Summary ?
GeneID1387
SymbolCREBBP
SynonymsCBP|KAT3A|RSTS
DescriptionCREB binding protein
ReferenceMIM:600140|HGNC:HGNC:2348|Ensembl:ENSG00000005339|HPRD:02534|Vega:OTTHUMG00000129431
Gene typeprotein-coding
Map location16p13.3
Pascal p-value0.019
Sherlock p-value0.399
Fetal beta1.687
SupportCompositeSet
Darnell FMRP targets
Chromatin Remodeling Genes

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0553 

Section I. Genetics and epigenetics annotation


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
C10orf1160.720.82
TAGLN0.720.78
VAMP50.710.86
MYL90.700.78
RHOC0.700.74
GSDMD0.690.75
METRN0.690.80
RRAS0.690.81
MUSTN10.680.80
SERPINB60.680.78
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
RNF214-0.59-0.80
TTC3-0.58-0.80
NFX1-0.58-0.79
TCERG1-0.58-0.81
ANKRD17-0.58-0.77
TMEM81-0.58-0.79
CKAP5-0.58-0.79
TOPBP1-0.58-0.78
C10orf137-0.58-0.79
SMARCC2-0.58-0.78

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004871signal transducer activityTAS7913207 |8028671 
GO:0003677DNA bindingIEA-
GO:0003700transcription factor activityTAS7913207 
GO:0003713transcription coactivator activityIDA12435739 |12586840 
GO:0003713transcription coactivator activityIEA-
GO:0003713transcription coactivator activityIPI8684459 
GO:0005515protein bindingIEA-
GO:0005524ATP bindingIEA-
GO:0004402histone acetyltransferase activityIDA11742995 
GO:0004402histone acetyltransferase activityIEA-
GO:0016740transferase activityIEA-
GO:0008270zinc ion bindingIEA-
GO:0016887ATPase activityIEA-
GO:0016407acetyltransferase activityIDA11742995 
GO:0016407acetyltransferase activityIEA-
GO:0046872metal ion bindingIEA-
GO:0051577MyoD bindingIDA8621548 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0001666response to hypoxiaTAS15261140 
GO:0006355regulation of transcription, DNA-dependentIDA12169688 
GO:0006355regulation of transcription, DNA-dependentIEA-
GO:0006461protein complex assemblyTAS7913207 
GO:0007165signal transductionNAS15261140 
GO:0018076N-terminal peptidyl-lysine acetylationIDA12435739 
GO:0016573histone acetylationIDA11742995 
GO:0016573histone acetylationIEA-
GO:0042592homeostatic processNAS15261140 
GO:0045893positive regulation of transcription, DNA-dependentIEA-
GO:0045941positive regulation of transcriptionIDA11742995 
GO:0045941positive regulation of transcriptionISS-
GO:0044419interspecies interaction between organismsIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0000123histone acetyltransferase complexIEA-
GO:0000940outer kinetochore of condensed chromosomeIEA-
GO:0005634nucleusIC12169688 
GO:0005634nucleusIEA-
GO:0005737cytoplasmTAS7913207 
GO:0016605PML bodyIDA17332504 

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ABCA1ABC-1 | ABC1 | CERP | FLJ14958 | HDLDT1 | MGC164864 | MGC165011 | TGDATP-binding cassette, sub-family A (ABC1), member 1Affinity Capture-WesternBioGRID11864601 
AIREAIRE1 | APECED | APS1 | APSI | PGA1autoimmune regulator-HPRD,BioGRID10748110 
AIREAIRE1 | APECED | APS1 | APSI | PGA1autoimmune regulatorAIRE isoform 1 interacts with CBPBIND10748110 
ALX1CART1ALX homeobox 1-HPRD12929931 
ARAIS | DHTR | HUMARA | KD | NR3C4 | SBMA | SMAX1 | TFMandrogen receptor-HPRD,BioGRID9482849 
ATF1EWS-ATF1 | FUS/ATF-1 | TREB36activating transcription factor 1-HPRD,BioGRID8663317 
ATF2CRE-BP1 | CREB2 | HB16 | MGC111558 | TREB7activating transcription factor 2Affinity Capture-Western
Reconstituted Complex
Two-hybrid
BioGRID9786917 
ATF4CREB-2 | CREB2 | TAXREB67 | TXREBactivating transcription factor 4 (tax-responsive enhancer element B67)Reconstituted ComplexBioGRID9295363 
BCL3BCL4 | D19S37B-cell CLL/lymphoma 3-HPRD10497212 
BNIP3LBNIP3a | NIXBCL2/adenovirus E1B 19kDa interacting protein 3-likeCBP interacts with Bnip3L.BIND15607964 
BRCA1BRCAI | BRCC1 | IRIS | PSCP | RNF53breast cancer 1, early onset-HPRD,BioGRID10655477 
