Gene Page: ALOX5
Summary ?
| GeneID | 240 |
| Symbol | ALOX5 |
| Synonyms | 5-LO|5-LOX|5LPG|LOG5 |
| Description | arachidonate 5-lipoxygenase |
| Reference | MIM:152390|HGNC:HGNC:435|Ensembl:ENSG00000012779|HPRD:01065|Vega:OTTHUMG00000018081 |
| Gene type | protein-coding |
| Map location | 10q11.2 |
| Pascal p-value | 0.976 |
| Sherlock p-value | 0.366 |
| Fetal beta | -1.816 |
| DMG | 1 (# studies) |
| eGene | Anterior cingulate cortex BA24 Cerebellar Hemisphere Cerebellum Cortex Frontal Cortex BA9 Myers' cis & trans Meta |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS | |
| DMG:Jaffe_2016 | Genome-wide DNA methylation analysis | This dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. | 1 |
Section I. Genetics and epigenetics annotation
Differentially methylated gene
| Probe | Chromosome | Position | Nearest gene | P (dis) | Beta (dis) | FDR (dis) | Study |
|---|---|---|---|---|---|---|---|
| cg19517653 | 10 | 45869456 | ALOX5 | 2.05E-9 | -0.018 | 1.65E-6 | DMG:Jaffe_2016 |
eQTL annotation
| SNP ID | Chromosome | Position | eGene | Gene Entrez ID | pvalue | qvalue | TSS distance | eQTL type |
|---|---|---|---|---|---|---|---|---|
| rs711251 | chr2 | 36706420 | ALOX5 | 240 | 0.03 | trans | ||
| rs16829545 | chr2 | 151977407 | ALOX5 | 240 | 1.262E-9 | trans | ||
| rs2665944 | chr8 | 140954619 | ALOX5 | 240 | 0.1 | trans | ||
| rs2393316 | chr10 | 59333070 | ALOX5 | 240 | 0.03 | trans | ||
| rs1526959 | chr12 | 79753789 | ALOX5 | 240 | 0.03 | trans | ||
| rs16955618 | chr15 | 29937543 | ALOX5 | 240 | 6.042E-11 | trans | ||
| rs7098434 | 10 | 45798202 | ALOX5 | ENSG00000012779.6 | 3.355E-6 | 0 | -71459 | gtex_brain_ba24 |
| rs11239430 | 10 | 45798374 | ALOX5 | ENSG00000012779.6 | 2.351E-7 | 0 | -71287 | gtex_brain_ba24 |
| rs10900195 | 10 | 45799950 | ALOX5 | ENSG00000012779.6 | 7.091E-7 | 0 | -69711 | gtex_brain_ba24 |
| rs11239432 | 10 | 45800116 | ALOX5 | ENSG00000012779.6 | 7.091E-7 | 0 | -69545 | gtex_brain_ba24 |
| rs9664826 | 10 | 45800542 | ALOX5 | ENSG00000012779.6 | 7.1E-7 | 0 | -69119 | gtex_brain_ba24 |
| rs9733175 | 10 | 45801334 | ALOX5 | ENSG00000012779.6 | 8.418E-7 | 0 | -68327 | gtex_brain_ba24 |
| rs11239434 | 10 | 45801657 | ALOX5 | ENSG00000012779.6 | 3.336E-8 | 0 | -68004 | gtex_brain_ba24 |
| rs9733422 | 10 | 45801761 | ALOX5 | ENSG00000012779.6 | 7.437E-7 | 0 | -67900 | gtex_brain_ba24 |
| rs55963543 | 10 | 45802587 | ALOX5 | ENSG00000012779.6 | 2.694E-8 | 0 | -67074 | gtex_brain_ba24 |
| rs12250005 | 10 | 45802622 | ALOX5 | ENSG00000012779.6 | 7.091E-7 | 0 | -67039 | gtex_brain_ba24 |
| rs17443340 | 10 | 45802666 | ALOX5 | ENSG00000012779.6 | 2.694E-8 | 0 | -66995 | gtex_brain_ba24 |
| rs17521948 | 10 | 45802739 | ALOX5 | ENSG00000012779.6 | 2.694E-8 | 0 | -66922 | gtex_brain_ba24 |
| rs11239435 | 10 | 45802840 | ALOX5 | ENSG00000012779.6 | 7.091E-7 | 0 | -66821 | gtex_brain_ba24 |
| rs10793613 | 10 | 45803078 | ALOX5 | ENSG00000012779.6 | 7.091E-7 | 0 | -66583 | gtex_brain_ba24 |
| rs11239436 | 10 | 45803674 | ALOX5 | ENSG00000012779.6 | 2.694E-8 | 0 | -65987 | gtex_brain_ba24 |
| rs12268890 | 10 | 45803909 | ALOX5 | ENSG00000012779.6 | 7.091E-7 | 0 | -65752 | gtex_brain_ba24 |
| rs7085353 | 10 | 45805222 | ALOX5 | ENSG00000012779.6 | 7.091E-7 | 0 | -64439 | gtex_brain_ba24 |
| rs10900197 | 10 | 45806427 | ALOX5 | ENSG00000012779.6 | 7.091E-7 | 0 | -63234 | gtex_brain_ba24 |
