SZGR2

Summary ?

GeneID	23389
Symbol	MED13L
Synonyms	MRFACD\|PROSIT240\|THRAP2\|TRAP240L
Description	mediator complex subunit 13 like
Reference	MIM:608771\|HGNC:HGNC:22962\|Ensembl:ENSG00000123066\|HPRD:10579\|Vega:OTTHUMG00000169404
Gene type	protein-coding
Map location	12q24.21
Pascal p-value	0.637
Sherlock p-value	0.951
Fetal beta	2.145
eGene	Myers' cis & trans
Support	CompositeSet Darnell FMRP targets

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:GWASdb	Genome-wide Association Studies	GWASdb records for schizophrenia
CV:PGCnp	Genome-wide Association Study	GWAS
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Expression	Meta-analysis of gene expression	P value: 2.285
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias	Click to show details

Section I. Genetics and epigenetics annotation

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	qvalue	eQTL type
rs17586554	chr2	232044747	MED13L	23389	0.05	trans
rs328970	chr5	125158530	MED13L	23389	0.08	trans
rs500416	chr17	75117851	MED13L	23389	0.03	trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
CSNK1E	0.97	0.96
PATZ1	0.97	0.92
MTA2	0.97	0.94
RBM15B	0.97	0.97
ILF3	0.97	0.98
SF1	0.97	0.97
LDB1	0.96	0.96
BRD1	0.96	0.96
SMARCA4	0.96	0.97
EHMT2	0.96	0.96

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
C5orf53	-0.76	-0.81
AF347015.31	-0.75	-0.91
MT-CO2	-0.74	-0.92
AF347015.27	-0.73	-0.89
S100B	-0.73	-0.86
AIFM3	-0.73	-0.77
AF347015.33	-0.72	-0.88
HLA-F	-0.72	-0.75
FXYD1	-0.72	-0.88
MT-CYB	-0.71	-0.88

Section III. Gene Ontology annotation

Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0006355	regulation of transcription, DNA-dependent	IEA		-
GO:0006350	transcription	IEA		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0000119	mediator complex	IEA		-
GO:0005634	nucleus	IEA		-