BRCA1BRCAI | BRCC1 | IRIS | PSCP | RNF53breast cancer 1, early onsetCBP interacts with BRCA1. This interaction was modelled on a demonstrated interaction between human BRCA1 and mouse CBP.BIND10655477 
CCNCCycCcyclin CCo-fractionationBioGRID9710619 
CCND1BCL1 | D11S287E | PRAD1 | U21B31cyclin D1CBP interacts with cyclin D1 promoter.BIND15808510 
CDC25B-cell division cycle 25 homolog B (S. pombe)-HPRD11689696 
CDK8K35 | MGC126074 | MGC126075cyclin-dependent kinase 8Affinity Capture-Western
Co-fractionation
BioGRID9710619 
CDKN1ACAP20 | CDKN1 | CIP1 | MDA-6 | P21 | SDI1 | WAF1 | p21CIP1cyclin-dependent kinase inhibitor 1A (p21, Cip1)CREBBP (CBP) interacts with the p21 promoter.BIND15710329 
CDKN1ACAP20 | CDKN1 | CIP1 | MDA-6 | P21 | SDI1 | WAF1 | p21CIP1cyclin-dependent kinase inhibitor 1A (p21, Cip1)CBP interacts with p21.BIND10764767 
CDX2CDX-3 | CDX3caudal type homeobox 2-HPRD,BioGRID10066780 
CITED1MSG1Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1-HPRD,BioGRID10722728 
CITED2MRG1 | P35SRJCbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2-HPRD,BioGRID9887100 
CREB1CREB | MGC9284cAMP responsive element binding protein 1CREB1 (CREB) interacts with CREBBP (CBP).BIND16007092 
CREB1CREB | MGC9284cAMP responsive element binding protein 1CBP interacts with CREB.BIND15454081 
CREB1CREB | MGC9284cAMP responsive element binding protein 1-HPRD,BioGRID9413984 
CREBBPCBP | KAT3A | RSTSCREB binding protein-HPRD11259575 
CSKMGC117393c-src tyrosine kinase-HPRD,BioGRID10801129 
CSNK2A1CK2A1 | CKIIcasein kinase 2, alpha 1 polypeptide-HPRD,BioGRID9685505 
CSNK2A2CK2A2 | CSNK2A1 | FLJ43934casein kinase 2, alpha prime polypeptide-HPRD,BioGRID9685505 
CTBP1BARS | MGC104684C-terminal binding protein 1CTBP1 interacts with CREBBP (CBP)BIND15834423 
CTNNB1CTNNB | DKFZp686D02253 | FLJ25606 | FLJ37923catenin (cadherin-associated protein), beta 1, 88kDaPhenotypic EnhancementBioGRID15782138 
CUX1CASP | CDP | CDP/Cut | CDP1 | COY1 | CUTL1 | CUX | Clox | Cux/CDP | GOLIM6 | Nbla10317 | p100 | p110 | p200 | p75cut-like homeobox 1-HPRD,BioGRID10852958 
DAXXBING2 | DAP6 | EAP1 | MGC126245 | MGC126246death-domain associated proteinCBP interacts with Daxx.BIND11799127 
DDX5DKFZp686J01190 | G17P1 | HLR1 | HUMP68 | p68DEAD (Asp-Glu-Ala-Asp) box polypeptide 5-HPRD,BioGRID12527917 
E2F1E2F-1 | RBAP1 | RBBP3 | RBP3E2F transcription factor 1Two-hybridBioGRID12748276 
E2F3DKFZp686C18211 | E2F-3 | KIAA0075 | MGC104598E2F transcription factor 3Two-hybridBioGRID12748276 
EBF1COE1 | EBF | FLJ39389 | FLJ41763 | O/E-1 | OLF1early B-cell factor 1-HPRD,BioGRID12748286 
EGR1AT225 | G0S30 | KROX-24 | NGFI-A | TIS8 | ZIF-268 | ZNF225early growth response 1-HPRD,BioGRID9806899 
EGR1AT225 | G0S30 | KROX-24 | NGFI-A | TIS8 | ZIF-268 | ZNF225early growth response 1CBP interacts with Egr1 promoter.BIND15225550 
EGR1AT225 | G0S30 | KROX-24 | NGFI-A | TIS8 | ZIF-268 | ZNF225early growth response 1CBP promoter interacts with Egr1.BIND15225550 
ESR1DKFZp686N23123 | ER | ESR | ESRA | Era | NR3A1estrogen receptor 1Affinity Capture-Western
Reconstituted Complex
BioGRID11113179 |11782371 
EVI1AML1-EVI-1 | EVI-1 | MDS1-EVI1 | MGC163392 | PRDM3ecotropic viral integration site 1-HPRD,BioGRID11568182 
EWSR1EWSEwing sarcoma breakpoint region 1-HPRD,BioGRID12459554 
FOSAP-1 | C-FOSv-fos FBJ murine osteosarcoma viral oncogene homologReconstituted ComplexBioGRID11782371 
FOXO1FKH1 | FKHR | FOXO1Aforkhead box O1-HPRD,BioGRID10973497 
FOXO4AFX | AFX1 | MGC120490 | MLLT7forkhead box O4-HPRD,BioGRID10973497 
GATA1ERYF1 | GF-1 | GF1 | NFE1GATA binding protein 1 (globin transcription factor 1)Reconstituted ComplexBioGRID12496368 
GLI3ACLS | GCPS | PAP-A | PAPA | PAPA1 | PAPB | PHS | PPDIVGLI-Kruppel family member GLI3Affinity Capture-Western
Reconstituted Complex
BioGRID10075717 
GTF2BTF2B | TFIIBgeneral transcription factor IIBReconstituted ComplexBioGRID11782371 |11864601 
