SZGR2

Summary ?

GeneID	1445
Symbol	CSK
Synonyms	-
Description	c-src tyrosine kinase
Reference	MIM:124095\|HGNC:HGNC:2444\|Ensembl:ENSG00000103653\|HPRD:00496\|Vega:OTTHUMG00000142814
Gene type	protein-coding
Map location	15q24.1
Pascal p-value	0.015
Sherlock p-value	0.374
Fetal beta	-0.145

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias	Click to show details
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 0.0102

Section I. Genetics and epigenetics annotation

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
UBE3A	0.97	0.97
IPO7	0.96	0.97
BCLAF1	0.96	0.97
DIS3	0.95	0.96
ZMYM2	0.95	0.96
FYTTD1	0.95	0.96
CAND1	0.95	0.97
KPNA4	0.95	0.95
SMEK2	0.95	0.95
PPP2R5E	0.95	0.96

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
FXYD1	-0.77	-0.86
MT-CO2	-0.75	-0.85
AF347015.31	-0.74	-0.83
AF347015.33	-0.73	-0.81
HIGD1B	-0.73	-0.84
IFI27	-0.72	-0.83
MT-CYB	-0.72	-0.81
TSC22D4	-0.71	-0.78
HSD17B14	-0.71	-0.76
AF347015.8	-0.71	-0.82

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0000166	nucleotide binding	IEA		-
GO:0005524	ATP binding	IEA		-
GO:0004715	non-membrane spanning protein tyrosine kinase activity	IEA		-
GO:0016740	transferase activity	IEA		-
GO:0008022	protein C-terminus binding	TAS		8890164
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0006468	protein amino acid phosphorylation	TAS		1945408
GO:0008285	negative regulation of cell proliferation	IEA		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005737	cytoplasm	TAS		8890164
GO:0005911	cell-cell junction	IEA		-
GO:0005886	plasma membrane	EXP		15574420
GO:0005886	plasma membrane	IPI		10790433

