SZGR2

Summary ?

GeneID	3303
Symbol	HSPA1A
Synonyms	HEL-S-103\|HSP70-1\|HSP70-1A\|HSP70.1\|HSP70I\|HSP72\|HSPA1
Description	heat shock protein family A (Hsp70) member 1A
Reference	MIM:140550\|HGNC:HGNC:5232\|Ensembl:ENSG00000204389\|HPRD:00774\|Vega:OTTHUMG00000031201
Gene type	protein-coding
Map location	6p21.3
Pascal p-value	1E-12
Sherlock p-value	0.748
Fetal beta	-0.325
eGene	Myers' cis & trans

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
DMG:Wockner_2014	Genome-wide DNA methylation analysis	This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24).	1
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
GSMA_I	Genome scan meta-analysis	Psr: 0.033
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenias	Click to show details
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 0.183

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg11485463	6	31783240	HSPA1A;HSPA1L	2.689E-4	-0.368	0.038	DMG:Wockner_2014

eQTL annotation

SNP ID	Chromosome	Position	eGene	Gene Entrez ID	qvalue	eQTL type
rs1879328	chr3	46568156	HSPA1A	3303	0.04	trans
rs7706288	chr5	141864248	HSPA1A	3303	0.15	trans
rs10842557		0	HSPA1A	3303	0.17	trans
rs35452	chr12	115539199	HSPA1A	3303	0.02	trans
rs16965683	chr15	38115683	HSPA1A	3303	0.09	trans
rs7215675	chr17	10905819	HSPA1A	3303	0.07	trans
rs2073206	chr20	948279	HSPA1A	3303	0.08	trans
rs8120542	chr20	24395092	HSPA1A	3303	0.19	trans
rs8114637	chr20	24395207	HSPA1A	3303	0.19	trans
rs9974024	chr20	24397274	HSPA1A	3303	0.19	trans
rs6515493	chr20	24401635	HSPA1A	3303	0.19	trans
rs6049703	chr20	24432425	HSPA1A	3303	0	trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0000166	nucleotide binding	IEA		-
GO:0005515	protein binding	IPI		15735003
GO:0005524	ATP binding	IEA		-
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0006950	response to stress	IEA		-

