Gene Page: KPNB1

Summary
GeneID  3837
Symbol  KPNB1
Synonyms  IMB1|IPOB|Impnb|MGC2155|MGC2156|MGC2157|NTF97
Description  karyopherin (importin) beta 1
See related  HGNC:6400|MIM:602738|Ensembl:ENSG00000108424|HPRD:04114|
Locus tag  -
Gene type  protein-coding
Map location  17q21.32
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
ExpressionExpressionP value: 2.337 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0008270zinc ion bindingTAS7615630 
GO:0008565protein transporter activityIEA-
GO:0008139nuclear localization sequence bindingTAS7627554 
GO:0019904protein domain specific bindingIPI11984006 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0000059protein import into nucleus, dockingIEA-
GO:0000060protein import into nucleus, translocationTAS7615630 
GO:0006607NLS-bearing substrate import into nucleusTAS7627554 
GO:0006610ribosomal protein import into nucleusIEA-
GO:0044419interspecies interaction between organismsIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolEXP1985200 |7559393 |9405152 
GO:0005634nucleusIEA-
GO:0005635nuclear envelopeIEA-
GO:0005643nuclear poreTAS7627554 
GO:0005654nucleoplasmEXP1985200 |7559393 |9405152 
GO:0005737cytoplasmTAS7615630 
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CD99MIC2 | MIC2X | MIC2YCD99 moleculeCD99 interacts with KPNB1.BIND15388255 
ELAVL1ELAV1 | HUR | Hua | MelGELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)-HPRD15037768 |15342649 
FGFR1BFGFR | CD331 | CEK | FGFBR | FLG | FLJ99988 | FLT2 | HBGFR | KAL2 | N-SAMfibroblast growth factor receptor 1-HPRD,BioGRID11257130 
H1F0H10 | H1FV | MGC5241H1 histone family, member 0in vitroBioGRID10228156 
IPO7FLJ14581 | Imp7 | MGC138673 | RANBP7importin 7-HPRD,BioGRID9214382 |10228156 
IPO8FLJ26580 | RANBP8importin 8-HPRD,BioGRID9214382 
KPNA1IPOA5 | NPI-1 | RCH2 | SRP1karyopherin alpha 1 (importin alpha 5)Reconstituted ComplexBioGRID9102465 |10523667 
KPNA2IPOA1 | QIP2 | RCH1 | SRP1alphakaryopherin alpha 2 (RAG cohort 1, importin alpha 1)Reconstituted ComplexBioGRID9323134 |10523667 
|11283257 
-HPRD8617226 
KPNA3IPOA4 | SRP1gamma | SRP4 | hSRP1karyopherin alpha 3 (importin alpha 4)Reconstituted ComplexBioGRID9435235 |10523667 
KPNA4IPOA3 | MGC12217 | MGC26703 | QIP1 | SRP3karyopherin alpha 4 (importin alpha 3)Reconstituted ComplexBioGRID10523667 
KPNA6FLJ11249 | IPOA7 | KPNA7 | MGC17918karyopherin alpha 6 (importin alpha 7)-HPRD,BioGRID10523667 
LYSTCHS | CHS1lysosomal trafficking regulator-HPRD,BioGRID11984006 
NUP153HNUP153 | N153nucleoporin 153kDa-HPRD9275187|10749866 
Reconstituted ComplexBioGRID10202161 |10749866 
|11266456 
NUP50MGC39961 | NPAP60 | NPAP60Lnucleoporin 50kDa-HPRD,BioGRID12176322 
NUP54MGC13407nucleoporin 54kDaReconstituted ComplexBioGRID11266456 
NUP62DKFZp547L134 | FLJ20822 | FLJ43869 | IBSN | MGC841 | SNDI | p62nucleoporin 62kDaReconstituted ComplexBioGRID9102465 |11266456 
