Summary ?
GeneID2770
SymbolGNAI1
SynonymsGi
DescriptionG protein subunit alpha i1
ReferenceMIM:139310|HGNC:HGNC:4384|Ensembl:ENSG00000127955|HPRD:00756|Vega:OTTHUMG00000023523
Gene typeprotein-coding
Map location7q21
Pascal p-value0.003
Sherlock p-value0.005
Fetal beta0.448
eGeneCaudate basal ganglia
Cerebellar Hemisphere
Myers' cis & trans
SupportCANABINOID
G-PROTEIN RELAY
SEROTONIN
Potential synaptic genes

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 1.2615 

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs6040607chr2011371092GNAI127700.14trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
TP53I130.760.76
RFXANK0.740.69
CAPG0.740.67
AKR7A20.720.66
TMEM1490.720.68
TIMP10.700.72
CLIC10.690.63
TMEM179B0.690.67
TMEM2160.690.50
AL031319.20.690.56
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
FBXW7-0.50-0.61
AL031003.1-0.47-0.56
RAB11FIP4-0.47-0.57
TRIM44-0.46-0.54
ERC2-0.45-0.58
SCN2A-0.45-0.59
KIF3A-0.45-0.57
STXBP5-0.44-0.56
DNAJC6-0.44-0.56
MADD-0.44-0.56

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0004871signal transducer activityIEA-
GO:0003924GTPase activityTAS2834384 
GO:0005515protein bindingIPI15537540 
GO:0005525GTP bindingIEA-
GO:0019001guanyl nucleotide bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007186G-protein coupled receptor protein signaling pathwayIEA-
GO:0007165signal transductionIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005834heterotrimeric G-protein complexTAS3110783 
GO:0005886plasma membraneTAS3139448 

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ADCY5AC5adenylate cyclase 5-HPRD,BioGRID9748257 
ADRA2AADRA2 | ADRA2R | ADRAR | ALPHA2AAR | ZNF32adrenergic, alpha-2A-, receptor-HPRD11732925 
CD47IAP | MER6 | OA3CD47 molecule-HPRD11306274 
CNR1CANN6 | CB-R | CB1 | CB1A | CB1K5 | CB1R | CNRcannabinoid receptor 1 (brain)-HPRD,BioGRID11168387 
CRHR1CRF-R | CRF1 | CRFR1 | CRH-R1h | CRHR | CRHR1fcorticotropin releasing hormone receptor 1-HPRD,BioGRID10598591 
DRD3D3DR | ETM1 | FET1 | MGC149204 | MGC149205dopamine receptor D3-HPRD10978845 
EPORMGC138358erythropoietin receptorReconstituted ComplexBioGRID12538595 
FFAR1FFA1R | GPCR40 | GPR40free fatty acid receptor 1-HPRD,BioGRID12496284 |12629551 
GPR1-G protein-coupled receptor 1-HPRD14530282 
GPR143OA1G protein-coupled receptor 143-HPRD,BioGRID10471510 
GPSM1AGS3 | DKFZp727I051G-protein signaling modulator 1 (AGS3-like, C. elegans)Reconstituted ComplexBioGRID14530282 
GPSM2LGN | PinsG-protein signaling modulator 2 (AGS3-like, C. elegans)LGN interacts with Galphai1.BIND15537540 
GPSM3C6orf9 | G18 | G18.1a | G18.1b | G18.2 | NG1G-protein signaling modulator 3 (AGS3-like, C. elegans)-HPRD,BioGRID14656218 
HRH4AXOR35 | BG26 | GPCR105 | GPRv53 | H4 | H4R | HH4R | MGC133027histamine receptor H4-HPRD10973974 
HTR2A5-HT2A | HTR25-hydroxytryptamine (serotonin) receptor 2A-HPRD11916537 