| rs17157697 | 10 | 45806859 | ALOX5 | ENSG00000012779.6 | 7.091E-7 | 0 | -62802 | gtex_brain_ba24 |
| rs112608205 | 10 | 45807211 | ALOX5 | ENSG00000012779.6 | 2.33E-6 | 0 | -62450 | gtex_brain_ba24 |
| rs72784585 | 10 | 45807259 | ALOX5 | ENSG00000012779.6 | 2.694E-8 | 0 | -62402 | gtex_brain_ba24 |
| rs10159580 | 10 | 45808011 | ALOX5 | ENSG00000012779.6 | 7.091E-7 | 0 | -61650 | gtex_brain_ba24 |
| rs11239437 | 10 | 45808367 | ALOX5 | ENSG00000012779.6 | 2.694E-8 | 0 | -61294 | gtex_brain_ba24 |
| rs7091103 | 10 | 45809358 | ALOX5 | ENSG00000012779.6 | 7.091E-7 | 0 | -60303 | gtex_brain_ba24 |
| rs58609159 | 10 | 45809402 | ALOX5 | ENSG00000012779.6 | 7.091E-7 | 0 | -60259 | gtex_brain_ba24 |
| rs11239438 | 10 | 45809454 | ALOX5 | ENSG00000012779.6 | 2.694E-8 | 0 | -60207 | gtex_brain_ba24 |
| rs11239439 | 10 | 45810077 | ALOX5 | ENSG00000012779.6 | 7.091E-7 | 0 | -59584 | gtex_brain_ba24 |
| rs72784588 | 10 | 45810412 | ALOX5 | ENSG00000012779.6 | 7.091E-7 | 0 | -59249 | gtex_brain_ba24 |
| rs72784589 | 10 | 45810710 | ALOX5 | ENSG00000012779.6 | 7.091E-7 | 0 | -58951 | gtex_brain_ba24 |
| rs72784590 | 10 | 45811373 | ALOX5 | ENSG00000012779.6 | 2.694E-8 | 0 | -58288 | gtex_brain_ba24 |
| rs59699764 | 10 | 45811556 | ALOX5 | ENSG00000012779.6 | 7.091E-7 | 0 | -58105 | gtex_brain_ba24 |
| rs10900200 | 10 | 45812541 | ALOX5 | ENSG00000012779.6 | 7.091E-7 | 0 | -57120 | gtex_brain_ba24 |
| rs7097693 | 10 | 45812837 | ALOX5 | ENSG00000012779.6 | 7.091E-7 | 0 | -56824 | gtex_brain_ba24 |
| rs7076567 | 10 | 45812852 | ALOX5 | ENSG00000012779.6 | 7.091E-7 | 0 | -56809 | gtex_brain_ba24 |
| rs7094238 | 10 | 45812936 | ALOX5 | ENSG00000012779.6 | 7.091E-7 | 0 | -56725 | gtex_brain_ba24 |
| rs7075983 | 10 | 45813117 | ALOX5 | ENSG00000012779.6 | 7.091E-7 | 0 | -56544 | gtex_brain_ba24 |
| rs11239441 | 10 | 45814066 | ALOX5 | ENSG00000012779.6 | 7.257E-7 | 0 | -55595 | gtex_brain_ba24 |
| rs10900203 | 10 | 45814362 | ALOX5 | ENSG00000012779.6 | 5.696E-7 | 0 | -55299 | gtex_brain_ba24 |
| rs10900204 | 10 | 45814511 | ALOX5 | ENSG00000012779.6 | 2.082E-6 | 0 | -55150 | gtex_brain_ba24 |
| rs72784593 | 10 | 45815734 | ALOX5 | ENSG00000012779.6 | 2.694E-8 | 0 | -53927 | gtex_brain_ba24 |
| rs11239442 | 10 | 45815756 | ALOX5 | ENSG00000012779.6 | 7.091E-7 | 0 | -53905 | gtex_brain_ba24 |
| rs11511614 | 10 | 45816305 | ALOX5 | ENSG00000012779.6 | 2.694E-8 | 0 | -53356 | gtex_brain_ba24 |
| rs11517274 | 10 | 45816409 | ALOX5 | ENSG00000012779.6 | 7.091E-7 | 0 | -53252 | gtex_brain_ba24 |
| rs111247775 | 10 | 45816436 | ALOX5 | ENSG00000012779.6 | 7.091E-7 | 0 | -53225 | gtex_brain_ba24 |
| rs11511615 | 10 | 45816494 | ALOX5 | ENSG00000012779.6 | 7.091E-7 | 0 | -53167 | gtex_brain_ba24 |
| rs11239443 | 10 | 45817117 | ALOX5 | ENSG00000012779.6 | 7.091E-7 | 0 | -52544 | gtex_brain_ba24 |
| rs11239445 | 10 | 45817185 | ALOX5 | ENSG00000012779.6 | 2.723E-7 | 0 | -52476 | gtex_brain_ba24 |
| rs11239446 | 10 | 45817189 | ALOX5 | ENSG00000012779.6 | 2.723E-7 | 0 | -52472 | gtex_brain_ba24 |
| rs60645843 | 10 | 45817451 | ALOX5 | ENSG00000012779.6 | 3.98E-7 | 0 | -52210 | gtex_brain_ba24 |
| rs12355422 | 10 | 45817674 | ALOX5 | ENSG00000012779.6 | 2.15E-8 | 0 | -51987 | gtex_brain_ba24 |
| rs58239275 | 10 | 45818029 | ALOX5 | ENSG00000012779.6 | 7.091E-7 | 0 | -51632 | gtex_brain_ba24 |
