Gene Page: SHANK2

Summary
GeneID  22941
Symbol  SHANK2
Synonyms  CORTBP1|CTTNBP1|ProSAP1|SHANK|SPANK-3
Description  SH3 and multiple ankyrin repeat domains 2
See related  HGNC:14295|MIM:603290|Ensembl:ENSG00000162105|HPRD:04479|
Locus tag  -
Gene type  protein-coding
Map location  11q13.3
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.061 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
ADNP0.950.96
CYTSA0.950.96
UBR50.940.95
LATS10.940.96
MGA0.940.94
ZNF518B0.940.97
NSD10.940.96
MED10.940.96
ARID20.940.95
HMGXB40.940.95
Top 10 negatively co-expressed genes
AF347015.31-0.70-0.88
FXYD1-0.70-0.88
HLA-F-0.69-0.76
AIFM3-0.69-0.76
MT-CO2-0.69-0.88
TSC22D4-0.68-0.79
S100B-0.68-0.82
AF347015.27-0.68-0.84
C5orf53-0.68-0.74
IFI27-0.67-0.85
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0030160GKAP/Homer scaffold activityNASSynap (GO term level: 6)10506216 
GO:0005515protein bindingIPI11583995 
GO:0005515protein bindingNAS-
GO:0017124SH3 domain bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007242intracellular signaling cascadeNAS-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0045211postsynaptic membraneIEASynap, Neurotransmitter (GO term level: 5)-
GO:0045202synapseIEAneuron, Synap, Neurotransmitter, Glial (GO term level: 2)-
GO:0005737cytoplasmIEA-
GO:0005886plasma membraneIEA-
GO:0030054cell junctionIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ARHGEF7BETA-PIX | COOL1 | DKFZp686C12170 | DKFZp761K1021 | KIAA0142 | KIAA0412 | Nbla10314 | P50 | P50BP | P85 | P85COOL1 | P85SPR | PAK3 | PIXBRho guanine nucleotide exchange factor (GEF) 7-HPRD,BioGRID12626503 
BAI2-brain-specific angiogenesis inhibitor 2-HPRD,BioGRID10964907 
BAIAP2BAP2 | IRSP53BAI1-associated protein 2-HPRD12504591 
CTTNEMS1 | FLJ34459cortactin-HPRD,BioGRID9742101 
DLG4FLJ97752 | FLJ98574 | PSD95 | SAP90discs, large homolog 4 (Drosophila)-HPRD,BioGRID10527873 
DLGAP1DAP-1 | DAP-1-ALPHA | DAP-1-BETA | GKAP | MGC88156 | SAPAP1 | hGKAPdiscs, large (Drosophila) homolog-associated protein 1-HPRD,BioGRID10527873 
DLGAP2DAP2 | SAPAP2discs, large (Drosophila) homolog-associated protein 2Two-hybridBioGRID10527873 
DLGAP3DAP3 | SAPAP3discs, large (Drosophila) homolog-associated protein 3Two-hybridBioGRID10527873 
DLGAP4DAP4 | KIAA0964 | MGC131862 | RP5-977B1.6 | SAPAP4discs, large (Drosophila) homolog-associated protein 4Two-hybridBioGRID10527873 
DNM2CMTDI1 | CMTDIB | DI-CMTB | DYN2 | DYNIIdynamin 2-HPRD,BioGRID11583995 
DYNLL1DLC1 | DLC8 | DNCL1 | DNCLC1 | LC8 | LC8a | MGC126137 | MGC126138 | PIN | hdlc1dynein, light chain, LC8-type 1Affinity Capture-WesternBioGRID10844022 
DYNLL2DNCL1B | Dlc2 | MGC17810dynein, light chain, LC8-type 2Affinity Capture-WesternBioGRID10844022 
LPHN1CIRL1 | CL1 | LEC2latrophilin 1-HPRD,BioGRID10964907 
LPHN2CIRL2 | CL2 | LEC1 | LPHH1latrophilin 2-HPRD,BioGRID10964907 
MYO5AGS1 | MYH12 | MYO5 | MYR12myosin VA (heavy chain 12, myoxin)Affinity Capture-WesternBioGRID10844022 
SSTR2-somatostatin receptor 2-HPRD10373412 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
SCHUETZ_BREAST_CANCER_DUCTAL_INVASIVE_DN 8453All SZGR genes in this pathway
FRASOR_TAMOXIFEN_RESPONSE_UP 5136All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_BASAL_UP 380215All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_UP 450256All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_UP 1821933All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_DN 805505All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_DN 537339All SZGR genes in this pathway