IGF1RCD221 | IGFIR | JTK13 | MGC142170 | MGC142172 | MGC18216insulin-like growth factor 1 receptor-HPRD,BioGRID10644671 
NGB-neuroglobinReconstituted ComplexBioGRID12860983 
NUMA1NUMAnuclear mitotic apparatus protein 1NuMA interacts with Galphai1.BIND15537540 
OPRM1KIAA0403 | MOR | MOR1 | OPRMopioid receptor, mu 1-HPRD,BioGRID12068084 
RASD1AGS1 | DEXRAS1 | MGC:26290RAS, dexamethasone-induced 1in vitro
Reconstituted Complex
BioGRID10840027 |11842095 
RGS10-regulator of G-protein signaling 10-HPRD,BioGRID9207071 
RGS12DKFZp761K1617 | DKFZp761K1817regulator of G-protein signaling 12-HPRD,BioGRID11387333 
RGS14-regulator of G-protein signaling 14-HPRD,BioGRID11387333 |11976690 
RGS16A28-RGS14 | A28-RGS14P | RGS-Rregulator of G-protein signaling 16Biochemical ActivityBioGRID10878019 
RGS18RGS13regulator of G-protein signaling 18-HPRD,BioGRID11955952 
RGS19GAIP | RGSGAIPregulator of G-protein signaling 19-HPRD,BioGRID8986788 |10364213 
RGS4DKFZp761F1924 | MGC2124 | MGC60244 | RGP4 | SCZD9regulator of G-protein signaling 4-HPRD,BioGRID9660808 |11507164 
RGS5MST092 | MST106 | MST129 | MSTP032 | MSTP092 | MSTP106 | MSTP129regulator of G-protein signaling 5Affinity Capture-WesternBioGRID11253162 
RGS7-regulator of G-protein signaling 7-HPRD,BioGRID9572280 
RIC8AMGC104517 | MGC131931 | MGC148073 | MGC148074 | RIC8 | synembrynresistance to inhibitors of cholinesterase 8 homolog A (C. elegans)-HPRD,BioGRID12509430 
S1PR1CHEDG1 | D1S3362 | ECGF1 | EDG-1 | EDG1 | FLJ58121 | S1P1sphingosine-1-phosphate receptor 1-HPRD,BioGRID8626678 
S1PR2AGR16 | EDG-5 | EDG5 | Gpcr13 | H218 | LPB2 | S1P2sphingosine-1-phosphate receptor 2-HPRD10488065 
S1PR3EDG-3 | EDG3 | FLJ37523 | FLJ93220 | LPB3 | MGC71696 | S1P3sphingosine-1-phosphate receptor 3-HPRD10488065 
S1PR5EDG8 | Edg-8 | S1P5 | SPPR-1 | SPPR-2sphingosine-1-phosphate receptor 5-HPRD11069896 
SSTR2-somatostatin receptor 2-HPRD,BioGRID7914078 
SSTR3-somatostatin receptor 3-HPRD,BioGRID8183236 
STRNMGC125642 | SG2NAstriatin, calmodulin binding protein-HPRD15569929 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG CHEMOKINE SIGNALING PATHWAY 190128All SZGR 2.0 genes in this pathway
KEGG AXON GUIDANCE 129103All SZGR 2.0 genes in this pathway
KEGG TIGHT JUNCTION 13486All SZGR 2.0 genes in this pathway
KEGG GAP JUNCTION 9068All SZGR 2.0 genes in this pathway
KEGG LEUKOCYTE TRANSENDOTHELIAL MIGRATION 11878All SZGR 2.0 genes in this pathway
KEGG LONG TERM DEPRESSION 7053All SZGR 2.0 genes in this pathway
KEGG PROGESTERONE MEDIATED OOCYTE MATURATION 8659All SZGR 2.0 genes in this pathway
KEGG MELANOGENESIS 10280All SZGR 2.0 genes in this pathway
BIOCARTA SPPA PATHWAY 2218All SZGR 2.0 genes in this pathway
BIOCARTA BIOPEPTIDES PATHWAY 4535All SZGR 2.0 genes in this pathway
BIOCARTA CXCR4 PATHWAY 2422All SZGR 2.0 genes in this pathway
BIOCARTA MPR PATHWAY 3428All SZGR 2.0 genes in this pathway
BIOCARTA GSK3 PATHWAY 2726All SZGR 2.0 genes in this pathway
