Gene Page: LHCGR
Summary ?
| GeneID | 3973 |
| Symbol | LHCGR |
| Synonyms | HHG|LCGR|LGR2|LH/CG-R|LH/CGR|LHR|LHRHR|LSH-R|ULG5 |
| Description | luteinizing hormone/choriogonadotropin receptor |
| Reference | MIM:152790|HGNC:HGNC:6585|Ensembl:ENSG00000138039|HPRD:01073|Vega:OTTHUMG00000129257 |
| Gene type | protein-coding |
| Map location | 2p21 |
| Pascal p-value | 0.04 |
Gene in Data Sources
| Gene set name | Method of gene set | Description | Info |
|---|---|---|---|
| CV:PGCnp | Genome-wide Association Study | GWAS |
Section I. Genetics and epigenetics annotation
Section II. Transcriptome annotation
General gene expression (GTEx)
Gene expression of temporal and spatial changes (BrainSpan)
Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.
Top co-expressed genes in brain regions
| Top 10 positively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| SSR1 | 0.90 | 0.92 |
| CPSF2 | 0.90 | 0.93 |
| FRS2 | 0.90 | 0.92 |
| ZNF24 | 0.90 | 0.93 |
| SCARB2 | 0.90 | 0.93 |
| TMF1 | 0.90 | 0.92 |
| AGPS | 0.90 | 0.91 |
| UTP14C | 0.89 | 0.92 |
| AGL | 0.89 | 0.93 |
| POLK | 0.89 | 0.91 |
| Top 10 negatively co-expressed genes | ||
| Gene | Pearson's Correlation | Spearman's Correlation |
| MT-CO2 | -0.65 | -0.73 |
| FXYD1 | -0.64 | -0.70 |
| AF347015.31 | -0.63 | -0.71 |
| IFI27 | -0.63 | -0.70 |
| CXCL14 | -0.63 | -0.71 |
| AF347015.21 | -0.62 | -0.70 |
| HIGD1B | -0.61 | -0.70 |
| MYL3 | -0.60 | -0.67 |
| AC018755.7 | -0.60 | -0.64 |
| AF347015.33 | -0.59 | -0.66 |
Section IV. Protein-protein interaction annotation
| Interactors | Aliases B | Official full name B | Experimental | Source | PubMed ID |
|---|---|---|---|---|---|
| ARRB2 | ARB2 | ARR2 | BARR2 | DKFZp686L0365 | arrestin, beta 2 | Reconstituted Complex | BioGRID | 11867621 |
| CGA | CG-ALPHA | FSHA | GPHA1 | GPHa | HCG | LHA | TSHA | glycoprotein hormones, alpha polypeptide | - | HPRD,BioGRID | 10342833 |
| CGB | CGB3 | hCGB | chorionic gonadotropin, beta polypeptide | - | HPRD | 2254302 |
| CHST9 | GALNAC4ST-2 | carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 9 | - | HPRD | 11445554 |
| GIPC1 | C19orf3 | GIPC | GLUT1CBP | Hs.6454 | IIP-1 | MGC15889 | MGC3774 | NIP | RGS19IP1 | SEMCAP | SYNECTIIN | SYNECTIN | TIP-2 | GIPC PDZ domain containing family, member 1 | Affinity Capture-Western Reconstituted Complex Two-hybrid | BioGRID | 14507927 |
| GIPC1 | C19orf3 | GIPC | GLUT1CBP | Hs.6454 | IIP-1 | MGC15889 | MGC3774 | NIP | RGS19IP1 | SEMCAP | SYNECTIIN | SYNECTIN | TIP-2 | GIPC PDZ domain containing family, member 1 | GIPC interacts with hLHR. | BIND | 14507927 |
| GNAI2 | GIP | GNAI2B | H_LUCA15.1 | H_LUCA16.1 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 | - | HPRD | 10493819 |
| GNAS | AHO | C20orf45 | GNAS1 | GPSA | GSA | GSP | MGC33735 | PHP1A | PHP1B | POH | dJ309F20.1.1 | dJ806M20.3.3 | GNAS complex locus | - | HPRD | 10493819 |
| LHB | CGB4 | LSH-B | hLHB | luteinizing hormone beta polypeptide | - | HPRD | 3470775 |
| LHCGR | FLJ41504 | LCGR | LGR2 | LH/CG-R | LH/CGR | LHR | LHRHR | LSH-R | luteinizing hormone/choriogonadotropin receptor | LH/CGr homodimerizes. | BIND | 15889138 |
| SLC9A3R1 | EBP50 | NHERF | NHERF1 | NPHLOP2 | solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 | hLHR interacts with EBP50. | BIND | 14507927 |
| TSHR | CHNG1 | LGR3 | MGC75129 | hTSHR-I | thyroid stimulating hormone receptor | - | HPRD | 1651314 |
Section V. Pathway annotation
| Pathway name | Pathway size | # SZGR 2.0 genes in pathway | Info |
|---|---|---|---|
| KEGG CALCIUM SIGNALING PATHWAY | 178 | 134 | All SZGR 2.0 genes in this pathway |
| KEGG NEUROACTIVE LIGAND RECEPTOR INTERACTION | 272 | 195 | All SZGR 2.0 genes in this pathway |
| PID ARF6 PATHWAY | 35 | 27 | All SZGR 2.0 genes in this pathway |
| REACTOME SIGNALING BY GPCR | 920 | 449 | All SZGR 2.0 genes in this pathway |
| REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS | 305 | 177 | All SZGR 2.0 genes in this pathway |
| REACTOME HORMONE LIGAND BINDING RECEPTORS | 10 | 8 | All SZGR 2.0 genes in this pathway |
| REACTOME GPCR DOWNSTREAM SIGNALING | 805 | 368 | All SZGR 2.0 genes in this pathway |
| REACTOME G ALPHA S SIGNALLING EVENTS | 121 | 82 | All SZGR 2.0 genes in this pathway |
| REACTOME GPCR LIGAND BINDING | 408 | 246 | All SZGR 2.0 genes in this pathway |
| BROWNE HCMV INFECTION 48HR DN | 504 | 323 | All SZGR 2.0 genes in this pathway |
| MATZUK MALE REPRODUCTION SERTOLI | 28 | 23 | All SZGR 2.0 genes in this pathway |
| YOSHIMURA MAPK8 TARGETS UP | 1305 | 895 | All SZGR 2.0 genes in this pathway |
| HOSHIDA LIVER CANCER LATE RECURRENCE DN | 69 | 48 | All SZGR 2.0 genes in this pathway |
| MIKKELSEN ES ICP WITH H3K4ME3 | 718 | 401 | All SZGR 2.0 genes in this pathway |
| SASSON RESPONSE TO GONADOTROPHINS UP | 91 | 59 | All SZGR 2.0 genes in this pathway |
| SASSON RESPONSE TO FORSKOLIN UP | 90 | 58 | All SZGR 2.0 genes in this pathway |
| KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR DN | 88 | 59 | All SZGR 2.0 genes in this pathway |
| KIM ALL DISORDERS CALB1 CORR DN | 37 | 20 | All SZGR 2.0 genes in this pathway |
| FIGUEROA AML METHYLATION CLUSTER 3 UP | 170 | 97 | All SZGR 2.0 genes in this pathway |
| FIGUEROA AML METHYLATION CLUSTER 4 UP | 112 | 64 | All SZGR 2.0 genes in this pathway |
| PANGAS TUMOR SUPPRESSION BY SMAD1 AND SMAD5 DN | 157 | 106 | All SZGR 2.0 genes in this pathway |