NUP98ADIR2 | NUP196 | NUP96nucleoporin 98kDa-HPRD,BioGRID9144189 
NUTF2NTF2 | PP15nuclear transport factor 2Reconstituted ComplexBioGRID9102465 
PTHLHHHM | MGC14611 | PLP | PTHR | PTHRPparathyroid hormone-like hormone-HPRD,BioGRID11401507 |12504010 
PTMAMGC104802 | TMSAprothymosin, alpha-HPRD11310559 
RANARA24 | Gsp1 | TC4RAN, member RAS oncogene familyFar Western
Reconstituted Complex		BioGRID9102465 |9135132 
|10779340 
-HPRD8576188 |9135132 
Interaction between KPNB1 (PDB ID: 1IBR_B) and RAN (PDB ID: 1IBR_A).BIND7615630 |7627554 
|8896452 |10367892 
RANBP1HTF9A | MGC88701RAN binding protein 1Reconstituted ComplexBioGRID10473610 |10779340 
RANBP2NUP358 | TRP1 | TRP2RAN binding protein 2-HPRD,BioGRID10473610 
RUNX1T1AML1T1 | CBFA2T1 | CDR | ETO | MGC2796 | MTG8 | MTG8b | ZMYND2runt-related transcription factor 1; translocated to, 1 (cyclin D-related)-HPRD,BioGRID10951564 
SMAD3DKFZp586N0721 | DKFZp686J10186 | HSPC193 | HsT17436 | JV15-2 | MADH3 | MGC60396SMAD family member 3-HPRD,BioGRID10846168 
SMAD4DPC4 | JIP | MADH4SMAD family member 4Affinity Capture-WesternBioGRID10846168 
SMN1BCD541 | SMA | SMA1 | SMA2 | SMA3 | SMA4 | SMA@ | SMN | SMNT | T-BCD541survival of motor neuron 1, telomeric-HPRD,BioGRID12095920 
SNUPNKPNBL | RNUT1 | Snurportin1snurportin 1-HPRD12095920 
SOX9CMD1 | CMPD1 | SRA1SRY (sex determining region Y)-box 9KPNB1 (importin beta) interacts with SOX9.BIND15889150 
-HPRD11323423 
SREBF2SREBP2 | bHLHd2sterol regulatory element binding transcription factor 2Reconstituted ComplexBioGRID11283257 
TERF1FLJ41416 | PIN2 | TRBF1 | TRF | TRF1 | hTRF1-AS | t-TRF1telomeric repeat binding factor (NIMA-interacting) 1Reconstituted ComplexBioGRID12135354 
TP53FLJ92943 | LFS1 | TRP53 | p53tumor protein p53-HPRD,BioGRID11297531 
TRADDHs.89862 | MGC11078TNFRSF1A-associated via death domain-HPRD14743216 
UBR5DD5 | EDD | EDD1 | FLJ11310 | HYD | KIAA0896 | MGC57263ubiquitin protein ligase E3 component n-recognin 5-HPRD12011095 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
BIOCARTA_RANMS_PATHWAY 107All SZGR genes in this pathway
PID_MET_PATHWAY 8060All SZGR genes in this pathway
PID_TCPTP_PATHWAY 4333All SZGR genes in this pathway
PID_NFAT_3PATHWAY 5447All SZGR genes in this pathway
PID_SMAD2_3PATHWAY 1713All SZGR genes in this pathway
REACTOME_ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES 6645All SZGR genes in this pathway
REACTOME_APOPTOSIS_INDUCED_DNA_FRAGMENTATION 1310All SZGR genes in this pathway
REACTOME_INTERFERON_SIGNALING 159116All SZGR genes in this pathway
REACTOME_APOPTOSIS 14894All SZGR genes in this pathway
REACTOME_INFLUENZA_LIFE_CYCLE 20372All SZGR genes in this pathway
REACTOME_HIV_INFECTION 207122All SZGR genes in this pathway
REACTOME_TRANSPORT_OF_RIBONUCLEOPROTEINS_INTO_THE_HOST_NUCLEUS 2719All SZGR genes in this pathway
REACTOME_HOST_INTERACTIONS_OF_HIV_FACTORS 13281All SZGR genes in this pathway
REACTOME_IMMUNE_SYSTEM 933616All SZGR genes in this pathway
