SZGR2

Summary ?

GeneID	2246
Symbol	FGF1
Synonyms	AFGF\|ECGF\|ECGF-beta\|ECGFA\|ECGFB\|FGF-1\|FGF-alpha\|FGFA\|GLIO703\|HBGF-1\|HBGF1
Description	fibroblast growth factor 1
Reference	MIM:131220\|HGNC:HGNC:3665\|Ensembl:ENSG00000113578\|HPRD:00567\|Vega:OTTHUMG00000059703
Gene type	protein-coding
Map location	5q31
Pascal p-value	0.216
Fetal beta	-4.468
Support	NEUROTROPHIN SIGNALING

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Association	A combined odds ratio method (Sun et al. 2008), association studies	1	Link to SZGene
GSMA_I	Genome scan meta-analysis	Psr: 0.0032
GSMA_IIA	Genome scan meta-analysis (All samples)	Psr: 0.00459
GSMA_IIE	Genome scan meta-analysis (European-ancestry samples)	Psr: 0.01718
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias	Click to show details

Section I. Genetics and epigenetics annotation

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
LRIG1	0.81	0.80
ACSS1	0.79	0.91
INPPL1	0.77	0.78
ACACB	0.74	0.76
STON2	0.74	0.76
AXL	0.74	0.87
TRIP6	0.73	0.81
NOTCH3	0.73	0.63
RFX4	0.73	0.80
PBXIP1	0.72	0.89

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
ACTR10	-0.42	-0.49
C20orf7	-0.42	-0.56
RALYL	-0.42	-0.54
VPS29	-0.42	-0.52
NHEDC2	-0.42	-0.55
MED19	-0.42	-0.62
TAF9	-0.42	-0.57
HMGCLL1	-0.42	-0.56
FARSB	-0.41	-0.57
ANKRD46	-0.41	-0.56

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005515	protein binding	IPI		10618369 \|14732692
GO:0008201	heparin binding	IEA		-
GO:0008083	growth factor activity	IEA		-
GO:0008083	growth factor activity	TAS		1693186
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0001525	angiogenesis	IEA		-
GO:0001759	induction of an organ	IEA		-
GO:0007165	signal transduction	NAS		3778488
GO:0008283	cell proliferation	IEA		-
GO:0008543	fibroblast growth factor receptor signaling pathway	EXP		17133345
GO:0009653	anatomical structure morphogenesis	TAS		1693186
GO:0007275	multicellular organismal development	TAS		10903182
GO:0030154	cell differentiation	IEA		-
GO:0030324	lung development	IEA		-
GO:0050679	positive regulation of epithelial cell proliferation	IEA		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005576	extracellular region	EXP		1697263 \|8622701 \|9139660 \|11294897 \|16597617
GO:0005578	proteinaceous extracellular matrix	IEA		-
GO:0005615	extracellular space	IEA		-

