Gene Page: MYOD1

Summary ?
GeneID4654
SymbolMYOD1
SynonymsMYF3|MYOD|PUM|bHLHc1
Descriptionmyogenic differentiation 1
ReferenceMIM:159970|HGNC:HGNC:7611|Ensembl:ENSG00000129152|HPRD:01166|Vega:OTTHUMG00000166358
Gene typeprotein-coding
Map location11p15.4
Pascal p-value0.558
Fetal beta-0.185
DMG1 (# studies)
eGeneMyers' cis & trans

Gene in Data Sources
Gene set name Method of gene setDescriptionInfo
CV:PGCnpGenome-wide Association StudyGWAS
DMG:Wockner_2014Genome-wide DNA methylation analysisThis dataset includes 4641 differentially methylated probes corresponding to 2929 unique genes between schizophrenia patients (n=24) and controls (n=24). 1
PMID:cooccurHigh-throughput literature-searchSystematic search in PubMed for genes co-occurring with SCZ keywords. A total of 3027 genes were included.
ExpressionMeta-analysis of gene expressionP value: 1.818 
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: schizophrenia,schizophreniasClick to show details
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 1 

Section I. Genetics and epigenetics annotation

@Differentially methylated gene

ProbeChromosomePositionNearest geneP (dis)Beta (dis)FDR (dis)Study
cg243226231117740430MYOD12.569E-4-0.5460.038DMG:Wockner_2014

@eQTL annotation

SNP IDChromosomePositioneGeneGene Entrez IDpvalueqvalueTSS distanceeQTL type
rs4757560chr1117690161MYOD146540.2cis

Section II. Transcriptome annotation

General gene expression (GTEx)

Not available

Gene expression during devlopment (BrainCloud)

Footnote:
A total of 269 time points ploted, with n=38 fetal samples (x=1:38). Each triangle represents one time point.

Gene expression of temporal and spatial changes (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes the lower 25% and upper 25% of the expression distribution.

No co-expressed genes in brain regions


Section III. Gene Ontology annotation

Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0003705RNA polymerase II transcription factor activity, enhancer bindingTAS1846704 
GO:0003713transcription coactivator activityTAS1846704 
GO:0008134transcription factor bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0007519skeletal muscle developmentTASneuron (GO term level: 8)3175662 
GO:0006357regulation of transcription from RNA polymerase II promoterTAS1846704 
GO:0006468protein amino acid phosphorylationTAS3175662 
GO:0007518myoblast cell fate determinationIEA-
GO:0007517muscle developmentTAS1846704 
GO:0007275multicellular organismal developmentIEA-
GO:0030154cell differentiationIEA-
GO:0045445myoblast differentiationIEA-
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0005634nucleusTAS3175662 
GO:0005667transcription factor complexIEA-