REACTOME_CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM 270204All SZGR genes in this pathway
REACTOME_APOPTOTIC_EXECUTION_PHASE 5437All SZGR genes in this pathway
ONKEN_UVEAL_MELANOMA_UP 783507All SZGR genes in this pathway
ZHONG_RESPONSE_TO_AZACITIDINE_AND_TSA_DN 7038All SZGR genes in this pathway
GARY_CD5_TARGETS_DN 431263All SZGR genes in this pathway
PUIFFE_INVASION_INHIBITED_BY_ASCITES_UP 8251All SZGR genes in this pathway
CASORELLI_ACUTE_PROMYELOCYTIC_LEUKEMIA_DN 663425All SZGR genes in this pathway
DIAZ_CHRONIC_MEYLOGENOUS_LEUKEMIA_UP 1382904All SZGR genes in this pathway
CHARAFE_BREAST_CANCER_LUMINAL_VS_MESENCHYMAL_DN 460312All SZGR genes in this pathway
TIMOFEEVA_GROWTH_STRESS_VIA_STAT1_DN 1612All SZGR genes in this pathway
HORIUCHI_WTAP_TARGETS_DN 310188All SZGR genes in this pathway
OSMAN_BLADDER_CANCER_UP 404246All SZGR genes in this pathway
OSWALD_HEMATOPOIETIC_STEM_CELL_IN_COLLAGEN_GEL_UP 233161All SZGR genes in this pathway
SENESE_HDAC3_TARGETS_DN 536332All SZGR genes in this pathway
KINSEY_TARGETS_OF_EWSR1_FLII_FUSION_UP 1278748All SZGR genes in this pathway
DODD_NASOPHARYNGEAL_CARCINOMA_DN 1375806All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_UP 552347All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_DN 770415All SZGR genes in this pathway
BERENJENO_TRANSFORMED_BY_RHOA_UP 536340All SZGR genes in this pathway
HWANG_PROSTATE_CANCER_MARKERS 2819All SZGR genes in this pathway
DARWICHE_PAPILLOMA_PROGRESSION_RISK 7444All SZGR genes in this pathway
LASTOWSKA_NEUROBLASTOMA_COPY_NUMBER_UP 181108All SZGR genes in this pathway
FARMER_BREAST_CANCER_APOCRINE_VS_LUMINAL 326213All SZGR genes in this pathway
PATIL_LIVER_CANCER 747453All SZGR genes in this pathway
LI_WILMS_TUMOR_ANAPLASTIC_UP 1912All SZGR genes in this pathway
PUJANA_BRCA1_PCC_NETWORK 16521023All SZGR genes in this pathway
NUYTTEN_NIPP1_TARGETS_DN 848527All SZGR genes in this pathway
LOPEZ_MBD_TARGETS 957597All SZGR genes in this pathway
LIU_BREAST_CANCER 3019All SZGR genes in this pathway
WEI_MYCN_TARGETS_WITH_E_BOX 795478All SZGR genes in this pathway
BENPORATH_CYCLING_GENES 648385All SZGR genes in this pathway
FERRANDO_T_ALL_WITH_MLL_ENL_FUSION_DN 8757All SZGR genes in this pathway
WANG_TARGETS_OF_MLL_CBP_FUSION_DN 4531All SZGR genes in this pathway
PARK_HSC_AND_MULTIPOTENT_PROGENITORS 5033All SZGR genes in this pathway
GALE_APL_WITH_FLT3_MUTATED_UP 5635All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN 1237837All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
JIANG_HYPOXIA_NORMAL 311205All SZGR genes in this pathway
LEE_CALORIE_RESTRICTION_MUSCLE_DN 5128All SZGR genes in this pathway
MONNIER_POSTRADIATION_TUMOR_ESCAPE_UP 393244All SZGR genes in this pathway
CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_4 307185All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_STIMULATED 1022619All SZGR genes in this pathway