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
CSNK2A1	CK2A1 \| CKII	casein kinase 2, alpha 1 polypeptide	-	HPRD,BioGRID	12145206
CSNK2A2	CK2A2 \| CSNK2A1 \| FLJ43934	casein kinase 2, alpha prime polypeptide	-	HPRD,BioGRID	12145206
CSNK2B	CK2B \| CK2N \| CSK2B \| G5A \| MGC138222 \| MGC138224	casein kinase 2, beta polypeptide	-	HPRD,BioGRID	12145206
FGF1	AFGF \| ECGF \| ECGF-beta \| ECGFA \| ECGFB \| FGF-alpha \| FGFA \| GLIO703 \| HBGF1	fibroblast growth factor 1 (acidic)	-	HPRD,BioGRID	9655399\|11069186
FGFBP1	FGFBP \| HBP17	fibroblast growth factor binding protein 1	-	HPRD,BioGRID	11509569
FGFR1	BFGFR \| CD331 \| CEK \| FGFBR \| FLG \| FLJ99988 \| FLT2 \| HBGFR \| KAL2 \| N-SAM	fibroblast growth factor receptor 1	Co-crystal Structure Reconstituted Complex	BioGRID	8576175 \|11030354
FGFR1	BFGFR \| CD331 \| CEK \| FGFBR \| FLG \| FLJ99988 \| FLT2 \| HBGFR \| KAL2 \| N-SAM	fibroblast growth factor receptor 1	-	HPRD	10336501 \|11032250
FGFR2	BEK \| BFR-1 \| CD332 \| CEK3 \| CFD1 \| ECT1 \| FLJ98662 \| JWS \| K-SAM \| KGFR \| TK14 \| TK25	fibroblast growth factor receptor 2	-	HPRD	10618369\|11069186
FGFR2	BEK \| BFR-1 \| CD332 \| CEK3 \| CFD1 \| ECT1 \| FLJ98662 \| JWS \| K-SAM \| KGFR \| TK14 \| TK25	fibroblast growth factor receptor 2	Co-crystal Structure Reconstituted Complex	BioGRID	8576175 \|10618369 \|11069186
FGFR3	ACH \| CD333 \| CEK2 \| HSFGFR3EX \| JTK4	fibroblast growth factor receptor 3	-	HPRD,BioGRID	10574949
FGFR4	CD334 \| JTK2 \| MGC20292 \| TKF	fibroblast growth factor receptor 4	-	HPRD,BioGRID	10336501 \|10736564
FIBP	FGFIBP \| FIBP-1	fibroblast growth factor (acidic) intracellular binding protein	-	HPRD,BioGRID	9806903
HSPA9	CSA \| GRP75 \| HSPA9B \| MGC4500 \| MOT \| MOT2 \| MTHSP75 \| PBP74 \| mot-2	heat shock 70kDa protein 9 (mortalin)	-	HPRD,BioGRID	10510314
NRP1	BDCA4 \| CD304 \| DKFZp686A03134 \| DKFZp781F1414 \| NP1 \| NRP \| VEGF165R	neuropilin 1	NRP1 (Npn-1) interacts with FGF1. This interaction was modeled on a demonstrated interaction between rat NRP1 and human FGF1.	BIND	15695515
S100A13	-	S100 calcium binding protein A13	-	HPRD,BioGRID	9712836 \|11432880\|11432880
SYT1	DKFZp781D2042 \| P65 \| SVP65 \| SYT	synaptotagmin I	-	HPRD,BioGRID	11432880

