Gene Page: GCLC

Summary ?
GeneID2729
SymbolGCLC
SynonymsGCL|GCS|GLCL|GLCLC
Descriptionglutamate-cysteine ligase catalytic subunit
ReferenceMIM:606857|HGNC:HGNC:4311|Ensembl:ENSG00000001084|HPRD:06032|Vega:OTTHUMG00000160220
Gene typeprotein-coding
Map location6p12
Pascal p-value0.442
Sherlock p-value0.919
Fetal beta-1.403
eGeneCerebellum
Cortex
Hippocampus
Myers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_IIEGenome scan meta-analysis (European-ancestry samples)Psr: 0.04433 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophreniasClick to show details
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 5 

Section I. Genetics and epigenetics annotation

@DNM table

GeneChromosomePositionRefAltTranscriptAA changeMutation typeSiftCG46TraitStudy
GCLCchr653387293TCNM_001197115
NM_001498		.
.		silent
silent		SchizophreniaDNM:Gulsuner_2013

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs6632306chrX35590460GCLC27290.07trans
rs1935404chrX35605181GCLC27290.1trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
GLUD20.950.95
GPC50.910.88
SUCLG20.900.88
GJA10.900.86
S1PR10.890.81
PLSCR40.890.89
ITM2C0.870.88
ADD30.860.88
KCNJ160.860.83
NT5E0.850.86
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
RTF1-0.53-0.57
CCAR1-0.50-0.59
DPF1-0.49-0.48
MPP3-0.49-0.49
GMIP-0.49-0.47
RP9-0.49-0.58
ZNF821-0.49-0.48
PHF14-0.49-0.56
AC011491.1-0.48-0.56
CHD3-0.48-0.47

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0016595glutamate bindingIDAglutamate (GO term level: 5)9841880 
GO:0004357glutamate-cysteine ligase activityIDAglutamate (GO term level: 6)8104187 |11972604 
GO:0004357glutamate-cysteine ligase activityIMPglutamate (GO term level: 6)16183645 
GO:0000287magnesium ion bindingIDA24639 
GO:0016874ligase activityIEA-
GO:0050662coenzyme bindingIPI9675072 |9841880 
GO:0046982protein heterodimerization activityIEA-
GO:0043531ADP bindingIDA24639 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006536glutamate metabolic processIDAglutamate (GO term level: 8)2294991 |12663448 
GO:0006534cysteine metabolic processIDA2294991 
GO:0019852L-ascorbic acid metabolic processIEA-
GO:0009410response to xenobiotic stimulusIEA-
GO:0009408response to heatIDA8104187 
GO:0009725response to hormone stimulusIDA8104187 
GO:0006750glutathione biosynthetic processIDA8104187 |10395918 
GO:0006750glutathione biosynthetic processIMP12663448 
GO:0006979response to oxidative stressIDA10395918 |11972604 
GO:0006916anti-apoptosisIDA10439045 
GO:0016481negative regulation of transcriptionIDA10439045 
GO:0031397negative regulation of protein ubiquitinationIEA-
GO:0032436positive regulation of proteasomal ubiquitin-dependent protein catabolic processIEA-
GO:0050880regulation of blood vessel sizeIMP12598062 
GO:0046685response to arsenicIEA-
GO:0045454cell redox homeostasisIDA10439045 
GO:0051900regulation of mitochondrial depolarizationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0017109glutamate-cysteine ligase complexIEAglutamate (GO term level: 8)-
GO:0005829cytosolIEA-