H3F3AH3.3A | H3F3 | MGC87782 | MGC87783H3 histone, family 3AH3F3A (Histone 3) interacts with CREBBP (CBP).BIND15616580 
HIF1AHIF-1alpha | HIF1 | HIF1-ALPHA | MOP1 | PASD8hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)-HPRD,BioGRID10202154 
HIPK2DKFZp686K02111 | FLJ23711 | PRO0593homeodomain interacting protein kinase 2-HPRD,BioGRID11740489 
HNF1AHNF1 | LFB1 | MODY3 | TCF1HNF1 homeobox ACBP interacts with the HNF-1 gene.BIND15616580 
HNF1AHNF1 | LFB1 | MODY3 | TCF1HNF1 homeobox A-HPRD,BioGRID10777539 
HNF4AFLJ39654 | HNF4 | HNF4a7 | HNF4a8 | HNF4a9 | MODY | MODY1 | NR2A1 | NR2A21 | TCF | TCF14hepatocyte nuclear factor 4, alphaCBP interacts with the HNF-4 gene.BIND15616580 
HNF4AFLJ39654 | HNF4 | HNF4a7 | HNF4a8 | HNF4a9 | MODY | MODY1 | NR2A1 | NR2A21 | TCF | TCF14hepatocyte nuclear factor 4, alpha-HPRD,BioGRID9434765 |10085149 
HOXB7HHO.C1 | HOX2 | HOX2C | Hox-2.3homeobox B7-HPRD,BioGRID10435624 
HSF1HSTF1heat shock transcription factor 1HSF1 interacts with CBP. This interaction was modeled on a demonstrated interaction between human HSF1 and CBP from an unspecified species.BIND14960326 
HTTHD | IT15huntingtinCBP interacts with htt. This interaction was modeled on a demonstrated interaction between CBP and htt from unspecified species.BIND10823891 
HTTHD | IT15huntingtin-HPRD,BioGRID11264541 
HTTHD | IT15huntingtinHtt interacts with CBP.BIND15225551 
ICAM1BB2 | CD54 | P3.58intercellular adhesion molecule 1CREBBP (CBP) interacts with the ICAM1 promoter.BIND15829968 
ING1p24ING1c | p33 | p33ING1 | p33ING1b | p47 | p47ING1ainhibitor of growth family, member 1Affinity Capture-WesternBioGRID12015309 
IRF3-interferon regulatory factor 3IRF-3 interacts with CBP.BIND15502848 
IRF3-interferon regulatory factor 3-HPRD,BioGRID10521456 
JDP2JUNDM2Jun dimerization protein 2-HPRD12101239 
JUNAP-1 | AP1 | c-Junjun oncogene-HPRD,BioGRID2138276 |9786917 
KAT2BCAF | P | P/CAF | PCAFK(lysine) acetyltransferase 2BAffinity Capture-Western
Co-fractionation
Reconstituted Complex
BioGRID9710619 |11864601 
KHDRBS1FLJ34027 | Sam68 | p62KH domain containing, RNA binding, signal transduction associated 1-HPRD,BioGRID12496368 
KLF1EKLFKruppel-like factor 1 (erythroid)Biochemical ActivityBioGRID11259590 
KLF13BTEB3 | FKLF2 | NSLP1 | RFLAT-1 | RFLAT1Kruppel-like factor 13Affinity Capture-Western
Biochemical Activity
Phenotypic Enhancement
BioGRID11748222 
KLF4EZF | GKLFKruppel-like factor 4 (gut)-HPRD,BioGRID10666450 
KLF5BTEB2 | CKLF | IKLFKruppel-like factor 5 (intestinal)-HPRD,BioGRID12682370 
MAFMGC71685 | c-MAFv-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)-HPRD,BioGRID11943779 
MAFMGC71685 | c-MAFv-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)CBP interacts with c-Maf. This interaction was modeled on a demonstrated interaction between CBP and c-Maf from unspecified sources.BIND11943779 
MAFGMGC13090 | MGC20149v-maf musculoaponeurotic fibrosarcoma oncogene homolog G (avian)-HPRD11154691 
MAML1KIAA0200 | Mam-1 | Mam1mastermind-like 1 (Drosophila)-HPRD,BioGRID12050117 
MBD2DKFZp586O0821 | DMTase | NY-CO-41methyl-CpG binding domain protein 2-HPRD12665568 
MED21SRB7 | SURB7mediator complex subunit 21Affinity Capture-WesternBioGRID9710619 
MGMT-O-6-methylguanine-DNA methyltransferase-HPRD,BioGRID11564893 
MLLALL-1 | CXXC7 | FLJ11783 | HRX | HTRX1 | KMT2A | MLL/GAS7 | MLL1A | TET1-MLL | TRX1myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)-HPRD,BioGRID11259575 |12205094 
MSX1HOX7 | HYD1msh homeobox 1-HPRD,BioGRID10215616 |11115394 
MYBCmyb | c-myb | c-myb_CDS | efgv-myb myeloblastosis viral oncogene homolog (avian)-HPRD,BioGRID12196545 
MYBL2B-MYB | BMYB | MGC15600v-myb myeloblastosis viral oncogene homolog (avian)-like 2-HPRD,BioGRID11423988 
MYOD1MYF3 | MYOD | PUM | bHLHc1myogenic differentiation 1Affinity Capture-Western
