Gene Page: MPHOSPH10

Summary ?
GeneID10199
SymbolMPHOSPH10
SynonymsCT90|MPP10|MPP10P|PPP1R106
DescriptionM-phase phosphoprotein 10
ReferenceMIM:605503|HGNC:HGNC:7213|Ensembl:ENSG00000124383|HPRD:10404|Vega:OTTHUMG00000129715
Gene typeprotein-coding
Map location2p13.3
Pascal p-value0.039
Sherlock p-value0.976
Fetal beta0.619
DMG1 (# studies)
eGeneMyers' cis & trans
Meta

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Jaffe_2016Genome-wide DNA methylation analysisThis dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg20921688271357800MPHOSPH107.65E-8-0.0061.81E-5DMG:Jaffe_2016

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs1807299chr3134470799MPHOSPH10101990.12trans
rs7778042chr729637891MPHOSPH10101990.19trans
rs3779536chr7127233976MPHOSPH10101990.06trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
SAMD9L0.600.74
C1S0.550.68
TRIM6-TRIM340.540.60
AC068989.20.540.64
XXbac-BPG116M5.10.530.64
PTPRC0.530.56
RSAD20.520.68
TLR30.520.56
C1QA0.510.55
PARP90.510.66
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
SOX11-0.43-0.42
HMGA1-0.41-0.49
H2AFY2-0.40-0.42
IGLON5-0.40-0.44
XKR7-0.40-0.45
HNRNPA0-0.40-0.44
ACTG1-0.40-0.45
LRRC3-0.39-0.44
TAX1BP3-0.39-0.45
VARS-0.39-0.49

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED UP 633376All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC UP 722443All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 17811082All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN DN 770415All SZGR 2.0 genes in this pathway
HAMAI APOPTOSIS VIA TRAIL UP 584356All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 16521023All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC NETWORK 779480All SZGR 2.0 genes in this pathway
WEI MYCN TARGETS WITH E BOX 795478All SZGR 2.0 genes in this pathway
GARCIA TARGETS OF FLI1 AND DAX1 DN 176104All SZGR 2.0 genes in this pathway
RICKMAN METASTASIS UP 344180All SZGR 2.0 genes in this pathway
PENG GLUTAMINE DEPRIVATION DN 337230All SZGR 2.0 genes in this pathway
RAMALHO STEMNESS UP 206118All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV SCC DN 12386All SZGR 2.0 genes in this pathway
WESTON VEGFA TARGETS 10871All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV NHEK DN 318220All SZGR 2.0 genes in this pathway
WESTON VEGFA TARGETS 3HR 7447All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP A 898516All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS DN 882538All SZGR 2.0 genes in this pathway
PHONG TNF RESPONSE NOT VIA P38 337236All SZGR 2.0 genes in this pathway