MARSON_BOUND_BY_FOXP3_UNSTIMULATED 1229713All SZGR genes in this pathway
MARSON_BOUND_BY_E2F4_UNSTIMULATED 728415All SZGR genes in this pathway
DAIRKEE_CANCER_PRONE_RESPONSE_BPA_E2 11865All SZGR genes in this pathway
ACEVEDO_LIVER_CANCER_UP 973570All SZGR genes in this pathway
TOYOTA_TARGETS_OF_MIR34B_AND_MIR34C 463262All SZGR genes in this pathway
BLUM_RESPONSE_TO_SALIRASIB_DN 342220All SZGR genes in this pathway
MUELLER_PLURINET 299189All SZGR genes in this pathway
WANG_TUMOR_INVASIVENESS_UP 374247All SZGR genes in this pathway
AGUIRRE_PANCREATIC_CANCER_COPY_NUMBER_UP 298174All SZGR genes in this pathway
HAN_SATB1_TARGETS_UP 395249All SZGR genes in this pathway
ROME_INSULIN_TARGETS_IN_MUSCLE_UP 442263All SZGR genes in this pathway
BOYAULT_LIVER_CANCER_SUBCLASS_G3_UP 188121All SZGR genes in this pathway
KAPOSI_LIVER_CANCER_MET_UP 1811All SZGR genes in this pathway
CAIRO_HEPATOBLASTOMA_CLASSES_UP 605377All SZGR genes in this pathway
YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_2 8650All SZGR genes in this pathway
KAMMINGA_SENESCENCE 4126All SZGR genes in this pathway
WHITFIELD_CELL_CYCLE_M_G1 14895All SZGR genes in this pathway
KARLSSON_TGFB1_TARGETS_UP 12778All SZGR genes in this pathway
CHICAS_RB1_TARGETS_SENESCENT 572352All SZGR genes in this pathway
WIERENGA_PML_INTERACTOME 4223All SZGR genes in this pathway
PILON_KLF1_TARGETS_DN 19721213All SZGR genes in this pathway
LEE_BMP2_TARGETS_DN 882538All SZGR genes in this pathway
PURBEY_TARGETS_OF_CTBP1_NOT_SATB1_UP 344215All SZGR genes in this pathway
FORTSCHEGGER_PHF8_TARGETS_UP 279155All SZGR genes in this pathway
PECE_MAMMARY_STEM_CELL_DN 14688All SZGR genes in this pathway
ABRAMSON_INTERACT_WITH_AIRE 4533All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-1014924991A,m8hsa-miR-101UACAGUACUGUGAUAACUGAAG
miR-14536421Ahsa-miR-145GUCCAGUUUUCCCAGGAAUCCCUU
miR-148/1522072131Ahsa-miR-148aUCAGUGCACUACAGAACUUUGU
hsa-miR-152brainUCAGUGCAUGACAGAACUUGGG
hsa-miR-148bUCAGUGCAUCACAGAACUUUGU
miR-1818768831A,m8hsa-miR-181abrainAACAUUCAACGCUGUCGGUGAGU
hsa-miR-181bSZAACAUUCAUUGCUGUCGGUGGG
hsa-miR-181cbrainAACAUUCAACCUGUCGGUGAGU
hsa-miR-181dbrainAACAUUCAUUGUUGUCGGUGGGUU
miR-182109310991Ahsa-miR-182UUUGGCAAUGGUAGAACUCACA
miR-1949539591Ahsa-miR-194UGUAACAGCAACUCCAUGUGGA
miR-19935411Ahsa-miR-199aCCCAGUGUUCAGACUACCUGUUC
hsa-miR-199bCCCAGUGUUUAGACUAUCUGUUC
miR-203.16356411Ahsa-miR-203UGAAAUGUUUAGGACCACUAG
miR-2186736791Ahsa-miR-218brainUUGUGCUUGAUCUAACCAUGU
miR-278728791A,m8hsa-miR-27abrainUUCACAGUGGCUAAGUUCCGC
hsa-miR-27bbrainUUCACAGUGGCUAAGUUCUGC
miR-342554560m8hsa-miR-342brainUCUCACACAGAAAUCGCACCCGUC
miR-361120812151A,m8hsa-miR-361brainUUAUCAGAAUCUCCAGGGGUAC
miR-377553559m8hsa-miR-377AUCACACAAAGGCAACUUUUGU
miR-9109511011Ahsa-miR-9SZUCUUUGGUUAUCUAGCUGUAUGA
miR-96109210991A,m8hsa-miR-96brainUUUGGCACUAGCACAUUUUUGC
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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