Phenotypic Enhancement
Reconstituted Complex
BioGRID9001254 |11463815 
MYOD1MYF3 | MYOD | PUM | bHLHc1myogenic differentiation 1-HPRD2176177 |9238849 
|11463815 
N4BP2B3BP | FLJ10680 | KIAA1413NEDD4 binding protein 2-HPRD,BioGRID12730195 
NAP1L1FLJ16112 | MGC23410 | MGC8688 | NAP1 | NAP1L | NRPnucleosome assembly protein 1-like 1CREBBP (CBP) interacts with NAP1L1 (NAP-1).BIND11940655 
NCOA1F-SRC-1 | KAT13A | MGC129719 | MGC129720 | NCoA-1 | RIP160 | SRC-1 | SRC1 | bHLHe42nuclear receptor coactivator 1Affinity Capture-MS
Biochemical Activity
Reconstituted Complex
Two-hybrid
BioGRID11113179 |11971985 
|15027889 
NCOA1F-SRC-1 | KAT13A | MGC129719 | MGC129720 | NCoA-1 | RIP160 | SRC-1 | SRC1 | bHLHe42nuclear receptor coactivator 1-HPRD11003650 |11113179 
NCOA3ACTR | AIB-1 | AIB1 | CAGH16 | CTG26 | KAT13B | MGC141848 | RAC3 | SRC3 | TNRC14 | TNRC16 | TRAM-1 | pCIPnuclear receptor coactivator 3Affinity Capture-MS
Co-fractionation
Two-hybrid
BioGRID11076796 |11971985 
NCOA3ACTR | AIB-1 | AIB1 | CAGH16 | CTG26 | KAT13B | MGC141848 | RAC3 | SRC3 | TNRC14 | TNRC16 | TRAM-1 | pCIPnuclear receptor coactivator 3ACTR interacts with CBP. This interaction was modeled on a demonstrated interaction between human ACTR and CBP from an unspecified species.BIND9267036 
NCOA3ACTR | AIB-1 | AIB1 | CAGH16 | CTG26 | KAT13B | MGC141848 | RAC3 | SRC3 | TNRC14 | TNRC16 | TRAM-1 | pCIPnuclear receptor coactivator 3SRC-3 interacts with CBP. This interaction was modelled on a demonstrated interaction between human SRC-3 and CBP from an unspecified species.BIND15383283 
NCOA3ACTR | AIB-1 | AIB1 | CAGH16 | CTG26 | KAT13B | MGC141848 | RAC3 | SRC3 | TNRC14 | TNRC16 | TRAM-1 | pCIPnuclear receptor coactivator 3CBP interacts with TRAM-1. This interaction was modelled on a demonstrated interaction between mouse CBP and human TRAM-1.BIND9346901 
NCOA3ACTR | AIB-1 | AIB1 | CAGH16 | CTG26 | KAT13B | MGC141848 | RAC3 | SRC3 | TNRC14 | TNRC16 | TRAM-1 | pCIPnuclear receptor coactivator 3-HPRD9445475 |11823864 
NCOA6AIB3 | ANTP | ASC2 | HOX1.1 | HOXA7 | KIAA0181 | NRC | PRIP | RAP250 | TRBPnuclear receptor coactivator 6Reconstituted Complex
Two-hybrid
BioGRID10567404 |11158331 
NEUROG1AKA | Math4C | NEUROD3 | bHLHa6 | ngn1neurogenin 1-HPRD,BioGRID11239394 
NFATC2KIAA0611 | NFAT1 | NFATPnuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2-HPRD,BioGRID9625762 
NFATC4NF-ATc4 | NFAT3nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4-HPRD,BioGRID11514544 
NFE2NF-E2 | p45nuclear factor (erythroid-derived 2), 45kDaAffinity Capture-Western
Biochemical Activity
Reconstituted Complex
BioGRID11154691 
NFE2L2NRF2nuclear factor (erythroid-derived 2)-like 2-HPRD,BioGRID11683914 
NKX2-1BCH | BHC | NK-2 | NKX2.1 | NKX2A | TEBP | TITF1 | TTF-1 | TTF1NK2 homeobox 1Two-hybridBioGRID11076796 
NLKDKFZp761G1211 | FLJ21033nemo-like kinase-HPRD14720327 
NPAS2FLJ23138 | MGC71151 | MOP4 | PASD4 | bHLHe9neuronal PAS domain protein 2Reconstituted ComplexBioGRID14645221 
NR3C1GCCR | GCR | GR | GRLnuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)-HPRD,BioGRID9649342 
NUP98ADIR2 | NUP196 | NUP96nucleoporin 98kDa-HPRD,BioGRID9858599 
ONECUT1HNF-6 | HNF6 | HNF6Aone cut homeobox 1-HPRD,BioGRID10811635 
PAX5BSAPpaired box 5CBP interacts with Pax5.BIND11799127 
PELP1HMX3 | MNAR | P160proline, glutamate and leucine rich protein 1-HPRD,BioGRID11481323 
PHOX2AARIX | CFEOM2 | FEOM2 | MGC52227 | NCAM2 | PMX2Apaired-like homeobox 2a-HPRD,BioGRID10644760 
PIAS3FLJ14651 | ZMIZ5protein inhibitor of activated STAT, 3Affinity Capture-WesternBioGRID14691252 
PMLMYL | PP8675 | RNF71 | TRIM19promyelocytic leukemia-HPRD10077561 |10610177 
|12142048 |12234245 
|12622724 
PMLMYL | PP8675 | RNF71 | TRIM19promyelocytic leukemiaAffinity Capture-Western
Reconstituted Complex
BioGRID10077561 |10610177 
|12622724 
