Gene Page: MARS

Summary ?
GeneID4141
SymbolMARS
SynonymsCMT2U|ILFS2|ILLD|METRS|MRS|MTRNS|SPG70
Descriptionmethionyl-tRNA synthetase
ReferenceMIM:156560|HGNC:HGNC:6898|Ensembl:ENSG00000166986|HPRD:08864|Vega:OTTHUMG00000169996
Gene typeprotein-coding
Map location12q13.3
Pascal p-value0.125
Sherlock p-value0.193
Fetal beta0.017
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizophreniasClick to show details
NetworkShortest path distance of core genes in the Human protein-protein interaction networkContribution to shortest path in PPI network: 0.0044 

Section I. Genetics and epigenetics annotation

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs10994209chr1061877705MARS41410.14trans

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
AC022100.10.830.82
GLTP0.830.83
ITPKB0.820.83
PRR5L0.820.75
WIPF10.820.82
GPRC5B0.810.80
TTYH20.810.82
KIAA17550.810.71
TJP20.810.83
LDB30.810.76
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
POLB-0.47-0.63
NR2C2AP-0.46-0.61
STMN1-0.46-0.55
MED19-0.44-0.56
FRG1-0.44-0.62
ALKBH2-0.42-0.59
ING4-0.42-0.54
COMMD3-0.42-0.58
STMN2-0.42-0.49
RPL24-0.42-0.66

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000049tRNA bindingIEA-
GO:0000166nucleotide bindingIEA-
GO:0005515protein bindingIPI17353931 
GO:0005524ATP bindingIEA-
GO:0004825methionine-tRNA ligase activityIEA-
GO:0004825methionine-tRNA ligase activityTAS8921912 
GO:0016874ligase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006431methionyl-tRNA aminoacylationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005737cytoplasmIEA-
GO:0005886plasma membraneIDA18029348 