Section IV. Protein-protein interaction annotation

InteractorsAliases BOfficial full name BExperimentalSourcePubMed ID
ASCL3HASH3 | SGN1 | bHLHa42achaete-scute complex homolog 3 (Drosophila)-HPRD11784080 
BHLHB3DEC2 | SHARP-1 | SHARP1 | bHLHe41basic helix-loop-helix domain containing, class B, 3-HPRD12657651 
BHLHB8MIST1 | bHLHa15basic helix-loop-helix domain containing, class B, 8-HPRD9482738 
BTG1-B-cell translocation gene 1, anti-proliferativeBTG1 interacts with MYOD1 (CMD1). This interaction was modeled on a demonstrated interaction between human BTG1 and chicken CMD1.BIND15674337 
CALM1CALML2 | CAMI | DD132 | PHKDcalmodulin 1 (phosphorylase kinase, delta)-HPRD10757985 
CALM2CAMII | PHKD | PHKD2calmodulin 2 (phosphorylase kinase, delta)-HPRD10757985 
CALM3PHKD | PHKD3calmodulin 3 (phosphorylase kinase, delta)-HPRD10757985 
CDC34E2-CDC34 | UBC3 | UBE2R1cell division cycle 34 homolog (S. cerevisiae)-HPRD9710583 
CDK4CMM3 | MGC14458 | PSK-J3cyclin-dependent kinase 4-HPRD,BioGRID10022835 |10601020 
CDKN1CBWCR | BWS | KIP2 | WBS | p57cyclin-dependent kinase inhibitor 1C (p57, Kip2)-HPRD,BioGRID10764802 
CIB2KIP2calcium and integrin binding family member 2-HPRD10764802 
CREBBPCBP | KAT3A | RSTSCREB binding proteinAffinity Capture-Western
Phenotypic Enhancement
Reconstituted Complex		BioGRID9001254 |11463815 
CREBBPCBP | KAT3A | RSTSCREB binding protein-HPRD2176177 |9238849 
|11463815 
CSRP3CLP | CMD1M | CMH12 | CRP3 | LMO4 | MGC14488 | MGC61993 | MLPcysteine and glycine-rich protein 3 (cardiac LIM protein)-HPRD,BioGRID9234731 
ELSPBP1E12 | HE12epididymal sperm binding protein 1Two-hybridBioGRID9242638 
EP300KAT3B | p300E1A binding protein p300-HPRD,BioGRID9001254 
EP300KAT3B | p300E1A binding protein p300p300 interacts with MyoD. This interaction is modelled on a demonstrated interaction between human and mouse p300 and MyoD from mouse and an unspecified species.BIND8621548 
HAND1Hxt | Thing1 | bHLHa27 | eHandheart and neural crest derivatives expressed 1-HPRD10924525 
HDAC1DKFZp686H12203 | GON-10 | HD1 | RPD3 | RPD3L1histone deacetylase 1-HPRD,BioGRID11285237 |11684023 
HEY1BHLHb31 | CHF2 | HERP2 | HESR1 | HRT-1 | MGC1274 | OAF1hairy/enhancer-of-split related with YRPW motif 1-HPRD,BioGRID11279181 
HSP90AA1FLJ31884 | HSP86 | HSP89A | HSP90A | HSP90N | HSPC1 | HSPCA | HSPCAL1 | HSPCAL4 | HSPN | Hsp89 | Hsp90 | LAP2heat shock protein 90kDa alpha (cytosolic), class A member 1-HPRD,BioGRID1406681 
ID1ID | bHLHb24inhibitor of DNA binding 1, dominant negative helix-loop-helix proteinAffinity Capture-Western
Two-hybrid		BioGRID8380166 |9242638 
|9528857 |15029197 
ID2GIG8 | ID2A | ID2H | MGC26389 | bHLHb26inhibitor of DNA binding 2, dominant negative helix-loop-helix protein-HPRD,BioGRID9242638 
ID3HEIR-1 | bHLHb25inhibitor of DNA binding 3, dominant negative helix-loop-helix protein-HPRD,BioGRID8759016 |9242638 
JUNAP-1 | AP1 | c-Junjun oncogene-HPRD,BioGRID1310896 
MDFII-MF | I-mfaMyoD family inhibitorAffinity Capture-Western
Reconstituted Complex
Two-hybrid		BioGRID8797820 
MEF2AADCAD1 | RSRFC4 | RSRFC9myocyte enhancer factor 2A-HPRD8548800|9418854 
MEF2C-myocyte enhancer factor 2CTwo-hybridBioGRID9418854 
MOSMGC119962 | MGC119963 | MSVv-mos Moloney murine sarcoma viral oncogene homolog-HPRD,BioGRID9001211 
MYOD1MYF3 | MYOD | PUM | bHLHc1myogenic differentiation 1Reconstituted ComplexBioGRID9184158 
NCOR1KIAA1047 | MGC104216 | N-CoR | TRAC1 | hCIT529I10 | hN-CoRnuclear receptor co-repressor 1Reconstituted ComplexBioGRID10406466 
NCOR2CTG26 | SMRT | SMRTE | SMRTE-tau | TNRC14 | TRAC-1 | TRAC1nuclear receptor co-repressor 2-HPRD10406466 
NR2F2ARP1 | COUP-TFII | COUPTFB | MGC117452 | SVP40 | TFCOUP2nuclear receptor subfamily 2, group F, member 2-HPRD,BioGRID9826778 
PABPN1OPMD | PAB2 | PABP2poly(A) binding protein, nuclear 1Affinity Capture-WesternBioGRID11371506 
PSMD4AF | AF-1 | ASF | MCB1 | Rpn10 | S5A | pUB-R5proteasome (prosome, macropain) 26S subunit, non-ATPase, 4-HPRD,BioGRID9235903 
RB1OSRC | RB | p105-Rb | pRb | pp110retinoblastoma 1-HPRD,BioGRID8381715 
RORADKFZp686M2414 | MGC119326 | MGC119329 | NR1F1 | ROR1 | ROR2 | ROR3 | RZR-ALPHA | RZRARAR-related orphan receptor A-HPRD,BioGRID9862959 
RXRAFLJ00280 | FLJ00318 | FLJ16020 | FLJ16733 | MGC102720 | NR2B1retinoid X receptor, alpha-HPRD,BioGRID9692544 
SNW1Bx42 | MGC119379 | NCOA-62 | PRPF45 | Prp45 | SKIIP | SKIPSNW domain containing 1Affinity Capture-WesternBioGRID11371506 
SP1-Sp1 transcription factor-HPRD,BioGRID10082523 
SRFMCM1serum response factor (c-fos serum response element-binding transcription factor)-HPRD8617811 
STAT3APRF | FLJ20882 | HIES | MGC16063signal transducer and activator of transcription 3 (acute-phase response factor)-HPRD,BioGRID12947115 
TCF3E2A | ITF1 | MGC129647 | MGC129648 | bHLHb21transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)-HPRD1649701 |9001211 
|9184158 
TCF3E2A | ITF1 | MGC129647 | MGC129648 | bHLHb21transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47)in vitro
in vivo
Reconstituted Complex
Two-hybrid		BioGRID1649701 |9184158 
|9242638 
TCF4E2-2 | ITF2 | MGC149723 | MGC149724 | PTHS | SEF2 | SEF2-1 | SEF2-1A | SEF2-1B | bHLHb19transcription factor 4-HPRD,BioGRID8576241 |8999959 
TWIST1ACS3 | BPES2 | BPES3 | SCS | TWIST | bHLHa38twist homolog 1 (Drosophila)-HPRD9343420 