POLR2AMGC75453 | POLR2 | POLRA | RPB1 | RPBh1 | RPO2 | RPOL2 | RpIILS | hRPB220 | hsRPB1polymerase (RNA) II (DNA directed) polypeptide A, 220kDa-HPRD,BioGRID9710619 
PPARGNR1C3 | PPARG1 | PPARG2 | PPARgammaperoxisome proliferator-activated receptor gammaReconstituted ComplexBioGRID10848596 
PROX1-prospero homeobox 1-HPRD11943779 
PTMAMGC104802 | TMSAprothymosin, alpha-HPRD,BioGRID11897665 
RBBP4NURF55 | RBAP48retinoblastoma binding protein 4-HPRD,BioGRID10866654 
RBBP7MGC138867 | MGC138868 | RbAp46retinoblastoma binding protein 7Reconstituted ComplexBioGRID10866654 
RELAMGC131774 | NFKB3 | p65v-rel reticuloendotheliosis viral oncogene homolog A (avian)-HPRD,BioGRID9548485 
RELAMGC131774 | NFKB3 | p65v-rel reticuloendotheliosis viral oncogene homolog A (avian)CBP interacts with p65.BIND9096323 
RELAMGC131774 | NFKB3 | p65v-rel reticuloendotheliosis viral oncogene homolog A (avian)RELA (NF-kappaB p65) interacts with CREBBP (CBP).BIND16007092 
RPA2REPA2 | RPA32replication protein A2, 32kDaAffinity Capture-WesternBioGRID17525332 
RPS6KA1HU-1 | MAPKAPK1A | RSK | RSK1ribosomal protein S6 kinase, 90kDa, polypeptide 1-HPRD8756728 
RPS6KA2HU-2 | MAPKAPK1C | RSK | RSK3 | S6K-alpha | S6K-alpha2 | p90-RSK3 | pp90RSK3ribosomal protein S6 kinase, 90kDa, polypeptide 2Affinity Capture-WesternBioGRID8756728 
RPS6KA3CLS | HU-3 | ISPK-1 | MAPKAPK1B | MRX19 | RSK | RSK2 | S6K-alpha3 | p90-RSK2 | pp90RSK2ribosomal protein S6 kinase, 90kDa, polypeptide 3-HPRD,BioGRID11564891 
SERTAD1SEI1 | TRIP-Br1SERTA domain containing 1-HPRD,BioGRID12736710 
SMAD1BSP1 | JV4-1 | JV41 | MADH1 | MADR1SMAD family member 1Affinity Capture-WesternBioGRID10673036 |11239394 
SMAD2JV18 | JV18-1 | MADH2 | MADR2 | MGC22139 | MGC34440 | hMAD-2 | hSMAD2SMAD family member 2CBP interacts with Smad2. This interaction was modeled on a demonstrated interaction between mouse CBP and Smad2 from an unspecified species.BIND15750622 
SMAD2JV18 | JV18-1 | MADH2 | MADR2 | MGC22139 | MGC34440 | hMAD-2 | hSMAD2SMAD family member 2CBP interacts with Smad2. This interaction was modeled on a demonstrated interaction between CBP from an unspecified species and human Smad2.BIND9679056 
SMAD3DKFZp586N0721 | DKFZp686J10186 | HSPC193 | HsT17436 | JV15-2 | MADH3 | MGC60396SMAD family member 3CBP interacts with Smad3. This interaction was modeled on a demonstrated interaction between mouse CBP and Smad3 from an unspecified species.BIND15750622 
SMARCA4BAF190 | BRG1 | FLJ39786 | SNF2 | SNF2-BETA | SNF2L4 | SNF2LB | SWI2 | hSNF2bSWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4Phenotypic EnhancementBioGRID11003650 
SMARCB1BAF47 | INI1 | RDT | SNF5 | SNF5L1 | Sfh1p | Snr1 | hSNFSSWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1Affinity Capture-Western
Co-fractionation
BioGRID9710619 
SNIP1FLJ12553 | RP3-423B22.3 | dJ423B22.2Smad nuclear interacting protein 1-HPRD,BioGRID10887155 
SRCAPDOMO1 | EAF1 | FLJ44499 | KIAA0309 | SWR1Snf2-related CREBBP activator protein-HPRD10347196 |11581372 
SREBF1SREBP-1c | SREBP1 | bHLHd1sterol regulatory element binding transcription factor 1Affinity Capture-Western
Far Western
BioGRID8918891 
SREBF2SREBP2 | bHLHd2sterol regulatory element binding transcription factor 2-HPRD,BioGRID8918891 
SRFMCM1serum response factor (c-fos serum response element-binding transcription factor)Affinity Capture-WesternBioGRID12622724 
SS18L1CREST | KIAA0693 | LP2261 | MGC26711 | MGC78386synovial sarcoma translocation gene on chromosome 18-like 1-HPRD,BioGRID14716005 
STAT1DKFZp686B04100 | ISGF-3 | STAT91signal transducer and activator of transcription 1, 91kDaStat1-beta interacts with CBP.BIND8986769 
STAT1DKFZp686B04100 | ISGF-3 | STAT91signal transducer and activator of transcription 1, 91kDaStat1-alpha interacts with CBP.BIND8986769 
STAT1DKFZp686B04100 | ISGF-3 | STAT91signal transducer and activator of transcription 1, 91kDa-HPRD,BioGRID8986769 
