Gene Page: PIAS3

Summary
GeneID  10401
Symbol  PIAS3
Synonyms  FLJ14651|ZMIZ5
Description  protein inhibitor of activated STAT, 3
See related  HGNC:16861|MIM:605987|Ensembl:ENSG00000131788|HPRD:09068|
Locus tag  -
Gene type  protein-coding
Map location  1q21
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GSMA_Igenome scan meta-analysisPsr: 0.0235 
GSMA_IIAgenome scan meta-analysis (All samples)Psr: 0.00814 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
FHL10.830.84
NAGA0.830.79
GLB10.820.79
HEATR20.810.85
SALL20.810.81
RP11-369J21.10.800.77
TCTN10.790.72
TCTN30.790.72
DOLK0.790.80
C1orf560.780.81
Top 10 negatively co-expressed genes
AF347015.27-0.59-0.68
MT-CO2-0.59-0.67
AF347015.21-0.58-0.71
AF347015.8-0.57-0.67
AF347015.31-0.57-0.66
AF347015.33-0.56-0.64
MT-CYB-0.54-0.63
AC098691.2-0.53-0.62
MT-ATP8-0.51-0.70
AF347015.2-0.51-0.64
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003676nucleic acid bindingIEA-
GO:0008270zinc ion bindingIEA-
GO:0051059NF-kappaB bindingIPI15140884 
GO:0019789SUMO ligase activityIEA-
GO:0046872metal ion bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006355regulation of transcription, DNA-dependentIEA-
GO:0006350transcriptionIEA-
GO:0006511ubiquitin-dependent protein catabolic processIEA-
GO:0016925protein sumoylationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIEA-
GO:0016607nuclear speckIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ARAIS | DHTR | HUMARA | KD | NR3C4 | SBMA | SMAX1 | TFMandrogen receptorTwo-hybridBioGRID11117529 
CREBBPCBP | KAT3A | RSTSCREB binding proteinAffinity Capture-WesternBioGRID14691252 
EP300KAT3B | p300E1A binding protein p300Affinity Capture-WesternBioGRID14691252 
GEMIN4DKFZp434B131 | DKFZp434D174 | HC56 | HCAP1 | HHRF-1 | p97gem (nuclear organelle) associated protein 4HCAP1 interacts with PIAS3BIND12869526 
GFI1FLJ94509 | GFI-1 | ZNF163growth factor independent 1 transcription repressorTwo-hybridBioGRID11060035 
HDAC1DKFZp686H12203 | GON-10 | HD1 | RPD3 | RPD3L1histone deacetylase 1-HPRD14691252 
HMGA2BABL | HMGI-C | HMGIC | LIPO | STQTL9high mobility group AT-hook 2Affinity Capture-Western
Two-hybrid		BioGRID11390395 
MITFMI | WS2A | bHLHe32microphthalmia-associated transcription factorAffinity Capture-Western
Reconstituted Complex
Two-hybrid		BioGRID11709556 
RELAMGC131774 | NFKB3 | p65v-rel reticuloendotheliosis viral oncogene homolog A (avian)Affinity Capture-Western
Reconstituted Complex
Two-hybrid		BioGRID15140884 
SMAD2JV18 | JV18-1 | MADH2 | MADR2 | MGC22139 | MGC34440 | hMAD-2 | hSMAD2SMAD family member 2-HPRD,BioGRID14691252 
SMAD3DKFZp586N0721 | DKFZp686J10186 | HSPC193 | HsT17436 | JV15-2 | MADH3 | MGC60396SMAD family member 3-HPRD,BioGRID14691252 
SMAD4DPC4 | JIP | MADH4SMAD family member 4-HPRD,BioGRID14691252 
STAT3APRF | FLJ20882 | HIES | MGC16063signal transducer and activator of transcription 3 (acute-phase response factor)-HPRD11429412 |12804609 
-HPRD,BioGRID11429412 
ZFHX3ATBF1 | ATBTzinc finger homeobox 3ATBF1 interacts with PIAS3.BIND14715251 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS 13898All SZGR genes in this pathway
KEGG_JAK_STAT_SIGNALING_PATHWAY 155105All SZGR genes in this pathway
