Gene Page: GRB7

Summary
GeneID  2886
Symbol  GRB7
Synonyms  -
Description  growth factor receptor-bound protein 7
See related  HGNC:4567|MIM:601522|Ensembl:ENSG00000141738|HPRD:03311|
Locus tag  -
Gene type  protein-coding
Map location  17q12
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0126 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
KCNB10.960.80
TRHDE0.960.89
DLGAP20.940.76
TMEM132D0.940.83
KCNMA10.920.84
SCN8A0.920.71
ATP2B20.920.74
EGR30.910.86
CREG20.910.86
DIRAS20.910.77
Top 10 negatively co-expressed genes
BCL7C-0.48-0.71
FADS2-0.45-0.47
RPL23A-0.44-0.65
C9orf46-0.43-0.59
TRAF4-0.43-0.61
SEMA4B-0.43-0.44
AC006276.2-0.42-0.50
RPLP1-0.42-0.62
GTF3C6-0.42-0.54
AC135586.1-0.41-0.54
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005070SH3/SH2 adaptor activityTAS9710451 
GO:0005515protein bindingIPI15806159 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007173epidermal growth factor receptor signaling pathwayTAS9710451 
GO:0007165signal transductionIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CALM1CALML2 | CAMI | DD132 | PHKDcalmodulin 1 (phosphorylase kinase, delta)Grb7 interacts with CaM. This interaction was modeled on a demonstrated interaction between human Grb7 and CaM from rat and an unspecified species.BIND15806159 
EGFRERBB | ERBB1 | HER1 | PIG61 | mENAepidermal growth factor receptor (erythroblastic leukemia viral (v-erb-b) oncogene homolog, avian)-HPRD9710451 
ERBB2CD340 | HER-2 | HER-2/neu | HER2 | NEU | NGL | TKR1v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian)-HPRD,BioGRID9079677 
ERBB3ErbB-3 | HER3 | LCCS2 | MDA-BF-1 | MGC88033 | c-erbB-3 | c-erbB3 | erbB3-S | p180-ErbB3 | p45-sErbB3 | p85-sErbB3v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)-HPRD,BioGRID9516479 
GRB2ASH | EGFRBP-GRB2 | Grb3-3 | MST084 | MSTP084growth factor receptor-bound protein 2-HPRD10377264 
INSRCD220 | HHF5insulin receptor-HPRD,BioGRID10803466 
KITC-Kit | CD117 | PBT | SCFRv-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog-HPRD,BioGRID10377264 
LY6G6FC6orf21 | G6f | LY6G6D | NG32lymphocyte antigen 6 complex, locus G6F-HPRD,BioGRID12852788 
PTK2FADK | FAK | FAK1 | pp125FAKPTK2 protein tyrosine kinase 2-HPRD,BioGRID10446223 
RETCDHF12 | HSCR1 | MEN2A | MEN2B | MTC1 | PTC | RET-ELE1 | RET51ret proto-oncogene-HPRD,BioGRID8631863 
RND1ARHS | FLJ42294 | RHO6 | RHOSRho family GTPase 1-HPRD,BioGRID10664463 
SFNYWHASstratifinAffinity Capture-MSBioGRID15778465 
TEKCD202B | TIE-2 | TIE2 | VMCM | VMCM1TEK tyrosine kinase, endothelial-HPRD10521483 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
ST_INTEGRIN_SIGNALING_PATHWAY 8262All SZGR genes in this pathway
PID_EPHB_FWD_PATHWAY 4038All SZGR genes in this pathway
PID_RET_PATHWAY 3929All SZGR genes in this pathway
PID_ANGIOPOIETIN_RECEPTOR_PATHWAY 5041All SZGR genes in this pathway
PID_FAK_PATHWAY 5945All SZGR genes in this pathway
