SZGR2

Summary ?

GeneID	3837
Symbol	KPNB1
Synonyms	IMB1\|IPO1\|IPOB\|Impnb\|NTF97
Description	karyopherin subunit beta 1
Reference	MIM:602738\|HGNC:HGNC:6400\|HPRD:04114\|
Gene type	protein-coding
Map location	17q21.32
Pascal p-value	0.595
Sherlock p-value	0.513
Fetal beta	0.112
DMG	2 (# studies)
Support	STRUCTURAL PLASTICITY CompositeSet Ascano FMRP targets

Gene in Data Sources

Gene set name	Method of gene set	Description	Info
DMG:Nishioka_2013	Genome-wide DNA methylation analysis	The authors investigated the methylation profiles of DNA in peripheral blood cells from 18 patients with first-episode schizophrenia (FESZ) and from 15 normal controls.	2
DMG:Wockner_2014	Genome-wide DNA methylation analysis	This dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24).	2
Expression	Meta-analysis of gene expression	P value: 2.337

Section I. Genetics and epigenetics annotation

Differentially methylated gene

Probe	Chromosome	Position	Nearest gene	P (dis)	Beta (dis)	FDR (dis)	Study
cg02415717	17	45727607	KPNB1	3.865E-4	-0.253	0.043	DMG:Wockner_2014
cg24438655	17	45727598	KPNB1		-0.019	0.61	DMG:Nishioka_2013

Section II. Transcriptome annotation

General gene expression (GTEx)

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions

Section III. Gene Ontology annotation

Molecular function	GO term	Evidence	Neuro keywords	PubMed ID
GO:0008270	zinc ion binding	TAS		7615630
GO:0008565	protein transporter activity	IEA		-
GO:0008139	nuclear localization sequence binding	TAS		7627554
GO:0019904	protein domain specific binding	IPI		11984006
Biological process	GO term	Evidence	Neuro keywords	PubMed ID
GO:0000059	protein import into nucleus, docking	IEA		-
GO:0000060	protein import into nucleus, translocation	TAS		7615630
GO:0006607	NLS-bearing substrate import into nucleus	TAS		7627554
GO:0006610	ribosomal protein import into nucleus	IEA		-
GO:0044419	interspecies interaction between organisms	IEA		-
Cellular component	GO term	Evidence	Neuro keywords	PubMed ID
GO:0005829	cytosol	EXP		1985200 \|7559393 \|9405152
GO:0005634	nucleus	IEA		-
GO:0005635	nuclear envelope	IEA		-
GO:0005643	nuclear pore	TAS		7627554
GO:0005654	nucleoplasm	EXP		1985200 \|7559393 \|9405152
GO:0005737	cytoplasm	TAS		7615630

