Gene Page: KLF2

Summary ?
GeneID10365
SymbolKLF2
SynonymsLKLF
DescriptionKruppel-like factor 2
ReferenceMIM:602016|HGNC:HGNC:6347|Ensembl:ENSG00000127528|HPRD:03602|Vega:OTTHUMG00000182330
Gene typeprotein-coding
Map location19p13.11
Pascal p-value0.157
Sherlock p-value0.499
Fetal beta-0.107
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs17131472chr191962966KLF2103653.594E-4trans
rs546975chr191963738KLF2103650.05trans
rs1862058chr216926283KLF2103650.15trans
rs12612914chr2111666928KLF2103650.1trans
rs2922180chr3125280472KLF2103650.06trans
rs2976809chr3125451738KLF2103650trans
rs9917710chr3176280218KLF2103650.09trans
rs10050805chr530805352KLF2103650.12trans
rs837115chr540736290KLF2103650.1trans
rs16894149chr561013724KLF2103650.17trans
rs6449550chr561034312KLF2103650.04trans
rs17056435chr5158453782KLF2103650.11trans
rs17135501chr62704474KLF2103650.03trans
rs17135521chr62707631KLF2103650.03trans
snp_a-17879260KLF2103650.03trans
rs6934246chr635154494KLF2103650.04trans
rs4711782chr644363229KLF2103650.15trans
rs6455226chr667930295KLF2103650trans
rs12056282chr718882202KLF2103650.14trans
rs10085826chr742504690KLF2103650.12trans
rs2199402chr89201002KLF2103650.08trans
rs7841407chr89243427KLF2103650.13trans
rs680372chr836999626KLF2103650.01trans
rs2061799chr997795003KLF2103650.12trans
rs7081666chr1047673800KLF2103650.01trans
rs1159612chr1085329057KLF2103652.005E-4trans
rs10886877chr1085425690KLF2103650.11trans
rs12359780chr1085446729KLF2103650.06trans
rs10886943chr1085455847KLF2103650.08trans
rs11199997chr1085456823KLF2103650.03trans
rs11049036chr1227650292KLF2103650.02trans
rs7303819chr1233990776KLF2103650.07trans
rs10879027chr1270237156KLF2103650.03trans
rs9529974chr1372821935KLF2103650.06trans
rs17073665chr1381541961KLF2103650.05trans
rs1457420chr1466958675KLF2103653.268E-4trans
rs12880065chr1470747905KLF2103650.09trans
rs17137819chr165372534KLF2103650trans
rs16958302chr1657647432KLF2103650.01trans
rs9907183chr179645471KLF2103650.17trans
rs11873703chr1861448702KLF2103650.14trans
rs2225630chr2010164852KLF2103650.02trans
rs6095741chr2048666589KLF2103652.995E-8trans
rs7265852chr2048823717KLF2103650.19trans
rs1888534chr2146750189KLF2103650.15trans
rs5915713chrX4077883KLF2103650.17trans
rs5991662chrX43335796KLF2103650trans
rs1545676chrX93530472KLF2103658.135E-5trans
rs242163chrX132311662KLF2103650.07trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
PTPRO0.890.94
ANKRD440.880.90
C8orf790.870.88
DOPEY20.870.93
TRIM360.870.93
CEP1700.860.95
MFAP30.860.92
ZEB20.860.83
SEMA3A0.850.91
LRP120.850.93
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AIFM3-0.61-0.81
HLA-F-0.61-0.81
HEPN1-0.61-0.78
TSC22D4-0.60-0.82
C5orf53-0.60-0.74
SLC16A11-0.60-0.68
LHPP-0.60-0.62
ALDOC-0.59-0.71
CLU-0.59-0.71
FBXO2-0.59-0.64

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS DN 463290All SZGR 2.0 genes in this pathway
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA UP 177110All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA DN 11679All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS BASAL UP 380215All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER BASAL VS MESENCHYMAL DN 5036All SZGR 2.0 genes in this pathway
RODRIGUES NTN1 TARGETS DN 158102All SZGR 2.0 genes in this pathway
OSMAN BLADDER CANCER UP 404246All SZGR 2.0 genes in this pathway
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL UP 233161All SZGR 2.0 genes in this pathway
GARGALOVIC RESPONSE TO OXIDIZED PHOSPHOLIPIDS BLACK UP 3522All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 8D DN 205127All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 10D DN 14290All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 16D DN 14383All SZGR 2.0 genes in this pathway
HOEBEKE LYMPHOID STEM CELL DN 8659All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION ERYTHROCYTE UP 157104All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION DN 329219All SZGR 2.0 genes in this pathway
NAGASHIMA NRG1 SIGNALING UP 176123All SZGR 2.0 genes in this pathway
