Gene Page: EPOR

Summary
GeneID  2057
Symbol  EPOR
Synonyms  MGC138358
Description  erythropoietin receptor
See related  HGNC:3416|MIM:133171|Ensembl:ENSG00000187266|HPRD:00587|
Locus tag  -
Gene type  protein-coding
Map location  19p13.3-p13.2
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
ZNF1480.940.96
IREB20.940.95
GSPT10.940.94
GTF3C40.940.95
EPM2AIP10.940.95
PPP2R5E0.940.94
BCLAF10.940.95
ZMYM20.930.94
ZMYM40.930.94
DIS30.930.94
Top 10 negatively co-expressed genes
MT-CO2-0.74-0.85
AF347015.31-0.73-0.83
FXYD1-0.71-0.82
MT-CYB-0.71-0.81
AF347015.33-0.71-0.79
HIGD1B-0.70-0.82
AF347015.8-0.70-0.82
IFI27-0.69-0.81
AF347015.27-0.69-0.79
AIFM3-0.69-0.73
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005085guanyl-nucleotide exchange factor activityIEA-
GO:0005515protein bindingIPI11781573 |15644415 
GO:0004900erythropoietin receptor activityIDA2163696 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007420brain developmentIEABrain (GO term level: 7)-
GO:0007165signal transductionIEA-
GO:0007165signal transductionNAS1668606 
GO:0007507heart developmentIEA-
GO:0007264small GTPase mediated signal transductionIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005576extracellular regionIEA-
GO:0005622intracellularIEA-
GO:0005886plasma membraneIEA-
GO:0005887integral to plasma membraneTAS1848667 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ATXN2LA2D | A2LG | A2LP | A2RPataxin 2-like-HPRD,BioGRID11784712 
CISHCIS | CIS-1 | G18 | SOCScytokine inducible SH2-containing protein-HPRD9774439 
-HPRD,BioGRID7796808 
CRKL-v-crk sarcoma virus CT10 oncogene homolog (avian)-like-HPRD,BioGRID11443118 
CSF2RBCD131 | CDw131 | IL3RB | IL5RBcolony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)-HPRD12488507 
EPOEP | MGC138142erythropoietin-HPRD,BioGRID9808045 |10318834 
Interaction between EPOR (PDB ID: 1EER_C) and EPO (PDB ID: 1EER_A).BIND9774108 
Interaction between EPOR (PDB ID: 1EER_B) and EPO (PDB ID: 1EER_A).BIND9774108 
EPORMGC138358erythropoietin receptorInteraction between EPOR (PDB ID: 1ERN_B) and EPOR (PDB ID: 1ERN_A).BIND8662530 |9974392 
GAB2KIAA0571GRB2-associated binding protein 2-HPRD10455108 
GNAI1Giguanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1Reconstituted ComplexBioGRID12538595 
GNB2L1Gnb2-rs1 | H12.3 | HLC-7 | PIG21 | RACK1guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1EPOR interacts with RACK-1. This interaction was modelled on a demonstrated interaction between EPOR from an unspecified species and human RACK-1.BIND12960323 
-HPRD,BioGRID12960323 
GRAPMGC64880GRB2-related adaptor protein-HPRD,BioGRID8647802 
GRB2ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084growth factor receptor-bound protein 2-HPRD,BioGRID7534299 
IRS2-insulin receptor substrate 2-HPRD,BioGRID9334184 
JAK2JTK10Janus kinase 2 (a protein tyrosine kinase)-HPRD,BioGRID8343951 |11779507 
KITC-Kit | CD117 | PBT | SCFRv-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog-HPRD11124255 
KITLGDKFZp686F2250 | KL-1 | Kitl | MGF | SCF | SF | SHEP7KIT ligand-HPRD11124255 
KLK3APS | KLK2A1 | PSA | hK3kallikrein-related peptidase 3-HPRD10374881 
LYNFLJ26625 | JTK8v-yes-1 Yamaguchi sarcoma viral related oncogene homolog-HPRD,BioGRID9573010 
MAPK1ERK | ERK2 | ERT1 | MAPK2 | P42MAPK | PRKM1 | PRKM2 | p38 | p40 | p41 | p41mapkmitogen-activated protein kinase 1-HPRD12538595 
MAPK3ERK1 | HS44KDAP | HUMKER1A | MGC20180 | P44ERK1 | P44MAPK | PRKM3mitogen-activated protein kinase 3-HPRD12538595 
PIK3R1GRB1 | p85 | p85-ALPHAphosphoinositide-3-kinase, regulatory subunit 1 (alpha)-HPRD,BioGRID7559499 
PTPN11BPTP3 | CFC | MGC14433 | NS1 | PTP-1D | PTP2C | SH-PTP2 | SH-PTP3 | SHP2protein tyrosine phosphatase, non-receptor type 11-HPRD,BioGRID8639815 
PTPN6HCP | HCPH | HPTP1C | PTP-1C | SH-PTP1 | SHP-1 | SHP-1L | SHP1protein tyrosine phosphatase, non-receptor type 6-HPRD,BioGRID7889566 