Section IV. Protein-protein interaction annotation

Interactors	Aliases B	Official full name B	Experimental	Source	PubMed ID
CD99	MIC2 \| MIC2X \| MIC2Y	CD99 molecule	CD99 interacts with KPNB1.	BIND	15388255
ELAVL1	ELAV1 \| HUR \| Hua \| MelG	ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)	-	HPRD	15037768 \|15342649
FGFR1	BFGFR \| CD331 \| CEK \| FGFBR \| FLG \| FLJ99988 \| FLT2 \| HBGFR \| KAL2 \| N-SAM	fibroblast growth factor receptor 1	-	HPRD,BioGRID	11257130
H1F0	H10 \| H1FV \| MGC5241	H1 histone family, member 0	in vitro	BioGRID	10228156
IPO7	FLJ14581 \| Imp7 \| MGC138673 \| RANBP7	importin 7	-	HPRD,BioGRID	9214382 \|10228156
IPO8	FLJ26580 \| RANBP8	importin 8	-	HPRD,BioGRID	9214382
KPNA1	IPOA5 \| NPI-1 \| RCH2 \| SRP1	karyopherin alpha 1 (importin alpha 5)	Reconstituted Complex	BioGRID	9102465 \|10523667
KPNA2	IPOA1 \| QIP2 \| RCH1 \| SRP1alpha	karyopherin alpha 2 (RAG cohort 1, importin alpha 1)	Reconstituted Complex	BioGRID	9323134 \|10523667 \|11283257
KPNA2	IPOA1 \| QIP2 \| RCH1 \| SRP1alpha	karyopherin alpha 2 (RAG cohort 1, importin alpha 1)	-	HPRD	8617226
KPNA3	IPOA4 \| SRP1gamma \| SRP4 \| hSRP1	karyopherin alpha 3 (importin alpha 4)	Reconstituted Complex	BioGRID	9435235 \|10523667
KPNA4	IPOA3 \| MGC12217 \| MGC26703 \| QIP1 \| SRP3	karyopherin alpha 4 (importin alpha 3)	Reconstituted Complex	BioGRID	10523667
KPNA6	FLJ11249 \| IPOA7 \| KPNA7 \| MGC17918	karyopherin alpha 6 (importin alpha 7)	-	HPRD,BioGRID	10523667
LYST	CHS \| CHS1	lysosomal trafficking regulator	-	HPRD,BioGRID	11984006
NUP153	HNUP153 \| N153	nucleoporin 153kDa	-	HPRD	9275187\|10749866
NUP153	HNUP153 \| N153	nucleoporin 153kDa	Reconstituted Complex	BioGRID	10202161 \|10749866 \|11266456
NUP50	MGC39961 \| NPAP60 \| NPAP60L	nucleoporin 50kDa	-	HPRD,BioGRID	12176322
NUP54	MGC13407	nucleoporin 54kDa	Reconstituted Complex	BioGRID	11266456
NUP62	DKFZp547L134 \| FLJ20822 \| FLJ43869 \| IBSN \| MGC841 \| SNDI \| p62	nucleoporin 62kDa	Reconstituted Complex	BioGRID	9102465 \|11266456
NUP98	ADIR2 \| NUP196 \| NUP96	nucleoporin 98kDa	-	HPRD,BioGRID	9144189
NUTF2	NTF2 \| PP15	nuclear transport factor 2	Reconstituted Complex	BioGRID	9102465