BIOCARTA EDG1 PATHWAY 2724All SZGR 2.0 genes in this pathway
BIOCARTA GPCR PATHWAY 3731All SZGR 2.0 genes in this pathway
BIOCARTA PAR1 PATHWAY 3728All SZGR 2.0 genes in this pathway
ST ADRENERGIC 3629All SZGR 2.0 genes in this pathway
ST MYOCYTE AD PATHWAY 2725All SZGR 2.0 genes in this pathway
PID ENDOTHELIN PATHWAY 6352All SZGR 2.0 genes in this pathway
PID LYSOPHOSPHOLIPID PATHWAY 6653All SZGR 2.0 genes in this pathway
PID ER NONGENOMIC PATHWAY 4135All SZGR 2.0 genes in this pathway
PID S1P S1P3 PATHWAY 2924All SZGR 2.0 genes in this pathway
PID S1P S1P4 PATHWAY 1411All SZGR 2.0 genes in this pathway
PID SHP2 PATHWAY 5846All SZGR 2.0 genes in this pathway
PID S1P S1P1 PATHWAY 2118All SZGR 2.0 genes in this pathway
PID CXCR4 PATHWAY 10278All SZGR 2.0 genes in this pathway
PID ERBB1 RECEPTOR PROXIMAL PATHWAY 3529All SZGR 2.0 genes in this pathway
PID S1P META PATHWAY 2114All SZGR 2.0 genes in this pathway
PID AR NONGENOMIC PATHWAY 3127All SZGR 2.0 genes in this pathway
PID HEDGEHOG GLI PATHWAY 4835All SZGR 2.0 genes in this pathway
PID CXCR3 PATHWAY 4334All SZGR 2.0 genes in this pathway
PID THROMBIN PAR1 PATHWAY 4332All SZGR 2.0 genes in this pathway
PID S1P S1P2 PATHWAY 2419All SZGR 2.0 genes in this pathway
REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES 186155All SZGR 2.0 genes in this pathway
REACTOME NEURONAL SYSTEM 279221All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY GPCR 920449All SZGR 2.0 genes in this pathway
REACTOME INTEGRATION OF ENERGY METABOLISM 12084All SZGR 2.0 genes in this pathway
REACTOME OPIOID SIGNALLING 7856All SZGR 2.0 genes in this pathway
REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY 139All SZGR 2.0 genes in this pathway
REACTOME NEUROTRANSMITTER RECEPTOR BINDING AND DOWNSTREAM TRANSMISSION IN THE POSTSYNAPTIC CELL 137110All SZGR 2.0 genes in this pathway
REACTOME PLC BETA MEDIATED EVENTS 4332All SZGR 2.0 genes in this pathway
REACTOME G PROTEIN ACTIVATION 2715All SZGR 2.0 genes in this pathway
REACTOME REGULATION OF INSULIN SECRETION 9365All SZGR 2.0 genes in this pathway
REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE 2515All SZGR 2.0 genes in this pathway
REACTOME GPCR DOWNSTREAM SIGNALING 805368All SZGR 2.0 genes in this pathway
REACTOME G ALPHA I SIGNALLING EVENTS 195114All SZGR 2.0 genes in this pathway
REACTOME G ALPHA S SIGNALLING EVENTS 12182All SZGR 2.0 genes in this pathway
REACTOME G ALPHA Z SIGNALLING EVENTS 4429All SZGR 2.0 genes in this pathway
REACTOME SIGNAL AMPLIFICATION 3119All SZGR 2.0 genes in this pathway
REACTOME ADP SIGNALLING THROUGH P2RY12 2110All SZGR 2.0 genes in this pathway
REACTOME GABA B RECEPTOR ACTIVATION 3826All SZGR 2.0 genes in this pathway
REACTOME GABA RECEPTOR ACTIVATION 5240All SZGR 2.0 genes in this pathway
REACTOME HEMOSTASIS 466331All SZGR 2.0 genes in this pathway
REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION 208138All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA DN 526357All SZGR 2.0 genes in this pathway
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN 663425All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS BASAL DN 455304All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS MESENCHYMAL DN 460312All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 6HR UP 8554All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 10D UP 194122All SZGR 2.0 genes in this pathway
TAKEDA TARGETS OF NUP98 HOXA9 FUSION 16D UP 175108All SZGR 2.0 genes in this pathway
AKL HTLV1 INFECTION UP 2716All SZGR 2.0 genes in this pathway
RHEIN ALL GLUCOCORTICOID THERAPY DN 362238All SZGR 2.0 genes in this pathway
TONKS TARGETS OF RUNX1 RUNX1T1 FUSION GRANULOCYTE UP 5534All SZGR 2.0 genes in this pathway
SENESE HDAC3 TARGETS DN 536332All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION DN 329219All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS DN 459276All SZGR 2.0 genes in this pathway
JAATINEN HEMATOPOIETIC STEM CELL UP 316190All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED UP 633376All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC DN 537339All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA UP 167All SZGR 2.0 genes in this pathway
GOZGIT ESR1 TARGETS UP 14984All SZGR 2.0 genes in this pathway
ENK UV RESPONSE EPIDERMIS DN 508354All SZGR 2.0 genes in this pathway
LANDIS BREAST CANCER PROGRESSION DN 7043All SZGR 2.0 genes in this pathway
DELYS THYROID CANCER DN 232154All SZGR 2.0 genes in this pathway
LINDGREN BLADDER CANCER CLUSTER 1 UP 12171All SZGR 2.0 genes in this pathway
LANDIS ERBB2 BREAST PRENEOPLASTIC DN 5533All SZGR 2.0 genes in this pathway
LANDIS ERBB2 BREAST TUMORS 324 DN 14993All SZGR 2.0 genes in this pathway
HU ANGIOGENESIS DN 3725All SZGR 2.0 genes in this pathway
HERNANDEZ ABERRANT MITOSIS BY DOCETACEL 4NM DN 76All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 DN 855609All SZGR 2.0 genes in this pathway
LIEN BREAST CARCINOMA METAPLASTIC VS DUCTAL UP 8351All SZGR 2.0 genes in this pathway
WANG RESPONSE TO BEXAROTENE DN 2919All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS DN 848527All SZGR 2.0 genes in this pathway
BUYTAERT PHOTODYNAMIC THERAPY STRESS UP 811508All SZGR 2.0 genes in this pathway
RICKMAN TUMOR DIFFERENTIATED WELL VS POORLY DN 382224All SZGR 2.0 genes in this pathway
GOTZMANN EPITHELIAL TO MESENCHYMAL TRANSITION DN 206136All SZGR 2.0 genes in this pathway
BENPORATH NANOG TARGETS 988594All SZGR 2.0 genes in this pathway
BENPORATH SOX2 TARGETS 734436All SZGR 2.0 genes in this pathway
STARK PREFRONTAL CORTEX 22Q11 DELETION UP 195138All SZGR 2.0 genes in this pathway
LE EGR2 TARGETS DN 10884All SZGR 2.0 genes in this pathway
NADLER OBESITY DN 4834All SZGR 2.0 genes in this pathway
LI WILMS TUMOR VS FETAL KIDNEY 1 UP 182119All SZGR 2.0 genes in this pathway