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
AIFM1	AIF \| MGC111425 \| PDCD8	apoptosis-inducing factor, mitochondrion-associated, 1	-	HPRD,BioGRID	11533664
APAF1	CED4 \| DKFZp781B1145	apoptotic peptidase activating factor 1	-	HPRD	10934467
APEX1	APE \| APE-1 \| APE1 \| APEN \| APEX \| APX \| HAP1 \| REF-1 \| REF1	APEX nuclease (multifunctional DNA repair enzyme) 1	-	HPRD	11133992
APOB	FLDB	apolipoprotein B (including Ag(x) antigen)	-	HPRD	9252351
AR	AIS \| DHTR \| HUMARA \| KD \| NR3C4 \| SBMA \| SMAX1 \| TFM	androgen receptor	Affinity Capture-Western	BioGRID	1540595
BAG1	RAP46	BCL2-associated athanogene	Reconstituted Complex	BioGRID	14517289
BAG2	BAG-2 \| KIAA0576 \| MGC149462 \| dJ417I1.2	BCL2-associated athanogene 2	-	HPRD	9873016
BAG3	BAG-3 \| BIS \| CAIR-1 \| MGC104307	BCL2-associated athanogene 3	-	HPRD,BioGRID	9873016\|10980614
BAG4	BAG-4 \| SODD	BCL2-associated athanogene 4	-	HPRD,BioGRID	11527400
BAT3	BAG-6 \| BAG6 \| D6S52E \| G3	HLA-B associated transcript 3	in vivo	BioGRID	11230127
BCL2	Bcl-2	B-cell CLL/lymphoma 2	-	HPRD,BioGRID	10354271
CDK9	C-2k \| CDC2L4 \| CTK1 \| PITALRE \| TAK	cyclin-dependent kinase 9	-	HPRD,BioGRID	10617616
CUL4A	-	cullin 4A	Affinity Capture-MS	BioGRID	12481031
DNAJB1	HSPF1 \| Hdj1 \| Hsp40 \| Sis1	DnaJ (Hsp40) homolog, subfamily B, member 1	-	HPRD	10593983
DNAJB11	ABBP-2 \| ABBP2 \| DJ9 \| EDJ \| ERdj3 \| ERj3 \| HEDJ \| PRO1080 \| UNQ537 \| hDj9	DnaJ (Hsp40) homolog, subfamily B, member 11	-	HPRD	11584023
EIF2AK1	HCR \| HRI \| KIAA1369	eukaryotic translation initiation factor 2-alpha kinase 1	in vivo	BioGRID	12149123
EIF2AK2	EIF2AK1 \| MGC126524 \| PKR \| PRKR	eukaryotic translation initiation factor 2-alpha kinase 2	-	HPRD	12397061
FANCC	FA3 \| FAC \| FACC \| FLJ14675	Fanconi anemia, complementation group C	Affinity Capture-Western Two-hybrid	BioGRID	12397061 \|14499622
FANCC	FA3 \| FAC \| FACC \| FLJ14675	Fanconi anemia, complementation group C	-	HPRD	11500375 \|12397061
GRIN1	NMDA1 \| NMDAR1 \| NR1	glutamate receptor, ionotropic, N-methyl D-aspartate 1	-	HPRD	10862698
HSF1	HSTF1	heat shock transcription factor 1	-	HPRD,BioGRID	9699716
HSF2	MGC117376 \| MGC156196 \| MGC75048	heat shock transcription factor 2	HSF2 interacts with hsp70i promoter.	BIND	15662014
HSP90AA1	FLJ31884 \| HSP86 \| HSP89A \| HSP90A \| HSP90N \| HSPC1 \| HSPCA \| HSPCAL1 \| HSPCAL4 \| HSPN \| Hsp89 \| Hsp90 \| LAP2	heat shock protein 90kDa alpha (cytosolic), class A member 1	Reconstituted Complex	BioGRID	12093808
HSPBP1	-	hsp70-interacting protein	-	HPRD	9830037
IKBKG	AMCBX1 \| FIP-3 \| FIP3 \| Fip3p \| IKK-gamma \| IP \| IP1 \| IP2 \| IPD2 \| NEMO	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma	Reconstituted Complex	BioGRID	11877453
KRT7	CK7 \| K2C7 \| K7 \| MGC129731 \| MGC3625 \| SCL	keratin 7	-	HPRD	11888936
MAP3K5	ASK1 \| MAPKKK5 \| MEKK5	mitogen-activated protein kinase kinase kinase 5	-	HPRD,BioGRID	12391142
MAP3K7IP2	FLJ21885 \| KIAA0733 \| TAB2	mitogen-activated protein kinase kinase kinase 7 interacting protein 2	-	HPRD	14743216
MSR1	CD204 \| SCARA1 \| SR-A \| phSR1 \| phSR2	macrophage scavenger receptor 1	-	HPRD,BioGRID	11785981
NQO1	DHQU \| DIA4 \| DTD \| NMOR1 \| NMORI \| QR1	NAD(P)H dehydrogenase, quinone 1	-	HPRD	11821413
NR3C1	GCCR \| GCR \| GR \| GRL	nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)	-	HPRD,BioGRID	12093808
PEX5	FLJ50634 \| FLJ50721 \| FLJ51948 \| PTS1-BP \| PTS1R \| PXR1	peroxisomal biogenesis factor 5	-	HPRD	11415446
PPP1R15A	GADD34	protein phosphatase 1, regulatory (inhibitor) subunit 15A	-	HPRD	12724406
PTMA	MGC104802 \| TMSA	prothymosin, alpha	-	HPRD	11310559
RBX1	BA554C12.1 \| MGC13357 \| MGC1481 \| RNF75 \| ROC1	ring-box 1	Affinity Capture-MS	BioGRID	12481031
RHOA	ARH12 \| ARHA \| RHO12 \| RHOH12	ras homolog gene family, member A	Affinity Capture-Western	BioGRID	12490434
SLC5A1	D22S675 \| NAGT \| SGLT1	solute carrier family 5 (sodium/glucose cotransporter), member 1	-	HPRD,BioGRID	12082088
SOX9	CMD1 \| CMPD1 \| SRA1	SRY (sex determining region Y)-box 9	-	HPRD,BioGRID	11356186
ST13	AAG2 \| FAM10A1 \| FAM10A4 \| FLJ27260 \| HIP \| HOP \| HSPABP \| HSPABP1 \| MGC129952 \| P48 \| PRO0786 \| SNC6	suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein)	in vivo	BioGRID	8887650
STIP1	HOP \| IEF-SSP-3521 \| P60 \| STI1 \| STI1L	stress-induced-phosphoprotein 1	-	HPRD	12161444
STUB1	CHIP \| HSPABP2 \| NY-CO-7 \| SDCCAG7 \| UBOX1	STIP1 homology and U-box containing protein 1	-	HPRD,BioGRID	10330192
TCERG1	CA150 \| MGC133200 \| TAF2S	transcription elongation regulator 1	-	HPRD	15456888
TOMM70A	FLJ90470	translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)	-	HPRD	12526792
TP53	FLJ92943 \| LFS1 \| TRP53 \| p53	tumor protein p53	-	HPRD	7811761
TRIM24	PTC6 \| RNF82 \| TF1A \| TIF1 \| TIF1A \| TIF1ALPHA \| hTIF1	tripartite motif-containing 24	-	HPRD	12677068
TTC1	FLJ46404 \| TPR1	tetratricopeptide repeat domain 1	-	HPRD	14503850

