Gene Page: LMX1A

Summary
GeneID  4009
Symbol  LMX1A
Synonyms  LMX-1|LMX1|LMX1.1|MGC87616
Description  LIM homeobox transcription factor 1, alpha
See related  HGNC:6653|MIM:600298|Ensembl:ENSG00000162761|HPRD:02623|
Locus tag  -
Gene type  protein-coding
Map location  1q22-q23
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 3 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
ZNF2760.920.92
TYK20.880.87
LRDD0.880.87
TUBGCP60.880.88
RHOT20.870.85
IDUA0.860.86
AC004410.10.860.87
MYO9B0.850.86
GIGYF10.850.87
RTEL10.850.83
Top 10 negatively co-expressed genes
AF347015.31-0.51-0.50
CLEC2B-0.51-0.60
AF347015.21-0.50-0.56
C1orf54-0.49-0.54
GNG11-0.49-0.56
GIMAP2-0.48-0.50
CARD16-0.48-0.51
B2M-0.48-0.44
NMI-0.47-0.49
LY96-0.47-0.56
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003677DNA bindingIEA-
GO:0003700transcription factor activityIEA-
GO:0008270zinc ion bindingIEA-
GO:0046872metal ion bindingIEA-
GO:0043565sequence-specific DNA bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007417central nervous system developmentIEABrain (GO term level: 6)-
GO:0007411axon guidanceIEAaxon (GO term level: 13)-
GO:0045665negative regulation of neuron differentiationIEAneuron (GO term level: 10)-
GO:0006355regulation of transcription, DNA-dependentIEA-
GO:0007275multicellular organismal developmentIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusIEA-
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ISL1Isl-1ISL LIM homeobox 1-HPRD,BioGRID9452425 
LHX3DKFZp762A2013 | LIM3 | M2-LHX3LIM homeobox 3Affinity Capture-Western
Reconstituted Complex		BioGRID9452425 
LMX1ALMX-1 | LMX1 | LMX1.1 | MGC87616LIM homeobox transcription factor 1, alphaReconstituted Complex
Two-hybrid		BioGRID9199284 |9452425 
TCF3E2A | ITF1 | MGC129647 | MGC129648 | bHLHb21transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)Reconstituted Complex
Two-hybrid		BioGRID9199284 
 
Pathway annotation
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
let-7/989149211A,m8hsa-let-7abrainUGAGGUAGUAGGUUGUAUAGUU
hsa-let-7bbrainUGAGGUAGUAGGUUGUGUGGUU
hsa-let-7cbrainUGAGGUAGUAGGUUGUAUGGUU
hsa-let-7dbrainAGAGGUAGUAGGUUGCAUAGU
hsa-let-7ebrainUGAGGUAGGAGGUUGUAUAGU
hsa-let-7fbrainUGAGGUAGUAGAUUGUAUAGUU
hsa-miR-98brainUGAGGUAGUAAGUUGUAUUGUU
hsa-let-7gSZUGAGGUAGUAGUUUGUACAGU
hsa-let-7ibrainUGAGGUAGUAGUUUGUGCUGU
miR-142-5p482488m8hsa-miR-142-5pCAUAAAGUAGAAAGCACUAC
hsa-miR-142-5pCAUAAAGUAGAAAGCACUAC
miR-181191819241Ahsa-miR-181abrainAACAUUCAACGCUGUCGGUGAGU
hsa-miR-181bSZAACAUUCAUUGCUGUCGGUGGG
hsa-miR-181cbrainAACAUUCAACCUGUCGGUGAGU
hsa-miR-181dbrainAACAUUCAUUGUUGUCGGUGGGUU
miR-29157515811Ahsa-miR-29aSZUAGCACCAUCUGAAAUCGGUU
hsa-miR-29bSZUAGCACCAUUUGAAAUCAGUGUU
hsa-miR-29cSZUAGCACCAUUUGAAAUCGGU
miR-324-5p120126m8hsa-miR-324-5pCGCAUCCCCUAGGGCAUUGGUGU
miR-3294084141Ahsa-miR-329brainAACACACCUGGUUAACCUCUUU
miR-3744494551Ahsa-miR-374UUAUAAUACAACCUGAUAAGUG
miR-37717921798m8hsa-miR-377AUCACACAAAGGCAACUUUUGU
hsa-miR-377AUCACACAAAGGCAACUUUUGU
miR-494195201m8hsa-miR-494brainUGAAACAUACACGGGAAACCUCUU
miR-91601661Ahsa-miR-9SZUCUUUGGUUAUCUAGCUGUAUGA
miR-93.hd/291-3p/294/295/302/372/373/5205245301Ahsa-miR-93brainAAAGUGCUGUUCGUGCAGGUAG
hsa-miR-302aUAAGUGCUUCCAUGUUUUGGUGA
hsa-miR-302bUAAGUGCUUCCAUGUUUUAGUAG
hsa-miR-302cUAAGUGCUUCCAUGUUUCAGUGG
hsa-miR-302dUAAGUGCUUCCAUGUUUGAGUGU
hsa-miR-372AAAGUGCUGCGACAUUUGAGCGU
hsa-miR-373GAAGUGCUUCGAUUUUGGGGUGU
hsa-miR-520eAAAGUGCUUCCUUUUUGAGGG
hsa-miR-520aAAAGUGCUUCCCUUUGGACUGU
hsa-miR-520bAAAGUGCUUCCUUUUAGAGGG
hsa-miR-520cAAAGUGCUUCCUUUUAGAGGGUU
hsa-miR-520dAAAGUGCUUCUCUUUGGUGGGUU
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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