SZGR2

Summary ?

GeneID	3654
Symbol	IRAK1
Synonyms	IRAK\|pelle
Description	interleukin 1 receptor associated kinase 1
Reference	MIM:300283\|HGNC:HGNC:6112\|Ensembl:ENSG00000184216\|HPRD:02235\|Vega:OTTHUMG00000024228
Gene type	protein-coding
Map location	Xq28
Sherlock p-value	0.276
Fetal beta	-0.324
Support	Potential synaptic genes

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
CV:PGCnp	Genome-wide Association Study	GWAS
PMID:cooccur	High-throughput literature-search	Systematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
Expression	Meta-analysis of gene expression	P value: 1.59
Literature	High-throughput literature-search	Co-occurance with Schizophrenia keywords: schizophrenia,schizophrenias	Click to show details
Network	Shortest path distance of core genes in the Human protein-protein interaction network	Contribution to shortest path in PPI network: 0.2114

Section I. Genetics and epigenetics annotation

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
ACSS1	0.84	0.87
RYR1	0.82	0.87
PRODH	0.82	0.81
PBXIP1	0.82	0.88
SCARA3	0.81	0.87
LRP10	0.81	0.86
SFXN5	0.80	0.86
LAMB2	0.80	0.83
TPCN1	0.80	0.83
GPR37L1	0.80	0.81

Top 10 negatively co-expressed genes
Gene	Pearson's Correlation	Spearman's Correlation
MED19	-0.59	-0.66
POLB	-0.58	-0.67
STMN1	-0.58	-0.64
FRG1	-0.57	-0.65
C11orf57	-0.57	-0.68
ASNSD1	-0.56	-0.62
MRPL44	-0.56	-0.66
BTF3L4	-0.56	-0.62
UBE2D2	-0.56	-0.59
COQ3	-0.56	-0.62

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0000166	nucleotide binding	IEA		-
GO:0000287	magnesium ion binding	IEA		-
GO:0004872	receptor activity	IEA		-
GO:0004704	NF-kappaB-inducing kinase activity	TAS		8599092
GO:0005149	interleukin-1 receptor binding	IEA		-
GO:0005515	protein binding	IEA		-
GO:0005524	ATP binding	IEA		-
GO:0004674	protein serine/threonine kinase activity	IEA		-
GO:0004674	protein serine/threonine kinase activity	NAS		11397809
GO:0016740	transferase activity	IEA		-
GO:0016563	transcription activator activity	NAS		11397809
GO:0042803	protein homodimerization activity	NAS		11397809
GO:0019901	protein kinase binding	ISS		-
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0007178	transmembrane receptor protein serine/threonine kinase signaling pathway	NAS		11397809
GO:0006468	protein amino acid phosphorylation	IEA		-
GO:0007250	activation of NF-kappaB-inducing kinase activity	IDA		11397809
GO:0007165	signal transduction	IEA		-
GO:0007165	signal transduction	NAS		10854325
GO:0032496	response to lipopolysaccharide	IEA		-
GO:0051259	protein oligomerization	IMP		16831874
GO:0019221	cytokine-mediated signaling pathway	IEA		-
GO:0031663	lipopolysaccharide-mediated signaling pathway	IEA		-
GO:0045941	positive regulation of transcription	NAS		11397809
GO:0046777	protein amino acid autophosphorylation	NAS		11397809
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005829	cytosol	EXP		10465784 \|12138165 \|14625308 \|16024789
GO:0045323	interleukin-1 receptor complex	NAS		10854325