STAT2ISGF-3 | MGC59816 | P113 | STAT113signal transducer and activator of transcription 2, 113kDa-HPRD,BioGRID8848048 |10464260 
STAT3APRF | FLJ20882 | HIES | MGC16063signal transducer and activator of transcription 3 (acute-phase response factor)Affinity Capture-WesternBioGRID11239394 
STAT3APRF | FLJ20882 | HIES | MGC16063signal transducer and activator of transcription 3 (acute-phase response factor)Stat3 was acetylated by CBP. This interaction was modeled on a demonstrated interaction between human Stat3 and CBP from an unspecified species.BIND15653507 
STAT6D12S1644 | IL-4-STAT | STAT6B | STAT6Csignal transducer and activator of transcription 6, interleukin-4 induced-HPRD,BioGRID10454341 |11574547 
TACC2AZU-1 | ECTACCtransforming, acidic coiled-coil containing protein 2TACC2 interacts with CBP.BIND14767476 
TCF12HEB | HTF4 | HsT17266 | bHLHb20transcription factor 12HEBa interacts with CBP. This interaction was modeled on a demonstrated interaction between HEBb and CBP.BIND15333839 
TCF12HEB | HTF4 | HsT17266 | bHLHb20transcription factor 12HEBb interacts with CBP.BIND15333839 
TCF3E2A | ITF1 | MGC129647 | MGC129648 | bHLHb21transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)-HPRD,BioGRID12435739 
TDG-thymine-DNA glycosylase-HPRD,BioGRID11864601 
TFF1BCEI | D21S21 | HP1.A | HPS2 | pNR-2 | pS2trefoil factor 1CBP interacts with pS2.BIND10490106 
TGS1DKFZp762A163 | FLJ22995 | NCOA6IP | PIMT | PIPMTtrimethylguanosine synthase homolog (S. cerevisiae)-HPRD,BioGRID11912212 
TNFSF10APO2L | Apo-2L | CD253 | TL2 | TRAILtumor necrosis factor (ligand) superfamily, member 10CBP interacts with the TNFSF10 promoter.BIND15619633 
TP53FLJ92943 | LFS1 | TRP53 | p53tumor protein p53-HPRD,BioGRID10848610 |11782467 
TP53FLJ92943 | LFS1 | TRP53 | p53tumor protein p53p53 interacts with CBP. This interaction was modeled on a demonstrated interaction between human p53 and CBP from an unspecified species.BIND10823891 
TRAM2KIAA0057translocation associated membrane protein 2-HPRD14612417 
TRERF1BCAR2 | FLJ21198 | HSA277276 | RAPA | RP1-139D8.5 | TReP-132 | dJ139D8.5transcriptional regulating factor 1-HPRD,BioGRID11349124 
TRIP4HsT17391thyroid hormone receptor interactor 4-HPRD,BioGRID10454579 
XRCC6CTC75 | CTCBF | G22P1 | KU70 | ML8 | TLAAX-ray repair complementing defective repair in Chinese hamster cells 6Reconstituted Complex
Two-hybrid
BioGRID9488450 
YWHAHYWHA1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide-HPRD11266503 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG CELL CYCLE 12884All SZGR 2.0 genes in this pathway
KEGG WNT SIGNALING PATHWAY 151112All SZGR 2.0 genes in this pathway
KEGG NOTCH SIGNALING PATHWAY 4735All SZGR 2.0 genes in this pathway
KEGG TGF BETA SIGNALING PATHWAY 8664All SZGR 2.0 genes in this pathway
KEGG ADHERENS JUNCTION 7553All SZGR 2.0 genes in this pathway
KEGG JAK STAT SIGNALING PATHWAY 155105All SZGR 2.0 genes in this pathway
KEGG LONG TERM POTENTIATION 7057All SZGR 2.0 genes in this pathway
KEGG MELANOGENESIS 10280All SZGR 2.0 genes in this pathway
KEGG HUNTINGTONS DISEASE 185109All SZGR 2.0 genes in this pathway
KEGG PATHWAYS IN CANCER 328259All SZGR 2.0 genes in this pathway
KEGG RENAL CELL CARCINOMA 7060All SZGR 2.0 genes in this pathway
KEGG PROSTATE CANCER 8975All SZGR 2.0 genes in this pathway
BIOCARTA RELA PATHWAY 1612All SZGR 2.0 genes in this pathway
BIOCARTA CSK PATHWAY 2420All SZGR 2.0 genes in this pathway
BIOCARTA CARM ER PATHWAY 3527All SZGR 2.0 genes in this pathway
BIOCARTA VDR PATHWAY 127All SZGR 2.0 genes in this pathway
BIOCARTA SET PATHWAY 116All SZGR 2.0 genes in this pathway
BIOCARTA IL7 PATHWAY 1714All SZGR 2.0 genes in this pathway
BIOCARTA PPARA PATHWAY 5843All SZGR 2.0 genes in this pathway
BIOCARTA PITX2 PATHWAY 1515All SZGR 2.0 genes in this pathway
BIOCARTA NFAT PATHWAY 5645All SZGR 2.0 genes in this pathway