PTHLH	HHM \| MGC14611 \| PLP \| PTHR \| PTHRP	parathyroid hormone-like hormone	-	HPRD,BioGRID	11401507 \|12504010
PTMA	MGC104802 \| TMSA	prothymosin, alpha	-	HPRD	11310559
RAN	ARA24 \| Gsp1 \| TC4	RAN, member RAS oncogene family	Far Western Reconstituted Complex	BioGRID	9102465 \|9135132 \|10779340
RAN	ARA24 \| Gsp1 \| TC4	RAN, member RAS oncogene family	-	HPRD	8576188 \|9135132
RAN	ARA24 \| Gsp1 \| TC4	RAN, member RAS oncogene family	Interaction between KPNB1 (PDB ID: 1IBR_B) and RAN (PDB ID: 1IBR_A).	BIND	7615630 \|7627554 \|8896452 \|10367892
RANBP1	HTF9A \| MGC88701	RAN binding protein 1	Reconstituted Complex	BioGRID	10473610 \|10779340
RANBP2	NUP358 \| TRP1 \| TRP2	RAN binding protein 2	-	HPRD,BioGRID	10473610
RUNX1T1	AML1T1 \| CBFA2T1 \| CDR \| ETO \| MGC2796 \| MTG8 \| MTG8b \| ZMYND2	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)	-	HPRD,BioGRID	10951564
SMAD3	DKFZp586N0721 \| DKFZp686J10186 \| HSPC193 \| HsT17436 \| JV15-2 \| MADH3 \| MGC60396	SMAD family member 3	-	HPRD,BioGRID	10846168
SMAD4	DPC4 \| JIP \| MADH4	SMAD family member 4	Affinity Capture-Western	BioGRID	10846168
SMN1	BCD541 \| SMA \| SMA1 \| SMA2 \| SMA3 \| SMA4 \| SMA@ \| SMN \| SMNT \| T-BCD541	survival of motor neuron 1, telomeric	-	HPRD,BioGRID	12095920
SNUPN	KPNBL \| RNUT1 \| Snurportin1	snurportin 1	-	HPRD	12095920
SOX9	CMD1 \| CMPD1 \| SRA1	SRY (sex determining region Y)-box 9	KPNB1 (importin beta) interacts with SOX9.	BIND	15889150
SOX9	CMD1 \| CMPD1 \| SRA1	SRY (sex determining region Y)-box 9	-	HPRD	11323423
SREBF2	SREBP2 \| bHLHd2	sterol regulatory element binding transcription factor 2	Reconstituted Complex	BioGRID	11283257
TERF1	FLJ41416 \| PIN2 \| TRBF1 \| TRF \| TRF1 \| hTRF1-AS \| t-TRF1	telomeric repeat binding factor (NIMA-interacting) 1	Reconstituted Complex	BioGRID	12135354
TP53	FLJ92943 \| LFS1 \| TRP53 \| p53	tumor protein p53	-	HPRD,BioGRID	11297531
TRADD	Hs.89862 \| MGC11078	TNFRSF1A-associated via death domain	-	HPRD	14743216
UBR5	DD5 \| EDD \| EDD1 \| FLJ11310 \| HYD \| KIAA0896 \| MGC57263	ubiquitin protein ligase E3 component n-recognin 5	-	HPRD	12011095