| rs11239448 | 10 | 45818132 | ALOX5 | ENSG00000012779.6 | 2.694E-8 | 0 | -51529 | gtex_brain_ba24 |
| rs11239449 | 10 | 45819160 | ALOX5 | ENSG00000012779.6 | 7.091E-7 | 0 | -50501 | gtex_brain_ba24 |
| rs11239450 | 10 | 45819173 | ALOX5 | ENSG00000012779.6 | 7.091E-7 | 0 | -50488 | gtex_brain_ba24 |
| rs12359174 | 10 | 45819286 | ALOX5 | ENSG00000012779.6 | 7.091E-7 | 0 | -50375 | gtex_brain_ba24 |
| rs72784596 | 10 | 45819509 | ALOX5 | ENSG00000012779.6 | 7.091E-7 | 0 | -50152 | gtex_brain_ba24 |
| rs7474648 | 10 | 45819914 | ALOX5 | ENSG00000012779.6 | 9.938E-8 | 0 | -49747 | gtex_brain_ba24 |
| rs1897004 | 10 | 45820323 | ALOX5 | ENSG00000012779.6 | 7.091E-7 | 0 | -49338 | gtex_brain_ba24 |
| rs12358563 | 10 | 45820691 | ALOX5 | ENSG00000012779.6 | 2.73E-8 | 0 | -48970 | gtex_brain_ba24 |
| rs1434888 | 10 | 45821017 | ALOX5 | ENSG00000012779.6 | 7.091E-7 | 0 | -48644 | gtex_brain_ba24 |
| rs12358970 | 10 | 45821340 | ALOX5 | ENSG00000012779.6 | 3.711E-8 | 0 | -48321 | gtex_brain_ba24 |
| rs11239452 | 10 | 45821859 | ALOX5 | ENSG00000012779.6 | 3.711E-8 | 0 | -47802 | gtex_brain_ba24 |
| rs7078251 | 10 | 45822056 | ALOX5 | ENSG00000012779.6 | 3.711E-8 | 0 | -47605 | gtex_brain_ba24 |
| rs55815607 | 10 | 45822970 | ALOX5 | ENSG00000012779.6 | 1.37E-7 | 0 | -46691 | gtex_brain_ba24 |
| rs56241716 | 10 | 45822973 | ALOX5 | ENSG00000012779.6 | 1.37E-7 | 0 | -46688 | gtex_brain_ba24 |
| rs55756337 | 10 | 45823160 | ALOX5 | ENSG00000012779.6 | 1.912E-7 | 0 | -46501 | gtex_brain_ba24 |
| rs145130933 | 10 | 45823184 | ALOX5 | ENSG00000012779.6 | 1.912E-7 | 0 | -46477 | gtex_brain_ba24 |
| rs149080895 | 10 | 45823185 | ALOX5 | ENSG00000012779.6 | 1.912E-7 | 0 | -46476 | gtex_brain_ba24 |
| rs11239454 | 10 | 45823400 | ALOX5 | ENSG00000012779.6 | 2.694E-8 | 0 | -46261 | gtex_brain_ba24 |
| rs11239455 | 10 | 45823456 | ALOX5 | ENSG00000012779.6 | 5.766E-8 | 0 | -46205 | gtex_brain_ba24 |
| rs12355176 | 10 | 45823812 | ALOX5 | ENSG00000012779.6 | 3.049E-8 | 0 | -45849 | gtex_brain_ba24 |
| rs12358325 | 10 | 45823863 | ALOX5 | ENSG00000012779.6 | 8.454E-8 | 0 | -45798 | gtex_brain_ba24 |
| rs12355179 | 10 | 45823878 | ALOX5 | ENSG00000012779.6 | 3.061E-7 | 0 | -45783 | gtex_brain_ba24 |
| rs11239456 | 10 | 45824201 | ALOX5 | ENSG00000012779.6 | 3.711E-8 | 0 | -45460 | gtex_brain_ba24 |
| rs11239459 | 10 | 45824747 | ALOX5 | ENSG00000012779.6 | 3.711E-8 | 0 | -44914 | gtex_brain_ba24 |
| rs11239460 | 10 | 45824785 | ALOX5 | ENSG00000012779.6 | 2.694E-8 | 0 | -44876 | gtex_brain_ba24 |
| rs11239461 | 10 | 45824875 | ALOX5 | ENSG00000012779.6 | 2.694E-8 | 0 | -44786 | gtex_brain_ba24 |
| rs11239462 | 10 | 45825080 | ALOX5 | ENSG00000012779.6 | 5.43E-8 | 0 | -44581 | gtex_brain_ba24 |
| rs11239463 | 10 | 45825155 | ALOX5 | ENSG00000012779.6 | 2.694E-8 | 0 | -44506 | gtex_brain_ba24 |
| rs12360419 | 10 | 45825659 | ALOX5 | ENSG00000012779.6 | 4.651E-7 | 0 | -44002 | gtex_brain_ba24 |
| rs12355722 | 10 | 45825666 | ALOX5 | ENSG00000012779.6 | 2.509E-7 | 0 | -43995 | gtex_brain_ba24 |
| rs200198290 | 10 | 45825917 | ALOX5 | ENSG00000012779.6 | 8.032E-8 | 0 | -43744 | gtex_brain_ba24 |
| rs28570111 | 10 | 45826108 | ALOX5 | ENSG00000012779.6 | 6.087E-8 | 0 | -43553 | gtex_brain_ba24 |
| rs28688874 | 10 | 45826179 | ALOX5 | ENSG00000012779.6 | 4.089E-8 | 0 | -43482 | gtex_brain_ba24 |
