Gene Page: ACHE

Summary ?
GeneID43
SymbolACHE
SynonymsACEE|ARACHE|N-ACHE|YT
Descriptionacetylcholinesterase (Yt blood group)
ReferenceMIM:100740|HGNC:HGNC:108|Ensembl:ENSG00000087085|HPRD:00010|Vega:OTTHUMG00000157033
Gene typeprotein-coding
Map location7q22
Pascal p-value4.263E-4
Sherlock p-value0.341
Fetal beta-1.183
DMG2 (# studies)

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Jaffe_2016Genome-wide DNA methylation analysisThis dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 2
DMG:Nishioka_2013Genome-wide DNA methylation analysisThe authors investigated the methylation profiles of DNA in peripheral blood cells from 18 patients with first-episode schizophrenia (FESZ) and from 15 normal controls. 2
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophrenic,schizophrenics,schizotypy,schizophrenias,schizotypalClick to show details
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 5 

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg085609427100492945ACHE-0.0160.91DMG:Nishioka_2013
cg272209687100493724ACHE1.02E-9-0.0131.18E-6DMG:Jaffe_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0017171serine hydrolase activityIDAglutamate (GO term level: 4)3954986 
GO:0042166acetylcholine bindingNASSynap, Neurotransmitter (GO term level: 4)1517212 
GO:0001540beta-amyloid bindingTAS11283752 
GO:0003990acetylcholinesterase activityIMP1517212 
GO:0004104cholinesterase activityIDA1517212 
GO:0004104cholinesterase activityIEA-
GO:0005518collagen bindingIDA12524166 
GO:0016787hydrolase activityIEA-
GO:0042803protein homodimerization activityNAS1517212 
GO:0043237laminin-1 bindingIDA12524166 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007416synaptogenesisTASSynap (GO term level: 6)11283752 
GO:0032223negative regulation of synaptic transmission, cholinergicICneuron, Cholinergic, Synap, Neurotransmitter (GO term level: 9)1517212 
GO:0001507acetylcholine catabolic process in synaptic cleftNASCholinergic, Synap (GO term level: 11)1517212 
GO:0002076osteoblast developmentIEP15454088 
GO:0007155cell adhesionTAS11283752 
GO:0006260DNA replicationTAS11283752 
GO:0008283cell proliferationTAS11283752 
GO:0009611response to woundingTAS11283752 
GO:0007517muscle developmentTAS11283752 
GO:0042982amyloid precursor protein metabolic processTAS12769797 
GO:0050714positive regulation of protein secretionTAS11283752 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0045202synapseIDAneuron, Synap, Neurotransmitter, Glial (GO term level: 2)8460160 
GO:0005794Golgi apparatusIDA15454088 
GO:0005576extracellular regionTAS11283752 
GO:0005605basal laminaNAS16289501 
GO:0016020membraneIEA-
GO:0005886plasma membraneIEA-
GO:0048471perinuclear region of cytoplasmIDA14766237 
GO:0030054cell junctionIEA-
GO:0031225anchored to membraneIEA-

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG GLYCEROPHOSPHOLIPID METABOLISM 7735All SZGR 2.0 genes in this pathway
PID ATF2 PATHWAY 5943All SZGR 2.0 genes in this pathway
REACTOME PHOSPHOLIPID METABOLISM 198112All SZGR 2.0 genes in this pathway
REACTOME SYNTHESIS OF PC 189All SZGR 2.0 genes in this pathway
REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS 8239All SZGR 2.0 genes in this pathway
REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES 186155All SZGR 2.0 genes in this pathway
REACTOME NEURONAL SYSTEM 279221All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF LIPIDS AND LIPOPROTEINS 478302All SZGR 2.0 genes in this pathway
CONCANNON APOPTOSIS BY EPOXOMICIN UP 239157All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 17811082All SZGR 2.0 genes in this pathway
GRAESSMANN RESPONSE TO MC AND DOXORUBICIN DN 770415All SZGR 2.0 genes in this pathway
MOTAMED RESPONSE TO ANDROGEN DN 65All SZGR 2.0 genes in this pathway
EBAUER TARGETS OF PAX3 FOXO1 FUSION UP 207128All SZGR 2.0 genes in this pathway
ROPERO HDAC2 TARGETS 11471All SZGR 2.0 genes in this pathway
SAKAI CHRONIC HEPATITIS VS LIVER CANCER DN 3624All SZGR 2.0 genes in this pathway
MORI SMALL PRE BII LYMPHOCYTE UP 8657All SZGR 2.0 genes in this pathway
KAUFFMANN DNA REPLICATION GENES 14787All SZGR 2.0 genes in this pathway
FERNANDEZ BOUND BY MYC 182116All SZGR 2.0 genes in this pathway
KANG IMMORTALIZED BY TERT DN 10267All SZGR 2.0 genes in this pathway
BLALOCK ALZHEIMERS DISEASE DN 1237837All SZGR 2.0 genes in this pathway
SU SALIVARY GLAND 169All SZGR 2.0 genes in this pathway
KAYO CALORIE RESTRICTION MUSCLE DN 8759All SZGR 2.0 genes in this pathway
JIANG AGING HYPOTHALAMUS DN 4031All SZGR 2.0 genes in this pathway
LEE AGING CEREBELLUM DN 8666All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 48HR DN 504323All SZGR 2.0 genes in this pathway
HILLION HMGA1 TARGETS 9071All SZGR 2.0 genes in this pathway
HILLION HMGA1B TARGETS 9268All SZGR 2.0 genes in this pathway
SANSOM APC MYC TARGETS 217138All SZGR 2.0 genes in this pathway
YOSHIMURA MAPK8 TARGETS UP 1305895All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3K4ME2 491319All SZGR 2.0 genes in this pathway
MIKKELSEN MCV6 HCP WITH H3K27ME3 435318All SZGR 2.0 genes in this pathway
MIKKELSEN IPS WITH HCP H3K27ME3 10276All SZGR 2.0 genes in this pathway
SYED ESTRADIOL RESPONSE 1915All SZGR 2.0 genes in this pathway
DANG BOUND BY MYC 1103714All SZGR 2.0 genes in this pathway
MIKKELSEN MEF HCP WITH H3K27ME3 590403All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 1HR DN 222147All SZGR 2.0 genes in this pathway
DUTERTRE ESTRADIOL RESPONSE 24HR DN 505328All SZGR 2.0 genes in this pathway
ZWANG TRANSIENTLY UP BY 2ND EGF PULSE ONLY 1725838All SZGR 2.0 genes in this pathway

Section VI. microRNA annotation

miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-286736801A,m8hsa-miR-28brainAAGGAGCUCACAGUCUAUUGAG
miR-3707197251Ahsa-miR-370brainGCCUGCUGGGGUGGAACCUGG
miR-503727733m8hsa-miR-503UAGCAGCGGGAACAGUUCUGCAG