REACTOME_SIGNALING_BY_SCF_KIT 7859All SZGR genes in this pathway
REACTOME_SIGNALING_BY_ERBB2 10178All SZGR genes in this pathway
REACTOME_CELL_SURFACE_INTERACTIONS_AT_THE_VASCULAR_WALL 9165All SZGR genes in this pathway
REACTOME_TIE2_SIGNALING 1713All SZGR genes in this pathway
REACTOME_SIGNALING_BY_PDGF 12293All SZGR genes in this pathway
REACTOME_DOWNSTREAM_SIGNAL_TRANSDUCTION 9576All SZGR genes in this pathway
REACTOME_HEMOSTASIS 466331All SZGR genes in this pathway
LIU_SOX4_TARGETS_DN 309191All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_UP 450256All SZGR genes in this pathway
BASAKI_YBX1_TARGETS_DN 384230All SZGR genes in this pathway
DELYS_THYROID_CANCER_UP 443294All SZGR genes in this pathway
BARIS_THYROID_CANCER_DN 5945All SZGR genes in this pathway
FARMER_BREAST_CANCER_CLUSTER_8 77All SZGR genes in this pathway
GRUETZMANN_PANCREATIC_CANCER_DN 203134All SZGR genes in this pathway
SIMBULAN_UV_RESPONSE_NORMAL_DN 3327All SZGR genes in this pathway
KIM_MYCN_AMPLIFICATION_TARGETS_DN 10359All SZGR genes in this pathway
BERTUCCI_INVASIVE_CARCINOMA_DUCTAL_VS_LOBULAR_UP 2517All SZGR genes in this pathway
MORI_PRE_BI_LYMPHOCYTE_UP 8054All SZGR genes in this pathway
NIKOLSKY_BREAST_CANCER_17Q11_Q21_AMPLICON 13378All SZGR genes in this pathway
JECHLINGER_EPITHELIAL_TO_MESENCHYMAL_TRANSITION_DN 6647All SZGR genes in this pathway
HALMOS_CEBPA_TARGETS_DN 4626All SZGR genes in this pathway
BANDRES_RESPONSE_TO_CARMUSTIN_MGMT_48HR_DN 161105All SZGR genes in this pathway
GAVIN_FOXP3_TARGETS_CLUSTER_P3 160103All SZGR genes in this pathway
SMID_BREAST_CANCER_ERBB2_UP 14783All SZGR genes in this pathway
GRADE_COLON_CANCER_UP 871505All SZGR genes in this pathway
MUELLER_PLURINET 299189All SZGR genes in this pathway
VART_KSHV_INFECTION_ANGIOGENIC_MARKERS_UP 165118All SZGR genes in this pathway
HOFFMANN_PRE_BI_TO_LARGE_PRE_BII_LYMPHOCYTE_DN 7561All SZGR genes in this pathway
COULOUARN_TEMPORAL_TGFB1_SIGNATURE_UP 10968All SZGR genes in this pathway
YAMASHITA_LIVER_CANCER_STEM_CELL_UP 4738All SZGR genes in this pathway
MIKKELSEN_MEF_ICP_WITH_H3K27ME3 206108All SZGR genes in this pathway
LOPEZ_EPITHELIOID_MESOTHELIOMA 1711All SZGR genes in this pathway
MIKKELSEN_ES_ICP_WITH_H3K4ME3 718401All SZGR genes in this pathway
MARTENS_TRETINOIN_RESPONSE_UP 857456All SZGR genes in this pathway
DUTERTRE_ESTRADIOL_RESPONSE_6HR_DN 9156All SZGR genes in this pathway
DUTERTRE_ESTRADIOL_RESPONSE_24HR_DN 505328All SZGR genes in this pathway
DELPUECH_FOXO3_TARGETS_UP 6849All SZGR genes in this pathway
LEE_BMP2_TARGETS_UP 745475All SZGR genes in this pathway
LIM_MAMMARY_STEM_CELL_DN 428246All SZGR genes in this pathway
ZWANG_EGF_INTERVAL_DN 214124All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-193332338m8hsa-miR-193aAACUGGCCUACAAAGUCCCAG
hsa-miR-193bAACUGGCCCUCAAAGUCCCGCUUU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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