| rs11239464 | 10 | 45826728 | ALOX5 | ENSG00000012779.6 | 2.694E-8 | 0 | -42933 | gtex_brain_ba24 |
| rs11517275 | 10 | 45827561 | ALOX5 | ENSG00000012779.6 | 3.711E-8 | 0 | -42100 | gtex_brain_ba24 |
| rs11517276 | 10 | 45827653 | ALOX5 | ENSG00000012779.6 | 3.711E-8 | 0 | -42008 | gtex_brain_ba24 |
| rs55902942 | 10 | 45828050 | ALOX5 | ENSG00000012779.6 | 2.694E-8 | 0 | -41611 | gtex_brain_ba24 |
| rs7098047 | 10 | 45828082 | ALOX5 | ENSG00000012779.6 | 3.711E-8 | 0 | -41579 | gtex_brain_ba24 |
| rs7089892 | 10 | 45828870 | ALOX5 | ENSG00000012779.6 | 3.711E-8 | 0 | -40791 | gtex_brain_ba24 |
| rs7069040 | 10 | 45829092 | ALOX5 | ENSG00000012779.6 | 2.694E-8 | 0 | -40569 | gtex_brain_ba24 |
| rs7069051 | 10 | 45829111 | ALOX5 | ENSG00000012779.6 | 3.711E-8 | 0 | -40550 | gtex_brain_ba24 |
| rs113105125 | 10 | 45830383 | ALOX5 | ENSG00000012779.6 | 3.711E-8 | 0 | -39278 | gtex_brain_ba24 |
| rs11239468 | 10 | 45831252 | ALOX5 | ENSG00000012779.6 | 3.711E-8 | 0 | -38409 | gtex_brain_ba24 |
| rs7906533 | 10 | 45831939 | ALOX5 | ENSG00000012779.6 | 3.711E-8 | 0 | -37722 | gtex_brain_ba24 |
| rs12355332 | 10 | 45832144 | ALOX5 | ENSG00000012779.6 | 3.711E-8 | 0 | -37517 | gtex_brain_ba24 |
| rs1594941 | 10 | 45832635 | ALOX5 | ENSG00000012779.6 | 3.711E-8 | 0 | -37026 | gtex_brain_ba24 |
| rs1836466 | 10 | 45832965 | ALOX5 | ENSG00000012779.6 | 7.091E-7 | 0 | -36696 | gtex_brain_ba24 |
| rs1836465 | 10 | 45833052 | ALOX5 | ENSG00000012779.6 | 3.711E-8 | 0 | -36609 | gtex_brain_ba24 |
| rs11239470 | 10 | 45833687 | ALOX5 | ENSG00000012779.6 | 2.694E-8 | 0 | -35974 | gtex_brain_ba24 |
| rs11239471 | 10 | 45833851 | ALOX5 | ENSG00000012779.6 | 3.711E-8 | 0 | -35810 | gtex_brain_ba24 |
| rs72786507 | 10 | 45834053 | ALOX5 | ENSG00000012779.6 | 3.711E-8 | 0 | -35608 | gtex_brain_ba24 |
| rs12360408 | 10 | 45834374 | ALOX5 | ENSG00000012779.6 | 2.694E-8 | 0 | -35287 | gtex_brain_ba24 |
| rs112663748 | 10 | 45835009 | ALOX5 | ENSG00000012779.6 | 3.711E-8 | 0 | -34652 | gtex_brain_ba24 |
| rs113448235 | 10 | 45835089 | ALOX5 | ENSG00000012779.6 | 2.694E-8 | 0 | -34572 | gtex_brain_ba24 |
| rs11522532 | 10 | 45835279 | ALOX5 | ENSG00000012779.6 | 3.711E-8 | 0 | -34382 | gtex_brain_ba24 |
| rs11523866 | 10 | 45835656 | ALOX5 | ENSG00000012779.6 | 2.694E-8 | 0 | -34005 | gtex_brain_ba24 |
| rs11523407 | 10 | 45835712 | ALOX5 | ENSG00000012779.6 | 2.694E-8 | 0 | -33949 | gtex_brain_ba24 |
| rs12357069 | 10 | 45836007 | ALOX5 | ENSG00000012779.6 | 2.694E-8 | 0 | -33654 | gtex_brain_ba24 |
| rs12358110 | 10 | 45836067 | ALOX5 | ENSG00000012779.6 | 2.66E-8 | 0 | -33594 | gtex_brain_ba24 |
| rs72786508 | 10 | 45836731 | ALOX5 | ENSG00000012779.6 | 2.694E-8 | 0 | -32930 | gtex_brain_ba24 |
| rs112653435 | 10 | 45836894 | ALOX5 | ENSG00000012779.6 | 2.694E-8 | 0 | -32767 | gtex_brain_ba24 |
| rs112137808 | 10 | 45836914 | ALOX5 | ENSG00000012779.6 | 2.694E-8 | 0 | -32747 | gtex_brain_ba24 |
| rs112860940 | 10 | 45837032 | ALOX5 | ENSG00000012779.6 | 2.694E-8 | 0 | -32629 | gtex_brain_ba24 |
| rs111756371 | 10 | 45837243 | ALOX5 | ENSG00000012779.6 | 2.694E-8 | 0 | -32418 | gtex_brain_ba24 |
| rs72788092 | 10 | 45837300 | ALOX5 | ENSG00000012779.6 | 2.694E-8 | 0 | -32361 | gtex_brain_ba24 |
| rs12359422 | 10 | 45837354 | ALOX5 | ENSG00000012779.6 | 1.599E-7 | 0 | -32307 | gtex_brain_ba24 |
| rs12354932 | 10 | 45837673 | ALOX5 | ENSG00000012779.6 | 3.532E-8 | 0 | -31988 | gtex_brain_ba24 |