Section V. Pathway annotation

Pathway name	Pathway size	# SZGR 2.0 genes in pathway	Info
BIOCARTA RANMS PATHWAY	10	7	All SZGR 2.0 genes in this pathway
PID MET PATHWAY	80	60	All SZGR 2.0 genes in this pathway
PID TCPTP PATHWAY	43	33	All SZGR 2.0 genes in this pathway
PID NFAT 3PATHWAY	54	47	All SZGR 2.0 genes in this pathway
PID SMAD2 3PATHWAY	17	13	All SZGR 2.0 genes in this pathway
REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES	66	45	All SZGR 2.0 genes in this pathway
REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION	13	10	All SZGR 2.0 genes in this pathway
REACTOME INTERFERON SIGNALING	159	116	All SZGR 2.0 genes in this pathway
REACTOME APOPTOSIS	148	94	All SZGR 2.0 genes in this pathway
REACTOME INFLUENZA LIFE CYCLE	203	72	All SZGR 2.0 genes in this pathway
REACTOME HIV INFECTION	207	122	All SZGR 2.0 genes in this pathway
REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS	27	19	All SZGR 2.0 genes in this pathway
REACTOME HOST INTERACTIONS OF HIV FACTORS	132	81	All SZGR 2.0 genes in this pathway
REACTOME IMMUNE SYSTEM	933	616	All SZGR 2.0 genes in this pathway
REACTOME CYTOKINE SIGNALING IN IMMUNE SYSTEM	270	204	All SZGR 2.0 genes in this pathway
REACTOME APOPTOTIC EXECUTION PHASE	54	37	All SZGR 2.0 genes in this pathway
ONKEN UVEAL MELANOMA UP	783	507	All SZGR 2.0 genes in this pathway
ZHONG RESPONSE TO AZACITIDINE AND TSA DN	70	38	All SZGR 2.0 genes in this pathway
GARY CD5 TARGETS DN	431	263	All SZGR 2.0 genes in this pathway
PUIFFE INVASION INHIBITED BY ASCITES UP	82	51	All SZGR 2.0 genes in this pathway
CASORELLI ACUTE PROMYELOCYTIC LEUKEMIA DN	663	425	All SZGR 2.0 genes in this pathway
DIAZ CHRONIC MEYLOGENOUS LEUKEMIA UP	1382	904	All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS MESENCHYMAL DN	460	312	All SZGR 2.0 genes in this pathway
TIMOFEEVA GROWTH STRESS VIA STAT1 DN	16	12	All SZGR 2.0 genes in this pathway
HORIUCHI WTAP TARGETS DN	310	188	All SZGR 2.0 genes in this pathway
OSMAN BLADDER CANCER UP	404	246	All SZGR 2.0 genes in this pathway
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL UP	233	161	All SZGR 2.0 genes in this pathway
SENESE HDAC3 TARGETS DN	536	332	All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP	1278	748	All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN	1375	806	All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY SERUM DEPRIVATION UP	552	347	All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN	1781	1082	All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN DN	770	415	All SZGR 2.0 genes in this pathway
BERENJENO TRANSFORMED BY RHOA UP	536	340	All SZGR 2.0 genes in this pathway
HWANG PROSTATE CANCER MARKERS	28	19	All SZGR 2.0 genes in this pathway
DARWICHE PAPILLOMA PROGRESSION RISK	74	44	All SZGR 2.0 genes in this pathway
LASTOWSKA NEUROBLASTOMA COPY NUMBER UP	181	108	All SZGR 2.0 genes in this pathway
FARMER BREAST CANCER APOCRINE VS LUMINAL	326	213	All SZGR 2.0 genes in this pathway
PATIL LIVER CANCER	747	453	All SZGR 2.0 genes in this pathway
LI WILMS TUMOR ANAPLASTIC UP	19	12	All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK	1652	1023	All SZGR 2.0 genes in this pathway
NUYTTEN NIPP1 TARGETS DN	848	527	All SZGR 2.0 genes in this pathway
LOPEZ MBD TARGETS	957	597	All SZGR 2.0 genes in this pathway
LIU BREAST CANCER	30	19	All SZGR 2.0 genes in this pathway
WEI MYCN TARGETS WITH E BOX	795	478	All SZGR 2.0 genes in this pathway
BENPORATH CYCLING GENES	648	385	All SZGR 2.0 genes in this pathway
FERRANDO T ALL WITH MLL ENL FUSION DN	87	57	All SZGR 2.0 genes in this pathway
WANG TARGETS OF MLL CBP FUSION DN	45	31	All SZGR 2.0 genes in this pathway
PARK HSC AND MULTIPOTENT PROGENITORS	50	33	All SZGR 2.0 genes in this pathway
