Gene Page: ACHE

Summary
GeneID  43
Symbol  ACHE
Synonyms  ARACHE|N-ACHE|YT
Description  acetylcholinesterase (Yt blood group)
See related  HGNC:108|MIM:100740|Ensembl:ENSG00000087085|HPRD:00010|
Locus tag  -
Gene type  protein-coding
Map location  7q22
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 5 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
Top 10 negatively co-expressed genes
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0017171serine hydrolase activityIDAglutamate (GO term level: 4)3954986 
GO:0042166acetylcholine bindingNASSynap, Neurotransmitter (GO term level: 4)1517212 
GO:0001540beta-amyloid bindingTAS11283752 
GO:0003990acetylcholinesterase activityIMP1517212 
GO:0004104cholinesterase activityIDA1517212 
GO:0004104cholinesterase activityIEA-
GO:0005518collagen bindingIDA12524166 
GO:0016787hydrolase activityIEA-
GO:0042803protein homodimerization activityNAS1517212 
GO:0043237laminin-1 bindingIDA12524166 
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007416synaptogenesisTASSynap (GO term level: 6)11283752 
GO:0032223negative regulation of synaptic transmission, cholinergicICneuron, Cholinergic, Synap, Neurotransmitter (GO term level: 9)1517212 
GO:0001507acetylcholine catabolic process in synaptic cleftNASCholinergic, Synap (GO term level: 11)1517212 
GO:0002076osteoblast developmentIEP15454088 
GO:0007155cell adhesionTAS11283752 
GO:0006260DNA replicationTAS11283752 
GO:0008283cell proliferationTAS11283752 
GO:0009611response to woundingTAS11283752 
GO:0007517muscle developmentTAS11283752 
GO:0042982amyloid precursor protein metabolic processTAS12769797 
GO:0050714positive regulation of protein secretionTAS11283752 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0045202synapseIDAneuron, Synap, Neurotransmitter, Glial (GO term level: 2)8460160 
GO:0005794Golgi apparatusIDA15454088 
GO:0005576extracellular regionTAS11283752 
GO:0005605basal laminaNAS16289501 
GO:0016020membraneIEA-
GO:0005886plasma membraneIEA-
GO:0048471perinuclear region of cytoplasmIDA14766237 
GO:0030054cell junctionIEA-
GO:0031225anchored to membraneIEA-
 
Protein-protein InteractionsShown by network
InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
APPAAA | ABETA | ABPP | AD1 | APPI | CTFgamma | CVAP | PN2amyloid beta (A4) precursor protein-HPRD,BioGRID12427014 
COL4A1arrestencollagen, type IV, alpha 1-HPRD12524166 
COLQEADcollagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase-HPRD12609505 
LAMA1LAMAlaminin, alpha 1-HPRD12524166 
LAMB1CLM | MGC142015laminin, beta 1-HPRD15474030 
LGTNHCA56ligatin-HPRD,BioGRID7085778 
PRIMA1PRIMAproline rich membrane anchor 1-HPRD11804574 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
KEGG_GLYCEROPHOSPHOLIPID_METABOLISM 7735All SZGR genes in this pathway
PID_ATF2_PATHWAY 5943All SZGR genes in this pathway
REACTOME_PHOSPHOLIPID_METABOLISM 198112All SZGR genes in this pathway
REACTOME_SYNTHESIS_OF_PC 189All SZGR genes in this pathway
REACTOME_GLYCEROPHOSPHOLIPID_BIOSYNTHESIS 8239All SZGR genes in this pathway
REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES 186155All SZGR genes in this pathway
REACTOME_NEURONAL_SYSTEM 279221All SZGR genes in this pathway
REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS 478302All SZGR genes in this pathway
CONCANNON_APOPTOSIS_BY_EPOXOMICIN_UP 239157All SZGR genes in this pathway
GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN 17811082All SZGR genes in this pathway
GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_DN 770415All SZGR genes in this pathway
MOTAMED_RESPONSE_TO_ANDROGEN_DN 65All SZGR genes in this pathway
EBAUER_TARGETS_OF_PAX3_FOXO1_FUSION_UP 207128All SZGR genes in this pathway
ROPERO_HDAC2_TARGETS 11471All SZGR genes in this pathway
SAKAI_CHRONIC_HEPATITIS_VS_LIVER_CANCER_DN 3624All SZGR genes in this pathway
MORI_SMALL_PRE_BII_LYMPHOCYTE_UP 8657All SZGR genes in this pathway
KAUFFMANN_DNA_REPLICATION_GENES 14787All SZGR genes in this pathway
FERNANDEZ_BOUND_BY_MYC 182116All SZGR genes in this pathway
KANG_IMMORTALIZED_BY_TERT_DN 10267All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN 1237837All SZGR genes in this pathway
SU_SALIVARY_GLAND 169All SZGR genes in this pathway
KAYO_CALORIE_RESTRICTION_MUSCLE_DN 8759All SZGR genes in this pathway
JIANG_AGING_HYPOTHALAMUS_DN 4031All SZGR genes in this pathway
LEE_AGING_CEREBELLUM_DN 8666All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_48HR_DN 504323All SZGR genes in this pathway
HILLION_HMGA1_TARGETS 9071All SZGR genes in this pathway
HILLION_HMGA1B_TARGETS 9268All SZGR genes in this pathway
SANSOM_APC_MYC_TARGETS 217138All SZGR genes in this pathway
YOSHIMURA_MAPK8_TARGETS_UP 1305895All SZGR genes in this pathway
MEISSNER_NPC_HCP_WITH_H3K4ME2 491319All SZGR genes in this pathway
MIKKELSEN_MCV6_HCP_WITH_H3K27ME3 435318All SZGR genes in this pathway
MIKKELSEN_IPS_WITH_HCP_H3K27ME3 10276All SZGR genes in this pathway
SYED_ESTRADIOL_RESPONSE 1915All SZGR genes in this pathway
DANG_BOUND_BY_MYC 1103714All SZGR genes in this pathway
MIKKELSEN_MEF_HCP_WITH_H3K27ME3 590403All SZGR genes in this pathway
BROWNE_HCMV_INFECTION_1HR_DN 222147All SZGR genes in this pathway
DUTERTRE_ESTRADIOL_RESPONSE_24HR_DN 505328All SZGR genes in this pathway
ZWANG_TRANSIENTLY_UP_BY_2ND_EGF_PULSE_ONLY 1725838All SZGR genes in this pathway
miRNA Targets ?
miRNA familyTarget positionmiRNA IDmiRNA seq
UTR startUTR endMatch method
miR-286736801A,m8hsa-miR-28brainAAGGAGCUCACAGUCUAUUGAG
miR-3707197251Ahsa-miR-370brainGCCUGCUGGGGUGGAACCUGG
miR-503727733m8hsa-miR-503UAGCAGCGGGAACAGUUCUGCAG
  • SZ: miRNAs which differentially expressed in brain cortex of schizophrenia patients comparing with control samples using microarray. Click here to see the list of SZ related miRNAs.
  • Brain: miRNAs which are expressed in brain based on miRNA microarray expression studies. Click here to see the list of brain related miRNAs.


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