| rs11517230 | 10 | 45838150 | ALOX5 | ENSG00000012779.6 | 2.694E-8 | 0 | -31511 | gtex_brain_ba24 |
| rs11517231 | 10 | 45838232 | ALOX5 | ENSG00000012779.6 | 1.931E-7 | 0 | -31429 | gtex_brain_ba24 |
| rs11517278 | 10 | 45838233 | ALOX5 | ENSG00000012779.6 | 1.72E-7 | 0 | -31428 | gtex_brain_ba24 |
| rs185308721 | 10 | 45838380 | ALOX5 | ENSG00000012779.6 | 1.397E-7 | 0 | -31281 | gtex_brain_ba24 |
| rs11517232 | 10 | 45838419 | ALOX5 | ENSG00000012779.6 | 3.555E-8 | 0 | -31242 | gtex_brain_ba24 |
| rs11511578 | 10 | 45838669 | ALOX5 | ENSG00000012779.6 | 9.946E-7 | 0 | -30992 | gtex_brain_ba24 |
| rs9702057 | 10 | 45839940 | ALOX5 | ENSG00000012779.6 | 3.544E-8 | 0 | -29721 | gtex_brain_ba24 |
| rs9702764 | 10 | 45839943 | ALOX5 | ENSG00000012779.6 | 2.488E-8 | 0 | -29718 | gtex_brain_ba24 |
| rs111413331 | 10 | 45840579 | ALOX5 | ENSG00000012779.6 | 1.207E-7 | 0 | -29082 | gtex_brain_ba24 |
| rs113591201 | 10 | 45840594 | ALOX5 | ENSG00000012779.6 | 1.207E-7 | 0 | -29067 | gtex_brain_ba24 |
| rs55807148 | 10 | 45840812 | ALOX5 | ENSG00000012779.6 | 1.058E-7 | 0 | -28849 | gtex_brain_ba24 |
| rs11517234 | 10 | 45840861 | ALOX5 | ENSG00000012779.6 | 1.207E-7 | 0 | -28800 | gtex_brain_ba24 |
| rs11517235 | 10 | 45841054 | ALOX5 | ENSG00000012779.6 | 5.041E-8 | 0 | -28607 | gtex_brain_ba24 |
| rs72788093 | 10 | 45841568 | ALOX5 | ENSG00000012779.6 | 1.848E-7 | 0 | -28093 | gtex_brain_ba24 |
| rs111435062 | 10 | 45841753 | ALOX5 | ENSG00000012779.6 | 1.124E-7 | 0 | -27908 | gtex_brain_ba24 |
| rs111646485 | 10 | 45842094 | ALOX5 | ENSG00000012779.6 | 2.694E-8 | 0 | -27567 | gtex_brain_ba24 |
| rs148767623 | 10 | 45842274 | ALOX5 | ENSG00000012779.6 | 5.205E-7 | 0 | -27387 | gtex_brain_ba24 |
| rs111575793 | 10 | 45842309 | ALOX5 | ENSG00000012779.6 | 3.052E-8 | 0 | -27352 | gtex_brain_ba24 |
| rs112865981 | 10 | 45842765 | ALOX5 | ENSG00000012779.6 | 1.273E-7 | 0 | -26896 | gtex_brain_ba24 |
| rs193227227 | 10 | 45842961 | ALOX5 | ENSG00000012779.6 | 1.688E-7 | 0 | -26700 | gtex_brain_ba24 |
| rs140571126 | 10 | 45842975 | ALOX5 | ENSG00000012779.6 | 6.74E-7 | 0 | -26686 | gtex_brain_ba24 |
| rs112778822 | 10 | 45843083 | ALOX5 | ENSG00000012779.6 | 1.294E-7 | 0 | -26578 | gtex_brain_ba24 |
| rs111734924 | 10 | 45843114 | ALOX5 | ENSG00000012779.6 | 1.124E-7 | 0 | -26547 | gtex_brain_ba24 |
| rs113279801 | 10 | 45843157 | ALOX5 | ENSG00000012779.6 | 1.124E-7 | 0 | -26504 | gtex_brain_ba24 |
| rs55908358 | 10 | 45843309 | ALOX5 | ENSG00000012779.6 | 3.02E-6 | 0 | -26352 | gtex_brain_ba24 |
| rs112072595 | 10 | 45843425 | ALOX5 | ENSG00000012779.6 | 7.94E-8 | 0 | -26236 | gtex_brain_ba24 |
| rs113396425 | 10 | 45843498 | ALOX5 | ENSG00000012779.6 | 7.312E-8 | 0 | -26163 | gtex_brain_ba24 |
| rs111843297 | 10 | 45843610 | ALOX5 | ENSG00000012779.6 | 1.468E-6 | 0 | -26051 | gtex_brain_ba24 |
| rs112376261 | 10 | 45843796 | ALOX5 | ENSG00000012779.6 | 1.124E-7 | 0 | -25865 | gtex_brain_ba24 |
| rs113213463 | 10 | 45843833 | ALOX5 | ENSG00000012779.6 | 1.124E-7 | 0 | -25828 | gtex_brain_ba24 |
| rs115931515 | 10 | 45843965 | ALOX5 | ENSG00000012779.6 | 1.513E-7 | 0 | -25696 | gtex_brain_ba24 |
| rs113868884 | 10 | 45844029 | ALOX5 | ENSG00000012779.6 | 1.124E-7 | 0 | -25632 | gtex_brain_ba24 |
| rs141057206 | 10 | 45844106 | ALOX5 | ENSG00000012779.6 | 1.124E-7 | 0 | -25555 | gtex_brain_ba24 |