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
AKT1	AKT \| MGC99656 \| PKB \| PKB-ALPHA \| PRKBA \| RAC \| RAC-ALPHA	v-akt murine thymoma viral oncogene homolog 1	-	HPRD,BioGRID	11976320
CHUK	IKBKA \| IKK-alpha \| IKK1 \| IKKA \| NFKBIKA \| TCF16	conserved helix-loop-helix ubiquitous kinase	Affinity Capture-Western	BioGRID	11096118
FADD	GIG3 \| MGC8528 \| MORT1	Fas (TNFRSF6)-associated via death domain	-	HPRD,BioGRID	11828002
HRAS	C-BAS/HAS \| C-H-RAS \| C-HA-RAS1 \| CTLO \| H-RASIDX \| HAMSV \| HRAS1 \| K-RAS \| N-RAS \| RASH1	v-Ha-ras Harvey rat sarcoma viral oncogene homolog	-	HPRD	11744690
IKBKB	FLJ40509 \| IKK-beta \| IKK2 \| IKKB \| MGC131801 \| NFKBIKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta	Affinity Capture-Western	BioGRID	11096118
IL1RAP	C3orf13 \| FLJ37788 \| IL-1RAcP \| IL1R3	interleukin 1 receptor accessory protein	-	HPRD,BioGRID	9371760
IRAK1	IRAK \| pelle	interleukin-1 receptor-associated kinase 1	IRAK interacts with itself and also autophosphorylates.	BIND	10383454
IRAK1BP1	AIP70 \| MGC138458 \| MGC138460 \| SIMPL	interleukin-1 receptor-associated kinase 1 binding protein 1	-	HPRD,BioGRID	11096118
IRAK2	IRAK-2 \| MGC150550	interleukin-1 receptor-associated kinase 2	IRAK interacts with IRAK-2 and forms a heterocomplex.	BIND	10383454
IRAK3	ASRT5 \| IRAK-M \| IRAKM	interleukin-1 receptor-associated kinase 3	IRAK interacts with IRAK-M and forms a heterocomplex.	BIND	10383454
IRAK4	IPD1 \| NY-REN-64 \| REN64	interleukin-1 receptor-associated kinase 4	-	HPRD,BioGRID	11960013
ITGAM	CD11B \| CR3A \| MAC-1 \| MAC1A \| MGC117044 \| MO1A \| SLEB6	integrin, alpha M (complement component 3 receptor 3 subunit)	-	HPRD,BioGRID	11701612
MAP3K7IP2	FLJ21885 \| KIAA0733 \| TAB2	mitogen-activated protein kinase kinase kinase 7 interacting protein 2	-	HPRD	11518704
MYD88	MYD88D	myeloid differentiation primary response gene (88)	IRAK does not interact with MyD88, whilst the kinase inactive mutant IRAK[Lys239Ser] does interact.	BIND	10383454
MYD88	MYD88D	myeloid differentiation primary response gene (88)	-	HPRD	10854325
MYD88	MYD88D	myeloid differentiation primary response gene (88)	Affinity Capture-Western	BioGRID	10383454 \|11976320
NTRK3	TRKC \| gp145(trkC)	neurotrophic tyrosine kinase, receptor, type 3	-	HPRD	12034707
PELI2	-	pellino homolog 2 (Drosophila)	-	HPRD	12370331
PELI2	-	pellino homolog 2 (Drosophila)	IRAK1 interacts with and phosphorylates PELI2.	BIND	12860405
PELI3	MGC35521	pellino homolog 3 (Drosophila)	-	HPRD	12874243
PRKCZ	PKC-ZETA \| PKC2	protein kinase C, zeta	-	HPRD,BioGRID	11937546
SIGIRR	MGC110992 \| TIR8	single immunoglobulin and toll-interleukin 1 receptor (TIR) domain	-	HPRD,BioGRID	12925853
SQSTM1	A170 \| OSIL \| PDB3 \| ZIP3 \| p60 \| p62 \| p62B	sequestosome 1	-	HPRD	12034707
SQSTM1	A170 \| OSIL \| PDB3 \| ZIP3 \| p60 \| p62 \| p62B	sequestosome 1	Affinity Capture-Western	BioGRID	10747026
TICAM2	MGC129876 \| MGC129877 \| TICAM-2 \| TIRAP3 \| TIRP \| TRAM	toll-like receptor adaptor molecule 2	-	HPRD	12721283
TIFA	MGC20791 \| T2BP \| T6BP \| TIFAA	TRAF-interacting protein with forkhead-associated domain	-	HPRD,BioGRID	12566447
TLR2	CD282 \| TIL4	toll-like receptor 2	-	HPRD,BioGRID	10395652
TOLLIP	FLJ33531 \| IL-1RAcPIP	toll interacting protein	-	HPRD,BioGRID	10854325
TRAF6	MGC:3310 \| RNF85	TNF receptor-associated factor 6	TRAF6 interacts with IRAK1. This interaction was modeled on a demonstrated interaction between TRAF6 and IRAK1, both from unspecified species.	BIND	15894263
TRAF6	MGC:3310 \| RNF85	TNF receptor-associated factor 6	-	HPRD,BioGRID	8837778