RODRIGUES_THYROID_CARCINOMA_DN 7752All SZGR genes in this pathway
GOZGIT_ESR1_TARGETS_DN 781465All SZGR genes in this pathway
ODONNELL_METASTASIS_UP 8258All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_UP 1037673All SZGR genes in this pathway
NIKOLSKY_BREAST_CANCER_11Q12_Q14_AMPLICON 15893All SZGR genes in this pathway
FLECHNER_BIOPSY_KIDNEY_TRANSPLANT_REJECTED_VS_OK_DN 546351All SZGR genes in this pathway
MOREAUX_MULTIPLE_MYELOMA_BY_TACI_UP 412249All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN 1237837All SZGR genes in this pathway
RODWELL_AGING_KIDNEY_NO_BLOOD_DN 15093All SZGR genes in this pathway
RODWELL_AGING_KIDNEY_DN 14588All SZGR genes in this pathway
RODWELL_AGING_KIDNEY_UP 487303All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_2 473224All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_5 482296All SZGR genes in this pathway
MASSARWEH_TAMOXIFEN_RESISTANCE_UP 578341All SZGR genes in this pathway
HAN_SATB1_TARGETS_UP 395249All SZGR genes in this pathway
HAN_SATB1_TARGETS_DN 442275All SZGR genes in this pathway
MEISSNER_ES_ICP_WITH_H3K4ME3 3417All SZGR genes in this pathway
MEISSNER_NPC_ICP_WITH_H3_UNMETHYLATED 2415All SZGR genes in this pathway
MEISSNER_BRAIN_ICP_WITH_H3K4ME3 3217All SZGR genes in this pathway
MIKKELSEN_MCV6_ICP_WITH_H3K27ME3 7446All SZGR genes in this pathway
NAKAYAMA_SOFT_TISSUE_TUMORS_PCA1_DN 7447All SZGR genes in this pathway
MARTENS_TRETINOIN_RESPONSE_UP 857456All SZGR genes in this pathway
ACOSTA_PROLIFERATION_INDEPENDENT_MYC_TARGETS_DN 11674All SZGR genes in this pathway
KRIEG_HYPOXIA_NOT_VIA_KDM3A 770480All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-101288328891Ahsa-miR-101UACAGUACUGUGAUAACUGAAG
hsa-miR-101UACAGUACUGUGAUAACUGAAG
miR-124/50648474853m8hsa-miR-506UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brainUAAGGCACGCGGUGAAUGCC
hsa-miR-506UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brainUAAGGCACGCGGUGAAUGCC
miR-130/30133583364m8hsa-miR-130abrainCAGUGCAAUGUUAAAAGGGCAU
hsa-miR-301CAGUGCAAUAGUAUUGUCAAAGC
hsa-miR-130bbrainCAGUGCAAUGAUGAAAGGGCAU
hsa-miR-454-3pUAGUGCAAUAUUGCUUAUAGGGUUU
miR-137271627231A,m8hsa-miR-137UAUUGCUUAAGAAUACGCGUAG
miR-142-5p332633331A,m8hsa-miR-142-5pCAUAAAGUAGAAAGCACUAC
miR-144340434101Ahsa-miR-144UACAGUAUAGAUGAUGUACUAG
hsa-miR-144UACAGUAUAGAUGAUGUACUAG
miR-186167316791Ahsa-miR-186CAAAGAAUUCUCCUUUUGGGCUU
miR-1933573363m8hsa-miR-19aUGUGCAAAUCUAUGCAAAACUGA
hsa-miR-19bUGUGCAAAUCCAUGCAAAACUGA
miR-218171317201A,m8hsa-miR-218brainUUGUGCUUGAUCUAACCAUGU
hsa-miR-218brainUUGUGCUUGAUCUAACCAUGU
miR-221/22248244830m8hsa-miR-221brainAGCUACAUUGUCUGCUGGGUUUC
hsa-miR-222brainAGCUACAUCUGGCUACUGGGUCUC
miR-2330453051m8hsa-miR-23abrainAUCACAUUGCCAGGGAUUUCC
hsa-miR-23bbrainAUCACAUUGCCAGGGAUUACC
miR-323304530511Ahsa-miR-323brainGCACAUUACACGGUCGACCUCU
miR-324-3p648654m8hsa-miR-324-3pCCACUGCCCCAGGUGCUGCUGG
miR-3348794885m8hsa-miR-33GUGCAUUGUAGUUGCAUUG
hsa-miR-33bGUGCAUUGCUGUUGCAUUGCA
miR-374157415801Ahsa-miR-374UUAUAAUACAACCUGAUAAGUG
miR-38133853391m8hsa-miR-381UAUACAAGGGCAAGCUCUCUGU
miR-495287428801Ahsa-miR-495brainAAACAAACAUGGUGCACUUCUUU
miR-7229323001A,m8hsa-miR-7SZUGGAAGACUAGUGAUUUUGUUG
miR-91271331Ahsa-miR-9SZUCUUUGGUUAUCUAGCUGUAUGA
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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