| rs145685327 | 10 | 45844112 | ALOX5 | ENSG00000012779.6 | 1.113E-7 | 0 | -25549 | gtex_brain_ba24 |
| rs76710941 | 10 | 45844527 | ALOX5 | ENSG00000012779.6 | 1.124E-7 | 0 | -25134 | gtex_brain_ba24 |
| rs112215719 | 10 | 45844817 | ALOX5 | ENSG00000012779.6 | 1.619E-7 | 0 | -24844 | gtex_brain_ba24 |
| rs113006359 | 10 | 45844959 | ALOX5 | ENSG00000012779.6 | 1.124E-7 | 0 | -24702 | gtex_brain_ba24 |
| rs113445700 | 10 | 45846048 | ALOX5 | ENSG00000012779.6 | 2.704E-8 | 0 | -23613 | gtex_brain_ba24 |
| rs142136944 | 10 | 45846199 | ALOX5 | ENSG00000012779.6 | 2.666E-8 | 0 | -23462 | gtex_brain_ba24 |
| rs72788095 | 10 | 45846404 | ALOX5 | ENSG00000012779.6 | 2.694E-8 | 0 | -23257 | gtex_brain_ba24 |
| rs72788096 | 10 | 45846569 | ALOX5 | ENSG00000012779.6 | 2.694E-8 | 0 | -23092 | gtex_brain_ba24 |
| rs375500425 | 10 | 45846746 | ALOX5 | ENSG00000012779.6 | 2.413E-8 | 0 | -22915 | gtex_brain_ba24 |
| rs1529828 | 10 | 45846799 | ALOX5 | ENSG00000012779.6 | 2.694E-8 | 0 | -22862 | gtex_brain_ba24 |
| rs1529829 | 10 | 45846862 | ALOX5 | ENSG00000012779.6 | 2.694E-8 | 0 | -22799 | gtex_brain_ba24 |
| rs1968475 | 10 | 45847600 | ALOX5 | ENSG00000012779.6 | 2.694E-8 | 0 | -22061 | gtex_brain_ba24 |
| rs372285144 | 10 | 45847637 | ALOX5 | ENSG00000012779.6 | 2.694E-8 | 0 | -22024 | gtex_brain_ba24 |
| rs2871740 | 10 | 45847747 | ALOX5 | ENSG00000012779.6 | 3.56E-8 | 0 | -21914 | gtex_brain_ba24 |
| rs145680806 | 10 | 45847969 | ALOX5 | ENSG00000012779.6 | 8.611E-8 | 0 | -21692 | gtex_brain_ba24 |
| rs10900209 | 10 | 45848100 | ALOX5 | ENSG00000012779.6 | 7.091E-7 | 0 | -21561 | gtex_brain_ba24 |
| rs35698621 | 10 | 45848421 | ALOX5 | ENSG00000012779.6 | 7.204E-7 | 0 | -21240 | gtex_brain_ba24 |
| rs12256027 | 10 | 45848714 | ALOX5 | ENSG00000012779.6 | 7.091E-7 | 0 | -20947 | gtex_brain_ba24 |
| rs11239480 | 10 | 45849370 | ALOX5 | ENSG00000012779.6 | 2.694E-8 | 0 | -20291 | gtex_brain_ba24 |
| rs12359547 | 10 | 45849953 | ALOX5 | ENSG00000012779.6 | 2.694E-8 | 0 | -19708 | gtex_brain_ba24 |
| rs72788101 | 10 | 45850449 | ALOX5 | ENSG00000012779.6 | 2.694E-8 | 0 | -19212 | gtex_brain_ba24 |
| rs72788102 | 10 | 45850676 | ALOX5 | ENSG00000012779.6 | 2.694E-8 | 0 | -18985 | gtex_brain_ba24 |
| rs72789705 | 10 | 45851052 | ALOX5 | ENSG00000012779.6 | 2.694E-8 | 0 | -18609 | gtex_brain_ba24 |
| rs11239482 | 10 | 45851414 | ALOX5 | ENSG00000012779.6 | 2.694E-8 | 0 | -18247 | gtex_brain_ba24 |
| rs72789735 | 10 | 45875554 | ALOX5 | ENSG00000012779.6 | 2.694E-8 | 0 | 5893 | gtex_brain_ba24 |
| rs11239496 | 10 | 45876385 | ALOX5 | ENSG00000012779.6 | 2.694E-8 | 0 | 6724 | gtex_brain_ba24 |
| rs11239501 | 10 | 45878800 | ALOX5 | ENSG00000012779.6 | 9.786E-7 | 0 | 9139 | gtex_brain_ba24 |
| rs11239506 | 10 | 45883471 | ALOX5 | ENSG00000012779.6 | 6.25E-7 | 0 | 13810 | gtex_brain_ba24 |
| rs112615252 | 10 | 45883774 | ALOX5 | ENSG00000012779.6 | 6.25E-7 | 0 | 14113 | gtex_brain_ba24 |
| rs7907779 | 10 | 45885477 | ALOX5 | ENSG00000012779.6 | 6.238E-7 | 0 | 15816 | gtex_brain_ba24 |
| rs55789336 | 10 | 45887115 | ALOX5 | ENSG00000012779.6 | 4.933E-7 | 0 | 17454 | gtex_brain_ba24 |
| rs55837212 | 10 | 45887118 | ALOX5 | ENSG00000012779.6 | 1.296E-6 | 0 | 17457 | gtex_brain_ba24 |
| rs149306926 | 10 | 45887272 | ALOX5 | ENSG00000012779.6 | 3.641E-6 | 0 | 17611 | gtex_brain_ba24 |