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG GLUTATHIONE METABOLISM 5034All SZGR 2.0 genes in this pathway
REACTOME SULFUR AMINO ACID METABOLISM 2417All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES 200136All SZGR 2.0 genes in this pathway
REACTOME BIOLOGICAL OXIDATIONS 13991All SZGR 2.0 genes in this pathway
REACTOME GLUTATHIONE CONJUGATION 2313All SZGR 2.0 genes in this pathway
REACTOME PHASE II CONJUGATION 7042All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP 1382904All SZGR 2.0 genes in this pathway
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL UP 233161All SZGR 2.0 genes in this pathway
GARGALOVIC RESPONSE TO OXIDIZED PHOSPHOLIPIDS YELLOW UP 3225All SZGR 2.0 genes in this pathway
MARKEY RB1 ACUTE LOF DN 228137All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION DN 234147All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL TGFB1 TARGETS DN 6244All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP 811508All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 6HR UP 176115All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 48HR UP 487286All SZGR 2.0 genes in this pathway
BENPORATH MYC MAX TARGETS 775494All SZGR 2.0 genes in this pathway
ZHANG RESPONSE TO IKK INHIBITOR AND TNF UP 223140All SZGR 2.0 genes in this pathway
MORI EMU MYC LYMPHOMA BY ONSET TIME UP 11069All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 2 DN 464276All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 1 UP 14085All SZGR 2.0 genes in this pathway
UEDA PERIFERAL CLOCK 169111All SZGR 2.0 genes in this pathway
SESTO RESPONSE TO UV C2 5439All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP 16911088All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 14HR UP 156101All SZGR 2.0 genes in this pathway
DAZARD RESPONSE TO UV NHEK DN 318220All SZGR 2.0 genes in this pathway
MONNIER POSTRADIATION TUMOR ESCAPE UP 393244All SZGR 2.0 genes in this pathway
SINGH NFE2L2 TARGETS 1512All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE BY GAMMA AND UV RADIATION 8865All SZGR 2.0 genes in this pathway
KYNG DNA DAMAGE UP 226164All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS UP 673430All SZGR 2.0 genes in this pathway
MARTINEZ RB1 TARGETS DN 543317All SZGR 2.0 genes in this pathway
MARTINEZ TP53 TARGETS DN 593372All SZGR 2.0 genes in this pathway
MARTINEZ RB1 AND TP53 TARGETS DN 591366All SZGR 2.0 genes in this pathway
ITO PTTG1 TARGETS UP 129All SZGR 2.0 genes in this pathway
GRADE COLON AND RECTAL CANCER UP 285167All SZGR 2.0 genes in this pathway
LABBE TGFB1 TARGETS DN 10864All SZGR 2.0 genes in this pathway
LABBE TARGETS OF TGFB1 AND WNT3A DN 10868All SZGR 2.0 genes in this pathway
BOYAULT LIVER CANCER SUBCLASS G1 DN 4026All SZGR 2.0 genes in this pathway
YAGI AML WITH 11Q23 REARRANGED 351238All SZGR 2.0 genes in this pathway
FONTAINE FOLLICULAR THYROID ADENOMA UP 7543All SZGR 2.0 genes in this pathway
GUTIERREZ CHRONIC LYMPHOCYTIC LEUKEMIA DN 5639All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC 1103714All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS UP 682433All SZGR 2.0 genes in this pathway
IKEDA MIR1 TARGETS UP 5339All SZGR 2.0 genes in this pathway
KRIEG HYPOXIA NOT VIA KDM3A 770480All SZGR 2.0 genes in this pathway
FORTSCHEGGER PHF8 TARGETS UP 279155All SZGR 2.0 genes in this pathway
ROESSLER LIVER CANCER METASTASIS UP 10772All SZGR 2.0 genes in this pathway
ZWANG CLASS 1 TRANSIENTLY INDUCED BY EGF 516308All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1/2063323381Ahsa-miR-1UGGAAUGUAAAGAAGUAUGUA
hsa-miR-206SZUGGAAUGUAAGGAAGUGUGUGG
hsa-miR-613AGGAAUGUUCCUUCUUUGCC
miR-185195261A,m8hsa-miR-18aUAAGGUGCAUCUAGUGCAGAUA
hsa-miR-18bUAAGGUGCAUCUAGUGCAGUUA
miR-433-3p100210091A,m8hsa-miR-433brainAUCAUGAUGGGCUCCUCGGUGU