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
BRF2BRFU | FLJ11052 | TFIIIB50BRF2, subunit of RNA polymerase III transcription initiation factor, BRF1-likeAffinity Capture-MSBioGRID17353931 
DARSDKFZp781B11202 | MGC111579aspartyl-tRNA synthetase-HPRD1651330 |9878398 
EPRSDKFZp313B047 | EARS | GLUPRORS | PARS | PIG32 | QARS | QPRSglutamyl-prolyl-tRNA synthetase-HPRD1651330 |9878398 
GIPC1C19orf3 | GIPC | GLUT1CBP | Hs.6454 | IIP-1 | MGC15889 | MGC3774 | NIP | RGS19IP1 | SEMCAP | SYNECTIIN | SYNECTIN | TIP-2GIPC PDZ domain containing family, member 1Affinity Capture-MSBioGRID17353931 
IARSFLJ20736 | IARS1 | ILRS | PRO0785isoleucyl-tRNA synthetase-HPRD1651330 |9878398 
ILKDKFZp686F1765 | P59integrin-linked kinaseAffinity Capture-MSBioGRID17353931 
KARSKARS2 | KIAA0070 | KRSlysyl-tRNA synthetase-HPRD1651330 
LARSFLJ10595 | FLJ21788 | HSPC192 | KIAA1352 | LARS1 | LEURS | LEUS | LRS | PIG44 | RNTLS | hr025Clleucyl-tRNA synthetase-HPRD1651330 |9878398 
MAFKFLJ32205 | MGC71717 | NFE2U | P18v-maf musculoaponeurotic fibrosarcoma oncogene homolog K (avian)-HPRD9878398 
MAPK14CSBP1 | CSBP2 | CSPB1 | EXIP | Mxi2 | PRKM14 | PRKM15 | RK | SAPK2A | p38 | p38ALPHAmitogen-activated protein kinase 14-HPRD9878398 
MCCDKFZp762O1615 | FLJ38893 | FLJ46755 | MCC1mutated in colorectal cancersAffinity Capture-MSBioGRID17353931 
PRKAB1AMPK | HAMPKb | MGC17785protein kinase, AMP-activated, beta 1 non-catalytic subunitAffinity Capture-MSBioGRID17353931 
QARSGLNRS | PRO2195glutaminyl-tRNA synthetase-HPRD1651330 
RARSArgRS | DALRD1 | MGC8641arginyl-tRNA synthetase-HPRD1651330 |9878398 
SCYE1AIMP1 | EMAP-2 | EMAP-II | EMAP2 | EMAPII | p43small inducible cytokine subfamily E, member 1 (endothelial monocyte-activating)-HPRD9878398 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG SELENOAMINO ACID METABOLISM 2618All SZGR 2.0 genes in this pathway
KEGG AMINOACYL TRNA BIOSYNTHESIS 4133All SZGR 2.0 genes in this pathway
REACTOME CYTOSOLIC TRNA AMINOACYLATION 2419All SZGR 2.0 genes in this pathway
REACTOME TRNA AMINOACYLATION 4234All SZGR 2.0 genes in this pathway
NAKAMURA CANCER MICROENVIRONMENT DN 4629All SZGR 2.0 genes in this pathway
SOTIRIOU BREAST CANCER GRADE 1 VS 3 UP 15184All SZGR 2.0 genes in this pathway
GARY CD5 TARGETS UP 473314All SZGR 2.0 genes in this pathway
PUIFFE INVASION INHIBITED BY ASCITES UP 8251All SZGR 2.0 genes in this pathway
CHARAFE BREAST CANCER LUMINAL VS BASAL UP 380215All SZGR 2.0 genes in this pathway
BASAKI YBX1 TARGETS UP 290177All SZGR 2.0 genes in this pathway
OSMAN BLADDER CANCER DN 406230All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS DN 459276All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN 1375806All SZGR 2.0 genes in this pathway
KOKKINAKIS METHIONINE DEPRIVATION 48HR UP 12895All SZGR 2.0 genes in this pathway
KOKKINAKIS METHIONINE DEPRIVATION 96HR UP 11784All SZGR 2.0 genes in this pathway
AMUNDSON RESPONSE TO ARSENITE 217143All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 16521023All SZGR 2.0 genes in this pathway
LIAO METASTASIS 539324All SZGR 2.0 genes in this pathway
BENPORATH ES 1 379235All SZGR 2.0 genes in this pathway
BENPORATH MYC MAX TARGETS 775494All SZGR 2.0 genes in this pathway
SHEPARD CRUSH AND BURN MUTANT UP 197110All SZGR 2.0 genes in this pathway
PENG LEUCINE DEPRIVATION UP 14293All SZGR 2.0 genes in this pathway
SMITH TERT TARGETS UP 14591All SZGR 2.0 genes in this pathway
PENG RAPAMYCIN RESPONSE DN 245154All SZGR 2.0 genes in this pathway
LI WILMS TUMOR VS FETAL KIDNEY 1 DN 163115All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN 1237837All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE INCIPIENT DN 165106All SZGR 2.0 genes in this pathway
MARCHINI TRABECTEDIN RESISTANCE DN 4934All SZGR 2.0 genes in this pathway
KRIGE AMINO ACID DEPRIVATION 2920All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR UP 953554All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR UP 783442All SZGR 2.0 genes in this pathway
HELLER SILENCED BY METHYLATION DN 10567All SZGR 2.0 genes in this pathway
RIZKI TUMOR INVASIVENESS 3D UP 210124All SZGR 2.0 genes in this pathway
ACEVEDO LIVER CANCER UP 973570All SZGR 2.0 genes in this pathway
ACEVEDO LIVER TUMOR VS NORMAL ADJACENT TISSUE UP 863514All SZGR 2.0 genes in this pathway
GRADE COLON AND RECTAL CANCER UP 285167All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL CULTURED VS FRESH UP 425298All SZGR 2.0 genes in this pathway
WEST ADRENOCORTICAL TUMOR UP 294199All SZGR 2.0 genes in this pathway
PODAR RESPONSE TO ADAPHOSTIN UP 14798All SZGR 2.0 genes in this pathway
BLUM RESPONSE TO SALIRASIB UP 245159All SZGR 2.0 genes in this pathway
MOOTHA PGC 420269All SZGR 2.0 genes in this pathway
TOOKER GEMCITABINE RESISTANCE DN 12284All SZGR 2.0 genes in this pathway
SHAFFER IRF4 TARGETS IN MYELOMA VS MATURE B LYMPHOCYTE 10176All SZGR 2.0 genes in this pathway
SHAFFER IRF4 TARGETS IN ACTIVATED B LYMPHOCYTE 8166All SZGR 2.0 genes in this pathway
SHAFFER IRF4 TARGETS IN ACTIVATED DENDRITIC CELL 6549All SZGR 2.0 genes in this pathway
GUTIERREZ CHRONIC LYMPHOCYTIC LEUKEMIA DN 5639All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC 1103714All SZGR 2.0 genes in this pathway
YAO TEMPORAL RESPONSE TO PROGESTERONE CLUSTER 11 10368All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 6HR UP 229149All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS DN 882538All SZGR 2.0 genes in this pathway
WAKABAYASHI ADIPOGENESIS PPARG RXRA BOUND 8D 882506All SZGR 2.0 genes in this pathway
RATTENBACHER BOUND BY CELF1 467251All SZGR 2.0 genes in this pathway
PECE MAMMARY STEM CELL UP 14675All SZGR 2.0 genes in this pathway