| rs41526545 | 10 | 45891215 | ALOX5 | ENSG00000012779.6 | 9.786E-7 | 0 | 21554 | gtex_brain_ba24 |
| rs17444064 | 10 | 45891700 | ALOX5 | ENSG00000012779.6 | 9.786E-7 | 0 | 22039 | gtex_brain_ba24 |
| rs6593484 | 10 | 45892557 | ALOX5 | ENSG00000012779.6 | 6.203E-7 | 0 | 22896 | gtex_brain_ba24 |
| rs11239512 | 10 | 45893620 | ALOX5 | ENSG00000012779.6 | 6.203E-7 | 0 | 23959 | gtex_brain_ba24 |
| rs11239515 | 10 | 45902055 | ALOX5 | ENSG00000012779.6 | 9.782E-7 | 0 | 32394 | gtex_brain_ba24 |
| rs11239516 | 10 | 45902537 | ALOX5 | ENSG00000012779.6 | 1.7E-6 | 0 | 32876 | gtex_brain_ba24 |
| rs11239517 | 10 | 45902810 | ALOX5 | ENSG00000012779.6 | 1.699E-6 | 0 | 33149 | gtex_brain_ba24 |
| rs11239519 | 10 | 45902852 | ALOX5 | ENSG00000012779.6 | 4.043E-6 | 0 | 33191 | gtex_brain_ba24 |
| rs11239520 | 10 | 45903367 | ALOX5 | ENSG00000012779.6 | 6.194E-7 | 0 | 33706 | gtex_brain_ba24 |
| rs72796464 | 10 | 45905894 | ALOX5 | ENSG00000012779.6 | 9.768E-7 | 0 | 36233 | gtex_brain_ba24 |
| rs56071381 | 10 | 45907136 | ALOX5 | ENSG00000012779.6 | 1.736E-6 | 0 | 37475 | gtex_brain_ba24 |
| rs10900215 | 10 | 45907454 | ALOX5 | ENSG00000012779.6 | 8.319E-8 | 0 | 37793 | gtex_brain_ba24 |
| rs77465787 | 10 | 45912154 | ALOX5 | ENSG00000012779.6 | 6.157E-7 | 0 | 42493 | gtex_brain_ba24 |
| rs11239523 | 10 | 45912237 | ALOX5 | ENSG00000012779.6 | 6.157E-7 | 0 | 42576 | gtex_brain_ba24 |
| rs11239524 | 10 | 45912771 | ALOX5 | ENSG00000012779.6 | 1.702E-6 | 0 | 43110 | gtex_brain_ba24 |
| rs12355888 | 10 | 45931564 | ALOX5 | ENSG00000012779.6 | 2.592E-6 | 0 | 61903 | gtex_brain_ba24 |
| rs11239534 | 10 | 45968590 | ALOX5 | ENSG00000012779.6 | 2.551E-6 | 0 | 98929 | gtex_brain_ba24 |
| rs11239540 | 10 | 45999209 | ALOX5 | ENSG00000012779.6 | 2.551E-6 | 0 | 129548 | gtex_brain_ba24 |
| rs146817305 | 10 | 46018523 | ALOX5 | ENSG00000012779.6 | 2.555E-6 | 0 | 148862 | gtex_brain_ba24 |
| rs200054362 | 10 | 46018525 | ALOX5 | ENSG00000012779.6 | 1.521E-6 | 0 | 148864 | gtex_brain_ba24 |
| rs11239572 | 10 | 46088061 | ALOX5 | ENSG00000012779.6 | 2.435E-6 | 0 | 218400 | gtex_brain_ba24 |
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression during devlopment (BrainCloud)
Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
No co-expressed genes in brain regions
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG ARACHIDONIC ACID METABOLISM | 58 | 36 | All SZGR 2.0 genes in this pathway |
| SCHUETZ BREAST CANCER DUCTAL INVASIVE UP | 351 | 230 | All SZGR 2.0 genes in this pathway |
| GARY CD5 TARGETS UP | 473 | 314 | All SZGR 2.0 genes in this pathway |
| DEURIG T CELL PROLYMPHOCYTIC LEUKEMIA UP | 368 | 234 | All SZGR 2.0 genes in this pathway |
| GAL LEUKEMIC STEM CELL DN | 244 | 153 | All SZGR 2.0 genes in this pathway |
| VECCHI GASTRIC CANCER ADVANCED VS EARLY UP | 175 | 120 | All SZGR 2.0 genes in this pathway |
| SMIRNOV CIRCULATING ENDOTHELIOCYTES IN CANCER UP | 158 | 103 | All SZGR 2.0 genes in this pathway |
| TAKEDA TARGETS OF NUP98 HOXA9 FUSION 3D DN | 31 | 19 | All SZGR 2.0 genes in this pathway |
| TAKEDA TARGETS OF NUP98 HOXA9 FUSION 8D DN | 205 | 127 | All SZGR 2.0 genes in this pathway |
| TONKS TARGETS OF RUNX1 RUNX1T1 FUSION GRANULOCYTE DN | 17 | 13 | All SZGR 2.0 genes in this pathway |
| ODONNELL TFRC TARGETS UP | 456 | 228 | All SZGR 2.0 genes in this pathway |
| ODONNELL TARGETS OF MYC AND TFRC UP | 83 | 50 | All SZGR 2.0 genes in this pathway |
