Gene Page: LRCH4

Summary
GeneID  4034
Symbol  LRCH4
Synonyms  FLJ40101|FLJ46315|LRN|LRRN1|LRRN4|PP14183|SAP25
Description  leucine-rich repeats and calponin homology (CH) domain containing 4
See related  HGNC:6691|Ensembl:ENSG00000077454|HPRD:10062|
Locus tag  -
Gene type  protein-coding
Map location  7q22
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
HLA-E0.820.85
GGT50.810.83
TINAGL10.790.79
TBX20.780.81
GPER0.780.82
LSR0.770.79
FGR0.770.78
C1QTNF10.770.80
A4GALT0.760.77
GRIN2C0.760.74
Top 10 negatively co-expressed genes
FRG1-0.66-0.73
COQ3-0.63-0.65
C18orf21-0.62-0.65
GNL3-0.61-0.63
DNAJC2-0.61-0.66
C11orf57-0.61-0.71
PAK1IP1-0.60-0.63
HELQ-0.60-0.59
SUPV3L1-0.60-0.64
SRP19-0.60-0.58
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0005515protein bindingIEA-
GO:0016564transcription repressor activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007399nervous system developmentTASneurite (GO term level: 5)9799793 
GO:0016481negative regulation of transcriptionIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005737cytoplasmIEA-
GO:0016605PML bodyIDA16449650 
 
InteractionsShown by Network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
CA8CA-VIII | CALS | CARP | MGC120502 | MGC99509carbonic anhydrase VIIITwo-hybridBioGRID16169070 
MDFII-MF | I-mfaMyoD family inhibitorTwo-hybridBioGRID16189514 
RTN4ASY | NI220/250 | NOGO | NOGO-A | NOGOC | NSP | NSP-CL | Nbla00271 | Nbla10545 | Nogo-B | Nogo-C | RTN-X | RTN4-A | RTN4-B1 | RTN4-B2 | RTN4-Creticulon 4Two-hybridBioGRID16189514 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
DEURIG_T_CELL_PROLYMPHOCYTIC_LEUKEMIA_UP 368234All SZGR genes in this pathway
GINESTIER_BREAST_CANCER_ZNF217_AMPLIFIED_DN 335193All SZGR genes in this pathway
SCIBETTA_KDM5B_TARGETS_DN 8155All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_UP 16911088All SZGR genes in this pathway
MCLACHLAN_DENTAL_CARIES_DN 245144All SZGR genes in this pathway
BANDRES_RESPONSE_TO_CARMUSTIN_WITHOUT_MGMT_48HR_DN 3225All SZGR genes in this pathway
MCLACHLAN_DENTAL_CARIES_UP 253147All SZGR genes in this pathway
AMUNDSON_POOR_SURVIVAL_AFTER_GAMMA_RADIATION_8G 9562All SZGR genes in this pathway
ENGELMANN_CANCER_PROGENITORS_DN 7044All SZGR genes in this pathway
SMID_BREAST_CANCER_NORMAL_LIKE_UP 476285All SZGR genes in this pathway
SENGUPTA_EBNA1_ANTICORRELATED 17385All SZGR genes in this pathway
PEDERSEN_METASTASIS_BY_ERBB2_ISOFORM_7 403240All SZGR genes in this pathway
FOSTER_KDM1A_TARGETS_DN 211119All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-124/5068086m8hsa-miR-506UAAGGCACCCUUCUGAGUAGA
hsa-miR-124brainUAAGGCACGCGGUGAAUGCC
miR-503819825m8hsa-miR-503UAGCAGCGGGAACAGUUCUGCAG
miR-9951021A,m8hsa-miR-9SZUCUUUGGUUAUCUAGCUGUAUGA
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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