KEGG_PATHWAYS_IN_CANCER 328259All SZGR genes in this pathway
KEGG_SMALL_CELL_LUNG_CANCER 8467All SZGR genes in this pathway
ST_JAK_STAT_PATHWAY 98All SZGR genes in this pathway
ST_STAT3_PATHWAY 1110All SZGR genes in this pathway
PID_SMAD2_3NUCLEAR_PATHWAY 8263All SZGR genes in this pathway
PID_AR_PATHWAY 6146All SZGR genes in this pathway
PID_IL6_7_PATHWAY 4740All SZGR genes in this pathway
PID_CMYB_PATHWAY 8461All SZGR genes in this pathway
SENGUPTA_NASOPHARYNGEAL_CARCINOMA_DN 349157All SZGR genes in this pathway
MULLIGHAN_NPM1_SIGNATURE_3_UP 341197All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_UP 1821933All SZGR genes in this pathway
GOZGIT_ESR1_TARGETS_DN 781465All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP 1142669All SZGR genes in this pathway
GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_UP 612367All SZGR genes in this pathway
BERENJENO_TRANSFORMED_BY_RHOA_DN 394258All SZGR genes in this pathway
MCBRYAN_PUBERTAL_BREAST_4_5WK_UP 271175All SZGR genes in this pathway
MCBRYAN_PUBERTAL_TGFB1_TARGETS_UP 169127All SZGR genes in this pathway
RIZ_ERYTHROID_DIFFERENTIATION 7751All SZGR genes in this pathway
RIZ_ERYTHROID_DIFFERENTIATION_CCNE1 4026All SZGR genes in this pathway
RIZ_ERYTHROID_DIFFERENTIATION_APOBEC2 2719All SZGR genes in this pathway
RIZ_ERYTHROID_DIFFERENTIATION_12HR 4335All SZGR genes in this pathway
RASHI_RESPONSE_TO_IONIZING_RADIATION_3 4831All SZGR genes in this pathway
GROSS_HYPOXIA_VIA_ELK3_UP 209139All SZGR genes in this pathway
BENPORATH_MYC_MAX_TARGETS 775494All SZGR genes in this pathway
GRADE_COLON_CANCER_UP 871505All SZGR genes in this pathway
GRADE_COLON_VS_RECTAL_CANCER_DN 5636All SZGR genes in this pathway
BLUM_RESPONSE_TO_SALIRASIB_DN 342220All SZGR genes in this pathway
LINDSTEDT_DENDRITIC_CELL_MATURATION_C 6949All SZGR genes in this pathway
SHEDDEN_LUNG_CANCER_GOOD_SURVIVAL_A4 196124All SZGR genes in this pathway
WORSCHECH_TUMOR_EVASION_AND_TOLEROGENICITY_UP 3019All SZGR genes in this pathway
YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_17 181101All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_1HR_DN 222147All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_4HR_DN 254158All SZGR genes in this pathway
MARTENS_TRETINOIN_RESPONSE_UP 857456All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN 19721213All SZGR genes in this pathway
DUAN_PRDM5_TARGETS 7952All SZGR genes in this pathway
FORTSCHEGGER_PHF8_TARGETS_DN 784464All SZGR genes in this pathway
FOSTER_KDM1A_TARGETS_DN 211119All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1/206238244m8hsa-miR-1UGGAAUGUAAAGAAGUAUGUA
hsa-miR-206SZUGGAAUGUAAGGAAGUGUGUGG
hsa-miR-613AGGAAUGUUCCUUCUUUGCC
miR-18774780m8hsa-miR-18aUAAGGUGCAUCUAGUGCAGAUA
hsa-miR-18bUAAGGUGCAUCUAGUGCAGUUA
miR-181916922m8hsa-miR-181abrainAACAUUCAACGCUGUCGGUGAGU
hsa-miR-181bSZAACAUUCAUUGCUGUCGGUGGG
hsa-miR-181cbrainAACAUUCAACCUGUCGGUGAGU
hsa-miR-181dbrainAACAUUCAUUGUUGUCGGUGGGUU
miR-324-3p263269m8hsa-miR-324-3pCCACUGCCCCAGGUGCUGCUGG
miR-4106906961Ahsa-miR-410AAUAUAACACAGAUGGCCUGU
miR-95725781Ahsa-miR-9SZUCUUUGGUUAUCUAGCUGUAUGA
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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