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG MAPK SIGNALING PATHWAY	267	205	All SZGR 2.0 genes in this pathway
KEGG REGULATION OF ACTIN CYTOSKELETON	216	144	All SZGR 2.0 genes in this pathway
KEGG PATHWAYS IN CANCER	328	259	All SZGR 2.0 genes in this pathway
KEGG MELANOMA	71	57	All SZGR 2.0 genes in this pathway
PID FGF PATHWAY	55	37	All SZGR 2.0 genes in this pathway
REACTOME NEGATIVE REGULATION OF FGFR SIGNALING	37	24	All SZGR 2.0 genes in this pathway
REACTOME INSULIN RECEPTOR SIGNALLING CASCADE	87	64	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR IN DISEASE	127	88	All SZGR 2.0 genes in this pathway
REACTOME ACTIVATED POINT MUTANTS OF FGFR2	16	11	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR1 MUTANTS	30	20	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1	11	8	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR3 MUTANTS	11	9	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR MUTANTS	44	29	All SZGR 2.0 genes in this pathway
REACTOME FRS2 MEDIATED CASCADE	36	27	All SZGR 2.0 genes in this pathway
REACTOME PI 3K CASCADE	56	39	All SZGR 2.0 genes in this pathway
REACTOME DOWNSTREAM SIGNALING OF ACTIVATED FGFR	100	74	All SZGR 2.0 genes in this pathway
REACTOME PHOSPHOLIPASE C MEDIATED CASCADE	54	40	All SZGR 2.0 genes in this pathway
REACTOME SHC MEDIATED CASCADE	28	19	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY INSULIN RECEPTOR	108	72	All SZGR 2.0 genes in this pathway
REACTOME FGFR LIGAND BINDING AND ACTIVATION	22	15	All SZGR 2.0 genes in this pathway
REACTOME FGFR2C LIGAND BINDING AND ACTIVATION	12	9	All SZGR 2.0 genes in this pathway
REACTOME FGFR4 LIGAND BINDING AND ACTIVATION	12	8	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY FGFR	112	80	All SZGR 2.0 genes in this pathway
REACTOME FGFR1 LIGAND BINDING AND ACTIVATION	14	9	All SZGR 2.0 genes in this pathway
REACTOME PI3K CASCADE	71	51	All SZGR 2.0 genes in this pathway
THUM SYSTOLIC HEART FAILURE UP	423	283	All SZGR 2.0 genes in this pathway
SENESE HDAC1 AND HDAC2 TARGETS DN	232	139	All SZGR 2.0 genes in this pathway
SENESE HDAC3 TARGETS DN	536	332	All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS UP	214	155	All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS 8HR UP	164	122	All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS 12HR UP	162	116	All SZGR 2.0 genes in this pathway
DELYS THYROID CANCER UP	443	294	All SZGR 2.0 genes in this pathway
ODONNELL METASTASIS UP	82	58	All SZGR 2.0 genes in this pathway
PEREZ TP53 TARGETS	1174	695	All SZGR 2.0 genes in this pathway
KHETCHOUMIAN TRIM24 TARGETS DN	8	7	All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS UP	769	437	All SZGR 2.0 genes in this pathway
NUYTTEN EZH2 TARGETS UP	1037	673	All SZGR 2.0 genes in this pathway
KOYAMA SEMA3B TARGETS UP	292	168	All SZGR 2.0 genes in this pathway
HE PTEN TARGETS UP	16	15	All SZGR 2.0 genes in this pathway
SHEN SMARCA2 TARGETS DN	357	212	All SZGR 2.0 genes in this pathway
LE EGR2 TARGETS DN	108	84	All SZGR 2.0 genes in this pathway
UEDA PERIFERAL CLOCK	169	111	All SZGR 2.0 genes in this pathway
FLECHNER BIOPSY KIDNEY TRANSPLANT REJECTED VS OK DN	546	351	All SZGR 2.0 genes in this pathway
GRANDVAUX IRF3 TARGETS DN	19	14	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 24HR DN	148	102	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP	1691	1088	All SZGR 2.0 genes in this pathway
LU AGING BRAIN UP	262	186	All SZGR 2.0 genes in this pathway
BAELDE DIABETIC NEPHROPATHY DN	434	302	All SZGR 2.0 genes in this pathway
MCDOWELL ACUTE LUNG INJURY DN	48	33	All SZGR 2.0 genes in this pathway
WENG POR TARGETS LIVER DN	20	11	All SZGR 2.0 genes in this pathway
ACEVEDO METHYLATED IN LIVER CANCER DN	940	425	All SZGR 2.0 genes in this pathway
LABBE TARGETS OF TGFB1 AND WNT3A DN	108	68	All SZGR 2.0 genes in this pathway
VART KSHV INFECTION ANGIOGENIC MARKERS UP	165	118	All SZGR 2.0 genes in this pathway
HINATA NFKB TARGETS FIBROBLAST UP	84	60	All SZGR 2.0 genes in this pathway
ZHANG TLX TARGETS 60HR UP	293	203	All SZGR 2.0 genes in this pathway
MIKKELSEN IPS LCP WITH H3K4ME3	174	100	All SZGR 2.0 genes in this pathway
WONG ADULT TISSUE STEM MODULE	721	492	All SZGR 2.0 genes in this pathway
MIKKELSEN ES LCP WITH H3K4ME3	142	80	All SZGR 2.0 genes in this pathway
MIKKELSEN NPC LCP WITH H3K4ME3	58	34	All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 14	143	86	All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS GROWING	243	155	All SZGR 2.0 genes in this pathway
KANG AR TARGETS DN	19	12	All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP B	549	316	All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS DN	553	343	All SZGR 2.0 genes in this pathway
SERVITJA LIVER HNF1A TARGETS DN	157	105	All SZGR 2.0 genes in this pathway
DELACROIX RAR BOUND ES	462	273	All SZGR 2.0 genes in this pathway
NABA SECRETED FACTORS	344	197	All SZGR 2.0 genes in this pathway
NABA MATRISOME ASSOCIATED	753	411	All SZGR 2.0 genes in this pathway
NABA MATRISOME	1028	559	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-143	1432	1438	m8	hsa-miR-143^brain	UGAGAUGAAGCACUGUAGCUCA

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: FGF1