| SENESE HDAC1 TARGETS DN | 260 | 143 | All SZGR 2.0 genes in this pathway |
| SENESE HDAC1 AND HDAC2 TARGETS DN | 232 | 139 | All SZGR 2.0 genes in this pathway |
| SENESE HDAC3 TARGETS DN | 536 | 332 | All SZGR 2.0 genes in this pathway |
| GRAHAM CML QUIESCENT VS NORMAL QUIESCENT DN | 47 | 32 | All SZGR 2.0 genes in this pathway |
| GRAHAM CML DIVIDING VS NORMAL QUIESCENT DN | 95 | 57 | All SZGR 2.0 genes in this pathway |
| GRAHAM NORMAL QUIESCENT VS NORMAL DIVIDING UP | 66 | 47 | All SZGR 2.0 genes in this pathway |
| GOZGIT ESR1 TARGETS UP | 149 | 84 | All SZGR 2.0 genes in this pathway |
| DELYS THYROID CANCER UP | 443 | 294 | All SZGR 2.0 genes in this pathway |
| GRUETZMANN PANCREATIC CANCER UP | 358 | 245 | All SZGR 2.0 genes in this pathway |
| PUJANA ATM PCC NETWORK | 1442 | 892 | All SZGR 2.0 genes in this pathway |
| BENPORATH SUZ12 TARGETS | 1038 | 678 | All SZGR 2.0 genes in this pathway |
| BENPORATH EED TARGETS | 1062 | 725 | All SZGR 2.0 genes in this pathway |
| SUNG METASTASIS STROMA UP | 110 | 70 | All SZGR 2.0 genes in this pathway |
| ROSS AML WITH PML RARA FUSION | 77 | 62 | All SZGR 2.0 genes in this pathway |
| LU IL4 SIGNALING | 94 | 56 | All SZGR 2.0 genes in this pathway |
| HASLINGER B CLL WITH 13Q14 DELETION | 24 | 18 | All SZGR 2.0 genes in this pathway |
| HADDAD B LYMPHOCYTE PROGENITOR | 293 | 193 | All SZGR 2.0 genes in this pathway |
| MCLACHLAN DENTAL CARIES DN | 245 | 144 | All SZGR 2.0 genes in this pathway |
| RODWELL AGING KIDNEY UP | 487 | 303 | All SZGR 2.0 genes in this pathway |
| MCLACHLAN DENTAL CARIES UP | 253 | 147 | All SZGR 2.0 genes in this pathway |
| KRIGE RESPONSE TO TOSEDOSTAT 6HR UP | 953 | 554 | All SZGR 2.0 genes in this pathway |
| KRIGE RESPONSE TO TOSEDOSTAT 24HR UP | 783 | 442 | All SZGR 2.0 genes in this pathway |
| AMBROSINI FLAVOPIRIDOL TREATMENT TP53 | 109 | 63 | All SZGR 2.0 genes in this pathway |
| BONOME OVARIAN CANCER SURVIVAL SUBOPTIMAL DEBULKING | 510 | 309 | All SZGR 2.0 genes in this pathway |
| NICK RESPONSE TO PROC TREATMENT DN | 27 | 18 | All SZGR 2.0 genes in this pathway |
| YOSHIMURA MAPK8 TARGETS UP | 1305 | 895 | All SZGR 2.0 genes in this pathway |
| RUTELLA RESPONSE TO CSF2RB AND IL4 DN | 315 | 201 | All SZGR 2.0 genes in this pathway |
| RUTELLA RESPONSE TO HGF DN | 235 | 144 | All SZGR 2.0 genes in this pathway |
| RUTELLA RESPONSE TO HGF VS CSF2RB AND IL4 UP | 408 | 276 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN MEF HCP WITH H3K27ME3 | 590 | 403 | All SZGR 2.0 genes in this pathway |
| BAE BRCA1 TARGETS UP | 75 | 47 | All SZGR 2.0 genes in this pathway |
| VERHAAK GLIOBLASTOMA MESENCHYMAL | 216 | 130 | All SZGR 2.0 genes in this pathway |
| PILON KLF1 TARGETS DN | 1972 | 1213 | All SZGR 2.0 genes in this pathway |
| BRUINS UVC RESPONSE LATE | 1137 | 655 | All SZGR 2.0 genes in this pathway |
| TORCHIA TARGETS OF EWSR1 FLI1 FUSION TOP20 UP | 20 | 14 | All SZGR 2.0 genes in this pathway |
| TORCHIA TARGETS OF EWSR1 FLI1 FUSION UP | 271 | 165 | All SZGR 2.0 genes in this pathway |
| PURBEY TARGETS OF CTBP1 NOT SATB1 DN | 448 | 282 | All SZGR 2.0 genes in this pathway |
| BOSCO ALLERGEN INDUCED TH2 ASSOCIATED MODULE | 151 | 86 | All SZGR 2.0 genes in this pathway |
| ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY | 1839 | 928 | All SZGR 2.0 genes in this pathway |