Gene Page: ASNS

Summary ?
GeneID440
SymbolASNS
SynonymsASNSD|TS11
Descriptionasparagine synthetase (glutamine-hydrolyzing)
ReferenceMIM:108370|HGNC:HGNC:753|Ensembl:ENSG00000070669|HPRD:00153|Vega:OTTHUMG00000022892
Gene typeprotein-coding
Map location7q21.3
Pascal p-value0.435
Sherlock p-value0.915
Fetal beta1.149
DMG1 (# studies)

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Jaffe_2016Genome-wide DNA methylation analysisThis dataset includes 2,104 probes/CpGs associated with SZ patients (n=108) compared to 136 controls at Bonferroni-adjusted P < 0.05. 1
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg12136088797501908ASNS4.08E-9-0.0122.49E-6DMG:Jaffe_2016


Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

Top co-expressed genes in brain regions

Top 10 positively co-expressed genes
GenePearson's Correlation Spearman's Correlation
FOLH10.930.86
ERMN0.920.93
OPALIN0.900.95
DBNDD20.900.92
CAPN30.890.89
TF0.890.93
TMEM1440.890.93
CNDP10.890.88
CLCA40.880.91
APOD0.880.94
Top 10 negatively co-expressed genes
GenePearson's Correlation Spearman's Correlation
NKIRAS2-0.63-0.77
CRMP1-0.60-0.75
HN1-0.60-0.76
KIAA1949-0.60-0.78
TUBB2B-0.60-0.81
C17orf70-0.59-0.74
ZNF821-0.59-0.75
TUBB-0.59-0.76
PODXL2-0.59-0.74
FGD1-0.59-0.73

Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0004066asparagine synthase (glutamine-hydrolyzing) activityEXPglutamate (GO term level: 6)2564390 
GO:0004066asparagine synthase (glutamine-hydrolyzing) activityIDAglutamate (GO term level: 6)2564390 |2569668 |2886907 
|16023613 
GO:0016874ligase activityIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0006529asparagine biosynthetic processIC2564390 
GO:0008652amino acid biosynthetic processIEA-
GO:0008152metabolic processIEA-
GO:0006541glutamine metabolic processIEA-
GO:0043066negative regulation of apoptosisIMP17409444 
GO:0042149cellular response to glucose starvationIDA10085239 
GO:0045931positive regulation of mitotic cell cycleIDA2569668 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005829cytosolEXP2564390 
GO:0005625soluble fractionIDA2564390 

Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
KEGG ALANINE ASPARTATE AND GLUTAMATE METABOLISM 3226All SZGR 2.0 genes in this pathway
KEGG NITROGEN METABOLISM 2316All SZGR 2.0 genes in this pathway
REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES 200136All SZGR 2.0 genes in this pathway
REACTOME DIABETES PATHWAYS 13391All SZGR 2.0 genes in this pathway
REACTOME PERK REGULATED GENE EXPRESSION 2914All SZGR 2.0 genes in this pathway
REACTOME ACTIVATION OF GENES BY ATF4 2612All SZGR 2.0 genes in this pathway
REACTOME UNFOLDED PROTEIN RESPONSE 8051All SZGR 2.0 genes in this pathway
REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION 1714All SZGR 2.0 genes in this pathway
NAKAMURA CANCER MICROENVIRONMENT DN 4629All SZGR 2.0 genes in this pathway
SCHUETZ BREAST CANCER DUCTAL INVASIVE DN 8453All SZGR 2.0 genes in this pathway
IGARASHI ATF4 TARGETS DN 9065All SZGR 2.0 genes in this pathway
GARY CD5 TARGETS UP 473314All SZGR 2.0 genes in this pathway
HOOI ST7 TARGETS UP 9457All SZGR 2.0 genes in this pathway
OSWALD HEMATOPOIETIC STEM CELL IN COLLAGEN GEL DN 275168All SZGR 2.0 genes in this pathway
UDAYAKUMAR MED1 TARGETS UP 13582All SZGR 2.0 genes in this pathway
ODONNELL TFRC TARGETS DN 13976All SZGR 2.0 genes in this pathway
SENESE HDAC3 TARGETS DN 536332All SZGR 2.0 genes in this pathway
TIEN INTESTINE PROBIOTICS 24HR DN 214133All SZGR 2.0 genes in this pathway
KINSEY TARGETS OF EWSR1 FLII FUSION UP 1278748All SZGR 2.0 genes in this pathway
KIM WT1 TARGETS DN 459276All SZGR 2.0 genes in this pathway
DODD NASOPHARYNGEAL CARCINOMA DN 1375806All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA POORLY DIFFERENTIATED UP 633376All SZGR 2.0 genes in this pathway
RODRIGUES THYROID CARCINOMA ANAPLASTIC UP 722443All SZGR 2.0 genes in this pathway
PACHER TARGETS OF IGF1 AND IGF2 UP 3527All SZGR 2.0 genes in this pathway
ENK UV RESPONSE KERATINOCYTE UP 530342All SZGR 2.0 genes in this pathway
CHIARADONNA NEOPLASTIC TRANSFORMATION CDC25 DN 153100All SZGR 2.0 genes in this pathway
GAUSSMANN MLL AF4 FUSION TARGETS C DN 1911All SZGR 2.0 genes in this pathway
SILIGAN TARGETS OF EWS FLI1 FUSION DN 189All SZGR 2.0 genes in this pathway
KAN RESPONSE TO ARSENIC TRIOXIDE 12380All SZGR 2.0 genes in this pathway
DARWICHE SKIN TUMOR PROMOTER DN 185115All SZGR 2.0 genes in this pathway
DARWICHE PAPILLOMA RISK LOW DN 165107All SZGR 2.0 genes in this pathway
DARWICHE PAPILLOMA RISK HIGH DN 180110All SZGR 2.0 genes in this pathway
DARWICHE SQUAMOUS CELL CARCINOMA DN 181107All SZGR 2.0 genes in this pathway
MAHADEVAN RESPONSE TO MP470 UP 2011All SZGR 2.0 genes in this pathway
APPIERTO RESPONSE TO FENRETINIDE DN 5135All SZGR 2.0 genes in this pathway
SCHLOSSER SERUM RESPONSE DN 712443All SZGR 2.0 genes in this pathway
AIYAR COBRA1 TARGETS UP 3925All SZGR 2.0 genes in this pathway
HERNANDEZ ABERRANT MITOSIS BY DOCETACEL 2NM UP 8157All SZGR 2.0 genes in this pathway
HERNANDEZ MITOTIC ARREST BY DOCETAXEL 2 UP 6445All SZGR 2.0 genes in this pathway
XU HGF SIGNALING NOT VIA AKT1 48HR UP 3520All SZGR 2.0 genes in this pathway
