKSAN VEAVDVAKRL QDYGFHAPTM 900
SWPVAGTLMI EPTESEDKAE LDRFCDAMIS IRQEIADIEE GRIDPRVNPL KMSPHSLTCV 960
TSSCWDRPYS REVAAFPLPF VKPENKFWPT IARIDDIYGD QHLVCTCPPM EVYESPFSEQ 1020
KRASS 1025

Abbreviation :
CLO : cleft lip only. CPO : cleft palate only. CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.

Protein structural annotations

3D structure in PDB database

There is no related protein structure for this gene.

Protein disorder information

Orthologous information

Relation Gene symbol Entrez ID UniProt ID Cleft type Developmental stage Species Evidence Details
1:1 orthologGLDC507688E1BJQ1Bos taurusPredictionMore>>
1:1 orthologGLDC481534A0A5F4C8B1Canis lupus familiarisPredictionMore>>
1:1 orthologGLDC102174205A0A452FM63Capra hircusPredictionMore>>
1:1 orthologGLDC2731P23378Homo sapiensPredictionMore>>
1:1 orthologGldc104174Q91W43CPOMus musculusPublicationMore>>
1:1 orthologGLDCA0A2I3RPM1Pan troglodytesPredictionMore>>
1:1 orthologA0A480TLS3Sus scrofaPredictionMore>>
1:1 orthologGLDC100343694G1SL36Oryctolagus cuniculusPredictionMore>>
1:1 orthologGldcA0A0G2JUZ5Rattus norvegicusPredictionMore>>
1:1 orthologgldcA0A0G2KSN1Danio rerioPredictionMore>>

Other genetic variants/mutations

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Gene Ontology (GO)/biological pathways

GO:Molecular Function

GO ID GO Term Evidence
GO:0004375 glycine dehydrogenase (decarboxylating) activityISO
GO:0004375 glycine dehydrogenase (decarboxylating) activityISS
GO:0004375 glycine dehydrogenase (decarboxylating) activityIBA
GO:0016594 glycine bindingISO
GO:0016594 glycine bindingIBA
GO:0016829 lyase activityIEA
GO:0019899 enzyme bindingISO
GO:0030170 pyridoxal phosphate bindingISO
GO:0030170 pyridoxal phosphate bindingIBA
GO:0042803 protein homodimerization activityISO
GO:0042803 protein homodimerization activityISS
GO:0070280 pyridoxal bindingISS

GO:Biological Process

GO ID GO Term Evidence
GO:0006546 glycine catabolic processISS
GO:0006546 glycine catabolic processISO
GO:0019464 glycine decarboxylation via glycine cleavage systemISO
GO:0019464 glycine decarboxylation via glycine cleavage systemIBA
GO:0036255 response to methylamineISS
GO:0055114 oxidation-reduction processIEA
GO:0065003 protein-containing complex assemblyISO
GO:1903442 response to lipoic acidISS
GO:1990830 cellular response to leukemia inhibitory factorIEP

GO:Cellular Component

GO ID GO Term Evidence
GO:0005654 nucleoplasmISO
GO:0005739 mitochondrionISO
GO:0005739 mitochondrionHDA
GO:0005739 mitochondrionIBA
GO:0005886 plasma membraneISO
GO:0005960 glycine cleavage complexISO
GO:0005960 glycine cleavage complexIBA

Reactome Pathway

Reactome ID Reactome Term Evidence
R-MMU-1430728 MetabolismIEA
R-MMU-389661 Glyoxylate metabolism and glycine degradationIEA
R-MMU-6783984 Glycine degradationIEA
R-MMU-71291 Metabolism of amino acids and derivativesIEA

Functional annotations

Keywords

Keyword ID Keyword Term
KW-0007 Acetylation
KW-0903 Direct protein sequencing
KW-0496 Mitochondrion
KW-0560 Oxidoreductase
KW-0663 Pyridoxal phosphate
KW-1185 Reference proteome
KW-0809 Transit peptide

Interpro

InterPro ID InterPro Term
IPR001597 ArAA_b-elim_lyase/Thr_aldolase
IPR003437 GcvP
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major

PROSITE

PROSITE ID PROSITE Term

Pfam

Pfam ID Pfam Term
PF01212 Beta_elim_lyase
PF02347 GDC-P

Protein-protein interaction

Protein-miRNA interaction