VERHAAK AML WITH NPM1 MUTATED DN 246180All SZGR 2.0 genes in this pathway
DEBIASI APOPTOSIS BY REOVIRUS INFECTION UP 314201All SZGR 2.0 genes in this pathway
GENTILE UV RESPONSE CLUSTER D4 5537All SZGR 2.0 genes in this pathway
WANG CISPLATIN RESPONSE AND XPC DN 228146All SZGR 2.0 genes in this pathway
GENTILE UV HIGH DOSE DN 312203All SZGR 2.0 genes in this pathway
SESTO RESPONSE TO UV C0 10772All SZGR 2.0 genes in this pathway
WELCSH BRCA1 TARGETS UP 198132All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 3D UP 210124All SZGR 2.0 genes in this pathway
BONOME OVARIAN CANCER SURVIVAL SUBOPTIMAL DEBULKING 510309All SZGR 2.0 genes in this pathway
LABBE TGFB1 TARGETS DN 10864All SZGR 2.0 genes in this pathway
LEE RECENT THYMIC EMIGRANT 227128All SZGR 2.0 genes in this pathway
HAN SATB1 TARGETS DN 442275All SZGR 2.0 genes in this pathway
CROONQUIST NRAS SIGNALING DN 7247All SZGR 2.0 genes in this pathway
VALK AML CLUSTER 10 3322All SZGR 2.0 genes in this pathway
VALK AML WITH EVI1 2515All SZGR 2.0 genes in this pathway
CHIANG LIVER CANCER SUBCLASS CTNNB1 UP 176110All SZGR 2.0 genes in this pathway
CHIANG LIVER CANCER SUBCLASS UNANNOTATED DN 193112All SZGR 2.0 genes in this pathway
YAGI AML WITH INV 16 TRANSLOCATION 422277All SZGR 2.0 genes in this pathway
YAGI AML WITH 11Q23 REARRANGED 351238All SZGR 2.0 genes in this pathway
ASGHARZADEH NEUROBLASTOMA POOR SURVIVAL DN 4630All SZGR 2.0 genes in this pathway
HOSHIDA LIVER CANCER SUBCLASS S2 11574All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS OLIGODENDROCYTE NUMBER CORR UP 756494All SZGR 2.0 genes in this pathway
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP 682440All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS CALB1 CORR UP 548370All SZGR 2.0 genes in this pathway
VERHAAK GLIOBLASTOMA NEURAL 12985All SZGR 2.0 genes in this pathway
BILANGES SERUM SENSITIVE VIA TSC1 2312All SZGR 2.0 genes in this pathway
FEVR CTNNB1 TARGETS UP 682433All SZGR 2.0 genes in this pathway
KOHOUTEK CCNT2 TARGETS 5835All SZGR 2.0 genes in this pathway
PHONG TNF RESPONSE NOT VIA P38 337236All SZGR 2.0 genes in this pathway
LIM MAMMARY STEM CELL UP 489314All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 1ST EGF PULSE ONLY 1839928All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-124/50616781684m8hsa-miR-506UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brainUAAGGCACGCGGUGAAUGCC
miR-18188941Ahsa-miR-181abrainAACAUUCAACGCUGUCGGUGAGU
hsa-miR-181bSZAACAUUCAUUGCUGUCGGUGGG
hsa-miR-181cbrainAACAUUCAACCUGUCGGUGAGU
hsa-miR-181dbrainAACAUUCAUUGUUGUCGGUGGGUU
miR-195495551Ahsa-miR-19aUGUGCAAAUCUAUGCAAAACUGA
hsa-miR-19bUGUGCAAAUCCAUGCAAAACUGA
miR-21818161822m8hsa-miR-218brainUUGUGCUUGAUCUAACCAUGU
miR-3204264331A,m8hsa-miR-320AAAAGCUGGGUUGAGAGGGCGAA
miR-3844784841Ahsa-miR-384AUUCCUAGAAAUUGUUCAUA
miR-4482652721A,m8hsa-miR-448UUGCAUAUGUAGGAUGUCCCAU
miR-485-3p174817551A,m8hsa-miR-485-3pGUCAUACACGGCUCUCCUCUCU