AMUNDSON RESPONSE TO ARSENITE 217143All SZGR 2.0 genes in this pathway
OXFORD RALA TARGETS UP 97All SZGR 2.0 genes in this pathway
OXFORD RALA OR RALB TARGETS UP 4823All SZGR 2.0 genes in this pathway
MOHANKUMAR TLX1 TARGETS DN 193112All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 16521023All SZGR 2.0 genes in this pathway
GROSS HYPOXIA VIA ELK3 DN 156106All SZGR 2.0 genes in this pathway
LIAO METASTASIS 539324All SZGR 2.0 genes in this pathway
CAFFAREL RESPONSE TO THC UP 3320All SZGR 2.0 genes in this pathway
CAFFAREL RESPONSE TO THC 24HR 5 DN 5935All SZGR 2.0 genes in this pathway
FUJIWARA PARK2 HEPATOCYTE PROLIFERATION UP 108All SZGR 2.0 genes in this pathway
FUJIWARA PARK2 IN LIVER CANCER DN 55All SZGR 2.0 genes in this pathway
SCHAEFFER PROSTATE DEVELOPMENT 48HR DN 428306All SZGR 2.0 genes in this pathway
PASQUALUCCI LYMPHOMA BY GC STAGE UP 283177All SZGR 2.0 genes in this pathway
NIKOLSKY BREAST CANCER 7Q21 Q22 AMPLICON 7633All SZGR 2.0 genes in this pathway
ONDER CDH1 TARGETS 1 UP 14085All SZGR 2.0 genes in this pathway
ROSS AML WITH PML RARA FUSION 7762All SZGR 2.0 genes in this pathway
BASSO B LYMPHOCYTE NETWORK 14396All SZGR 2.0 genes in this pathway
PENG LEUCINE DEPRIVATION UP 14293All SZGR 2.0 genes in this pathway
LAMB CCND1 TARGETS 1914All SZGR 2.0 genes in this pathway
PENG GLUCOSE DEPRIVATION UP 4826All SZGR 2.0 genes in this pathway
SMITH TERT TARGETS UP 14591All SZGR 2.0 genes in this pathway
JECHLINGER EPITHELIAL TO MESENCHYMAL TRANSITION UP 7151All SZGR 2.0 genes in this pathway
VANTVEER BREAST CANCER METASTASIS DN 12165All SZGR 2.0 genes in this pathway
TARTE PLASMA CELL VS PLASMABLAST DN 309206All SZGR 2.0 genes in this pathway
BYSTRYKH HEMATOPOIESIS STEM CELL QTL TRANS 882572All SZGR 2.0 genes in this pathway
PENG RAPAMYCIN RESPONSE DN 245154All SZGR 2.0 genes in this pathway
ZHAN MULTIPLE MYELOMA CD1 VS CD2 UP 6647All SZGR 2.0 genes in this pathway
MATSUDA NATURAL KILLER DIFFERENTIATION 475313All SZGR 2.0 genes in this pathway
LEI MYB TARGETS 318215All SZGR 2.0 genes in this pathway
LI WILMS TUMOR VS FETAL KIDNEY 1 DN 163115All SZGR 2.0 genes in this pathway
NADLER OBESITY DN 4834All SZGR 2.0 genes in this pathway
HESS TARGETS OF HOXA9 AND MEIS1 UP 6544All SZGR 2.0 genes in this pathway
IVANOVA HEMATOPOIESIS MATURE CELL 293160All SZGR 2.0 genes in this pathway
KAYO AGING MUSCLE UP 244165All SZGR 2.0 genes in this pathway
GAJATE RESPONSE TO TRABECTEDIN UP 6745All SZGR 2.0 genes in this pathway
HENDRICKS SMARCA4 TARGETS DN 5334All SZGR 2.0 genes in this pathway
RODWELL AGING KIDNEY NO BLOOD UP 222139All SZGR 2.0 genes in this pathway
RODWELL AGING KIDNEY UP 487303All SZGR 2.0 genes in this pathway
BROWNE HCMV INFECTION 12HR UP 11168All SZGR 2.0 genes in this pathway
TSENG IRS1 TARGETS UP 11371All SZGR 2.0 genes in this pathway
WENG POR DOSAGE 219All SZGR 2.0 genes in this pathway
SESTO RESPONSE TO UV C7 6844All SZGR 2.0 genes in this pathway
SATO SILENCED BY METHYLATION IN PANCREATIC CANCER 1 419273All SZGR 2.0 genes in this pathway