GALE APL WITH FLT3 MUTATED UP	56	35	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN	1237	837	All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE UP	1691	1088	All SZGR 2.0 genes in this pathway
JIANG HYPOXIA NORMAL	311	205	All SZGR 2.0 genes in this pathway
LEE CALORIE RESTRICTION MUSCLE DN	51	28	All SZGR 2.0 genes in this pathway
MONNIER POSTRADIATION TUMOR ESCAPE UP	393	244	All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 4	307	185	All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 STIMULATED	1022	619	All SZGR 2.0 genes in this pathway
MARSON BOUND BY FOXP3 UNSTIMULATED	1229	713	All SZGR 2.0 genes in this pathway
MARSON BOUND BY E2F4 UNSTIMULATED	728	415	All SZGR 2.0 genes in this pathway
DAIRKEE CANCER PRONE RESPONSE BPA E2	118	65	All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER UP	973	570	All SZGR 2.0 genes in this pathway
TOYOTA TARGETS OF MIR34B AND MIR34C	463	262	All SZGR 2.0 genes in this pathway
BLUM RESPONSE TO SALIRASIB DN	342	220	All SZGR 2.0 genes in this pathway
MUELLER PLURINET	299	189	All SZGR 2.0 genes in this pathway
WANG TUMOR INVASIVENESS UP	374	247	All SZGR 2.0 genes in this pathway
AGUIRRE PANCREATIC CANCER COPY NUMBER UP	298	174	All SZGR 2.0 genes in this pathway
HAN SATB1 TARGETS UP	395	249	All SZGR 2.0 genes in this pathway
ROME INSULIN TARGETS IN MUSCLE UP	442	263	All SZGR 2.0 genes in this pathway
BOYAULT LIVER CANCER SUBCLASS G3 UP	188	121	All SZGR 2.0 genes in this pathway
KAPOSI LIVER CANCER MET UP	18	11	All SZGR 2.0 genes in this pathway
CAIRO HEPATOBLASTOMA CLASSES UP	605	377	All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 2	86	50	All SZGR 2.0 genes in this pathway
KAMMINGA SENESCENCE	41	26	All SZGR 2.0 genes in this pathway
WHITFIELD CELL CYCLE M G1	148	95	All SZGR 2.0 genes in this pathway
KARLSSON TGFB1 TARGETS UP	127	78	All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS SENESCENT	572	352	All SZGR 2.0 genes in this pathway
WIERENGA PML INTERACTOME	42	23	All SZGR 2.0 genes in this pathway
PILON KLF1 TARGETS DN	1972	1213	All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS DN	882	538	All SZGR 2.0 genes in this pathway
PURBEY TARGETS OF CTBP1 NOT SATB1 UP	344	215	All SZGR 2.0 genes in this pathway
FORTSCHEGGER PHF8 TARGETS UP	279	155	All SZGR 2.0 genes in this pathway
PECE MAMMARY STEM CELL DN	146	88	All SZGR 2.0 genes in this pathway
ABRAMSON INTERACT WITH AIRE	45	33	All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA family	Target position			miRNA ID	miRNA seq
miRNA family	UTR start	UTR end	Match method	miRNA ID	miRNA seq
miR-101	492	499	1A,m8	hsa-miR-101	UACAGUACUGUGAUAACUGAAG
miR-145	36	42	1A	hsa-miR-145	GUCCAGUUUUCCCAGGAAUCCCUU
miR-148/152	207	213	1A	hsa-miR-148a	UCAGUGCACUACAGAACUUUGU
				hsa-miR-152^brain	UCAGUGCAUGACAGAACUUGGG
				hsa-miR-148b	UCAGUGCAUCACAGAACUUUGU
miR-181	876	883	1A,m8	hsa-miR-181a^brain	AACAUUCAACGCUGUCGGUGAGU
				hsa-miR-181b^SZ	AACAUUCAUUGCUGUCGGUGGG
				hsa-miR-181c^brain	AACAUUCAACCUGUCGGUGAGU
				hsa-miR-181d^brain	AACAUUCAUUGUUGUCGGUGGGUU
miR-182	1093	1099	1A	hsa-miR-182	UUUGGCAAUGGUAGAACUCACA
miR-194	953	959	1A	hsa-miR-194	UGUAACAGCAACUCCAUGUGGA
miR-199	35	41	1A	hsa-miR-199a	CCCAGUGUUCAGACUACCUGUUC
miR-199	35	41	1A	hsa-miR-199b	CCCAGUGUUUAGACUAUCUGUUC
miR-203.1	635	641	1A	hsa-miR-203	UGAAAUGUUUAGGACCACUAG
miR-218	673	679	1A	hsa-miR-218^brain	UUGUGCUUGAUCUAACCAUGU
miR-27	872	879	1A,m8	hsa-miR-27a^brain	UUCACAGUGGCUAAGUUCCGC
miR-27	872	879	1A,m8	hsa-miR-27b^brain	UUCACAGUGGCUAAGUUCUGC
miR-342	554	560	m8	hsa-miR-342^brain	UCUCACACAGAAAUCGCACCCGUC
miR-361	1208	1215	1A,m8	hsa-miR-361^brain	UUAUCAGAAUCUCCAGGGGUAC
miR-377	553	559	m8	hsa-miR-377	AUCACACAAAGGCAACUUUUGU
miR-9	1095	1101	1A	hsa-miR-9^SZ	UCUUUGGUUAUCUAGCUGUAUGA
miR-96	1092	1099	1A,m8	hsa-miR-96^brain	UUUGGCACUAGCACAUUUUUGC

SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.

Gene Page: KPNB1