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG SPLICEOSOME	128	72	All SZGR 2.0 genes in this pathway
KEGG MAPK SIGNALING PATHWAY	267	205	All SZGR 2.0 genes in this pathway
KEGG ENDOCYTOSIS	183	132	All SZGR 2.0 genes in this pathway
KEGG ANTIGEN PROCESSING AND PRESENTATION	89	65	All SZGR 2.0 genes in this pathway
KEGG PRION DISEASES	35	28	All SZGR 2.0 genes in this pathway
BIOCARTA TID PATHWAY	19	15	All SZGR 2.0 genes in this pathway
BIOCARTA P53HYPOXIA PATHWAY	23	21	All SZGR 2.0 genes in this pathway
BIOCARTA PPARA PATHWAY	58	43	All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE LIVE UP	485	293	All SZGR 2.0 genes in this pathway
SAMOLS TARGETS OF KHSV MIRNAS DN	62	35	All SZGR 2.0 genes in this pathway
NOJIMA SFRP2 TARGETS UP	31	23	All SZGR 2.0 genes in this pathway
GARGALOVIC RESPONSE TO OXIDIZED PHOSPHOLIPIDS BLUE UP	136	80	All SZGR 2.0 genes in this pathway
HOEBEKE LYMPHOID STEM CELL DN	86	59	All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE FIMA UP	544	308	All SZGR 2.0 genes in this pathway
ZHOU INFLAMMATORY RESPONSE LPS UP	431	237	All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS DN	459	276	All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS 8HR UP	164	122	All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS 12HR UP	162	116	All SZGR 2.0 genes in this pathway
MARKEY RB1 CHRONIC LOF UP	115	78	All SZGR 2.0 genes in this pathway
CONCANNON APOPTOSIS BY EPOXOMICIN UP	239	157	All SZGR 2.0 genes in this pathway
BARRIER CANCER RELAPSE NORMAL SAMPLE DN	31	19	All SZGR 2.0 genes in this pathway
VETTER TARGETS OF PRKCA AND ETS1 DN	16	10	All SZGR 2.0 genes in this pathway
MAHADEVAN RESPONSE TO MP470 DN	19	11	All SZGR 2.0 genes in this pathway
DAUER STAT3 TARGETS DN	50	34	All SZGR 2.0 genes in this pathway
DACOSTA UV RESPONSE VIA ERCC3 UP	309	199	All SZGR 2.0 genes in this pathway
WOOD EBV EBNA1 TARGETS UP	110	71	All SZGR 2.0 genes in this pathway
STANHILL HRAS TRANSFROMATION UP	8	5	All SZGR 2.0 genes in this pathway
WEI MYCN TARGETS WITH E BOX	795	478	All SZGR 2.0 genes in this pathway
FUJIWARA PARK2 HEPATOCYTE PROLIFERATION UP	10	8	All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 12HR UP	116	79	All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 48HR DN	428	306	All SZGR 2.0 genes in this pathway
DEN INTERACT WITH LCA5	26	21	All SZGR 2.0 genes in this pathway
BENPORATH EED TARGETS	1062	725	All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3	1118	744	All SZGR 2.0 genes in this pathway
CERVERA SDHB TARGETS 1 DN	38	22	All SZGR 2.0 genes in this pathway
UEDA CENTRAL CLOCK	88	62	All SZGR 2.0 genes in this pathway
LAMB CCND1 TARGETS	19	14	All SZGR 2.0 genes in this pathway
MENSSEN MYC TARGETS	53	35	All SZGR 2.0 genes in this pathway
BROCKE APOPTOSIS REVERSED BY IL6	144	98	All SZGR 2.0 genes in this pathway
LEI MYB TARGETS	318	215	All SZGR 2.0 genes in this pathway
GERY CEBP TARGETS	126	90	All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS EARLY PROGENITOR	532	309	All SZGR 2.0 genes in this pathway
GENTILE UV LOW DOSE UP	27	19	All SZGR 2.0 genes in this pathway
