| Tag | Content |
|---|---|
| Uniprot ID | E1BJQ1 |
| Entrez ID | 507688 |
| Genbank protein ID | |
| Genbank nucleotide ID | NM_001192951.1 |
| Ensembl protein ID | ENSBTAP00000036556 |
| Ensembl nucleotide ID | ENSBTAG00000025903 |
| Gene name | Glycine cleavage system P protein |
| Gene symbol | GLDC |
| Organism | Bos taurus |
| NCBI taxa ID | 9913 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | The glycine cleavage system catalyzes the degradation of glycine. |
| Sequence | MQTCARAWGL RLGCGVGGGR RLAGGAGPRW APRGRDRSSG GGDSGGAGAS RLLERLLPRH 60 DDFARRHIGP GDKDQKEMLQ ALGLASVDEL IEKTIPASIR LKRPLKMDDP VCENEILATL 120 HAISNKNQIW RSYIGMGYYN CSVPQTILRN LLENSGWITQ YTPYQPEVSQ GRLESLLNYQ 180 TMVCDITGLD MANASLLDEA TAAAEAMQLC HRQNKRRKFF VDPRCHPQTI AVVQTRAKYS 240 GVLIELKLPH EMDFSSKDVS GVLFQYPDTE GKVEDFTELV ERAHEAGSLA CCATDLLALC 300 ILRPPGEFGV DIALGSSQRF GVPLGYGGPH AAFFAVRENL VRMMPGRMVG VTRDVSGKEV 360 YRLALQTREQ HIRRDKATSN ICTAQALLAN MAVMFAIYHG SHGLEHIARR VHNATLILSE 420 GLKRAGHQLQ HDLFFDTLKI QCGCSVKEVL GRAAQRQINI RLFEDGTLGI SLDETVNEKD 480 LDDLLWIFGC ESSAELVAES MGEERRGILG TAFKRTSPFL THQVFNSYHS ETNIVRYMKR 540 LENKDISLVH SMIPLGSCTM KLNSSSELTP ITWKEFANIH PFVPLDQAQG YQQLFRELEK 600 DLCELTGYDR ISFQPNSGAQ GEYAGLASIR AYLDAKGETH RTVCLIPKSA HGTNPASAHM 660 AGMRIQPVEV DKYGNIDAAH LKAMVDKHKE NLAAIMITYP STNGVFEENI GDVCDLIHLH 720 GGQVYLDGAN MNAQVGLCRP GDFGSDVSHL NLHKTFCIPH GGGGPGMGPI GVKKHLVPFL 780 PNHPIISLKP SEDAQALGTV SAAPWGSSCI LPISWAYIKM MGGKGLKQAT EIAILNANYM 840 AKRLEKHYRV LFRGARGYVA HEFILDTRPF KKSANIEAVD VAKRLQDYGF HAPTMSWPVA 900 GTLMIEPTES EDKAELDRFC DAMISIRQEI ADIEEGRIDP RVNPLKMSPH SLTCVTSSHW 960 DRPYSREVAA FPLPFVKPEN KFWPTISRID DIYGDQHLVC TCPPMDVYES PFSEQKRASS 1020 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | GLDC | 507688 | E1BJQ1 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | GLDC | 481534 | A0A5F4C8B1 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | GLDC | 102174205 | A0A452FM63 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | GLDC | 2731 | P23378 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Gldc | 104174 | Q91W43 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | GLDC | A0A2I3RPM1 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | A0A480TLS3 | Sus scrofa | Prediction | More>> | ||||
| 1:1 ortholog | GLDC | 100343694 | G1SL36 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Gldc | A0A0G2JUZ5 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | gldc | A0A0G2KSN1 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005960 | glycine cleavage complex |
| GO:0005739 | mitochondrion |
| GO:0016594 | glycine binding |
| GO:0004375 | glycine dehydrogenase (decarboxylating) activity |
| GO:0016829 | lyase activity |
| GO:0030170 | pyridoxal phosphate binding |
| GO:0019464 | glycine decarboxylation via glycine cleavage system |