Gene Page: DAO

Summary ?
GeneID1610
SymbolDAO
SynonymsDAAO|DAMOX|OXDA
DescriptionD-amino-acid oxidase
ReferenceMIM:124050|HGNC:HGNC:2671|Ensembl:ENSG00000110887|HPRD:15917|Vega:OTTHUMG00000169360
Gene typeprotein-coding
Map location12q24
Pascal p-value0.269
Fetal beta0.061
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
AssociationA combined odds ratio method (Sun et al. 2008), association studies3Link to SZGene
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophreniasClick to show details
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 46 

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs2502827chr1176044216DAO16100.08trans
rs17572651chr1218943612DAO16108.48E-6trans
snp_a-19197940DAO16100.04trans
rs16829545chr2151977407DAO16104.606E-11trans
rs3845734chr2171125572DAO16100.14trans
rs7584986chr2184111432DAO16102.161E-13trans
rs9810143chr35060209DAO16100.08trans
rs4488887chr4177695833DAO16100.13trans
rs10491487chr580323367DAO16102.491E-5trans
rs1368303chr5147672388DAO16101.667E-6trans
rs1929769chr640765977DAO16100.02trans
rs4897051chr6149118925DAO16100.04trans
rs3118341chr925185518DAO16100.11trans
rs9406868chr925223372DAO16100.07trans
rs11139334chr984209393DAO16100.13trans
rs17263352chr9124811572DAO16100.15trans
rs7074445chr1088088121DAO16100.04trans
rs17410931chr1098912175DAO16100.13trans
rs754765chr10132013664DAO16100.06trans
rs11612748chr1259007670DAO16100.04trans
rs17104720chr1477127308DAO16100.18trans
rs6574467chr1479179744DAO16100.01trans
rs10146003chr1479191170DAO16100.01trans
rs16955618chr1529937543DAO16103.078E-24trans
snp_a-18308940DAO16100.11trans
rs17681878chr1834767223DAO16100.1trans
rs17085767chr1869839397DAO16100.05trans
rs6019060chr2046965832DAO16100.01trans
rs749043chr2046995700DAO16100.02trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
RHOC0.790.81
MTCP1NB0.720.73
PSME20.720.71
FGGY0.710.74
CD630.710.73
S100A160.700.75
C1orf610.680.77
CD580.670.67
C1orf540.670.73
NKAIN40.660.71
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
PRDM2-0.68-0.77
A2BP1-0.67-0.78
MAGI2-0.64-0.71
CNNM2-0.63-0.70
BRPF3-0.63-0.71
AC016910.1-0.63-0.73
ANK3-0.63-0.73
ZBTB38-0.63-0.71
UBP1-0.62-0.71
HERC1-0.62-0.72

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0003884D-amino-acid oxidase activityIEA-
GO:0003884D-amino-acid oxidase activityTAS1356107 
GO:0005524ATP bindingIEA-
GO:0004812aminoacyl-tRNA ligase activityIEA-
GO:0016491oxidoreductase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006418tRNA aminoacylation for protein translationIEA-
GO:0008152metabolic processIEA-
GO:0006551leucine metabolic processIEA-
GO:0055114oxidation reductionIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005737cytoplasmIEA-
GO:0005777peroxisomeNAS2901986 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG GLYCINE SERINE AND THREONINE METABOLISM 3126All SZGR 2.0 genes in this pathway
KEGG ARGININE AND PROLINE METABOLISM 5439All SZGR 2.0 genes in this pathway
KEGG PEROXISOME 7847All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES 200136All SZGR 2.0 genes in this pathway
GAZDA DIAMOND BLACKFAN ANEMIA ERYTHROID DN 493298All SZGR 2.0 genes in this pathway
SHEN SMARCA2 TARGETS DN 357212All SZGR 2.0 genes in this pathway
SANSOM APC TARGETS DN 366238All SZGR 2.0 genes in this pathway
MOREAUX MULTIPLE MYELOMA BY TACI UP 412249All SZGR 2.0 genes in this pathway
MOREAUX B LYMPHOCYTE MATURATION BY TACI UP 9258All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE INCIPIENT UP 390242All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 16911088All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 3D UP 210124All SZGR 2.0 genes in this pathway
CHIANG LIVER CANCER SUBCLASS PROLIFERATION DN 17997All SZGR 2.0 genes in this pathway
CHIANG LIVER CANCER SUBCLASS POLYSOMY7 UP 7950All SZGR 2.0 genes in this pathway
WOO LIVER CANCER RECURRENCE DN 8054All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SUBCLASS S3 266180All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA DN 267160All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA CLASSES DN 210141All SZGR 2.0 genes in this pathway