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
REACTOME DEVELOPMENTAL BIOLOGY	396	292	All SZGR 2.0 genes in this pathway
REACTOME PPARA ACTIVATES GENE EXPRESSION	104	72	All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS	478	302	All SZGR 2.0 genes in this pathway
REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM	168	115	All SZGR 2.0 genes in this pathway
REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION	72	53	All SZGR 2.0 genes in this pathway
DAVICIONI MOLECULAR ARMS VS ERMS UP	332	228	All SZGR 2.0 genes in this pathway
HOOI ST7 TARGETS UP	94	57	All SZGR 2.0 genes in this pathway
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA UP	177	110	All SZGR 2.0 genes in this pathway
DOANE RESPONSE TO ANDROGEN DN	241	146	All SZGR 2.0 genes in this pathway
WANG CLIM2 TARGETS DN	186	114	All SZGR 2.0 genes in this pathway
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL DN	275	168	All SZGR 2.0 genes in this pathway
HOEBEKE LYMPHOID STEM CELL UP	95	64	All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS 12HR UP	162	116	All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED DN	805	505	All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC DN	537	339	All SZGR 2.0 genes in this pathway
FARMER BREAST CANCER APOCRINE VS LUMINAL	326	213	All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN	855	609	All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 COMMON DN	483	336	All SZGR 2.0 genes in this pathway
MOHANKUMAR TLX1 TARGETS UP	414	287	All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP	811	508	All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 48HR DN	428	306	All SZGR 2.0 genes in this pathway
DEBIASI APOPTOSIS BY REOVIRUS INFECTION UP	314	201	All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV NHEK DN	318	220	All SZGR 2.0 genes in this pathway
DOUGLAS BMI1 TARGETS UP	566	371	All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 4	307	185	All SZGR 2.0 genes in this pathway
SANSOM APC TARGETS	212	121	All SZGR 2.0 genes in this pathway
FOSTER TOLERANT MACROPHAGE DN	409	268	All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL DN	701	446	All SZGR 2.0 genes in this pathway
BONOME OVARIAN CANCER SURVIVAL OPTIMAL DEBULKING	246	152	All SZGR 2.0 genes in this pathway
CHUNG BLISTER CYTOTOXICITY DN	44	29	All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO CSF2RB AND IL4 UP	338	225	All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF DN	235	144	All SZGR 2.0 genes in this pathway
RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 DN	245	150	All SZGR 2.0 genes in this pathway
VANTVEER BREAST CANCER ESR1 UP	167	99	All SZGR 2.0 genes in this pathway
BRUNEAU HEART GREAT VESSELS AND VALVULOGENESIS	8	8	All SZGR 2.0 genes in this pathway
SHEDDEN LUNG CANCER GOOD SURVIVAL A12	317	177	All SZGR 2.0 genes in this pathway
YAGI AML WITH 11Q23 REARRANGED	351	238	All SZGR 2.0 genes in this pathway
STEIN ESR1 TARGETS	85	55	All SZGR 2.0 genes in this pathway
STEIN ESTROGEN RESPONSE NOT VIA ESRRA	18	12	All SZGR 2.0 genes in this pathway
KYNG WERNER SYNDROM AND NORMAL AGING DN	225	124	All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN	1972	1213	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-128	121	128	1A,m8	hsa-miR-128a	UCACAGUGAACCGGUCUCUUUU
miR-128	121	128	1A,m8	hsa-miR-128b	UCACAGUGAACCGGUCUCUUUC
miR-129-5p	1952	1958	1A	hsa-miR-129^brain	CUUUUUGCGGUCUGGGCUUGC
				hsa-miR-129-5p	CUUUUUGCGGUCUGGGCUUGCU
				hsa-miR-129^brain	CUUUUUGCGGUCUGGGCUUGC
				hsa-miR-129-5p	CUUUUUGCGGUCUGGGCUUGCU
miR-134	945	951	1A	hsa-miR-134^brain	UGUGACUGGUUGACCAGAGGG
miR-141/200a	159	165	m8	hsa-miR-141	UAACACUGUCUGGUAAAGAUGG
miR-141/200a	159	165	m8	hsa-miR-200a	UAACACUGUCUGGUAACGAUGU
miR-185	993	999	m8	hsa-miR-185^brain	UGGAGAGAAAGGCAGUUC
miR-19	328	335	1A,m8	hsa-miR-19a	UGUGCAAAUCUAUGCAAAACUGA
miR-19	328	335	1A,m8	hsa-miR-19b	UGUGCAAAUCCAUGCAAAACUGA
miR-204/211	1013	1019	m8	hsa-miR-204^brain	UUCCCUUUGUCAUCCUAUGCCU
miR-204/211	1013	1019	m8	hsa-miR-211	UUCCCUUUGUCAUCCUUCGCCU
miR-224	223	229	m8	hsa-miR-224	CAAGUCACUAGUGGUUCCGUUUA
miR-26	1141	1148	1A,m8	hsa-miR-26a^brain	UUCAAGUAAUCCAGGAUAGGC
miR-26	1141	1148	1A,m8	hsa-miR-26b^SZ	UUCAAGUAAUUCAGGAUAGGUU
miR-27	122	128	m8	hsa-miR-27a^brain	UUCACAGUGGCUAAGUUCCGC
miR-27	122	128	m8	hsa-miR-27b^brain	UUCACAGUGGCUAAGUUCUGC
miR-361	1626	1632	m8	hsa-miR-361^brain	UUAUCAGAAUCUCCAGGGGUAC
miR-363	2077	2083	1A	hsa-miR-363	AUUGCACGGUAUCCAUCUGUAA
miR-381	1764	1771	1A,m8	hsa-miR-381	UAUACAAGGGCAAGCUCUCUGU
miR-448	2163	2169	m8	hsa-miR-448	UUGCAUAUGUAGGAUGUCCCAU
miR-450	2079	2085	1A	hsa-miR-450	UUUUUGCGAUGUGUUCCUAAUA
miR-493-5p	2208	2215	1A,m8	hsa-miR-493-5p	UUGUACAUGGUAGGCUUUCAUU
miR-496	2391	2397	1A	hsa-miR-496	AUUACAUGGCCAAUCUC
miR-544	2280	2287	1A,m8	hsa-miR-544	AUUCUGCAUUUUUAGCAAGU
miR-7	1391	1397	1A	hsa-miR-7^SZ	UGGAAGACUAGUGAUUUUGUUG

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: MED13L