BIOCARTA NTHI PATHWAY 2420All SZGR 2.0 genes in this pathway
BIOCARTA PML PATHWAY 1712All SZGR 2.0 genes in this pathway
BIOCARTA TGFB PATHWAY 1914All SZGR 2.0 genes in this pathway
BIOCARTA CARM1 PATHWAY 1311All SZGR 2.0 genes in this pathway
BIOCARTA WNT PATHWAY 2624All SZGR 2.0 genes in this pathway
ST DIFFERENTIATION PATHWAY IN PC12 CELLS 4535All SZGR 2.0 genes in this pathway
PID SMAD2 3NUCLEAR PATHWAY 8263All SZGR 2.0 genes in this pathway
PID HDAC CLASSIII PATHWAY 2520All SZGR 2.0 genes in this pathway
PID E2F PATHWAY 7448All SZGR 2.0 genes in this pathway
PID HIF2PATHWAY 3429All SZGR 2.0 genes in this pathway
PID MYC ACTIV PATHWAY 7962All SZGR 2.0 genes in this pathway
PID PS1 PATHWAY 4639All SZGR 2.0 genes in this pathway
PID TCPTP PATHWAY 4333All SZGR 2.0 genes in this pathway
PID HDAC CLASSI PATHWAY 6650All SZGR 2.0 genes in this pathway
PID NFAT 3PATHWAY 5447All SZGR 2.0 genes in this pathway
PID REG GR PATHWAY 8260All SZGR 2.0 genes in this pathway
PID FOXO PATHWAY 4943All SZGR 2.0 genes in this pathway
PID AJDISS 2PATHWAY 4838All SZGR 2.0 genes in this pathway
PID P53 DOWNSTREAM PATHWAY 13794All SZGR 2.0 genes in this pathway
PID AR TF PATHWAY 5338All SZGR 2.0 genes in this pathway
PID IFNG PATHWAY 4034All SZGR 2.0 genes in this pathway
PID FOXM1 PATHWAY 4030All SZGR 2.0 genes in this pathway
PID CMYB PATHWAY 8461All SZGR 2.0 genes in this pathway
PID RETINOIC ACID PATHWAY 3023All SZGR 2.0 genes in this pathway
PID HEDGEHOG GLI PATHWAY 4835All SZGR 2.0 genes in this pathway
PID KIT PATHWAY 5240All SZGR 2.0 genes in this pathway
PID HIF1 TFPATHWAY 6652All SZGR 2.0 genes in this pathway
PID P53 REGULATION PATHWAY 5950All SZGR 2.0 genes in this pathway
PID RB 1PATHWAY 6546All SZGR 2.0 genes in this pathway
PID HNF3A PATHWAY 4429All SZGR 2.0 genes in this pathway
PID HES HEY PATHWAY 4839All SZGR 2.0 genes in this pathway
PID IL12 STAT4 PATHWAY 3329All SZGR 2.0 genes in this pathway
REACTOME DEVELOPMENTAL BIOLOGY 396292All SZGR 2.0 genes in this pathway
REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION 3627All SZGR 2.0 genes in this pathway
REACTOME PPARA ACTIVATES GENE EXPRESSION 10472All SZGR 2.0 genes in this pathway
REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION 2917All SZGR 2.0 genes in this pathway
REACTOME RORA ACTIVATES CIRCADIAN EXPRESSION 2417All SZGR 2.0 genes in this pathway
REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION 2416All SZGR 2.0 genes in this pathway
REACTOME PRE NOTCH EXPRESSION AND PROCESSING 4424All SZGR 2.0 genes in this pathway
REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION 4628All SZGR 2.0 genes in this pathway
REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA 2316All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY NOTCH1 7046All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF HYPOXIA INDUCIBLE FACTOR HIF BY OXYGEN 2517All SZGR 2.0 genes in this pathway
REACTOME GENERIC TRANSCRIPTION PATHWAY 352181All SZGR 2.0 genes in this pathway
REACTOME NOTCH HLH TRANSCRIPTION PATHWAY 138All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS 478302All SZGR 2.0 genes in this pathway
REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM 168115All SZGR 2.0 genes in this pathway
REACTOME TRAF6 MEDIATED IRF7 ACTIVATION 3026All SZGR 2.0 genes in this pathway
REACTOME CIRCADIAN CLOCK 5340All SZGR 2.0 genes in this pathway
REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION 132101All SZGR 2.0 genes in this pathway
REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY 1410All SZGR 2.0 genes in this pathway
REACTOME RIG I MDA5 MEDIATED INDUCTION OF IFN ALPHA BETA PATHWAYS 7357All SZGR 2.0 genes in this pathway
REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION 7253All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY NOTCH 10364All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS 466331All SZGR 2.0 genes in this pathway