WANG SMARCE1 TARGETS DN	371	218	All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS 2 DN	830	547	All SZGR 2.0 genes in this pathway
KAYO AGING MUSCLE UP	244	165	All SZGR 2.0 genes in this pathway
CUI TCF21 TARGETS DN	31	23	All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 8HR UP	105	73	All SZGR 2.0 genes in this pathway
ZHU CMV ALL UP	120	89	All SZGR 2.0 genes in this pathway
DELLA RESPONSE TO TSA AND BUTYRATE	21	17	All SZGR 2.0 genes in this pathway
SATO SILENCED EPIGENETICALLY IN PANCREATIC CANCER	49	30	All SZGR 2.0 genes in this pathway
MOREIRA RESPONSE TO TSA UP	28	23	All SZGR 2.0 genes in this pathway
ZHANG ANTIVIRAL RESPONSE TO RIBAVIRIN UP	30	21	All SZGR 2.0 genes in this pathway
SESTO RESPONSE TO UV C0	107	72	All SZGR 2.0 genes in this pathway
ZHU CMV 24 HR UP	93	65	All SZGR 2.0 genes in this pathway
YIH RESPONSE TO ARSENITE C1	24	14	All SZGR 2.0 genes in this pathway
HELLER SILENCED BY METHYLATION UP	282	183	All SZGR 2.0 genes in this pathway
HELLER SILENCED BY METHYLATION DN	105	67	All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS DN	292	189	All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION UP	461	298	All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION DN	281	179	All SZGR 2.0 genes in this pathway
COATES MACROPHAGE M1 VS M2 DN	78	44	All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 3D DN	270	181	All SZGR 2.0 genes in this pathway
HANN RESISTANCE TO BCL2 INHIBITOR DN	48	31	All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER UP	973	570	All SZGR 2.0 genes in this pathway
ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE UP	863	514	All SZGR 2.0 genes in this pathway
MISHRA CARCINOMA ASSOCIATED FIBROBLAST DN	24	13	All SZGR 2.0 genes in this pathway
LIN NPAS4 TARGETS UP	163	100	All SZGR 2.0 genes in this pathway
CADWELL ATG16L1 TARGETS DN	70	43	All SZGR 2.0 genes in this pathway
KRISHNAN FURIN TARGETS UP	12	6	All SZGR 2.0 genes in this pathway
YAUCH HEDGEHOG SIGNALING PARACRINE UP	149	85	All SZGR 2.0 genes in this pathway
MOOTHA HUMAN MITODB 6 2002	429	260	All SZGR 2.0 genes in this pathway
VANASSE BCL2 TARGETS UP	40	25	All SZGR 2.0 genes in this pathway
YAGI AML WITH INV 16 TRANSLOCATION	422	277	All SZGR 2.0 genes in this pathway
KUROKAWA LIVER CANCER EARLY RECURRENCE UP	12	9	All SZGR 2.0 genes in this pathway
TIAN TNF SIGNALING NOT VIA NFKB	22	16	All SZGR 2.0 genes in this pathway
WONG ADULT TISSUE STEM MODULE	721	492	All SZGR 2.0 genes in this pathway
CHANDRAN METASTASIS UP	221	135	All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 5	30	22	All SZGR 2.0 genes in this pathway
DASU IL6 SIGNALING UP	59	44	All SZGR 2.0 genes in this pathway
WANG RESPONSE TO GSK3 INHIBITOR SB216763 DN	374	217	All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 2 DN	336	211	All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP B	549	316	All SZGR 2.0 genes in this pathway
DALESSIO TSA RESPONSE	29	16	All SZGR 2.0 genes in this pathway
PHONG TNF RESPONSE NOT VIA P38	337	236	All SZGR 2.0 genes in this pathway
SMIRNOV RESPONSE TO IR 2HR DN	55	35	All SZGR 2.0 genes in this pathway

Gene Page: HSPA1A