Gene Page: USH1C
Summary ?
GeneID | 10083 |
Symbol | USH1C |
Synonyms | AIE-75|DFNB18|DFNB18A|NY-CO-37|NY-CO-38|PDZ-45|PDZ-73|PDZ-73/NY-CO-38|PDZ73|PDZD7C|ush1cpst |
Description | USH1 protein network component harmonin |
Reference | MIM:605242|HGNC:HGNC:12597|Ensembl:ENSG00000006611|HPRD:09241|Vega:OTTHUMG00000166323 |
Gene type | protein-coding |
Map location | 11p14.3 |
Pascal p-value | 0.013 |
Gene in Data Sources
Gene set name | Method of gene set | Description | Info |
---|---|---|---|
CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
Top 10 positively co-expressed genes | ||
Gene | Pearson's Correlation | Spearman's Correlation |
ZNF830 | 0.85 | 0.88 |
GTPBP4 | 0.85 | 0.87 |
MRFAP1L1 | 0.85 | 0.89 |
EIF4E2 | 0.84 | 0.87 |
PPP2R2D | 0.84 | 0.86 |
GLOD4 | 0.84 | 0.87 |
SPATS2 | 0.84 | 0.86 |
ANKLE2 | 0.84 | 0.86 |
RNF34 | 0.83 | 0.84 |
TERF1 | 0.83 | 0.84 |
Top 10 negatively co-expressed genes | ||
Gene | Pearson's Correlation | Spearman's Correlation |
MT-CO2 | -0.77 | -0.79 |
AF347015.33 | -0.75 | -0.78 |
AF347015.31 | -0.75 | -0.79 |
FXYD1 | -0.74 | -0.78 |
MT-CYB | -0.74 | -0.78 |
AF347015.8 | -0.74 | -0.78 |
AF347015.27 | -0.73 | -0.79 |
AF347015.2 | -0.73 | -0.76 |
AF347015.15 | -0.72 | -0.78 |
AF347015.26 | -0.71 | -0.75 |
Section V. Pathway annotation
Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
---|---|---|---|
BIOCARTA TID PATHWAY | 19 | 15 | All SZGR 2.0 genes in this pathway |
RODRIGUES NTN1 TARGETS DN | 158 | 102 | All SZGR 2.0 genes in this pathway |
PEREZ TP53 TARGETS | 1174 | 695 | All SZGR 2.0 genes in this pathway |
SHEN SMARCA2 TARGETS DN | 357 | 212 | All SZGR 2.0 genes in this pathway |
JEON SMAD6 TARGETS DN | 19 | 14 | All SZGR 2.0 genes in this pathway |
BLALOCK ALZHEIMERS DISEASE INCIPIENT UP | 390 | 242 | All SZGR 2.0 genes in this pathway |
BLALOCK ALZHEIMERS DISEASE UP | 1691 | 1088 | All SZGR 2.0 genes in this pathway |
ABE INNER EAR | 48 | 26 | All SZGR 2.0 genes in this pathway |
ACEVEDO LIVER CANCER WITH H3K27ME3 DN | 228 | 114 | All SZGR 2.0 genes in this pathway |
WU SILENCED BY METHYLATION IN BLADDER CANCER | 55 | 42 | All SZGR 2.0 genes in this pathway |
WANG RECURRENT LIVER CANCER UP | 20 | 13 | All SZGR 2.0 genes in this pathway |
FIGUEROA AML METHYLATION CLUSTER 5 DN | 50 | 31 | All SZGR 2.0 genes in this pathway |