Gene Page: OPA1

Summary
GeneID  4976
Symbol  OPA1
Synonyms  FLJ12460|KIAA0567|MGM1|NPG|NTG|largeG
Description  optic atrophy 1 (autosomal dominant)
See related  HGNC:8140|MIM:605290|Ensembl:ENSG00000198836|HPRD:05596|
Locus tag  -
Gene type  protein-coding
Map location  3q28-q29|3q28-q29
 
Gene in Data Sources
Gene set name Method of gene set Evidence Info
LiteratureHigh-throughput literature-searchCo-occurance with Schizophrenia keywords: [schizophrenias, schizophrenic, schizophrenia]Click to show detail
GO_AnnotationMapping neuro-related keywords to Gene Ontology annotationsHits with neuro-related keywords: 2 
 
General Gene Expression (microarray) ?
 
Gene Expression in Brain Regions (new)
 
Top co-expressed genes in Brain Regions (new)
GenePearson's Correlation Spearman's Correlation
Top 10 positively co-expressed genes
GPR1830.630.32
CD690.600.23
IL1B0.580.24
S100A90.580.26
CCL30.570.48
C5AR10.560.44
IL80.550.37
RP11-208G20.10.520.25
S100A80.520.23
S100A120.510.21
Top 10 negatively co-expressed genes
GTF2H2-0.19-0.12
ANP32C-0.17-0.11
PCDHA9-0.16-0.06
AL139819.3-0.16-0.17
AC019043.1-0.16-0.15
FAM21B-0.16-0.01
HRCT1-0.16-0.21
GRIN2B-0.16-0.09
PLEC1-0.15-0.08
AC004449.1-0.15-0.05
Gene Ontology
Molecular functionGO termEvidenceNeuro keywordsPubMed ID
GO:0000166nucleotide bindingIEA-
GO:0000287magnesium ion bindingNAS11017080 
GO:0003924GTPase activityTAS11017080 
GO:0005525GTP bindingIEA-
Biological processGO termEvidenceNeuro keywordsPubMed ID
GO:0019896axon transport of mitochondrionTASaxon (GO term level: 9)11017080 
GO:0000266mitochondrial fissionTAS12509422 
GO:0008053mitochondrial fusionTAS12509422 
GO:0007605sensory perception of soundIEA-
GO:0007601visual perceptionIMP11017080 
GO:0007007inner mitochondrial membrane organizationIDA12509422 
GO:0006915apoptosisIEA-
GO:0050896response to stimulusIEA-
GO:0045768positive regulation of anti-apoptosisIDA12509422 
Cellular componentGO termEvidenceNeuro keywordsPubMed ID
GO:0030425dendriteISSneuron, axon, dendrite (GO term level: 6)11847212 
GO:0005739mitochondrionIEA-
GO:0005741mitochondrial outer membraneIDA12504110 
GO:0005758mitochondrial intermembrane spaceISS11847212 
GO:0016020membraneIEA-
GO:0016021integral to membraneIEA-
GO:0030061mitochondrial cristaIDA12504110 
 
Pathway annotation
Pathway namePathway size# SZGR genes in pathwayInfo
PICCALUGA_ANGIOIMMUNOBLASTIC_LYMPHOMA_DN 13686All SZGR genes in this pathway
LIU_SOX4_TARGETS_DN 309191All SZGR genes in this pathway
SLEBOS_HEAD_AND_NECK_CANCER_WITH_HPV_UP 8443All SZGR genes in this pathway
TIEN_INTESTINE_PROBIOTICS_2HR_DN 8853All SZGR genes in this pathway
TIEN_INTESTINE_PROBIOTICS_24HR_UP 557331All SZGR genes in this pathway
HAMAI_APOPTOSIS_VIA_TRAIL_UP 584356All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_DN 855609All SZGR genes in this pathway
DACOSTA_UV_RESPONSE_VIA_ERCC3_COMMON_DN 483336All SZGR genes in this pathway
NUYTTEN_EZH2_TARGETS_DN 1024594All SZGR genes in this pathway
LOCKWOOD_AMPLIFIED_IN_LUNG_CANCER 214139All SZGR genes in this pathway
WEI_MYCN_TARGETS_WITH_E_BOX 795478All SZGR genes in this pathway
GEORGES_TARGETS_OF_MIR192_AND_MIR215 893528All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_DN 1237837All SZGR genes in this pathway
KAAB_HEART_ATRIUM_VS_VENTRICLE_DN 261183All SZGR genes in this pathway
BLALOCK_ALZHEIMERS_DISEASE_INCIPIENT_DN 165106All SZGR genes in this pathway
MARSON_BOUND_BY_E2F4_UNSTIMULATED 728415All SZGR genes in this pathway
STEIN_ESRRA_TARGETS_UP 388234All SZGR genes in this pathway
MARTINEZ_RB1_TARGETS_UP 673430All SZGR genes in this pathway
MARTINEZ_TP53_TARGETS_UP 602364All SZGR genes in this pathway
MARTINEZ_RB1_AND_TP53_TARGETS_UP 601369All SZGR genes in this pathway
BONOME_OVARIAN_CANCER_SURVIVAL_OPTIMAL_DEBULKING 246152All SZGR genes in this pathway
MOOTHA_HUMAN_MITODB_6_2002 429260All SZGR genes in this pathway
MILI_PSEUDOPODIA_HAPTOTAXIS_UP 518299All SZGR genes in this pathway
STEIN_ESRRA_TARGETS 535325All SZGR genes in this pathway
PYEON_CANCER_HEAD_AND_NECK_VS_CERVICAL_UP 19395All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_2_DN 336211All SZGR genes in this pathway
JOHNSTONE_PARVB_TARGETS_3_DN 918550All SZGR genes in this pathway
LEE_BMP2_TARGETS_DN 882538All SZGR genes in this pathway


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