SHC1FLJ26504 | SHC | SHCASHC (Src homology 2 domain containing) transforming protein 1-HPRD,BioGRID8400282 
SOCS2CIS2 | Cish2 | SOCS-2 | SSI-2 | SSI2 | STATI2suppressor of cytokine signaling 2-HPRD,BioGRID11781573 
SOCS3ATOD4 | CIS3 | Cish3 | MGC71791 | SOCS-3 | SSI-3 | SSI3suppressor of cytokine signaling 3-HPRD,BioGRID10882725 |12027890 
STAT5AMGF | STAT5signal transducer and activator of transcription 5A-HPRD,BioGRID8977232 
SYKDKFZp313N1010 | FLJ25043 | FLJ37489spleen tyrosine kinase-HPRD,BioGRID9852052 
SYP-synaptophysinReconstituted ComplexBioGRID7534299 
VAV1VAVvav 1 guanine nucleotide exchange factor-HPRD,BioGRID9162069 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_CYTOKINE_CYTOKINE_RECEPTOR_INTERACTION 267161All SZGR genes in this pathway
KEGG_JAK_STAT_SIGNALING_PATHWAY 155105All SZGR genes in this pathway
KEGG_HEMATOPOIETIC_CELL_LINEAGE 8860All SZGR genes in this pathway
BIOCARTA_EPO_PATHWAY 1913All SZGR genes in this pathway
BIOCARTA_EPONFKB_PATHWAY 1111All SZGR genes in this pathway
PID_KIT_PATHWAY 5240All SZGR genes in this pathway
PID_EPO_PATHWAY 3429All SZGR genes in this pathway
PUIFFE_INVASION_INHIBITED_BY_ASCITES_UP 8251All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
RODRIGUES_NTN1_TARGETS_DN 158102All SZGR genes in this pathway
OSMAN_BLADDER_CANCER_DN 406230All SZGR genes in this pathway
KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_UP 1278748All SZGR genes in this pathway
KIM_WT1_TARGETS_12HR_UP 162116All SZGR genes in this pathway
LUI_THYROID_CANCER_PAX8_PPARG_UP 4429All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_TTD_UP 6439All SZGR genes in this pathway
LUI_THYROID_CANCER_CLUSTER_1 5133All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_UP 309199All SZGR genes in this pathway
SPIELMAN_LYMPHOBLAST_EUROPEAN_VS_ASIAN_DN 584395All SZGR genes in this pathway
LIU_NASOPHARYNGEAL_CARCINOMA 7038All SZGR genes in this pathway
AMIT_EGF_RESPONSE_120_MCF10A 4328All SZGR genes in this pathway
AMIT_SERUM_RESPONSE_20_MCF10A 2110All SZGR genes in this pathway
BASSO_B_LYMPHOCYTE_NETWORK 14396All SZGR genes in this pathway
FRASOR_RESPONSE_TO_ESTRADIOL_DN 8252All SZGR genes in this pathway
MANALO_HYPOXIA_UP 207145All SZGR genes in this pathway
LEI_MYB_TARGETS 318215All SZGR genes in this pathway
MUNSHI_MULTIPLE_MYELOMA_UP 8152All SZGR genes in this pathway
IVANOVA_HEMATOPOIESIS_MATURE_CELL 293160All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
XU_GH1_EXOGENOUS_TARGETS_UP 8550All SZGR genes in this pathway
XU_GH1_AUTOCRINE_TARGETS_UP 268157All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_UP 953554All SZGR genes in this pathway
KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_UP 783442All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_2 473224All SZGR genes in this pathway
STEIN_ESRRA_TARGETS_UP 388234All SZGR genes in this pathway
SMID_BREAST_CANCER_LUMINAL_B_UP 172109All SZGR genes in this pathway
SMID_BREAST_CANCER_BASAL_DN 701446All SZGR genes in this pathway
QI_PLASMACYTOMA_UP 259185All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
SHEDDEN_LUNG_CANCER_GOOD_SURVIVAL_A5 7032All SZGR genes in this pathway
STEIN_ESRRA_TARGETS 535325All SZGR genes in this pathway
YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_15 3523All SZGR genes in this pathway
NAKAMURA_ADIPOGENESIS_EARLY_DN 3827All SZGR genes in this pathway
NAKAMURA_ADIPOGENESIS_LATE_DN 3825All SZGR genes in this pathway
DUTERTRE_ESTRADIOL_RESPONSE_24HR_DN 505328All SZGR genes in this pathway
ACOSTA_PROLIFERATION_INDEPENDENT_MYC_TARGETS_DN 11674All SZGR genes in this pathway
MIYAGAWA_TARGETS_OF_EWSR1_ETS_FUSIONS_UP 259159All SZGR genes in this pathway
HOLLEMAN_VINCRISTINE_RESISTANCE_ALL_UP 2716All SZGR genes in this pathway
DURAND_STROMA_NS_UP 162103All SZGR genes in this pathway
SMIRNOV_RESPONSE_TO_IR_2HR_DN 5535All SZGR genes in this pathway


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