| Tag | Content |
|---|---|
| Uniprot ID | A0A5F4C8B1 |
| Entrez ID | 481534 |
| Genbank protein ID | |
| Genbank nucleotide ID | XM_538655.5 |
| Ensembl protein ID | ENSCAFP00000049202 |
| Ensembl nucleotide ID | ENSCAFG00000001416 |
| Gene name | Glycine cleavage system P protein |
| Gene symbol | GLDC |
| Organism | Canis lupus familiaris |
| NCBI taxa ID | 9615 |
| Cleft type | |
| Developmental stage | |
| Data sources | Homology search |
| Reference | |
| Functional description | The glycine cleavage system catalyzes the degradation of glycine. |
| Sequence | MQTCARAWGL RVGCGVGARG GGGGGRRLAA GAGPRWGPRA RDSSGDSSGA GDSRLLERLL 60 PRHDHFARRH IGPGDKDQRE MLQALGLASI DELIEKTVPA SIRLKRPLKM EDPVCENEIL 120 TKLHAISSKN QIWRSYMGMG YYNCFVPQTI LRNLLENAGW ITQYTPYQPE VSQGRLESLL 180 NYQTMVCDIT GMDMANASLL DEATAAAEAM QLCHRHNKRK RFFVDPRCHP QTIAVVQTRA 240 KYNGVLIELK LPHEMDFSGK DVSGVLFQYP DTEGKVEDFT ELVERAHQMG SLACCATDLL 300 ALCILKPPGE FGVDIALGSS QRFGVPLGYG GPHAAFFAVR ESLVRMMPGR MVGVTRDATG 360 KEVYRLALQT REQHIRRDKA TSNICTAQAL LANMAAMFAI YHGSRGLEHI ARRVHNATLI 420 LSEGLKRAGH QLQHDLFFDT LKIQCGCSVK EVLDRATQRQ VNFRLFEDGT LGISLDETVN 480 EKDLDDLLWI FGCESSAELV AESMGEEQRG IPGTAFKRTS SFLTHQVFNS YHSETNIVRY 540 MKKLENKDIS LVHSMIPLGS CTMKLNSSSE LTPITWKEFA NIHPFVPLDQ AQGYQQLFRE 600 LEKDLCELTG YDRISFQPNS GAQGEYAGLA TIRAYLDGKG EGHRTVCLIP KSAHGTNPAS 660 AHMAGMKIQP VEVDKYGNID TAHLKAMVDK HKENLAAIMI TYPSTNGVFE ENIGDVCDLI 720 HQNGGQVYLD GANMNAQVGI CRPGDFGSDV SHLNLHKTFC IPHGGGGPGM GPIGVKKHLA 780 PFLPNHPIVS VKPSEDDRPV GTVSAAPWGS SSILPISWAY IKMMGGKGLK QATEIAILNA 840 NYMAKRLEKH YRVLFRGARG YVAHEFILDT RPFKKSANIE AVDVAKRLQD YGFHAPTMSW 900 PVAGTLMVEP TESEDKAELD RFCDAMISIR QEIADIEEGR IDPRVNPLKM SPHSLTCVTS 960 SRWDRPYSRE VAAFPLPFVK PENKFWPTIA RIDDIYGDQH LVCTCPPMEV YESPFSEQKR 1020 ASS 1023 |
Abbreviation :
CLO : cleft lip only. CPO : cleft palate only.
CLP : cleft lip and palate. CL/P : cleft lip with/without cleft palate.
For humans: CL/P, CLO, CPO, and CLP. For mice: CLO, CLP, and CPO.
| Relation | Gene symbol | Entrez ID | UniProt ID | Cleft type | Developmental stage | Species | Evidence | Details |
|---|---|---|---|---|---|---|---|---|
| 1:1 ortholog | GLDC | 507688 | E1BJQ1 | Bos taurus | Prediction | More>> | ||
| 1:1 ortholog | GLDC | 481534 | A0A5F4C8B1 | Canis lupus familiaris | Prediction | More>> | ||
| 1:1 ortholog | GLDC | 102174205 | A0A452FM63 | Capra hircus | Prediction | More>> | ||
| 1:1 ortholog | GLDC | 2731 | P23378 | Homo sapiens | Prediction | More>> | ||
| 1:1 ortholog | Gldc | 104174 | Q91W43 | CPO | Mus musculus | Publication | More>> | |
| 1:1 ortholog | GLDC | A0A2I3RPM1 | Pan troglodytes | Prediction | More>> | |||
| 1:1 ortholog | A0A480TLS3 | Sus scrofa | Prediction | More>> | ||||
| 1:1 ortholog | GLDC | 100343694 | G1SL36 | Oryctolagus cuniculus | Prediction | More>> | ||
| 1:1 ortholog | Gldc | A0A0G2JUZ5 | Rattus norvegicus | Prediction | More>> | |||
| 1:1 ortholog | gldc | A0A0G2KSN1 | Danio rerio | Prediction | More>> |
| GO ID | GO Term |
|---|---|
| GO:0005739 | mitochondrion |
| GO:0004375 | glycine dehydrogenase (decarboxylating) activity |
| GO:0016829 | lyase activity |
| GO:0006546 | glycine catabolic process |