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
ARRB1	ARB1 \| ARR1	arrestin, beta 1	-	HPRD,BioGRID	10753943
CAV1	CAV \| MSTP085 \| VIP21	caveolin 1, caveolae protein, 22kDa	-	HPRD,BioGRID	11805080
CBL	C-CBL \| CBL2 \| RNF55	Cas-Br-M (murine) ecotropic retroviral transforming sequence	-	HPRD,BioGRID	11149930
CD247	CD3-ZETA \| CD3H \| CD3Q \| CD3Z \| T3Z \| TCRZ	CD247 molecule	-	HPRD	9172452
CD44	CDW44 \| CSPG8 \| ECMR-III \| HCELL \| IN \| LHR \| MC56 \| MDU2 \| MDU3 \| MGC10468 \| MIC4 \| MUTCH-I \| Pgp1	CD44 molecule (Indian blood group)	-	HPRD	11084024
CDH5	7B4 \| CD144 \| FLJ17376	cadherin 5, type 2 (vascular endothelium)	CDH5 (VE-cadherin) interacts with CSK.	BIND	15861137
CREBBP	CBP \| KAT3A \| RSTS	CREB binding protein	-	HPRD,BioGRID	10801129
CSK	MGC117393	c-src tyrosine kinase	CSK autophosphorylates. This interaction was modeled on a demonstrated interaction using CSK from an unspecified species.	BIND	12588871
DAB2	DOC-2 \| DOC2 \| FLJ26626	disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)	-	HPRD,BioGRID	12473651
DAG1	156DAG \| A3a \| AGRNR \| DAG	dystroglycan 1 (dystrophin-associated glycoprotein 1)	Affinity Capture-Western Reconstituted Complex	BioGRID	11724572
DOK3	DOKL \| FLJ22570 \| FLJ39939	docking protein 3	-	HPRD	10733577 \|14993273
EGFR	ERBB \| ERBB1 \| HER1 \| PIG61 \| mENA	epidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)	Affinity Capture-MS	BioGRID	16729043
ERBB3	ErbB-3 \| HER3 \| LCCS2 \| MDA-BF-1 \| MGC88033 \| c-erbB-3 \| c-erbB3 \| erbB3-S \| p180-ErbB3 \| p45-sErbB3 \| p85-sErbB3	v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)	Affinity Capture-MS	BioGRID	16729043
FYN	MGC45350 \| SLK \| SYN	FYN oncogene related to SRC, FGR, YES	-	HPRD,BioGRID	8262983
HNRNPK	CSBP \| FLJ41122 \| HNRPK \| TUNP	heterogeneous nuclear ribonucleoprotein K	-	HPRD,BioGRID	12052863
IGF1R	CD221 \| IGFIR \| JTK13 \| MGC142170 \| MGC142172 \| MGC18216	insulin-like growth factor 1 receptor	CSK interacts with IGF-IR.	BIND	10026153
IGF1R	CD221 \| IGFIR \| JTK13 \| MGC142170 \| MGC142172 \| MGC18216	insulin-like growth factor 1 receptor	-	HPRD,BioGRID	10026153
INSR	CD220 \| HHF5	insulin receptor	CSK interacts with IR.	BIND	10026153
INSR	CD220 \| HHF5	insulin receptor	-	HPRD,BioGRID	10026153
PAG1	CBP \| FLJ37858 \| MGC138364 \| PAG	phosphoprotein associated with glycosphingolipid microdomains 1	-	HPRD,BioGRID	10790433
PECAM1	CD31 \| PECAM-1	platelet/endothelial cell adhesion molecule	-	HPRD,BioGRID	9624175
PLD2	-	phospholipase D2	-	HPRD	12697812
PTK2	FADK \| FAK \| FAK1 \| pp125FAK	PTK2 protein tyrosine kinase 2	-	HPRD,BioGRID	7529872
PTPN12	PTP-PEST \| PTPG1	protein tyrosine phosphatase, non-receptor type 12	-	HPRD	11158295
PXN	FLJ16691	paxillin	-	HPRD,BioGRID	7529872
RASA1	CM-AVM \| CMAVM \| DKFZp434N071 \| GAP \| PKWS \| RASA \| RASGAP \| p120GAP \| p120RASGAP	RAS p21 protein activator (GTPase activating protein) 1	-	HPRD,BioGRID	7544435
RGS16	A28-RGS14 \| A28-RGS14P \| RGS-R	regulator of G-protein signaling 16	CSK phosphorylates RGS16. This interaction was modeled on a demonstrated interaction between CSK from an unspecified species and human RSG16.	BIND	12588871
SDC3	N-syndecan \| SDCN \| SYND3	syndecan 3	-	HPRD,BioGRID	9553134
SHC1	FLJ26504 \| SHC \| SHCA	SHC (Src homology 2 domain containing) transforming protein 1	-	HPRD,BioGRID	10037694 \|12048194
SIT1	MGC125908 \| MGC125909 \| MGC125910 \| RP11-331F9.5 \| SIT	signaling threshold regulating transmembrane adaptor 1	-	HPRD	11433379
SRC	ASV \| SRC1 \| c-SRC \| p60-Src	v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian)	-	HPRD,BioGRID	7513429
TGFB1I1	ARA55 \| HIC-5 \| HIC5 \| TSC-5	transforming growth factor beta 1 induced transcript 1	Reconstituted Complex	BioGRID	9858471
YTHDC1	KIAA1966 \| YT521 \| YT521-B	YTH domain containing 1	Affinity Capture-Western Biochemical Activity	BioGRID	15175272

