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| GeneID |
2900
|
| Symbol |
GRIK4
|
| Synonyms |
EAA1|GRIK|KA1
|
| Description |
glutamate receptor, ionotropic, kainate 4 |
| See related |
HGNC:4582|MIM:600282|Ensembl:ENSG00000149403|HPRD:02613| |
| Locus tag |
- |
| Gene type |
protein-coding |
| Map location |
11q22.3 |
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| Gene set name |
Method of gene set |
Evidence |
Info |
| Association | A combined odds ratio method (Sun et al. 2008), association studies | 1 | Link to SZGene | | GSMA_I | genome scan meta-analysis | Psr: 0.006 | | | Literature | High-throughput literature-search | Co-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia] | Click to show detail | | GO_Annotation | Mapping neuro-related keywords to Gene Ontology annotations | Hits with neuro-related keywords: 7 | | | Network | Shortest path distance of core genes in the Human protein-protein interaction network | Contribution to shortest path in PPI network: 31 | |
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| General Gene Expression (microarray) ? |
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| Gene Expression in Brain Regions (new) |
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| Top co-expressed genes in Brain Regions (new) |
|
| Gene | Pearson's Correlation | Spearman's Correlation | | |
| Top 10 positively co-expressed genes |
| PCDHA13 | 0.87 | 0.88 | | |
| MYO16 | 0.86 | 0.86 | | |
| PCDHAC1 | 0.84 | 0.83 | | |
| PCDHA1 | 0.83 | 0.85 | | |
| CXXC4 | 0.80 | 0.85 | | |
| GNAZ | 0.79 | 0.84 | | |
| CHN2 | 0.79 | 0.87 | | |
| AC079061.1 | 0.79 | 0.88 | | |
| HMGCS1 | 0.78 | 0.82 | | |
| C12orf68 | 0.78 | 0.80 | | |
Top 10 negatively co-expressed genes | | MT-CO2 | -0.56 | -0.62 | | |
| AF347015.31 | -0.56 | -0.60 | | |
| AF347015.33 | -0.56 | -0.58 | | |
| AC021016.1 | -0.55 | -0.61 | | |
| FXYD1 | -0.55 | -0.55 | | |
| AF347015.27 | -0.55 | -0.57 | | |
| AF347015.8 | -0.54 | -0.61 | | |
| AF347015.2 | -0.54 | -0.61 | | |
| MT-CYB | -0.54 | -0.58 | | |
| S100B | -0.53 | -0.54 | | |
|
| Molecular function | GO term | Evidence | Neuro keywords | PubMed ID |
|---|
| GO:0005234 | extracellular-glutamate-gated ion channel activity | IEA | glutamate (GO term level: 11) | - |
| GO:0015277 | kainate selective glutamate receptor activity | TAS | glutamate (GO term level: 8) | 8263508 |
| GO:0004872 | receptor activity | IEA | | - |
| GO:0005515 | protein binding | IEA | | - |
| GO:0005216 | ion channel activity | IEA | | - |
| Biological process | GO term | Evidence | Neuro keywords | PubMed ID |
|---|
| GO:0007268 | synaptic transmission | TAS | neuron, Synap, Neurotransmitter (GO term level: 6) | 8263508 |
| GO:0007215 | glutamate signaling pathway | TAS | glutamate (GO term level: 7) | 8263508 |
| GO:0006811 | ion transport | IEA | | - |
| Cellular component | GO term | Evidence | Neuro keywords | PubMed ID |
|---|
| GO:0042734 | presynaptic membrane | IEA | neuron, axon, Synap (GO term level: 5) | - |
| GO:0032983 | kainate selective glutamate receptor complex | IEA | glutamate (GO term level: 10) | - |
| GO:0045211 | postsynaptic membrane | IEA | Synap, Neurotransmitter (GO term level: 5) | - |
| GO:0045202 | synapse | IEA | neuron, Synap, Neurotransmitter, Glial (GO term level: 2) | - |
| GO:0005624 | membrane fraction | IEA | | - |
| GO:0005886 | plasma membrane | IEA | | - |
| GO:0005887 | integral to plasma membrane | TAS | | 8263508 |
| GO:0030054 | cell junction | IEA | | - |
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