JAATINEN HEMATOPOIETIC STEM CELL DN 226132All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA UP 1821933All SZGR 2.0 genes in this pathway
ENK UV RESPONSE EPIDERMIS DN 508354All SZGR 2.0 genes in this pathway
CHIARADONNA NEOPLASTIC TRANSFORMATION KRAS DN 14295All SZGR 2.0 genes in this pathway
CHIARADONNA NEOPLASTIC TRANSFORMATION CDC25 DN 153100All SZGR 2.0 genes in this pathway
VANHARANTA UTERINE FIBROID DN 6745All SZGR 2.0 genes in this pathway
GAUSSMANN MLL AF4 FUSION TARGETS A DN 9061All SZGR 2.0 genes in this pathway
HAMAI APOPTOSIS VIA TRAIL DN 186107All SZGR 2.0 genes in this pathway
CHASSOT SKIN WOUND 109All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS DN 848527All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 6HR DN 514330All SZGR 2.0 genes in this pathway
PASQUALUCCI LYMPHOMA BY GC STAGE DN 165104All SZGR 2.0 genes in this pathway
AMIT EGF RESPONSE 40 HELA 4229All SZGR 2.0 genes in this pathway
MORI PRE BI LYMPHOCYTE DN 7749All SZGR 2.0 genes in this pathway
SHEPARD CRUSH AND BURN MUTANT UP 197110All SZGR 2.0 genes in this pathway
JECHLINGER EPITHELIAL TO MESENCHYMAL TRANSITION DN 6647All SZGR 2.0 genes in this pathway
NING CHRONIC OBSTRUCTIVE PULMONARY DISEASE UP 157105All SZGR 2.0 genes in this pathway
YU MYC TARGETS DN 5538All SZGR 2.0 genes in this pathway
MOREAUX MULTIPLE MYELOMA BY TACI UP 412249All SZGR 2.0 genes in this pathway
REN ALVEOLAR RHABDOMYOSARCOMA DN 408274All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE INCIPIENT UP 390242All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 16911088All SZGR 2.0 genes in this pathway
CHEN LVAD SUPPORT OF FAILING HEART UP 10369All SZGR 2.0 genes in this pathway
YAMAZAKI TCEB3 TARGETS DN 215132All SZGR 2.0 genes in this pathway
GEORGANTAS HSC MARKERS 7147All SZGR 2.0 genes in this pathway
CHEN PDGF TARGETS 199All SZGR 2.0 genes in this pathway
BURTON ADIPOGENESIS PEAK AT 0HR 6348All SZGR 2.0 genes in this pathway
ZHENG BOUND BY FOXP3 491310All SZGR 2.0 genes in this pathway
KONDO EZH2 TARGETS 245148All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS UP 317208All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION UP 461298All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 2D UP 6946All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER DN 540340All SZGR 2.0 genes in this pathway
MITSIADES RESPONSE TO APLIDIN UP 439257All SZGR 2.0 genes in this pathway
WEST ADRENOCORTICAL TUMOR DN 546362All SZGR 2.0 genes in this pathway
PODAR RESPONSE TO ADAPHOSTIN UP 14798All SZGR 2.0 genes in this pathway
ICHIBA GRAFT VERSUS HOST DISEASE 35D DN 4934All SZGR 2.0 genes in this pathway
MARSHALL VIRAL INFECTION RESPONSE DN 2921All SZGR 2.0 genes in this pathway
SWEET LUNG CANCER KRAS DN 435289All SZGR 2.0 genes in this pathway
LEE EARLY T LYMPHOCYTE DN 5736All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K4ME3 AND H3K27ME3 1069729All SZGR 2.0 genes in this pathway
VALK AML CLUSTER 4 3117All SZGR 2.0 genes in this pathway
UZONYI RESPONSE TO LEUKOTRIENE AND THROMBIN 3726All SZGR 2.0 genes in this pathway
WONG ADULT TISSUE STEM MODULE 721492All SZGR 2.0 genes in this pathway
MARTENS BOUND BY PML RARA FUSION 456287All SZGR 2.0 genes in this pathway
HIRSCH CELLULAR TRANSFORMATION SIGNATURE UP 242159All SZGR 2.0 genes in this pathway
WIERENGA STAT5A TARGETS UP 217131All SZGR 2.0 genes in this pathway
WIERENGA STAT5A TARGETS GROUP2 6038All SZGR 2.0 genes in this pathway
MIYAGAWA TARGETS OF EWSR1 ETS FUSIONS UP 259159All SZGR 2.0 genes in this pathway
PASINI SUZ12 TARGETS UP 11265All SZGR 2.0 genes in this pathway
KASLER HDAC7 TARGETS 2 DN 3223All SZGR 2.0 genes in this pathway
PURBEY TARGETS OF CTBP1 NOT SATB1 DN 448282All SZGR 2.0 genes in this pathway
DELACROIX RAR BOUND ES 462273All SZGR 2.0 genes in this pathway
RAO BOUND BY SALL4 227149All SZGR 2.0 genes in this pathway
SMIRNOV RESPONSE TO IR 2HR DN 5535All SZGR 2.0 genes in this pathway
SMIRNOV RESPONSE TO IR 6HR DN 11469All SZGR 2.0 genes in this pathway