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG CHEMOKINE SIGNALING PATHWAY	190	128	All SZGR 2.0 genes in this pathway
KEGG NEUROTROPHIN SIGNALING PATHWAY	126	103	All SZGR 2.0 genes in this pathway
KEGG REGULATION OF ACTIN CYTOSKELETON	216	144	All SZGR 2.0 genes in this pathway
KEGG EPITHELIAL CELL SIGNALING IN HELICOBACTER PYLORI INFECTION	68	44	All SZGR 2.0 genes in this pathway
BIOCARTA CSK PATHWAY	24	20	All SZGR 2.0 genes in this pathway
BIOCARTA SRCRPTP PATHWAY	11	9	All SZGR 2.0 genes in this pathway
BIOCARTA CELL2CELL PATHWAY	14	11	All SZGR 2.0 genes in this pathway
BIOCARTA INTEGRIN PATHWAY	38	29	All SZGR 2.0 genes in this pathway
ST T CELL SIGNAL TRANSDUCTION	45	33	All SZGR 2.0 genes in this pathway
SIG BCR SIGNALING PATHWAY	46	38	All SZGR 2.0 genes in this pathway
ST B CELL ANTIGEN RECEPTOR	40	32	All SZGR 2.0 genes in this pathway
PID BCR 5PATHWAY	65	50	All SZGR 2.0 genes in this pathway
PID TCR PATHWAY	66	51	All SZGR 2.0 genes in this pathway
PID PTP1B PATHWAY	52	40	All SZGR 2.0 genes in this pathway
PID CD8 TCR PATHWAY	53	42	All SZGR 2.0 genes in this pathway
PID CXCR4 PATHWAY	102	78	All SZGR 2.0 genes in this pathway
PID PDGFRB PATHWAY	129	103	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY EGFR IN CANCER	109	80	All SZGR 2.0 genes in this pathway
REACTOME TCR SIGNALING	54	46	All SZGR 2.0 genes in this pathway
REACTOME GAB1 SIGNALOSOME	38	29	All SZGR 2.0 genes in this pathway
REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	16	15	All SZGR 2.0 genes in this pathway
REACTOME INTEGRIN CELL SURFACE INTERACTIONS	79	48	All SZGR 2.0 genes in this pathway
REACTOME INTEGRIN ALPHAIIB BETA3 SIGNALING	27	17	All SZGR 2.0 genes in this pathway
REACTOME PD1 SIGNALING	18	14	All SZGR 2.0 genes in this pathway
REACTOME COSTIMULATION BY THE CD28 FAMILY	63	48	All SZGR 2.0 genes in this pathway
REACTOME PLATELET AGGREGATION PLUG FORMATION	36	23	All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS	466	331	All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM	933	616	All SZGR 2.0 genes in this pathway
REACTOME ADAPTIVE IMMUNE SYSTEM	539	350	All SZGR 2.0 genes in this pathway
REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION	208	138	All SZGR 2.0 genes in this pathway
FULCHER INFLAMMATORY RESPONSE LECTIN VS LPS UP	579	346	All SZGR 2.0 genes in this pathway
HORIUCHI WTAP TARGETS DN	310	188	All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE UP	134	93	All SZGR 2.0 genes in this pathway
GRUETZMANN PANCREATIC CANCER UP	358	245	All SZGR 2.0 genes in this pathway
CEBALLOS TARGETS OF TP53 AND MYC DN	38	31	All SZGR 2.0 genes in this pathway
SPIELMAN LYMPHOBLAST EUROPEAN VS ASIAN UP	479	299	All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK	1442	892	All SZGR 2.0 genes in this pathway
WEI MYCN TARGETS WITH E BOX	795	478	All SZGR 2.0 genes in this pathway
MAGRANGEAS MULTIPLE MYELOMA IGG VS IGA DN	26	16	All SZGR 2.0 genes in this pathway
NING CHRONIC OBSTRUCTIVE PULMONARY DISEASE UP	157	105	All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA CD1 AND CD2 DN	51	32	All SZGR 2.0 genes in this pathway
LEE CALORIE RESTRICTION NEOCORTEX UP	83	66	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP	1691	1088	All SZGR 2.0 genes in this pathway
JACKSON DNMT1 TARGETS UP	77	57	All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 STIMULATED	1022	619	All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED	1229	713	All SZGR 2.0 genes in this pathway
AMUNDSON POOR SURVIVAL AFTER GAMMA RADIATION 2G	171	96	All SZGR 2.0 genes in this pathway
ACEVEDO NORMAL TISSUE ADJACENT TO LIVER TUMOR DN	354	216	All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER DN	540	340	All SZGR 2.0 genes in this pathway
ZHAN V1 LATE DIFFERENTIATION GENES DN	15	13	All SZGR 2.0 genes in this pathway
YAGI AML WITH T 8 21 TRANSLOCATION	368	247	All SZGR 2.0 genes in this pathway
DANG REGULATED BY MYC DN	253	192	All SZGR 2.0 genes in this pathway
MARTENS BOUND BY PML RARA FUSION	456	287	All SZGR 2.0 genes in this pathway
LU EZH2 TARGETS UP	295	155	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-140	635	641	m8	hsa-miR-140^brain	AGUGGUUUUACCCUAUGGUAG
miR-216	303	309	m8	hsa-miR-216	UAAUCUCAGCUGGCAACUGUG
miR-24	92	98	m8	hsa-miR-24^SZ	UGGCUCAGUUCAGCAGGAACAG
miR-299-5p	634	640	1A	hsa-miR-299-5p	UGGUUUACCGUCCCACAUACAU
miR-342	616	622	1A	hsa-miR-342^brain	UCUCACACAGAAAUCGCACCCGUC
miR-365	374	380	m8	hsa-miR-365	UAAUGCCCCUAAAAAUCCUUAU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: CSK