REACTOME INNATE IMMUNE SYSTEM 279178All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM 933616All SZGR 2.0 genes in this pathway
BORCZUK MALIGNANT MESOTHELIOMA UP 305185All SZGR 2.0 genes in this pathway
GARGALOVIC RESPONSE TO OXIDIZED PHOSPHOLIPIDS BLUE UP 13680All SZGR 2.0 genes in this pathway
KOKKINAKIS METHIONINE DEPRIVATION 48HR UP 12895All SZGR 2.0 genes in this pathway
KOKKINAKIS METHIONINE DEPRIVATION 96HR UP 11784All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 17811082All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE DN 712443All SZGR 2.0 genes in this pathway
SCHEIDEREIT IKK INTERACTING PROTEINS 5845All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN 855609All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 COMMON DN 483336All SZGR 2.0 genes in this pathway
PUJANA BREAST CANCER LIT INT NETWORK 10173All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP 811508All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS 957597All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 6HR DN 514330All SZGR 2.0 genes in this pathway
SMITH TERT TARGETS UP 14591All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT OK VS DONOR UP 555346All SZGR 2.0 genes in this pathway
THEILGAARD NEUTROPHIL AT SKIN WOUND DN 225163All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 DN 830547All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 16911088All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV NHEK DN 318220All SZGR 2.0 genes in this pathway
KRASNOSELSKAYA ILF3 TARGETS DN 4638All SZGR 2.0 genes in this pathway
DURCHDEWALD SKIN CARCINOGENESIS DN 264168All SZGR 2.0 genes in this pathway
MONNIER POSTRADIATION TUMOR ESCAPE UP 393244All SZGR 2.0 genes in this pathway
SANSOM APC MYC TARGETS 217138All SZGR 2.0 genes in this pathway
SANSOM APC TARGETS REQUIRE MYC 210123All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE BY GAMMA AND UV RADIATION 8865All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE DN 195135All SZGR 2.0 genes in this pathway
IWANAGA CARCINOGENESIS BY KRAS UP 170107All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER UP 973570All SZGR 2.0 genes in this pathway
BONOME OVARIAN CANCER SURVIVAL SUBOPTIMAL DEBULKING 510309All SZGR 2.0 genes in this pathway
GRADE COLON CANCER UP 871505All SZGR 2.0 genes in this pathway
GRESHOCK CANCER COPY NUMBER UP 323240All SZGR 2.0 genes in this pathway
ROME INSULIN TARGETS IN MUSCLE DN 204114All SZGR 2.0 genes in this pathway
PLASARI TGFB1 SIGNALING VIA NFIC 1HR DN 10677All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-137759765m8hsa-miR-137UAUUGCUUAAGAAUACGCGUAG
miR-1539961002m8hsa-miR-153UUGCAUAGUCACAAAAGUGA
miR-186107910851Ahsa-miR-186CAAAGAAUUCUCCUUUUGGGCUU
miR-200bc/4295185251A,m8hsa-miR-200bUAAUACUGCCUGGUAAUGAUGAC
hsa-miR-200cUAAUACUGCCGGGUAAUGAUGG
hsa-miR-429UAAUACUGUCUGGUAAAACCGU
miR-237377431Ahsa-miR-23abrainAUCACAUUGCCAGGGAUUUCC
hsa-miR-23bbrainAUCACAUUGCCAGGGAUUACC
miR-267447501Ahsa-miR-26abrainUUCAAGUAAUCCAGGAUAGGC
hsa-miR-26bSZUUCAAGUAAUUCAGGAUAGGUU
hsa-miR-26abrainUUCAAGUAAUCCAGGAUAGGC
hsa-miR-26bSZUUCAAGUAAUUCAGGAUAGGUU
miR-30-3p49561A,m8hsa-miR-30a-3pCUUUCAGUCGGAUGUUUGCAGC
hsa-miR-30e-3pCUUUCAGUCGGAUGUUUACAGC
miR-330634640m8hsa-miR-330brainGCAAAGCACACGGCCUGCAGAGA
miR-3616456521A,m8hsa-miR-361brainUUAUCAGAAUCUCCAGGGGUAC
miR-376c734740m8hsa-miR-376cAACAUAGAGGAAAUUCCACG
miR-381101810241Ahsa-miR-381UAUACAAGGGCAAGCUCUCUGU
miR-410112111271Ahsa-miR-410AAUAUAACACAGAUGGCCUGU
miR-488183189m8hsa-miR-488CCCAGAUAAUGGCACUCUCAA
miR-493-5p923929m8hsa-miR-493-5pUUGUACAUGGUAGGCUUUCAUU
miR-4951581641Ahsa-miR-495brainAAACAAACAUGGUGCACUUCUUU
hsa-miR-495brainAAACAAACAUGGUGCACUUCUUU
miR-54310981104m8hsa-miR-543AAACAUUCGCGGUGCACUUCU
hsa-miR-543AAACAUUCGCGGUGCACUUCU