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
KEGG APOPTOSIS	88	62	All SZGR 2.0 genes in this pathway
KEGG TOLL LIKE RECEPTOR SIGNALING PATHWAY	102	88	All SZGR 2.0 genes in this pathway
KEGG NEUROTROPHIN SIGNALING PATHWAY	126	103	All SZGR 2.0 genes in this pathway
KEGG LEISHMANIA INFECTION	72	56	All SZGR 2.0 genes in this pathway
BIOCARTA GSK3 PATHWAY	27	26	All SZGR 2.0 genes in this pathway
BIOCARTA NFKB PATHWAY	23	19	All SZGR 2.0 genes in this pathway
BIOCARTA IL1R PATHWAY	33	29	All SZGR 2.0 genes in this pathway
BIOCARTA TOLL PATHWAY	37	31	All SZGR 2.0 genes in this pathway
PID IL1 PATHWAY	34	28	All SZGR 2.0 genes in this pathway
PID P75 NTR PATHWAY	69	51	All SZGR 2.0 genes in this pathway
PID TOLL ENDOGENOUS PATHWAY	25	19	All SZGR 2.0 genes in this pathway
REACTOME SIGNALLING BY NGF	217	167	All SZGR 2.0 genes in this pathway
REACTOME TRIF MEDIATED TLR3 SIGNALING	74	54	All SZGR 2.0 genes in this pathway
REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES	12	8	All SZGR 2.0 genes in this pathway
REACTOME P75NTR SIGNALS VIA NFKB	14	10	All SZGR 2.0 genes in this pathway
REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL	11	8	All SZGR 2.0 genes in this pathway
REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING	81	61	All SZGR 2.0 genes in this pathway
REACTOME TAK1 ACTIVATES NFKB BY PHOSPHORYLATION AND ACTIVATION OF IKKS COMPLEX	23	17	All SZGR 2.0 genes in this pathway
REACTOME MAP KINASE ACTIVATION IN TLR CASCADE	50	37	All SZGR 2.0 genes in this pathway
REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1	16	9	All SZGR 2.0 genes in this pathway
REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION	18	12	All SZGR 2.0 genes in this pathway
REACTOME SIGNALING BY ILS	107	86	All SZGR 2.0 genes in this pathway
REACTOME IL1 SIGNALING	39	30	All SZGR 2.0 genes in this pathway
REACTOME IRAK1 RECRUITS IKK COMPLEX	10	8	All SZGR 2.0 genes in this pathway
REACTOME TRAF6 MEDIATED INDUCTION OF NFKB AND MAP KINASES UPON TLR7 8 OR 9 ACTIVATION	77	57	All SZGR 2.0 genes in this pathway
REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING	10	9	All SZGR 2.0 genes in this pathway
REACTOME NFKB AND MAP KINASES ACTIVATION MEDIATED BY TLR4 SIGNALING REPERTOIRE	72	53	All SZGR 2.0 genes in this pathway
REACTOME MYD88 MAL CASCADE INITIATED ON PLASMA MEMBRANE	83	63	All SZGR 2.0 genes in this pathway
REACTOME INNATE IMMUNE SYSTEM	279	178	All SZGR 2.0 genes in this pathway
REACTOME ACTIVATED TLR4 SIGNALLING	93	69	All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM	933	616	All SZGR 2.0 genes in this pathway
REACTOME TOLL RECEPTOR CASCADES	118	84	All SZGR 2.0 genes in this pathway
REACTOME NOD1 2 SIGNALING PATHWAY	30	22	All SZGR 2.0 genes in this pathway
REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM	270	204	All SZGR 2.0 genes in this pathway
REACTOME NUCLEOTIDE BINDING DOMAIN LEUCINE RICH REPEAT CONTAINING RECEPTOR NLR SIGNALING PATHWAYS	46	33	All SZGR 2.0 genes in this pathway
NAKAMURA TUMOR ZONE PERIPHERAL VS CENTRAL UP	285	181	All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA UP	783	507	All SZGR 2.0 genes in this pathway
BASAKI YBX1 TARGETS UP	290	177	All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 1 UP	380	236	All SZGR 2.0 genes in this pathway
MULLIGHAN MLL SIGNATURE 2 UP	418	263	All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC UP	722	443	All SZGR 2.0 genes in this pathway
KOKKINAKIS METHIONINE DEPRIVATION 48HR DN	64	39	All SZGR 2.0 genes in this pathway
KOKKINAKIS METHIONINE DEPRIVATION 96HR DN	75	50	All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 4 5WK UP	271	175	All SZGR 2.0 genes in this pathway