WENG POR TARGETS LIVER UP 4129All SZGR 2.0 genes in this pathway
KRASNOSELSKAYA ILF3 TARGETS DN 4638All SZGR 2.0 genes in this pathway
KRIGE AMINO ACID DEPRIVATION 2920All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 6HR UP 953554All SZGR 2.0 genes in this pathway
KRIGE RESPONSE TO TOSEDOSTAT 24HR UP 783442All SZGR 2.0 genes in this pathway
CREIGHTON ENDOCRINE THERAPY RESISTANCE 1 528324All SZGR 2.0 genes in this pathway
PELLICCIOTTA HDAC IN ANTIGEN PRESENTATION UP 6440All SZGR 2.0 genes in this pathway
STEIN ESRRA TARGETS UP 388234All SZGR 2.0 genes in this pathway
HELLER SILENCED BY METHYLATION DN 10567All SZGR 2.0 genes in this pathway
POS RESPONSE TO HISTAMINE DN 119All SZGR 2.0 genes in this pathway
POS HISTAMINE RESPONSE NETWORK 3222All SZGR 2.0 genes in this pathway
HUANG FOXA2 TARGETS UP 4528All SZGR 2.0 genes in this pathway
SMID BREAST CANCER BASAL UP 648398All SZGR 2.0 genes in this pathway
BOQUEST STEM CELL CULTURED VS FRESH UP 425298All SZGR 2.0 genes in this pathway
CHO NR4A1 TARGETS 3322All SZGR 2.0 genes in this pathway
PODAR RESPONSE TO ADAPHOSTIN UP 14798All SZGR 2.0 genes in this pathway
CHEN HOXA5 TARGETS 9HR UP 223132All SZGR 2.0 genes in this pathway
CUI GLUCOSE DEPRIVATION 6044All SZGR 2.0 genes in this pathway
BLUM RESPONSE TO SALIRASIB UP 245159All SZGR 2.0 genes in this pathway
TOOKER GEMCITABINE RESISTANCE DN 12284All SZGR 2.0 genes in this pathway
CHAUHAN RESPONSE TO METHOXYESTRADIOL UP 5132All SZGR 2.0 genes in this pathway
VANTVEER BREAST CANCER ESR1 DN 240153All SZGR 2.0 genes in this pathway
AGUIRRE PANCREATIC CANCER COPY NUMBER UP 298174All SZGR 2.0 genes in this pathway
COULOUARN TEMPORAL TGFB1 SIGNATURE UP 10968All SZGR 2.0 genes in this pathway
STEIN ESRRA TARGETS 535325All SZGR 2.0 genes in this pathway
BOYLAN MULTIPLE MYELOMA PCA3 UP 8054All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS OLIGODENDROCYTE NUMBER CORR UP 756494All SZGR 2.0 genes in this pathway
KIM BIPOLAR DISORDER OLIGODENDROCYTE DENSITY CORR UP 682440All SZGR 2.0 genes in this pathway
KIM ALL DISORDERS CALB1 CORR UP 548370All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS GROWING 243155All SZGR 2.0 genes in this pathway
CHICAS RB1 TARGETS CONFLUENT 567365All SZGR 2.0 genes in this pathway
CHYLA CBFA2T3 TARGETS DN 242146All SZGR 2.0 genes in this pathway
JOHNSTONE PARVB TARGETS 3 DN 918550All SZGR 2.0 genes in this pathway
LEE BMP2 TARGETS DN 882538All SZGR 2.0 genes in this pathway
PURBEY TARGETS OF CTBP1 AND SATB1 UP 8752All SZGR 2.0 genes in this pathway
SERVITJA LIVER HNF1A TARGETS UP 13596All SZGR 2.0 genes in this pathway
HUANG GATA2 TARGETS DN 7252All SZGR 2.0 genes in this pathway
KRIEG KDM3A TARGETS NOT HYPOXIA 208107All SZGR 2.0 genes in this pathway
GUILLAUMOND KLF10 TARGETS UP 5139All SZGR 2.0 genes in this pathway
FORTSCHEGGER PHF8 TARGETS UP 279155All SZGR 2.0 genes in this pathway
RAO BOUND BY SALL4 227149All SZGR 2.0 genes in this pathway
ACEVEDO FGFR1 TARGETS IN PROSTATE CANCER MODEL DN 308187All SZGR 2.0 genes in this pathway