Section V. Pathway annotation

Pathway namePathway size# SZGR 2.0 genes in pathwayInfo
BIOCARTA HDAC PATHWAY 3225All SZGR 2.0 genes in this pathway
PID SMAD2 3NUCLEAR PATHWAY 8263All SZGR 2.0 genes in this pathway
PID HDAC CLASSIII PATHWAY 2520All SZGR 2.0 genes in this pathway
PID CMYB PATHWAY 8461All SZGR 2.0 genes in this pathway
PID RB 1PATHWAY 6546All SZGR 2.0 genes in this pathway
PID HES HEY PATHWAY 4839All SZGR 2.0 genes in this pathway
REACTOME DEVELOPMENTAL BIOLOGY 396292All SZGR 2.0 genes in this pathway
REACTOME MYOGENESIS 2820All SZGR 2.0 genes in this pathway
DAVICIONI PAX FOXO1 SIGNATURE IN ARMS UP 5938All SZGR 2.0 genes in this pathway
DAVICIONI MOLECULAR ARMS VS ERMS UP 332228All SZGR 2.0 genes in this pathway
DAVICIONI TARGETS OF PAX FOXO1 FUSIONS UP 255177All SZGR 2.0 genes in this pathway
DAVICIONI RHABDOMYOSARCOMA PAX FOXO1 FUSION UP 6437All SZGR 2.0 genes in this pathway
GRAESSMANN APOPTOSIS BY DOXORUBICIN DN 17811082All SZGR 2.0 genes in this pathway
MARKS ACETYLATED NON HISTONE PROTEINS 159All SZGR 2.0 genes in this pathway
PUJANA BRCA1 PCC NETWORK 16521023All SZGR 2.0 genes in this pathway
SCHLESINGER METHYLATED DE NOVO IN CANCER 8864All SZGR 2.0 genes in this pathway
BENPORATH SUZ12 TARGETS 1038678All SZGR 2.0 genes in this pathway
BENPORATH EED TARGETS 1062725All SZGR 2.0 genes in this pathway
BENPORATH ES WITH H3K27ME3 1118744All SZGR 2.0 genes in this pathway
BENPORATH PRC2 TARGETS 652441All SZGR 2.0 genes in this pathway
REN ALVEOLAR RHABDOMYOSARCOMA UP 9864All SZGR 2.0 genes in this pathway
DELASERNA MYOD TARGETS UP 8951All SZGR 2.0 genes in this pathway
JIANG HYPOXIA NORMAL 311205All SZGR 2.0 genes in this pathway
XU GH1 AUTOCRINE TARGETS UP 268157All SZGR 2.0 genes in this pathway
BANDRES RESPONSE TO CARMUSTIN MGMT 48HR DN 161105All SZGR 2.0 genes in this pathway
LOPES METHYLATED IN COLON CANCER UP 2720All SZGR 2.0 genes in this pathway
NIKOLSKY OVERCONNECTED IN BREAST CANCER 2219All SZGR 2.0 genes in this pathway
YAMASHITA METHYLATED IN PROSTATE CANCER 5729All SZGR 2.0 genes in this pathway
GRADE COLON CANCER UP 871505All SZGR 2.0 genes in this pathway
MEISSNER NPC HCP WITH H3 UNMETHYLATED 536296All SZGR 2.0 genes in this pathway
MEISSNER BRAIN HCP WITH H3K27ME3 269159All SZGR 2.0 genes in this pathway
MIKKELSEN MCV6 HCP WITH H3K27ME3 435318All SZGR 2.0 genes in this pathway
MIKKELSEN MEF HCP WITH H3K27ME3 590403All SZGR 2.0 genes in this pathway
MARTENS TRETINOIN RESPONSE UP 857456All SZGR 2.0 genes in this pathway