MCBRYAN PUBERTAL BREAST 6 7WK DN	79	54	All SZGR 2.0 genes in this pathway
DARWICHE SKIN TUMOR PROMOTER UP	142	96	All SZGR 2.0 genes in this pathway
DARWICHE PAPILLOMA RISK LOW DN	165	107	All SZGR 2.0 genes in this pathway
DARWICHE PAPILLOMA RISK HIGH DN	180	110	All SZGR 2.0 genes in this pathway
DARWICHE SQUAMOUS CELL CARCINOMA DN	181	107	All SZGR 2.0 genes in this pathway
KLEIN TARGETS OF BCR ABL1 FUSION	45	34	All SZGR 2.0 genes in this pathway
SCHLOSSER MYC TARGETS AND SERUM RESPONSE DN	47	34	All SZGR 2.0 genes in this pathway
PATIL LIVER CANCER	747	453	All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK	1652	1023	All SZGR 2.0 genes in this pathway
PUJANA ATM PCC NETWORK	1442	892	All SZGR 2.0 genes in this pathway
PUJANA CHEK2 PCC NETWORK	779	480	All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS	957	597	All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS IMPRINTED AND X LINKED	17	8	All SZGR 2.0 genes in this pathway
WEI MYCN TARGETS WITH E BOX	795	478	All SZGR 2.0 genes in this pathway
LIAO METASTASIS	539	324	All SZGR 2.0 genes in this pathway
GEORGES TARGETS OF MIR192 AND MIR215	893	528	All SZGR 2.0 genes in this pathway
GOLDRATH HOMEOSTATIC PROLIFERATION	171	102	All SZGR 2.0 genes in this pathway
WANG TARGETS OF MLL CBP FUSION DN	45	31	All SZGR 2.0 genes in this pathway
ZHAN V2 LATE DIFFERENTIATION GENES	45	34	All SZGR 2.0 genes in this pathway
REN ALVEOLAR RHABDOMYOSARCOMA DN	408	274	All SZGR 2.0 genes in this pathway
PAL PRMT5 TARGETS UP	203	135	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP	1691	1088	All SZGR 2.0 genes in this pathway
RODWELL AGING KIDNEY UP	487	303	All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS STEM CELL AND PROGENITOR	681	420	All SZGR 2.0 genes in this pathway
KAAB FAILED HEART VENTRICLE DN	41	28	All SZGR 2.0 genes in this pathway
LEE CALORIE RESTRICTION MUSCLE DN	51	28	All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS DN	292	189	All SZGR 2.0 genes in this pathway
HELLER HDAC TARGETS SILENCED BY METHYLATION DN	281	179	All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER UP	973	570	All SZGR 2.0 genes in this pathway
ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE UP	863	514	All SZGR 2.0 genes in this pathway
CHUNG BLISTER CYTOTOXICITY UP	134	84	All SZGR 2.0 genes in this pathway
GRADE COLON CANCER UP	871	505	All SZGR 2.0 genes in this pathway
GRADE COLON AND RECTAL CANCER UP	285	167	All SZGR 2.0 genes in this pathway
WANG TUMOR INVASIVENESS DN	210	128	All SZGR 2.0 genes in this pathway
HSIAO HOUSEKEEPING GENES	389	245	All SZGR 2.0 genes in this pathway
FONTAINE PAPILLARY THYROID CARCINOMA DN	80	53	All SZGR 2.0 genes in this pathway
FOURNIER ACINAR DEVELOPMENT LATE 2	277	172	All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 14	143	86	All SZGR 2.0 genes in this pathway
DASU IL6 SIGNALING UP	59	44	All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS OLIGODENDROCYTE NUMBER CORR UP	756	494	All SZGR 2.0 genes in this pathway
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP	682	440	All SZGR 2.0 genes in this pathway
BRUINS UVC RESPONSE VIA TP53 GROUP A	898	516	All SZGR 2.0 genes in this pathway
KRIEG HYPOXIA NOT VIA KDM3A	770	480	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-134	1274	1280	1A	hsa-miR-134^brain	UGUGACUGGUUGACCAGAGGG
miR-142-3p	1278	1285	1A,m8	hsa-miR-142-3p	UGUAGUGUUUCCUACUUUAUGGA
miR-146	56	63	1A,m8	hsa-miR-146a	UGAGAACUGAAUUCCAUGGGUU
				hsa-miR-146b^brain	UGAGAACUGAAUUCCAUAGGCU
				hsa-miR-146a	UGAGAACUGAAUUCCAUGGGUU
				hsa-miR-146b^brain	UGAGAACUGAAUUCCAUAGGCU

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: IRAK1